Lamin Type AProgeriaNuclear LaminaMuscular Dystrophy, Emery-DreifussAging, PrematureLipodystrophyLaminsNuclear EnvelopeCell Nucleus ShapeWerner SyndromeFarnesyltranstransferaseLamin Type BNuclear ProteinsFibroblastsProtein PrecursorsSkin AbnormalitiesMutationCockayne SyndromeCell NucleusGenetic Diseases, InbornMembrane ProteinsPrenylationCell AgingSyndromeMetalloendopeptidasesProtein PrenylationTrichothiodystrophy SyndromesAgingDisease Models, AnimalRecQ HelicasesLongevityBone Demineralization, PathologicMice, KnockoutEhlers-Danlos SyndromeGalactosyltransferasesPhenotypeProtein Modification, TranslationalOrganelle ShapeContractureDNA RepairExodeoxyribonucleasesMaxillofacial AbnormalitiesAbnormalities, MultipleEndonucleasesDNA DamageSomatotrophsCells, CulturedAtaxia TelangiectasiaBone Diseases, DevelopmentalAlkyl and Aryl TransferasesHeterochromatin