Treatment of sialorrhea in patients. Medical search. Frequent questions

In July 2016, the US Food and Drug Administration (FDA) approved abobotulinumtoxinA (Dysport) for injection for the treatment of lower-limb spasticity in pediatric patients two years of age and older. (wikipedia.org)
[52] [53] AbobotulinumtoxinA is the first and only FDA-approved botulinum toxin for the treatment of pediatric lower limb spasticity. (wikipedia.org)
The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults, particularly in those patients who have underlying conditions that would predispose them to these symptoms. (xeomin360.com)
Botulinum toxin injections in spastic muscles or salivary glands can be very helpful in managing spasticity or sialorrhea/drooling, respectively. (medscape.com)
Pain and spasticity in head and neck cancer patients (7-9). (mypcnow.org)

To quantify the impact of sialorrhea on the QoL of children with CP, as reported by their parents or caregivers. (jhrlmc.com)
The significant numerical values reflecting poor social integration and lowered activity participation underscore the urgent need for comprehensive management strategies to alleviate the impact of sialorrhea. (jhrlmc.com)
Understanding the impact of sialorrhea on individuals with Parkinson's. (britishjournalofcommunitynursing.com)

The first adverse event studied was clozapine-induced sialorrhea (CIS), a common adverse event. (go.jp)
All interventions were for clozapine-induced sialorrhea in subjects with mental disorders. (bvsalud.org)

Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination. (libella.fr)
Chronic migraine patients will meet with a doctor first to determine if botulinum toxin is appropriate for your condition. (uwhealth.org)
The Company's diverse neuroscience portfolio includes approved treatments for epilepsy, migraine, attention-deficit hyperactivity disorder (ADHD), hypomobility in Parkinson's Disease (PD), cervical dystonia, chronic sialorrhea, dyskinesia in PD patients receiving levodopa-based therapy, and drug-induced extrapyramidal reactions in adult patients. (quiverquant.com)

PubMed Central/PsycInfo/Cochrane Central database/Clinicaltrials.gov/WHO-ICTRP and the Chinese Electronic Journal Database (Qikan.cqvip.com) were searched for published/unpublished RCTs of antipsychotic-induced sialorrhea (any definition) in adults, up to 06/12/2023. (bvsalud.org)
ROCKVILLE, Md. , Oct. 25, 2023 (GLOBE NEWSWIRE) -- Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN), a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases, today announced that the Company expects to report financial and business results for the third quarter of 2023 after the market closes on Wednesday, November 8, 2023 . (supernus.com)

Sialorrhea, characterized by uncontrollable drooling, is notably prevalent among children with Cerebral Palsy (CP). (jhrlmc.com)
Sialorrhea in children with cerebral palsy. (jhrlmc.com)

APDA Parkinson's Treatments Botulinum toxin (botox) injections - can they help your symptoms of Parkinson's disease? (apdaparkinson.org)
and Osmolex ER for the treatment of Parkinson's disease and drug-induced extrapyramidal reaction in adult patients. (companieslogo.com)
There are various potential symptoms a patient may experience due to Parkinson's disease. (jfkpdadvocate.com)
In summary, botulinum toxin is a safe and effective treatment option to reduce the frequency and severity of several symptoms of Parkinson's disease. (jfkpdadvocate.com)
If you experience symptoms of cervical dystonia, limb dystonia, sialorrhea, or overactive bladder due to Parkinson's disease, consider asking your physician if treatment with botulinum toxin is an option for you. (jfkpdadvocate.com)
Armstrong MJ, Okun MS. Diagnosis and treatment of Parkinson's disease: a review. (britishjournalofcommunitynursing.com)
NeuroHealing is developing a novel treatment for sialorrhea (drooling or un-controlled salivation), a major non-motor complaint of Parkinson's Disease patients and often described as the major debilitating social problem in many neurological conditions including Cerebral Palsy, ALS, TBI and stroke. (neurohealing.com)
Sialorrhea Randomized trials show BoNT injections into salivary glands are beneficial for sialorrhea from many neurologic conditions (CP, amyotrophic lateral sclerosis, Parkinson's disease, multiple system atrophy, corticobasal degeneration), with results lasting several months (16-18). (mypcnow.org)
Carbidopa and Levodopa tablets, USP are a combination of carbidopa and levodopa for the treatment of Parkinson's disease and syndrome. (nih.gov)
Administration of dopamine is ineffective in the treatment of Parkinson's disease apparently because it does not cross the blood-brain barrier. (nih.gov)

