Treatment of depression disease depressive disorder treatment resistant. Medical search. Frequent questions

Psychiatric Obsessive Compulsi Suicidal ideation or behavior Remission Severe Anxiety disorders Children and Adolescents 2020 Recurrent Dysthymia Premenstrual Dysphori Bipolar depression Psilocybin Acute 2019 Adolescents Psychiatry Refractory Mental Disorders Centers for Diseas Antidepressants Psychotherapy Ketamine Breakthrough Therapy Designation Medication Individuals with schizophrenia Chronic Situational Depression Parkinson's Disease Major depressive Therapies Symptoms of major Deep brain stimu Episodes Pharmacological Olanzapine Transcranial Magnetic St Electroconvulsive Therapy Efficacy Biomarkers Antidepressant treatment Schizophrenia and bipolar disorder Clinical trials Outcomes Patients with depression Adjunctive Unipolar Depression Severity Neuropsychiatric Diagnosis Montgomery-Åsbe Alzheimer's Borderline personal Behavioral Economic burden of depression Causes of Treatment-Resistant Esketamine

Among the study's outcomes, the investigators identified psychiatric and nonpsychiatric comorbid conditions, antidepressant treatments, healthcare resource utilization, lost workdays, all-cause mortality, and intentional self-harm. (medpagetoday.com)
In this cohort study, TRD was a common variant of MDD when including patients from both healthcare types [psychiatric or nonpsychiatric], which is associated with a high disease burden for both patients and society," the authors wrote. (medpagetoday.com)
We update these findings using recent data, focusing on MDD alone and accounting for comorbid physical and psychiatric disorders. (psychiatrist.com)
In addition, although recent literature highlights the importance of comorbidities among people with depression, 10 , 11 prior estimates focused on the cost of depression alone, with no attention to the added economic burden from physical and psychiatric comorbidities. (psychiatrist.com)
The first-line psychiatric treatment for schizophrenia is antipsychotic medication. (wikipedia.org)
Amongst these agents, there has been an increased interest in the use of psilocybin for the treatment of numerous psychiatric disorders (2). (researchgate.net)
The association of treatment resistance with physical and psychiatric comorbidities remains unclear in elderly patients with late-onset major depressive disorder (MDD). (psychiatrist.com)
Psychiatric disorders in older primary care patients. (psychiatrist.com)
Despite decades of basic science, clinical neuroscience, and psychiatric research, the pathophysiology of major depression is not well understood ( 2 ). (psychiatryonline.org)
Serotonin Syndrome and MAOIs: Do not use MAOIs intended to treat psychiatric disorders with fluoxetine or within 5 weeks of stopping treatment with fluoxetine. (nih.gov)
Do not use fluoxetine within 14 days of stopping an MAOI intended to treat psychiatric disorders. (nih.gov)
Explore the controversial group of psychiatric medications, the antipsychotics, that are so often used to treat the challenging behavioral symptoms of Alzheimer's disease, in part two of a three-part series. (brightfocus.org)
The antipsychotics are named for their use in treating major psychiatric disorders characterized by symptoms of psychosis, a term derived from Greek roots meaning an abnormal condition of the mind. (brightfocus.org)
This study aimed to estimate the population-attributable risk of psychiatric disorders associated with suicide among Taiwanese youth aged 10-24 years. (cambridge.org)
We used multivariable logistic regression to estimate suicide odds ratios for psychiatric disorders. (cambridge.org)
The population-attributable fractions (PAF) were calculated for each psychiatric disorder. (cambridge.org)
Overall, 44.8% of suicides had a psychiatric disorder, while only 7.9% of the comparisons had a psychiatric disorder. (cambridge.org)
The top three psychiatric conditions of the largest PAFs were major depressive disorder, dysthymia, and sleep disorder. (cambridge.org)
Post-Traumatic Stress Disorder (PTSD) requires trauma, but trauma history is strongly connected with a number of psychiatric disorders. (shroomsdeliverycanada.com)
According to some data, Major Depressive Disorder (MDD) is the psychiatric disorder that develops most frequently after trauma. (shroomsdeliverycanada.com)
Deep learning applications for the classification of psychiatric disorders using neuroimaging data: Systematic review and meta-analysis. (cdc.gov)
We use Electroconvulsive Therapy (ECT) to treat a number of psychiatric conditions, including depression. (massgeneral.org)
The Division of Neurotherapeutics at Mass General focuses on neurotherapeutic interventions for severe, treatment-resistant psychiatric illnesses. (massgeneral.org)
For many years, the initial response to depression treatment has been psychiatric medications and talk therapy. (neurowellnessspa.com)
These programs include partial hospitalization, day treatment, and intensive outpatient programs and are designed to help mitigate acute safety risks and the need for inpatient psychiatric hospitalization. (medscape.com)
Attempts to treat psychiatric disorders with electromagnetism are far from new. (beppemicalleftrigona.com)
By 1840 a 'magneto-electric device', attributed to DuBois Raymond, was being used on patients with psychiatric disorders in Europe and North America. (beppemicalleftrigona.com)
But, within several years of its discovery, non-focal rTMS from circular coils was being delivered to patients with psychiatric disorders. (beppemicalleftrigona.com)
A few years later, however, the treatment of psychiatric disorders with TMS had been transformed by neuroimaging studies and by improved understanding of TMS effects. (beppemicalleftrigona.com)
Off-label use of ketamine, the anesthetic-turned-potential treatment for resistant depression, is soaring in the United States and has many experts in the psychiatric community concerned. (medscape.com)
Clinical Psychiatry, often referred to as mental health or psychiatric medicine, is a medical specialty that focuses on the diagnosis, treatment, and prevention of mental, emotional, and behavioral disorders. (dissertation-help.uk)
Analyzing the role of neuroinflammation in the development of psychiatric disorders. (dissertation-help.uk)
Examining the role of inflammation in the pathophysiology of neurodegenerative disorders and its implications for psychiatric symptoms. (dissertation-help.uk)
Exploring the use of psychedelic-assisted therapy in treating various psychiatric disorders. (dissertation-help.uk)
Exploring the interplay of psychiatric disorders and anesthetic considerations in clinical psychiatry and clinical anesthesiology . (dissertation-help.uk)
Electroconvulsive therapy (ECT) has been demonstrated to be an effective and safe treatment for many psychiatric disorders. (medscape.com)
Toxoplasma gondii infection is present and increases the possibility of developing schizophrenia and depression in Lemus Buitrago LF, Osegueda Asencio DJ, individuals with no previous history, including the ability to worsen previous psychiatric conditions, making it difficult for Fuentes Rodríguez VC. (bvsalud.org)

