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  • blood
  • A patient's reaction to treatment is closely monitored by physical exams, blood tests, and other tests. (wsfa.com)
  • Studies comparing bone marrow to PBSC transplantation have shown that PBSCs are associated with a shorter period of neutropenia and red blood cell and platelet transfusion dependence, with an equal probability of acute and chronic GVHD. (hawaii.edu)
  • Pharmacodynamics are measured by measuring proteasome inhibition in peripheral blood mononuclear cells. (wikipedia.org)
  • The much greater sensitivity of myeloma cell lines and mantle cell lines to proteasome inhibition compared with normal peripheral blood mononuclear cells and most other cancer cell lines is poorly understood. (wikipedia.org)
  • the CFU-Hill population is an early outgrowth, formed by plating peripheral blood mononuclear cells on fibronectin-coated dishes, allowing adhesion and depleting non-adherent cells, and isolating discrete colonies. (wikipedia.org)
  • A similar method is to culture the peripheral blood mononuclear fraction in supplemented endothelial growth medium, removing the non-adherent cells, and isolating the remaining. (wikipedia.org)
  • ECFCs are isolated by plating peripheral blood mononuclear fraction on collagen-coated plates, removing non-adherent cells, and culturing for weeks until the emergence of colonies with a distinctive cobblestone morphology. (wikipedia.org)
  • The Worldwide Network for Blood and Marrow Transplantation reported the millionth transplant to have been undertaken in December 2012. (wikipedia.org)
  • In collaboration with Dr . Shahin Raffi in 1994, a bone marrow-derived endothelial progenitor cell was identified and shown to play an important role in the development of the blood supply of developing tumors. (wikipedia.org)
  • PEST stands for Papilledema, evidence of Extravascular volume overload (ascites, pleural effusion, pericardial effusion, and lower extremity edema), Sclerotic bone lesions, and Thrombocytosis/erythrocytosis (i.e. increased in blood platelets and red blood cells). (wikipedia.org)
  • induce
  • Tr1 cells are self or non-self antigen specific and their key role is to induce and maintain peripheral tolerance and suppress tissue inflammation in autoimmunity and graft vs. host disease. (wikipedia.org)
  • dose
  • The side effects of radiation therapy depend on the treatment dose and the part of the body that is treated. (wsfa.com)
  • Therefore, oral mucositis can be a dose-limiting condition, disrupting a patient's optimal cancer treatment plan and consequentially decreasing their chances of survival. (wikipedia.org)
  • endothelial
  • Although bone marrow-derived cells do appear to localize to injured vessels and promote an angiogenic switch, other studies have suggested these cells do not contribute directly to the functional endothelium, instead acting via paracrine methods to provide support for the resident endothelial cells. (wikipedia.org)
  • acute and chronic
  • 2010 Application of HLA-A*0201/WT1 pentamer combined with intracellular IFNgamma+ staining in detecting circulating WT1 specific T cells in leukemia 2010 "Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients", published in Int J Hematol. (wikipedia.org)
  • patient's
  • It is aimed to enable liver regeneration, decrease fibrosis rate, improve patient's health conditions, increase ceruloplasmin synthesis, ameliorate disorder of copper metabolism, decrease the need for chelating agents, increase living standards of patients, and prolong waiting time for liver transplantation. (clinicaltrials.gov)
  • Lymphoma
  • EATL can be classified as an extranodal peripheral T cell lymphoma, a category it shares with hepatosplenic T cell lymphoma and panniculitic T cell lymphoma. (wikipedia.org)
  • The peripheral index for T-cell lymphoma is useful in defining prognosis for enteropathy-associated T-cell lymphoma. (wikipedia.org)
  • Genetic
  • The first somatic treatment that produced a permanent genetic change was performed in 1993. (wikipedia.org)
  • Tragically, this left a waiting list of children with virtually nowhere else in Britain to go for treatment of their genetic diseases and inborn errors. (wikipedia.org)
  • However Professor Hobbs had founded the COrrection of GEnetic diseases by Transplantation or COGENT movement, with a charitable trust which attracted £13 million 1971-2007. (wikipedia.org)