Approval for the treatment of cervical dystonia and glabellar lines followed in 2000 and 2002, respectively. (todaysrdh.com)
There have been post-marketing reports of serious breathing difficulties, including respiratory failure, in patients with cervical dystonia treated with botulinum toxin products. (xeomin360.com)
Cervical dystonia (abnormal neck muscle contractions), sialorrhea (drooling), and some forms of urinary dysfunction such as overactive bladder are FDA-approved uses for botulinum toxin. (jfkpdadvocate.com)
the only FDA-approved pediatric indication is cervical dystonia in patients over age 16. (mypcnow.org)

ROCKVILLE, Md. , Aug. 18, 2020 (GLOBE NEWSWIRE) -- Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN), a pharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases, today reported financial results for the second quarter of 2020 and associated Company developments. (supernus.com)
Recruitment has resumed in the Phase III program in adult patients, after being put on hold in March 2020 due to the impact of the COVID-19 pandemic. (supernus.com)

If treatment doesn't help as expected, we can consider changing your dose or your injection site. (uwhealth.org)
If treatment doesn't help as expected, we could consider changing your dose or your injection site. (uwhealth.org)
Long-term safety and efficacy data on botulinum toxin type A: an injection for sialorrhea. (ucdenver.edu)
Practical Aspects Treatment with BoNTs involves direct, localized injection of a saline solution containing the diluted toxin at the site of intended action (intramuscular or subcutaneous). (mypcnow.org)
Depending on injection site, patient age, and tolerance of the procedure, sedation or even general anesthesia may be required, introducing additional risks. (mypcnow.org)

Metabolic acidosis in these patients is usually refractory to correction with bicarbonate. (wikipedia.org)
D. Sifrim and F. Zerbib, "Diagnosis and Management of Patients with Reflux Symptoms Refractory to Proton Pump Inhibitors," Gut, Vol. 61, No. 9, 2012, pp. 1340-1354. (scirp.org)

Type A botulinum toxin strain was first approved by the FDA under the trade name Botox in 1989 for the treatment of strabismus, blepharospasm, and hemifacial spasms. (todaysrdh.com)

In North America, 20% of dentists are providing Botox as part of comprehensive dental treatment plans for excessive gingival display, orthodontic relapse due to severe muscle movement, sialorrhea, trigeminal neuralgia, hemifacial spasms (HMS), and temporomandibular joint disorders, and oromandibular pain. (todaysrdh.com)
A randomized controlled trial (RCT) suggested that BoNT reduces pain severity and attack frequency in trigeminal neuralgia (13) and should be considered for patients who cannot tolerate other standard treatments due to toxicities. (mypcnow.org)

This salivary gland dysfunction presents a multidimensional challenge to oral health professionals who must be well versed in sialorrhea's causes and progression in order to effectively treatment plan. (dimensionsofdentalhygiene.com)
Botulinum toxin works by reducing the signalling between a nerve and muscle, or in the case of sialorrhea between a nerve and salivary gland. (jfkpdadvocate.com)

Drooling (sialorrhea) is the unintentional loss of saliva from the mouth. (medscape.com)
Drooling is a significant disability for a large number of pediatric and adult patients with cerebral palsy and for a smaller number of patients with other types of neurologic or cognitive impairment. (medscape.com)
Because the lifespan of cerebral palsy patients is often shortened, more than 85% of patients with problems controlling drooling are younger than 21 years. (medscape.com)
Drooling - Likely due to the decreased swallowing rate of patients with PD, sialorrhea, or drooling, can be a feature of the disease. (apdaparkinson.org)
The purpose of this study is to determine the safety and efficacy of Myobloc in ALS patients who are having excessive drooling. (neals.org)
The primary goal of the study is to determine if the patient perceives a benefit from the Myobloc in controlling excessive drooling. (neals.org)
With sialorrhea, we hope to decrease the excess amount of saliva produced by the salivary glands and decrease or eliminate drooling. (jfkpdadvocate.com)

The patient displays excessive, uncontrollable motions that combine slow writhing movements with fast, dance-like muscle contractions. (lazygozo.in)

and Oxtellar XR, an extended release oxcarbazepine for the monotherapy treatment of partial onset epilepsy seizures in adults and children between 6 to 17 years of age. (companieslogo.com)

Most often, oropharyngeal dysphagia occurs in patients with neurologic conditions or muscular disorders that affect skeletal muscles. (msdmanuals.com)

Patients with epilepsy are prescribed anti-seizure drugs. (lazygozo.in)
We are developing a broad range of novel CNS product candidates including new potential treatments for hypomobility in PD, epilepsy, depression, and other CNS disorders. (supernus.com)