Acute management of anxiety disorders, obsessive-compulsive disorder, and specific phobias through antidepressant use. (appi.org)
Her passion and expertise include treatment of severe, medication-resistant Major Depressive Disorders and Obsessive-Compulsive Disorder. (eastsidetmswellness.com)

This year, its label was expanded to include an indication for major depressive disorder with suicidal ideation or behavior based on the phase III ASPIRE studies . (medpagetoday.com)
The drug's indication was expanded in 2020 to include major depressive disorder and acute suicidal ideation or behavior. (medscape.com)

Response speed and rate of remission in primary and specialty care of elderly patients with depression. (psychiatrist.com)
Participants in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study who achieved remission after 12 weeks of treatment withcognitive behavior therapy, duloxetine, or. (researchgate.net)
6,7 The unstable remission rate could be due to multiple factors, including increased previous depressive episodes, high anxiety levels, medical burden, or neurodegenerative illness. (psychiatrictimes.com)
Furthermore, older adults with LLD tend to have a poor response to treatment with antidepressants, with the remission rates ranging between 55% and 81% in a first-line trial of selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs). (psychiatrictimes.com)
Difficult-to-treat depression: A clinical and research roadmap for when remission is elusive. (sheppardpratt.org)
For those not achieving remission, additional treatment steps are often required. (medscape.com)
5,6 Achieving and sustaining complete remission early in the treatment sequence is a crucial goal for patients with MDD. (ahdbonline.com)
While the agents in current use help many patients, more than half of those treated fail to achieve remission and are resistant to treatment with a first-line antidepressant. (uspharmacist.com)
Subjects took an average of nearly 6 weeks to respond, and about 7 weeks to achieve remission from depressive symptoms. (uspharmacist.com)
When Someone does not experience remission from major depression, we need to ask ourselves why, and come up with new solutions. (shrinksinsneakers.com)
From the STAR*D study we know that only 50% of patients respond to the first antidepressant treatment and only 33% achieve remission. (shrinksinsneakers.com)
According to Usona, the short-acting drug could impart profound alterations in consciousness and could enable long-term remission of depressive symptoms. (pharmaphorum.com)

In United Kingdom and Australia it is approved for schizophrenia, moderate to severe manic episodes, alone, or in combination with lithium or valproate and the short-term treatment of acute manic episodes associated with Bipolar I Disorder. (wikipedia.org)
17 Thus, a PHQ-9 score of 10 or greater usually indicates that the depressive symptoms are severe enough to initiate a medication or treatment alteration. (psychiatrictimes.com)
Vagus Nerve Stimulation: Changing the Paradigm for Chronic Severe Depression? (sheppardpratt.org)
Compared with 2017-2018 National Health and Nutrition Examination Survey data, adults reported a significant uptick in mild, moderate, and severe major depressive symptoms this year. (medpagetoday.com)
Someone with more severe overall depression scores may perform better at work than someone with perceived cognitive dysfunction from depression. (shrinksinsneakers.com)
Since then, psilocybin's use as a treatment for anxiety and depression in end-of-life care, alcoholism, tobacco addiction, severe depression, and treatment-resistant depression has shown positive early safety and efficacy findings. (shroomsdeliverycanada.com)
The Intravenous (IV) Ketamine Clinic for Depression at Massachusetts General Hospital offers patients and their professional providers access to ketamine treatment for severe and refractory depression. (massgeneral.org)
In mild cases, psychosocial interventions are often recommended as first-line treatments, whereas in the more severe cases, medication in addition to psychotherapeutic intervention is often recommended. (medscape.com)
In 2017, Sanacora, who also is director of the Yale Depression Research Program at the Yale School of Medicine, was the lead author of a consensus statement that sought to help physicians administer ketamine safely and appropriately in patients with severe depression and other mood disorders. (medscape.com)
Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities. (msdmanuals.com)
Depressive Disorders in Children and Adolescents Depressive disorders are characterized by sadness or irritability that is severe or persistent enough to interfere with functioning or cause considerable distress. (msdmanuals.com)
have severe liver disease. (who.int)

Olanzapine has been shown to be helpful in addressing a range of anxiety and depressive symptoms in individuals with schizophrenia and schizoaffective disorders, and has since been used in the treatment of a range of mood and anxiety disorders. (wikipedia.org)
27,189 patients with late-onset MDD were included, among whom 16.6% had the diagnosis of anxiety disorders, 1.5% had alcohol use disorders, and 1.6% had substance use disorder. (psychiatrist.com)
High occurrence of mood and anxiety disorders among older adults: The National Comorbidity Survey Replication. (psychiatrist.com)
The impact of depression is greatest for those who do not benefit from standard treatments," said -Michael E. Thase, MD, Professor of Psychiatry and Director of the Mood and Anxiety Disorders Treatment and Research Program, Perelman School of Medicine, University of Pennsylvania, and a principal investigator of esketamine. (ahdbonline.com)
Other areas of expertise include treating medically stable eating disorders, anxiety disorders, bipolar disorder, and borderline personality disorder. (eastsidetmswellness.com)
Assessing the efficacy of exercise as an adjunctive treatment for anxiety disorders in a clinical population. (dissertation-help.uk)
He conducts clinical and translational research aimed at understanding the biological basis of mood and anxiety disorders in order to point the way towards new, more effective treatments. (va.gov)
In addition to his research and educational activities, Dr. Murrough oversees a clinical program at Mount Sinai focused on evidence-based treatments for treatment-resistant depression and other refractory forms of mood and anxiety disorders. (va.gov)

