• The ischemic stroke accounts for the 87% of all cases, which results from the cerebral arteries occlusion due to thrombosis, atherosclerosis and platelets plug ( 3 ). (frontiersin.org)
  • In the treatment of acute cerebral infarction, it is possible to remove the arterial thrombosis as early as possible, make the occlusion of the cerebral artery repasses, restore or improve the blood supply of the infarct area, prevent the ischemia reperfusion injury, save the ischemic penumbra, prevent the irreversible injury of ischemic brain tissue, and reduce the mortality and the rate of disability. (crimsonpublishers.com)
  • The behavioral performance of both the niacin-treated and control rats was found to be impaired following occlusion-reperfusion, but the niacin-treated rats were far less impaired. (life-enhancement.com)
  • In the treatment of acute ischemic stroke, immediate recanalization of the occluded artery, using systemic or local thrombolysis, is optimal for restoring the blood flow and rescuing the ischemic brain from complete infarction. (nih.gov)
  • Cerebral reperfusion, or hyperperfusion, syndrome is a rare but serious complication that can occur following rapid revascularization of a partially or completely occluded artery with successful thrombolytic therapy, successful thrombectomy, carotid enterectomy (CEA), or carotid artery stenting (CAS). (medscape.com)
  • Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
  • Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
  • Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
  • Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
  • In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
  • Cerebral ischemia-reperfusion injury (CIRI) caused by ischemic stroke seriously affects the prognosis of stroke patients. (sciencegate.app)
  • Stroke is caused not only by arterial thrombosis but also by cerebral venous thrombosis. (frontiersin.org)
  • This review summarizes the pathophysiological mechanisms, etiology, epidemiology, symptomatology, diagnosis, and treatment heterogeneity of venous thrombosis and compares it with arterial stroke. (frontiersin.org)
  • The aim is to provide a reference for a comprehensive understanding of venous thrombosis and a scientific understanding of various pathophysiological mechanisms and clinical features related to venous thrombosis, which will contribute to understanding the pathogenesis of intravenous stroke and provide insight into diagnosis, treatment, and prevention. (frontiersin.org)
  • Hypoxia and ischemia of the brain are key pathophysiological mechanisms of ischemic stroke ( 5 , 6 ). (frontiersin.org)
  • The molecular pathological hallmarks of arterial stroke and cerebral venous thrombosis. (frontiersin.org)
  • According to the theory of TCM, cerebral ischaemia, which is also called stroke, can be induced by hyperactivity of liver Yang, disordered diet, stagnation of blood, etc. (biomedcentral.com)
  • Cerebral infarction (cerebral infarction), also known as acute ischemic stroke (acute cerebral ischemic stroke), refers to the necrosis of the localized brain tissue caused by cerebral blood circulation disorder, ischemia and hypoxia. (crimsonpublishers.com)
  • Cerebral infarction is the most common type of stroke, accounting for 60%-80% of all strokes. (crimsonpublishers.com)
  • According to the study, the number of people who died of cerebral infarction was as high as one million and five hundred thousand people, the annual growth rate were 8.7%, and the economic burden and social burden caused by stroke were very heavy. (crimsonpublishers.com)
  • All of these highlight the urgency and importance of stroke prevention and treatment. (crimsonpublishers.com)
  • We demonstrated that treatment with NPD1, RvD1, and combination therapy provides high-grade neurobehavioral recovery and decreases ischemic core and penumbra volumes even when administered up to 6 h after stroke. (springer.com)
  • The treatment of ischemic stroke is to administer tissue plasminogen activator (t-PA) within 4.5 h of stroke onset, and only 5-8% of patients qualify for this therapy (Liaw and Liebeskind 2020 ). (springer.com)
  • 2019 ). Despite active stroke research, all treatments have failed to show favorable clinical outcomes. (springer.com)
  • Similarly, levels of NLRP1 and NLRP3 inflammasome proteins, IL-1 β and IL-18 were elevated in ipsilateral brain tissues of cerebral I/R mice and stroke patients. (scienceopen.com)
  • Caspase-1 inhibitor treatment protected cultured cortical neurons and brain cells in vivo in experimental stroke models. (scienceopen.com)