There is no surgical treatment for FTD/MND, but consider gastrostomy tube feeding for patients with severe bulbar symptoms, severe dysphagia, and relatively mild dementia and limb weakness. (medscape.com)

NH001 promotes consciousness and improves the functional outcome in patients in a post-traumatic coma, vegetative state or minimally conscious state. (neurohealing.com)
NeuroHealing has designed two clinical trials to study the safety and efficacy of NH001 in accelerating the recovery and improving the functional outcome of post TBI vegetative state and minimally conscious state patients. (neurohealing.com)

Botulinum toxin is also an off-label but common clinical treatment option for limb dystonia. (jfkpdadvocate.com)

2004, Gastroparesis cardinal symptom index (GCSI): Development and validation of a patient reported assessment of severity of gastroparesis symptoms. (accscience.com)

In addition, patients usually show severe hyperventillation due to profound metabolic acidosis mostly related to lactic acidosis. (wikipedia.org)
Real-world and clinical trial data support that clozapine is the only effective antipsychotic for treatment resistant schizophrenia and other severe mental illnesses. (medicscenter.com)
Dr Meyer is an internationally recognised speaker on psychopharmacology and the treatment of severe mental illness, and is Distinguished Fellow of the American Psychiatric Association. (medicscenter.com)

Patients may develop seizures and/or neuropathological spasms. (wikipedia.org)

J. P. Henry, A. Lenaerts and G. Ligny, "Diagnosis and Treatment of Gastroesophageal Reflux in the Adult: Guidelines Recommended by French and Belgian Consensus," Revue Médicale de Bruxelles, Vol. 22, 2001, pp. 27-32. (scirp.org)
therefore, diagnosis is important to patients and families. (medscape.com)
Emergency physicians should be familiar with amyotrophic lateral sclerosis (ALS) and should consider the diagnosis in patients with motor symptoms and signs of hyperreflexia. (medscape.com)
Further information on the diagnosis of and treatment for ALS is available from the European Federation of Neurological Societies . (medscape.com)
Refer patients to a neurologist, preferably a neuromuscular specialist experienced in the diagnosis and treatment of neuromuscular diseases. (medscape.com)
In this review, we summarize the pathophysiological basis, clinical manifestation, diagnosis, and treatment of GI symptoms in patients with PD. (accscience.com)
The diagnosis is a real challenge to the entire professional team, especially if the patient does not reside in endemic areas and also by the vast possibility of differential diagnoses, including the results of laboratory and anatomopathological tests. (bvsalud.org)
The aim of this study is to report a rare case of mucocutaneous leishmaniasis, discussing ways of diagnosis and treatment. (bvsalud.org)

A double-blind, randomized and comparative clinical trial study was designed to characterize the efficacy and safety of a fixed dose combination of magaldrate (800 mg)/dom peridone (10 mg) against domperidone alone (10 mg), in patients with gastroesophageal reflux symptoms. (scirp.org)
Evidence-based management of bruxism is hampered by the limited number of randomized controlled studies available for assessing the efficacy of various treatment strategies, the historical lack of understanding with respect to the etiology of the condition, and the changing diagnostic criteria by which bruxism is defined. (medscape.com)
However, clozapine is underutilized for two reasons: misunderstandings of its efficacy benefits and misapprehension of, limited knowledge or misinformation about the management of treatment related risks and adverse effects. (medicscenter.com)

Botulinum toxin injections can be used as a treatment for migraines and movement disorders. (uwhealth.org)

Botox may be commonly associated with smoothing wrinkles, but the treatments are well-positioned to become the standard of care with multiple dental procedures, including cosmetics, orthodontics, and the management of temporomandibular joint disorders. (todaysrdh.com)
A 2016 study used intramuscular injections of Botox in the masseter muscle and found positive alterations in pain intensity and decreased number of hours and days monthly that patients were affected by TTH. (todaysrdh.com)
Who is Botox treatment for? (uwhealth.org)
Highly trained neurologists provide Botox treatments at UW Health. (uwhealth.org)

For nocturnal sialorrhea, neither benzamides nor atropine outperformed the placebo. (bvsalud.org)

Glycopyrrolate, atropine drops, and scopolamine patches are treatments for sialorrhea. (lazygozo.in)