Current evidence-supported interventions include cognitive-behavioral therapy (CBT), pharmacotherapy, or a combination of both should be offered as treatment for children and adolescents with major depressive disorder (MDD). (medscape.com)
Cognitive-behavioral therapy has been shown in multiple randomized clinical trials to be effective in the treatment of mild-to-moderate MDDs in children and adolescents. (medscape.com)
[ 47 ] More studies that compare the complementary and differential effects of the various types of psychotherapy in children and adolescents with depression are needed. (medscape.com)
A Cochrane Database of Systematic Reviews study found that both targeted and universal depression prevention programs may effectively prevent the onset of depressive disorder in children and adolescents when compared with no intervention. (medscape.com)
Alert Lurasidone (Latuda) Gets FDA Nod for Bipolar Depression in Kids Lurasidone is now indicated for the treatment of major depressive episodes associated with bipolar I disorder in children and adolescents aged 10 to 17 years. (medscape.com)

NEW YORK , June 26, 2020 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company developing novel therapies for the management of central nervous system (CNS) disorders, today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation for AXS-05 for the treatment of Alzheimer's disease (AD) agitation. (gcs-web.com)
In 2020, Health Canada began granting exemptions under the Controlled Drugs and Substances Act to provide psychedelics treatment to patients suffering from end-of-life psychological distress, treatment-resistant depression and major depressive disorder. (canadapsilocybin.com)

Recurrent episodes in major depressive disorder (MDD) are common but the neuroimaging features predictive of recurrence are not established. (researchgate.net)
6,7 The median time to a recurrent depressive episode tends to be short in LLD. (psychiatrictimes.com)
In 2000, Berman et al published the first double-blind, placebo-controlled, crossover trial evaluating the use a single dose of 0.5 mg/kg ketamine over 40 minutes in eight patients with recurrent unipolar major depression and one with bipolar disorder, which showed progressive decreases in depressive symptoms within 3 days of treatment. (uspharmacist.com)
Epilepsy is a brain disorder characterized by brief, recurrent disturbances in the normal electri cal functions of the brain that result in seizures. (cdc.gov)

The economic burden of depression in the United States-including major depressive disorder (MDD), bipolar disorder, and dysthymia-was estimated at $83.1 billion in 2000. (psychiatrist.com)
2,3 The economic burden of depression, including MDD, bipolar disorder, and dysthymia, has also increased from an estimated $83.1 billion in 2000 to $210.5 billion in 2010. (uspharmacist.com)
Our findings of high PAF from major depressive disorder, dysthymia, and sleep disorder to youth suicides suggest that youth suicide prevention that focuses on detecting and treating mental illness may usefully target these disorders. (cambridge.org)

Alexa has extensive experience treating multiple forms of depression including Medication Resistant Depression, Post Partum Depression, Major Depression, Situational Depression, Premenstrual Dysphoric Disorder, and Persistent Depressive Disorder. (eastsidetmswellness.com)
It is also marketed for the treatment of premenstrual dysphoric disorder (Sarafem ® , fluoxetine hydrochloride). (rxlist.com)

It is recommended in combination with fluoxetine as a first-line therapy for acute bipolar depression, and as a second-line treatment by itself for the maintenance treatment of bipolar disorder. (wikipedia.org)
The Network for Mood and Anxiety Treatments recommends olanzapine as a first-line maintenance treatment in bipolar disorder and the combination of olanzapine with fluoxetine as second-line treatment for bipolar depression. (wikipedia.org)
A 2014 meta-analysis concluded that olanzapine with fluoxetine was the most effective among nine treatments for bipolar depression included in the analysis. (wikipedia.org)
Use of selective serotonin reuptake inhibitors, MAOIs, and tricyclic antidepressants in major depressive disorder, bipolar depression, psychotic depression, and treatment-resistant depression. (appi.org)
8 Ketamine has generated significant interest in the treatment of MDD, bipolar depression, and in depression with suicidal ideation after the publication of a number of studies demonstrating its rapid-acting antidepressant effect following low IV doses. (uspharmacist.com)

Although not yet FDA approved, new JAMA Psychiatry research suggested synthetic psilocybin -- the compound naturally occurring in magic mushrooms -- may be a promising treatment for major depressive disorder. (medpagetoday.com)
In November 2019, the FDA granted Breakthrough Therapy Designation for psilocybin in the treatment of major depressive disorder. (medpagetoday.com)
The Food and Drug Administration has designated psilocybin- and 3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy as "breakthrough therapies" for the treatment of refractory MDD and PTSD, respectively. (shroomsdeliverycanada.com)
The use of psilocybin in several phase 2 multi-site clinical trials for the treatment of major depressive disorder (MDD) and treatment-resistant depression (TRD) is also now being conducted (listed down below). (shroomsdeliverycanada.com)
The largest of them, conducted in Europe and North America, is a major multicenter randomized controlled phase 2b trial of single doses of psilocybin administered to patients with treatment-resistant depression. (shroomsdeliverycanada.com)
The FDA has tagged psilocybin, the illegal psychoactive compound found in 'magic mushrooms', as a potential breakthrough treatment for major depressive disorder. (pharmaphorum.com)
A US-based non-profit medical research organisation, the Usona Institute, is developing psilocybin to treat major depressive disorder (MDD), and has just launched a phase 2 trial. (pharmaphorum.com)
In October last year the FDA granted COMPASS Pathways' psilocybin-based drug the same status in treatment-resistant depression - but the indication suggested in this case is broader and would allow for earlier treatment. (pharmaphorum.com)
Although there are several existing MDD treatments, Usona said the Breakthrough Therapy Designation recognises that psilocybin may offer a clinically significant improvement over these therapies. (pharmaphorum.com)
In the UK, the Medical Research Council backed the proof-of-concept study of psilocybin for treatment-resistant depression at Imperial College London in 2015. (pharmaphorum.com)
We are dedicated to automating and facilitating the process for Canadian patients who wish to use psilocybin as a treatment modality. (canadapsilocybin.com)
Psilocybin is showing promising results in clinical trials where it's being used to treat mental health disorders such as treatment resistant depression, anxiety, PTSD, substance abuse issues. (canadapsilocybin.com)

It is approved by FDA for the following indications: schizophrenia Acute treatment of manic or mixed episodes associated with bipolar I disorder and maintenance treatment of bipolar I disorder. (wikipedia.org)
Olanzapine is recommended by the National Institute for Health and Care Excellence as a first-line therapy for the treatment of acute mania in bipolar disorder. (wikipedia.org)
It is being developed for the acute treatment of migraine and has demonstrated positive results in clinical trials. (sickeconomics.com)
AXS-07 has received a Breakthrough Therapy designation from the FDA for the acute treatment of migraine. (sickeconomics.com)
Psychotherapy appears to be a useful initial acute treatment for mild-to-moderate depression. (medscape.com)