  • regimen
  • Determine the tumor response rate, disease stabilization, best overall response, time to progression, time to treatment failure, and overall survival in patients treated with this regimen. (clinicaltrials.gov)
  • outcomes
  • They are forms of thalassemia caused by reduced or absent synthesis of the beta chains of hemoglobin that result in variable outcomes ranging from severe anemia to clinically asymptomatic individuals. (wikipedia.org)
  • clinical
  • In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission. (wikipedia.org)
  • John Raymond Hobbs MRCS, FRCP, FRCPath, FRCPaed (17 April 1929 - 13 July 2008) was a professor who was at the forefront of the techniques of clinical immunology, protein biochemistry and bone marrow transplantation, specifically in child health. (wikipedia.org)
  • tissue
  • More severe nerve injury like axonotmesis or neurotmesis warrant the repair of the epineurium because the connective tissue is damaged. (wikipedia.org)
  • clonal plasma
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • lesions
  • Clinically, the typical initial presentation of BPDCN is presence of asymptomatic cutaneous lesions that are subsequently followed by bone marrow involvement and leukemic dissemination (5, 10). (czytelniamedyczna.pl)
  • No evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency related to the paraprotein, and No evidence of another B-cell proliferative disorder. (wikipedia.org)
  • lymphocytes
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. (wikipedia.org)
  • It is a life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages, characterised by proliferation of morphologically benign lymphocytes and macrophages that secrete high amounts of inflammatory cytokines. (wikipedia.org)
  • Both forms are characterized by the overwhelming activation of normal T lymphocytes and macrophages, invariably leading to clinical and haematologic alterations and death in the absence of treatment. (wikipedia.org)
  • lymphoid
  • BPDCN are characterized by co-expression of CD4 and CD56 antigens in the absence of any specific myeloid or lymphoid lineage or markers, primary skin infiltrations followed by bone marrow involvement, and aggressive clinical course. (czytelniamedyczna.pl)
  • lupus
  • For example, systemic lupus erythematosus with severe lupus nephritis may respond to pulsed cyclophosphamide. (wikipedia.org)
  • First trimester exposure to cyclophosphamide for the treatment of cancer or lupus displays a pattern of anomalies labeled "cyclophosphamide embryopathy," including growth restriction, ear and facial abnormalities, absence of digits and hypoplastic limbs. (wikipedia.org)
  • Intermittent dosing of cyclophosphamide decreases cumulative drug dose, reduces bladder exposure to acrolein and has equal efficacy to daily treatment in the management of lupus nephritis. (wikipedia.org)
  • Unlike rheumatoid arthritis, lupus arthritis is less disabling and usually does not cause severe destruction of the joints. (wikipedia.org)
  • Systemic
  • Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e. treatments whose efficacy is confined to the anatomic area where they are applied) for cancer such as radiation therapy, surgery or hyperthermia therapy. (wikipedia.org)
  • laboratory
  • Regular and frequent laboratory evaluations are required to monitor kidney function, avoid drug-induced bladder complications and screen for bone marrow toxicity. (wikipedia.org)
  • antibiotics
  • Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. (wikipedia.org)
  • A large meta-analysis of randomized controlled trials found linezolid to be more effective than glycopeptide antibiotics (such as vancomycin and teicoplanin) and beta-lactam antibiotics in the treatment of skin and soft tissue infections (SSTIs) caused by Gram-positive bacteria, and smaller studies appear to confirm its superiority over teicoplanin in the treatment of all serious Gram-positive infections. (wikipedia.org)
  • A 2008 meta-analysis of 18 randomized controlled trials, however, found that linezolid treatment failed as often as other antibiotics, regardless of whether patients had osteomyelitis. (wikipedia.org)
  • No significant difference appears in treatment success rates between linezolid, glycopeptides, or appropriate beta-lactam antibiotics in the treatment of pneumonia. (wikipedia.org)
  • Connective