For patient education information, see the Brain and Nervous System Center , as well as Dementia Overview , Dementia Medication Overview , and Dementia in Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) . (medscape.com)
Similar sounds can occur in patients who are not imminently dying, such as brain injuries or amyotrophic lateral sclerosis (ALS) in which increased production of saliva (sialorrhea), or decreased clearance of secretions occurs. (allfiveoceans.com)
Physical and occupational therapy and speech pathology consultations assist the patient with amyotrophic lateral sclerosis (ALS) in maintaining strength, daily living activities, and communication skills (as demonstrated in the image below). (medscape.com)
Patient with amyotrophic lateral sclerosis (ALS) using eye-gaze computer device to conduct business and communicate. (medscape.com)

A multidisciplinary strategy should be used in the treatment of cerebral palsy. (lazygozo.in)
This activity addresses cerebral palsy evaluation, treatment, and complications and emphasizes the value of a multidisciplinary team approach to managing it. (lazygozo.in)

We identified a standard core set of patient-reported symptoms and health-related quality-of-life (HRQOL) domains to be assessed in head and neck (H&N) cancer clinical trials. (duke.edu)
This core set of 12 H&N-specific, patient-reported symptoms and HRQOL domains should be assessed in future H&N cancer clinical trials. (duke.edu)
Lazarus, H., Fitzmartin, R. D., and Goldenheim, P. D. A multi-investigator clinical evaluation of oral controlled-release morphine (MS Contin tablets) administered to cancer patients. (libella.fr)
Preclinical and development activities are ongoing, with the initiation of the Phase II clinical program in patients with treatment-resistant depression targeted for the second half of 2021. (supernus.com)
To a much lesser extent, some tremors may benefit from treatment with botulinum toxin, though clinical evidence for this is currently lacking. (jfkpdadvocate.com)
In response to worldwide efforts to promote clozapine use, this user-friendly Handbook provides clinicians with evidence-based approaches for patient management, as well as logical approaches to the management of clinical situations and adverse effects. (medicscenter.com)
The first clinical trial, a pilot open-label study, treated patients at two clinical sites with dramatic responses. (neurohealing.com)
Relationship of vitamin D deficiency to clinical outcomes in critically ill patients. (ucdenver.edu)

If a patient with TTH reports a decrease in headache intensity after the management of TMJD, a correlation between the two may be confirmed. (todaysrdh.com)
Although GI symptoms decrease the life quality of patients with PD, there is often less focus on GI symptoms compared with motor symptoms. (accscience.com)

When affecting the oral mucosa, the disease becomes destructive or ulcerovegetative and granulomatous, followed by the presence of rough granulations and deep grooves, typically associated with painful symptoms, swallowing difficulty, sialorrhea, fetid odor and bleeding. (bvsalud.org)
Patient has had a significant burden of disease or impact to activities of daily living due to condition (i.e., impairment in work performance/productivity, frequent change of clothing, difficulty in relationships and/or social gatherings, etc. (exploremyplan.com)
Patients complain of difficulty initiating swallowing, nasal regurgitation, and tracheal aspiration followed by coughing. (msdmanuals.com)

It may be used in functional intestinal disorders to reduce symptoms such as those seen in mild dysenteries, diverticulitis and acute enterocolitis, as an adjunct in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and functional gastrointestinal disorders, and in the treatment of neurogenic bladder and neurogenic bowel disturbances (including the splenic flexure syndrome and neurogenic colon). (empr.com)

Management of sialorrhoea in motor neuron disease: a survey of current UK practice. (ox.ac.uk)
Our objective was to better understand UK-wide practice in managing sialorrhoea in motor neuron disease among specialist clinicians. (ox.ac.uk)
We used a survey of neurologists in the UK with a special interest in motor neuron disease designed to establish clinicians' attitudes towards treatment options and resources for sialorrhoea management. (ox.ac.uk)
Patients with motor neuron disease (MND) are generally free of cognitive impairment, but evidence is growing to support an association between MND and frontal lobe or frontotemporal dementia (FTD). (medscape.com)

Scholars@Duke publication: Recommended patient-reported core set of symptoms to measure in head and neck cancer treatment trials. (duke.edu)
Treatment with botulinum toxins may weaken neck muscles that serve as accessory muscles of ventilation. (xeomin360.com)

Sialorrhea: a guide to etiology, assessment, and management. (jhrlmc.com)

Treatment strategies varied, reflecting the lack of evidence based guidelines. (ox.ac.uk)
Treatment strategies for FTD may apply to FTD/MND, but this is not known for certain. (medscape.com)
Dental teams can use these strategies to encourage medication adherence among patients and avoid possible adverse drug interactions. (dimensionsofdentalhygiene.com)