To put this into context, comparative data from the 2019 National Health Interview Survey reported that only 18.5% of American adults had major depressive symptoms prior to the pandemic. (medpagetoday.com)
First approved in March 2019, the nasal spray used as an adjunct with an oral antidepressant was originally indicated for treatment-resistant depression. (medpagetoday.com)
2019), it's surprising that the idea of treatment resistance primarily considers a pharmacological standpoint. (psychologytoday.com)
Chief among these was the 2019 FDA approval of esketamine, a nasal formulation of ketamine, for the treatment of resistant depression. (medscape.com)
METHODS: Data from US patients treated with BPaL between 14 October 2019 and 30 April 2022 were compiled and analyzed by the BPaL Implementation Group (BIG), including baseline examination and laboratory, electrocardiographic, and clinical monitoring throughout treatment and follow-up. (cdc.gov)
In this cohort, effective treatment required less than half the duration recommended in 2019 US guidelines for drug-resistant tuberculosis. (cdc.gov)
Comorbidities and clinical outcomes in adult- and juvenile-onset Huntington's disease: a study of linked Swedish National Registries (2002-2019). (lu.se)

Brent et al reported that individual supportive treatment was considerably less efficacious than CBT in adolescents who were depressed. (medscape.com)
Assessing the effectiveness of school-based mental health programs in reducing anxiety and depression in adolescents. (dissertation-help.uk)
Mood disorders can occur in adults, adolescents, or children. (msdmanuals.com)

The esketamine Phase 2 clinical trial data presented by Janssen in May 2016 at the Society of Biological Psychiatry 71st Annual Scientific Meeting in Atlanta, Georgia, provided preliminary clinical evidence to support the Breakthrough Therapy Designation for major depressive disorder with imminent risk for suicide. (jnj.com)
She worked as a Registered Nurse at the University of Iowa in inpatient psychiatry with a focus on eating and mood disorders, and outpatient with Electroconvulsive Therapy (ECT). (eastsidetmswellness.com)
Pharmacological agents weren't the only advancements seen this year, as an accelerated, high-dose transcranial magnetic stimulation therapy helped significantly reduce symptoms of treatment-resistant depression in a small study reported in the American Journal of Psychiatry . (medpagetoday.com)
Earlier this year, the ASPREE trial published in JAMA Psychiatry found that low-dose aspirin was of no help in preventing depression among older adults. (medpagetoday.com)
Psychiatry is really art based in science and if you try to approach mental health treatment from a strictly scientific basis you will never help anyone. (shrinksinsneakers.com)
Psychiatry is actively testing a unique treatment strategy called drug-assisted psychotherapy, which combines pharmacological and psychological techniques. (shroomsdeliverycanada.com)
Experts from the Department of Neurology , Department of Neurosurgery , Department of Psychiatry , the Athinoula A. Martinos Center for Biomedical Imaging and beyond develop and implement neurotherapeutics and associated diagnostics for individuals with complex brain disorders affecting cognition, behavior, emotion, sensory and motor functioning. (massgeneral.org)
Our expert care team offers a range of effective treatments, including in-network psychiatry , transcranial magnetic stimulation (TMS) , and Spravato , to help address each patient's unique symptoms and health goals. (neurowellnessspa.com)
Dr. Murrough is Associate Professor of Psychiatry and Neuroscience, Director of the Depression and Anxiety Center for Discovery and Treatment , faculty member of the Friedman Brain Institute, and a primary principal investigator of the Center of Excellence in Neuropharmacology, all at the Icahn School of Medicine at Mount Sinai. (va.gov)
The time has come to ask if we have invented a science (psychiatry) that has little to do with reality, and to answer that, the creation of multicentric data bases is proposed, in which biological (not just brain based), social, personal, clinical, etc. variables are integrated, to finally obtain correlations that allow us a reclassification of brain pathology that would be useful to offer integral and personalized treatments. (bvsalud.org)

Treatment-resistant (refractory) depression has been a fertile topic for several decades (e.g. (psychologytoday.com)
In 1996, Thase wrote, "The role of personality disorders in the management of chronic, treatment-refractory depressive states is one of the least studied, yet more interesting topics in the treatment of mood disorder . (psychologytoday.com)

1. Depression and Other Common Mental Disorders. (psychiatrist.com)
mental health problems, including substance-use disorders, are associated with increased risk of HIV infection and AIDS and interfere with their treatment, and conversely some mental disorders occur as a direct result of HIV infection. (who.int)
Besides these behavioural risks, mental disorders may also interfere with the ability to acquire and/or use information about HIV/AIDS and thus to practise safer behaviours or increase the likelihood of situations occurring in which risk behaviours are more common. (who.int)
A narrative bibliographic review article was done with the search of original and review articles in international scientific mentales en adultos journals, in English and Spanish listing the relationship between the seroprevalence of T. gondii and the development of mental disorders in the adult population. (bvsalud.org)

Centers for Disease Control and Prevention. (cdc.gov)

Treatment-resistant depression (TRD) was defined as unresponsiveness to at least 2 antidepressants, and treatment-resistant tendency (TRT) was defined as unresponsiveness to the first antidepressant. (psychiatrist.com)
1 Among patients who receive treatment, approximately 30% have treatment-resistant depression (ie, an inadequate response to ≥2 different antidepressants at adequate dosing and duration during a depressive episode). (ahdbonline.com)
Pharmacologic treatments for MDD include 1 or more antidepressants, including serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), atypical antidepressants, tricyclics, tetracyclics, and monoamine oxidase inhibitors (MAOIs), among others. (ahdbonline.com)
The second book in the Evidence-Based Guides series, The Evidence-Based Guide to Antidepressant Medications, provides a clear reference to the current knowledge and evidence base for the use of antidepressants among a variety of patients across a wide range of disorders. (appi.org)
Understand the principles of safe prescribing of antidepressants, especially the newer second-generation selective serotonin reuptake inhibitors (SSRI), serotonin norepinephrine reuptake inhibitors (SNRI), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs) in older adults with depression. (mhmedical.com)
While there appears to be no definitive, standardized definition for treatment resistant-depression (TRD), it is generally accepted as failure to respond to at least two adequate trials of different classes of antidepressants, an adequate trial being defined as an adequate dose given for an adequate duration (i.e., 6 or 8 weeks). (uspharmacist.com)
The FDA has also approved a new nasal spray called esketamine (Spravato) for treatment-resistant depression, which can be taken alongside oral antidepressants under supervision from your doctor. (healthyplace.com)