  • More severe nerve injury like axonotmesis or neurotmesis warrant the repair of the epineurium because the connective tissue is damaged. (wikipedia.org)
  • mild to severe
  • The pain can range from mild to severe cramping or stabbing pain that occurs on both sides of the pelvis, in the lower back and rectal area, and even down the legs. (wikipedia.org)
  • Symptoms vary between people and may be mild to severe. (wikipedia.org)
  • cell
  • We investigated whether AM enhances bone marrow cell-induced angiogenesis. (ahajournals.org)
  • Truly endothelial, BOEC are progeny of a transplantable cell that originates in bone marrow, a putative endothelial progenitor. (jci.org)
  • Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513. (nih.gov)
  • The β -glucan isolated from G. frondosa promotes the recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity [ 18 ]. (hindawi.com)
  • Research into new treatments for spinal cord injuries includes stem cell implantation, engineered materials for tissue support, epidural spinal stimulation, and wearable robotic exoskeletons. (wikipedia.org)
  • Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)
  • G-CSF stem cell transplants are used in treatment of leukemia, lymphoma and multiple myeloma resulting in prolonged remission and, in some cases, cure. (wikipedia.org)
  • In collaboration with Dr . Shahin Raffi in 1994, a bone marrow-derived endothelial progenitor cell was identified and shown to play an important role in the development of the blood supply of developing tumors. (wikipedia.org)
  • symptoms
  • MGUS resembles multiple myeloma and similar diseases, but the levels of antibody are lower, the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, and it has no symptoms or major problems. (wikipedia.org)
  • There is no cure for endometriosis, but a number of treatments may improve symptoms. (wikipedia.org)
  • Surgical removal of endometriosis may be used to treat those whose symptoms are not manageable with other treatments. (wikipedia.org)
  • significantly
  • In vivo , the BMP2/PDLSC group showed significantly more new bone formation and re-osseointegration in peri-implantitis defects compared to the other groups. (celltherapynews.com)
  • It was ultimately determined to be no more effective than normal treatment, and to have significantly higher side effects, including treatment-related death. (wikipedia.org)
  • Thus
  • The problem with Phase II studies was explained thus: If you have a hundred patients and you give them a treatment applicable to all 100, and two are alive after 10 years, that is a 2% absolute survival rate. (wikipedia.org)
  • remission
  • The treating facility in the US was able to find an HLA match for Arjan, but unfortunately the new treatment, was not able to put him in remission which is a necessity for a BMT, and we lost him in Oct 2012 . (change.org)
  • efficacy
  • Cyclophosphamide, used in combination with thalidomide or lenalidomide and dexamethasone has documented efficacy as an off-label treatment of AL amyloidosis. (wikipedia.org)
  • Cancer
  • Gabriel N. Hortobagyi, M.D., Journal of the National Cancer Institute, July 5, 1995 This selection bias makes the treatment look better, because candidates who would have fared better under any condition were selected. (wikipedia.org)
  • Oral mucositis is a common and often debilitating complication of cancer treatment. (wikipedia.org)
  • For most cancer treatment, about 5-15% of patients get mucositis. (wikipedia.org)
  • Therefore, oral mucositis can be a dose-limiting condition, disrupting a patient's optimal cancer treatment plan and consequentially decreasing their chances of survival. (wikipedia.org)
  • In breast cancer, a significant improvement in patient survival was achieved since G-CSF reduced inter-treatment time. (wikipedia.org)
  • 2011: Lifetime Achievement Award, Cancer Research and Treatment Fund 2013: The C. Chester Stock Award, (Memorial Sloan-Kettering Cancer Center) Dr Moore received his Bachelor of Medicine degree in 1963 and his Doctor of Philosophy degree in 1967 from the University of Oxford. (wikipedia.org)
  • rats
  • Daily food intake was reduced, and the stimulatory effect of GHS treatment on feeding was abolished in Tg rats. (jci.org)
  • high
  • Although remarkably high copy number of EBV DNA was detected in PBMCs after completion of the HLH-2004 protocol, rituximab treatment resulted in a dramatic decrease of EBV DNA to undetectable levels. (paperity.org)