Clinicians estimated seeing a total of 1391 newly diagnosed patients with MND in 2011. (ox.ac.uk)
Forty-two percent of patients reviewed in clinicians' last clinic had sialorrhoea and 46% of those with sialorrhoea had uncontrolled symptoms. (ox.ac.uk)

1 This is consistent with the Braak hypothesis suggesting that PD patients have Lewy body pathology in autonomic centres and nerves that include the dorsal motor nucleus of the glossopharyngeal and vagal nerves, gastrointestinal submucosal plexus and postganglionic sympathetic nervous system, which is present in the pre-motor stage before nigral involvement. (bmj.com)

Early propranolol treatment induces lung heme-oxygenase-1, attenuates metabolic dysfunction, and improves survival following experimental sepsis. (ucdenver.edu)

Short-Term Treatment with Proton Pump Inhibitors, H2-Receptor Antagonists and Prokinetics for Gastro-Oesophageal Reflux Disease-Like Symptoms and Endoscopy Negative Reflux Disease," Cochrane Database of Systematic Reviews, Vol. 11, 2010, Article ID: CD002095. (scirp.org)
While ALS is a slowly progressive disease, a precipitous event may occur to bring the patient to the emergency department (ED), such as an infection or respiratory compromise. (medscape.com)
No specific medications are available for treatment of Pelizaeus-Merzbacher disease. (medscape.com)
Since, almost all patients with ALS die of their disease, mortality rates for ALS individuals remains constant. (freedissertation.com)
Does a breathlessness intervention service ('CBIS') reduce stress significantly more than usual care in breathless patients with advanced non-malignant disease and their carers? (ctu.co.uk)

Hyoscyamine sulfate is an anticholinergic agent used as adjunctive therapy in the treatment of peptic ulcer. (empr.com)

Patients may require immediate medical attention should they develop problems with swallowing, speech, or respiratory disorders. (xeomin360.com)
This may result in critical loss of breathing capacity in patients with respiratory disorders who may have become dependent upon these accessory muscles. (xeomin360.com)
Patients may present to the ED with either an aspiration event or neuromuscular respiratory failure with CO2 retention. (medscape.com)
Refer to a pulmonologist if respiratory failure is imminent and patient wishes allow. (medscape.com)

The use of XEOMIN in patients with a known hypersensitivity to any botulinum neurotoxin or to any of the excipients (human albumin, sucrose), could lead to a life-threatening allergic reaction. (xeomin360.com)

Food allergic dog and cat patients can represent some of the greatest challenges, but also some of the most rewarding outcomes, in small animal practice. (veterinarypracticenews.com)
ObjectiveThe purpose of this study is to evaluate the effectiveness of oral, intratympanic steroid (IT) and Hyperbaric Oxygen therapy (HBOT) based treatments on hearing outcomes in patients with Sudden sensorineural hearing loss (SSNHL). (ubc.ca)

Compared to other psychiatric disorders, we found a lack of high-quality randomized controlled trials for pharmacological and nonpharmacological treatments. (bvsalud.org)

The company is engaged in developing and commercializing products for the treatment of central nervous system diseases, including neurological and psychiatric disorders. (quiverquant.com)

In addition, magaldrate/domperidone combination improved in a statistically manner the quality of life of patients with gastroesophageal reflux respect to monotherapy , and more patients perceived the combination as a better treatment. (scirp.org)

The number of injections is determined using the PREEMPT protocol and adjusted based on your specific treatment needs. (uwhealth.org)

UW Health offers the most advanced treatments and therapies. (uwhealth.org)
Symptomatic treatments, such as levodopa therapies, may permit the patient better mobility. (nih.gov)

Spasticity5

Impact of Sialorrhea3

Clozapine-induced sialorrhea2

Chronic3

20232

Children with cerebral palsy2

Parkinson's Disease10

Cervical4

20202

Injection5

Refractory2

Blepharospasm1

Trigeminal neuralgia2

Salivary gland2

Drooling7

Muscle contractions1

Adults1

Neurologic1

Epilepsy2

Dysphagia1

Outcome2

Dystonia1

Gastroparesis1

Severe3

Seizures1

Diagnosis8

Efficacy3

Botulinum toxin injections1

Botox4

Nocturnal1

Atropine1

Amyotrophic4

Cerebral2

Clinical8

Decrease2

Difficulty3

Disturbances1

Motor Neuron4

Neck2

Etiology1

Strategies3

Clinicians2

Gastrointestinal1

Dysfunction1

Disease5

Anticholinergic1

Respiratory4

Hypersensitivity to any botulinum1

Outcomes2

Trials1

Disorders1

Quality of L1

Injections1

Therapies2