In addition, 46.2% (n=5907) of patients received psychotherapy at some point before initiation of their third treatment. (medpagetoday.com)
Some researchers have begun investigating the efficacy of psychotherapy in conjunction with pharmacology for treatment-resistant depression cases. (psychologytoday.com)
They found that the former was more efficacious, and opined that psychotherapy should be included in treatment-resistant depression guidelines. (psychologytoday.com)
You may need to try other medications, attend psychotherapy, go to support groups or ask your doctor about neurostimulation treatments like electroconvulsive therapy (ECT) or vagus nerve stimulation (VNS) . (healthyplace.com)
The TMS Clinical Service at Massachusetts General Hospital provides non-invasive treatment for patients with major depressive disorder who are unable to find relief through antidepressant medications or psychotherapy. (massgeneral.org)
Psychodynamic psychotherapy, interpersonal therapy (IPT), cognitive-behavioral therapy (CBT), behavior therapy, family therapy, supportive psychotherapy, and group psychotherapy have all been used for the treatment of youths with MDD. (medscape.com)
Treatment usually consists of medications, psychotherapy, or both and sometimes electroconvulsive therapy (ECT) or rapid transcranial magnetic stimulation (rTMS). (msdmanuals.com)

Research continues to delineate the most effective role for ketamine in depression, and how its use might foster the development of similar agents with a longer duration. (uspharmacist.com)
In a scenario where enthusiasm for the drug is larger than the body of evidence supporting its clinical use, support is growing for the creation of a ketamine registry to collect data on dosage, treatment frequency, adverse events, and long-term outcomes in patients receiving the therapy for depression and other mental health conditions. (medscape.com)
Research now suggests ketamine reduces symptoms in patients with treatment-resistant depression (TRD). (medscape.com)
Studies linking ketamine to relief of depressive symptoms are small and mostly retrospective, and none has offered longitudinal information on long-term outcomes, including side effects and the risk of addiction. (medscape.com)

TITUSVILLE, N.J., Aug. 16, 2016 - Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, announced today that the U.S. Food and Drug Administration (FDA) has granted a Breakthrough Therapy Designation for esketamine, an investigational antidepressant medication, for the indication of major depressive disorder with imminent risk for suicide. (jnj.com)
Earlier this year, the developer Sage Therapeutics announced that the FDA granted this agent Breakthrough Therapy Designation for the treatment of postpartum depression and major depressive disorder. (medpagetoday.com)
The Breakthrough Therapy designation for AXS-05 in AD agitation was supported by the recent positive results from the pivotal Phase 2/3 ADVANCE-1 study, a randomized, double-blind, controlled, multicenter U.S. trial in which 366 Alzheimer's disease patients were treated with AXS-05, bupropion, or placebo. (gcs-web.com)
This marks the second Breakthrough Therapy designation received by Axsome for AXS-05, the first being for the treatment of major depressive disorder, and highlights the potential of AXS-05 to address unmet medical needs in multiple difficult-to-treat CNS disorders. (gcs-web.com)

Furthermore, it is critical to assess adherence to medication and treatment. (psychiatrictimes.com)
Patients may not take their medications daily due to factors such as cognitive dysfunction, poor insight, ambivalence about treatment, worries about medication adverse effects, or the misleading concern that the medications have addictive properties. (psychiatrictimes.com)
Medication management in geriatric patients, including antidepressant use among depressed elderly patients with dementia, stroke, or Parkinson's disease. (appi.org)
Antipsychotics form the mainstay of medication treatment of schizophrenia and they play major roles in the treatment of depression with psychotic features and bipolar disorder. (brightfocus.org)
She is passionate about helping patients overcome their depressive state and continue on as their medication management provider if needed. (eastsidetmswellness.com)
Are you taking medication to treat your depression? (eastsidetmswellness.com)
Here is yet another example of something that is very important for depression treatment outcomes that medication cannot fix. (shrinksinsneakers.com)
Should we stop attempting to use medication for the symptoms of depression? (shrinksinsneakers.com)
These markers can be used not only to assist the development of new treatment compounds, but also for a personalized approach to treat patients with depression and related disorders by individual dose titration with an active medication, which targets this system. (karger.com)
Bipolar disorder in primary care: Medication treatment by co-located psychiatrists versus primary care clinicians supported by psychiatrists. (va.gov)
0.84% reported having active epilepsy (i.e., a history of epilepsy and currently taking medication or reporting one or more seizures during the past 3 months), and 0.75% were classified as having inactive epilepsy (i.e., a history of epilepsy or seizure disorder but currently not taking medicine to control epilepsy and no seizures in the 3 months preceding the survey). (cdc.gov)

Analyzing the relationship between neurocognitive deficits and functional outcomes in individuals with schizophrenia spectrum disorders. (dissertation-help.uk)

Ongoing experimental studies of subcallosal cingulate deep brain stimulation (SCC DBS) for treatment-resistant depression (TRD) show a differential timeline of behavioral effects with rapid changes after initial stimulation, and both early and delayed changes over the course of ongoing chronic stimulation. (researchgate.net)
Methods: Flinders Sensitive Line (FSL) and congenitally learned helpless (cLH) rats as well as their respective controls received chronic-intermittent or chronic-continuous DBS to the ventromedial prefrontal cortex (vmPFC, rodent analog to the Cg25 area), NAcc, MFB, or subthalamic nucleus (STN) and were subjected to a battery of behavioral tests investigating depression- and reward-associated behavior. (fu-berlin.de)
Ulcerative colitis (UC) is a chronic intermittent relapsing disorder of the large intestine and rectum, characterized by diarrhea, abdominal pain, rectal bleeding, fever, and weight loss. (clarivate.com)
Considering the chronic fallout from significantly maladaptive interpersonal styles of personality-disordered people, this isn't surprising. (psychologytoday.com)
Treatment-resistant depression (TRD) is a chronic and disabling condition that affects around a third of patients being treated for major depressive disorder (MDD) in the U.S. Although depression in all its forms can be debilitating, those who don't respond to conventional treatments have been found to carry a higher suicide risk than those who do respond to depression treatment . (healthyplace.com)
Using a machine learning approach to investigate factors associated with treatment-resistant depression among adults with chronic non-cancer pain conditions and major depressive disorder. (cdc.gov)
If you or a loved one is experiencing depression, whether it's major, chronic, manic, prenatal, bipolar, postpartum, or any other type of depression, contact us today to learn more about TMS and how we can help. (neurowellnessspa.com)
β asthmatic attack and maintenance treatment of chronic asthma. (johogo.com)
β stimulants are less amoxicillin 500 mg 21 capsules price in chronic bronchitis, possibly because in this disease bronchoconstriction is due to reflex stimulation of acetylcholine receptors following stimulation of local irritant receptors in lung tissue. (johogo.com)

Major depression and situational depression are both mental health conditions characterized by persistent feelings of sadness and loss of interest in activities. (mentalhealth.com)
What is situational depression? (mentalhealth.com)
Situational depression, clinically known as adjustment disorder with depressed mood , is when an individual shows signs of depression following a stressful life event or circumstance. (mentalhealth.com)
Major depression and situational depression share many of the same symptoms. (mentalhealth.com)

Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus interna (GPi) have differential therapeutic effects for Parkinson's disease (PD) that drive patient selection. (researchgate.net)
Pimavanserin (Nuplazid), which is approved specifically for use in treating psychotic symptoms associated with Parkinson's Disease, is a serotonin receptor antagonist without the dopamine receptor antagonism that links the other antipsychotics to parkinsonian neurological side effects. (brightfocus.org)
In July, the phase II CLARITY trial found that the atypical antipsychotic pimavanserin (Nuplazid), already approved for the treatment of Parkinson's disease psychosis, failed as an adjunctive treatment for major depressive disorder. (medpagetoday.com)
PDKit: A data science toolkit for the digital assessment of Parkinson's Disease. (cdc.gov)

Researchers in Sweden found that 1 in 9 patients with unipolar major depressive disorder experienced an episode that fulfilled the criteria for treatment-resistant depression, a condition associated with greater rates of anxiety, stress, sleep disorders, and substance use disorder versus patients without TRD. (medpagetoday.com)
In this population-based, observational cohort study, Dr. Lundberg and his colleagues used data from the Stockholm Major Depressive Disorder (MDD) Cohort for episodes of MDD recorded between January 1, 2012, and December 31, 2017, that fulfilled the predefined criteria for TRD-at least three consecutive pharmacologic antidepressant treatments. (medpagetoday.com)
The median time from the start of a major depressive episode to TRD was 552 days, and selective serotonin reuptake inhibitors were the most common class of antidepressant treatment in all treatment steps. (medpagetoday.com)
If approved by the FDA, esketamine would be one of the first new approaches to treat major depressive disorder available to patients in the last 50 years. (jnj.com)
This designation reinforces the potential of esketamine as a novel treatment for patients with major depressive disorder who are at imminent risk for suicide, a condition for which there currently is no approved treatment and which represents a major public health challenge. (jnj.com)
Major depressive disorder affects approximately 16 million people in the U.S. 4 and 121 million people worldwide. (jnj.com)
Individuals with depression, including major depressive disorder, experience continuous suffering from a serious, biologically based disease which can prevent them from enjoying life and functioning normally. (jnj.com)
AXS-05 is Axsome's lead drug candidate, a therapeutic for the treatment of major depressive disorders and resistant depression disorders. (fxempire.com)
Imaging studies of major depressive disorder have reported structural and functional abnormalities in a variety of spatially diverse brain regions. (psychiatryonline.org)
A total of 92 publications reporting 152 experiments were identified, collectively representing 2,928 patients with major depressive disorder. (psychiatryonline.org)
Major depressive disorder is the single largest contributor to disability worldwide, affecting as many as 300 million people annually ( 1 ). (psychiatryonline.org)
Late-life depression (LLD) is prevalent and defined as major depressive disorder in adults 65 years and older. (psychiatrictimes.com)
Introduction: Deep brain stimulation (DBS) is an effective tool to therapeutically modulate pathological neural activity and has recently been promoted as potential treatment for major depressive disorders (MDD). (fu-berlin.de)
Major depressive disorder (MDD) is a serious, life-threatening mental disorder that affects approximately 17.3 million adults, or nearly 7.1% of the US adult population. (ahdbonline.com)
These two newer antipsychotics, along with quetiapine (Seroquel), carry an FDA indication to assist in the primary treatment of major depressive disorder. (brightfocus.org)
Numerous antidepressant therapies are available to treat major depressive disorder (MDD), many of which have long been generic and are entrenched in medical practice. (clarivate.com)
A national study of depression found that nearly all the respondents who reported a major depressive disorder also reported that their social and/or work lives were negatively affected by their illness. (eastsidetmswellness.com)
This particular survey found women were more likely than men to receive mental health treatment, while young adults ages 18 to 29 had the highest rates of major depressive disorder out of any age group. (medpagetoday.com)
With this rise in major depressive disorder instigated by the pandemic, the antidepressant sertraline (Zoloft) was even added to the FDA's shortage list early in June. (medpagetoday.com)
With these new threats against mental health, development of new major depressive disorder treatments is needed now more than ever. (medpagetoday.com)
It has shown promise in the treatment of major depressive disorder (MDD), treatment-resistant depression (TRD), Alzheimer's disease agitation, and smoking cessation. (sickeconomics.com)
The symptoms of TRD are the same as the symptoms of major depressive disorder, except they do not respond to treatment. (healthyplace.com)
You may be genetically predisposed to major depressive disorder, or your DNA could make certain medicines less effective. (healthyplace.com)
PMID 23648227 ] Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: a meta-analysis. (snpedia.com)
Simply put, this involves treatment of Major Depressive Disorder in adult patients who have failed to achieve satisfactory improvement from two prior antidepressant medications, at or above the minimal effective dose and duration in the current episode. (beppemicalleftrigona.com)
Major depressive disorder (MDD) is a mood disorder characterized by a continuous low mood. (mentalhealth.com)
A diagnosis of major depressive disorder can be made if at least five of the following DSM criteria are met. (mentalhealth.com)

Esketamine is a non-competitive and subtype non-selective activity-dependent N-methyl-D-aspartate (NMDA) receptor antagonist, which has a novel mechanism of action, meaning it works differently than currently available therapies for depression. (jnj.com)
Adagio Therapeutics is a clinical-stage biopharmaceutical company established in the United States that specializes in the discovery, development, and commercialization of antibody-based therapies for infectious diseases. (fxempire.com)
Multiple treatment options-topical therapies, oral drugs, phototherapy, and biologics-are available to treat psoriasis. (clarivate.com)
The biotechnology industry is renowned for its potential to revolutionize healthcare through innovative therapies and treatments. (sickeconomics.com)
The company was founded in 2012 with a focus on developing novel therapies for central nervous system (CNS) disorders. (sickeconomics.com)
The company strives to identify patient subpopulations that may respond better to their therapies, allowing for more targeted and effective treatments. (sickeconomics.com)
The FDA gives the designation to drugs where evidence demonstrates they could be a substantial improvement over available therapies for serious or life-threatening diseases. (pharmaphorum.com)
Our mission is to drive the development of new mechanism-driven therapies through a richer understanding of how neurologic disease affects behavior. (massgeneral.org)

Not only are symptoms of major depression far more prevalent during the pandemic, but the severity of symptoms has also increased. (medpagetoday.com)
This discussion will focus on the treatment of these individuals by first explaining what symptoms predict poor response to treatment and what symptoms of major depression result in the most psychosocial dysfunction. (shrinksinsneakers.com)

Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD)¹. (researchgate.net)
Background: Deep brain stimulation of the subcallosal cingulate area (SCC-DBS) is a promising neuromodulatory therapy for treatment-resistant depression (TRD). (researchgate.net)
Massachusetts General Hospital provides deep brain stimulation as a treatment for a variety of neurological disorders, including XDP. (massgeneral.org)

The investigators also found anxiety, stress, sleep disorders, and substance use disorder were more common comorbid conditions in TRD episodes. (medpagetoday.com)
Adjunct to valproate, carbamazepine or lithium in the treatment of manic or mixed episodes associated with bipolar I disorder combination olanzapine/fluoxetine for the treatment of depressive episodes associated with bipolar I disorder. (wikipedia.org)

The term 'treatment-resistant depression' only takes into account failed pharmacological interventions. (psychologytoday.com)

Olanzapine (sold under the trade name Zyprexa among others) is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. (wikipedia.org)
Treatment with olanzapine (like clozapine) may result in increased weight gain and increased glucose and cholesterol levels when compared to most other second-generation antipsychotic drugs used to treat schizophrenia. (wikipedia.org)
A review on the efficacy of olanzapine as maintenance therapy in patients with bipolar disorder was published by Dando & Tohen in 2006. (wikipedia.org)
Olanzapine is no less effective than lithium or valproate and more effective than placebo in treating bipolar disorder. (wikipedia.org)
Olanzapine has been studied for the treatment of hyperactivity, aggressive behavior, and repetitive behaviors in autism. (wikipedia.org)
Olanzapine is frequently prescribed off-label for the treatment of insomnia, including difficulty falling asleep and staying asleep, even though such use is not recommended. (wikipedia.org)
Olanzapine carries an indication for treatment of resistant depression when used in combination with fluoxetine (Prozac). (brightfocus.org)

Eastside TMS and Wellness Center was established for the treatment of major depression using the revolutionary FDA approved treatment, Transcranial Magnetic Stimulation. (eastsidetmswellness.com)
She is dedicated to providing the best treatment options to patients and is an expert in the field of Brain Stimulation Technologies, such as Transcranial Magnetic Stimulation. (eastsidetmswellness.com)
If you're experiencing lingering symptoms, unwanted side effects, or if you want to supplement your current treatments, you might consider transcranial magnetic stimulation, or TMS. (neurowellnessspa.com)
Transcranial Magnetic Stimulation (TMS) therapy is a non-invasive, non-drug, and FDA-cleared treatment with zero downtime that is safe and effective for depression, anxiety, OCD and more. (neurowellnessspa.com)

Electroconvulsive therapy (ECT) can help some people with bipolar disorder. (medscape.com)

[ 9 ] In the 1960s, randomized clinical trials of the efficacy of ECT versus medications in the treatment of depression showed response rates that were significantly higher with ECT. (medscape.com)

Episodic Memory-Related Imaging Features as Valuable Biomarkers for the Diagnosis of Alzheimer's Disease: A Multicenter Study Based on Machine Learning. (cdc.gov)

The median time from the start of the first antidepressant treatment to the start of the second was 165 days (IQR 72 to 375 days). (medpagetoday.com)
Approximately one-fourth of elderly patients responded poorly to the first antidepressant treatment during the first year of late-onset MDD. (psychiatrist.com)
A subpopulation of older adults meet criteria for late-life treatment-resistant depression (LLTRD), defined as failure to respond to 2 or more adequate trials of antidepressant treatment. (psychiatrictimes.com)

Research focuses on a variety of issues related to several mental health conditions affecting Veterans that range from PTSD and depression to schizophrenia and bipolar disorder. (va.gov)
Reorganization of the functional connectome from rest to a visual perception task in schizophrenia and bipolar disorder. (va.gov)

IntroductionPsilocybin is a psychedelic tryptamine that has shown promise in recent clinical trials for the treatment of depression and substance use disorders. (researchgate.net)
The program in treatment-resistant depression is currently in Phase 3, with six ongoing clinical trials. (jnj.com)
The ADG20 (adintrevimab), a neutralizing antibody in Phase 3 clinical trials for the treatment and prevention of COVID19, is the company's lead product candidate. (fxempire.com)
In phase 3 clinical trials, we saw this therapy provide sustained improvement to patients with treatment-resistant depression. (ahdbonline.com)

Outcomes of geriatric depression. (psychiatrist.com)
Esketamine is available only through certified physicians' offices or clinics under a Risk Evaluation and Mitigation Strategy (REMS) program, because of the risk for serious adverse outcomes resulting from sedation and dissociation caused by esketamine treatment and the potential for abuse and misuse. (ahdbonline.com)
Making anhedonia a primary target of treatment would be wise if we want to improve outcomes in depression. (shrinksinsneakers.com)
only one-third of persons start treatment, and outcomes are often inadequate. (cdc.gov)

Consistently Anhedonia and concentration are rated by patients with depression as the most debilitating. (shrinksinsneakers.com)
Functional imaging studies using positron emission tomography (PET) and single photon emission computed tomography (SPECT) have examined resting cerebral blood flow and glucose metabolism in patients with depression. (beppemicalleftrigona.com)

Durability of symptomatic responses obtained with adjunctive vagus nerve stimulation in treatment-resistant depression. (sheppardpratt.org)
The maker Acadia Pharmaceuticals announced that 34 mg of once-daily pimavanserin as an adjunctive treatment to standard antidepressant therapy failed to reach the primary endpoint of a significant total score change on the Hamilton Depression Rating Scale after 5 weeks. (medpagetoday.com)

This hypothesis is, in part, supported by an early rTMS study, which showed that a 2 week protocol of high-frequency rTMS in the region of the left DLPFC affects both prefrontal and paralimbic activities in patients suffering from bipolar as well as unipolar depression (Teneback, 1999). (beppemicalleftrigona.com)

The severity of MDD, which was defined at the time of diagnosis by the self-rating Montgomery-Åsberg Depression Rating Scale, was identified as the most important prognostic factor for TRD (C index = 0.69). (medpagetoday.com)
Several instruments can be used to assess depression severity in older adults with LLTRD, such as the Geriatric Depression Scale and the Beck Depression Inventory. (psychiatrictimes.com)
Another standard tool is the Patient Health Questionnaire (PHQ-9), a self-administered measure consisting of 9 items and scores ranging between 0 and 27, with higher scores indicating higher severity of depression. (psychiatrictimes.com)
What we know is that subjective measures of cognitive dysfunction are a better predictor of workplace performance than total depression severity. (shrinksinsneakers.com)

Neuropsychiatric disease classification using functional connectomics - results of the connectomics in neuroimaging transfer learning challenge. (cdc.gov)
Japanese pharma group Otsuka has signed an agreement to acquire Canada's Mindset Pharma, a specialist in psychedelic medicines for neuropsychiatric disorders. (pharmaphorum.com)
Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)

The Mass General Epilepsy Service offers diagnosis, treatment, and consultations for seizure disorders, including surgical evaluations, and specialized care for first seizure events. (massgeneral.org)
Any diagnosis of adjustment disorder needs to take cultural differences into account when determining what counts as an extreme reaction to a given stressor. (mentalhealth.com)

Looking at 21 adults who underwent this therapy, depressive symptoms significantly improved by a mean of 5 points on the Montgomery-Åsberg Depression Rating Scale (MADRS) after only 5 days of treatment. (medpagetoday.com)
The subject has a Montgomery Åsberg Depression Rating Scale (MADRS) total score of =28 predose on Day 1. (who.int)

We look forward to working with the FDA over the coming months as we advance the development of AXS-05 for the treatment of Alzheimer's disease agitation. (gcs-web.com)
A Review of Automated Techniques for Assisting the Early Detection of Alzheimer's Disease with a Focus on EEG. (cdc.gov)

Assessing the impact of childhood maltreatment on the neurobiological markers associated with borderline personality disorder. (dissertation-help.uk)

In part one of this three-part discussion of behavioral symptoms associated with Major Neurocognitive Disorder (previously called "dementia" and abbreviated here as MaND), we explored the behaviors of apathy, agitation, inappropriate sexual behavior, and sleep disturbance in people with MaND. (brightfocus.org)
We call that a behavioral disorder because we imagine healthy people don't see the crows, healthy people don't choose death over life. (cdc.gov)
And we say that behavioral disorders are caused by "mental" diseases to distinguish them from "real" diseases-infections, tumors, broken bones, burst blood vessels, polio. (cdc.gov)
Sometimes we even believe that people with mental diseases and behavioral disorders suffer more from weakness of spirit and flaws of character than from genuine disease. (cdc.gov)

1 In 2010, the economic burden of depression was estimated at $210 billion in the US 2 and depression was the second leading cause of disability, accounting for almost 20% of all years of life lost to disability and premature death. (eastsidetmswellness.com)

What Are the Causes of Treatment-Resistant Depression? (healthyplace.com)

Esketamine was first granted this designation for treatment-resistant depression in November 2013. (jnj.com)
At the end of the induction phase (weeks 1-4), the evidence of therapeutic benefit should be assessed to establish whether continued esketamine treatment is needed. (ahdbonline.com)

Anatomy9

Organisms1

Diseases16

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Psychiatry and Psychology86

Phenomena and Processes19

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena12

Humanities1

Information Science6

Named Groups4

Health Care44

Geographicals3

Psychiatric37

Obsessive Compulsi2

Suicidal ideation or behavior2

Remission12

Severe12

Anxiety disorders8

Children and Adolescents5

20202

Recurrent4

Dysthymia3

Premenstrual Dysphori2

Bipolar depression5

Psilocybin12

Acute5

20197

Adolescents3

Psychiatry10

Refractory2

Mental Disorders4

Centers for Diseas1

Antidepressants7

Psychotherapy7

Ketamine4

Breakthrough Therapy Designation4

Medication11

Individuals with schizophrenia1

Chronic9

Situational Depression4

Parkinson's Disease4

Major depressive27

Therapies8

Symptoms of major2

Deep brain stimu3

Episodes2

Pharmacological1

Olanzapine7

Transcranial Magnetic St4

Electroconvulsive Therapy1

Efficacy1

Biomarkers1

Antidepressant treatment3

Schizophrenia and bipolar disorder2

Clinical trials4

Outcomes4

Patients with depression2

Adjunctive2

Unipolar Depression1

Severity4

Neuropsychiatric3

Diagnosis2

Montgomery-Åsbe2

Alzheimer's2

Borderline personal1

Behavioral4

Economic burden of depression1

Causes of Treatment-Resistant1

Esketamine2