  • IVIg treatment protected neurons in experimental stroke models by a mechanism involving suppression of NLRP1 and NLRP3 inflammasome activity. (scienceopen.com)
  • Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. (scienceopen.com)
  • Therefore, we aimed to find the neuroprotective role of this peptide on I/R induced cerebral damage after experimental stroke associated with hyperglycemia using C57BL/6J Ins2Akita/+ mice. (hku.hk)
  • As a countermeasure, vascular recanalization is currently the most efficacious treatment for acute ischemic stroke. (biomedcentral.com)
  • Tissue plasminogen activator (tPA) thrombolysis, remains to be the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. (nih.gov)
  • Of note, ischemia-induced BBB damage in the early stroke stages is increasingly appreciated to negatively affect the safety and efficacy profiles of thrombolytic therapy for ischemic stroke. (nih.gov)
  • Astroglial and microglial/macrophage P2 purinoceptors-mediated neuroinflammation and hyperplasia in peri-infarct hippocampal CA1 and sensorimotor cortex were attenuated by EA treatment after ischemic stroke accompanied by the improved motor and memory behavior performance. (biomedcentral.com)
  • The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. (biomedcentral.com)
  • These data may help in the development of effective and widely applicable pharmacological treatments for ischemic stroke patients with traditional medicines. (biomedcentral.com)
  • FKBP5 Exacerbates Impairments in Cerebral Ischemic Stroke by Inducing Autophagy via the AKT/FOXO3 Pathway. (shengsci.com)
  • Cerebral ischemic stroke is regarded as one of the most serious diseases in the human central nervous system. (shengsci.com)
  • Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia PLOS ONE. (nottingham.ac.uk)
  • The impact of gender on stroke pathology and treatment. (nottingham.ac.uk)
  • Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). (msdmanuals.com)
  • and proximal arterial stenosis with hypotension that decreases cerebral blood flow in arterial watershed zones (hemodynamic stroke). (msdmanuals.com)
  • Multicenter cohort study of patients with acute ischemic stroke who underwent a brain computed tomography perfusion and were scheduled to undergo reperfusion therapy. (medscape.com)
  • Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage. (medscape.com)
  • [ 1 ] A recent hypothesis to explain the migraine-stroke association, based on experimental data obtained in mice expressing familial hemiplegic migraine type 1 mutations, is that the cerebral hyperexcitability phenotype associated with migraine might sensitize brain tissue to ischemia. (medscape.com)
  • Based on these premises, taking advantage of the reliability of computed tomography perfusion (CTP) imaging in the estimation of cerebral tissue viability in both clinical and research settings, [ 4 ] we conducted a case-control study comparing CTP maps of migraineurs and nonmigraineurs patients with acute ischemic stroke aimed at investigating whether a personal history of migraine is associated with vulnerability to brain ischemia. (medscape.com)
  • SUF pretreatment effectively improved the neurological function and cerebral infarction of MCAO rats, inhibited excessive inflammation in rats, protected the BBB, and inhibited cell apoptosis in brain tissue. (sciencegate.app)
  • The neurological outcomes, infarction volumes and the level of astroglial and microglial/macrophage hyperplasia, inflammatory cytokine and P2X7R and P2Y1R expression in the peri-infarct hippocampal CA1and sensorimotor cortex were investigated after IS to evaluate the MCAO/R model and therapeutic mechanism of EA treatment. (biomedcentral.com)
  • The mouse model of cerebral artery ischemia/reperfusion injury was established to test the anticerebral ischemia-reperfusion injury activity of the puerarin derivatives. (hindawi.com)
  • The aim of this study was to investigate the influence of atorvastatin on the opening of the mitochondrial permeability transition pore (MPTP) and the expression of cytochrome C (Cyt C) in Sprague-Dawley rats with cerebral ischemia-reperfusion (I/R). The rat model of cerebral artery ischemia was established by the suture-occluded method with ischemia for 2 h and reperfusion for 72 h. (geneticsmr.com)
  • Several mechanisms have been proposed for the pathogenesis of cerebral reperfusion injury. (medscape.com)
  • Therefore, the study of VaD pathogenesis and development of effective treatment options have become an important issue in pharmaceutical and clinical research. (hindawi.com)
  • At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. (biomedcentral.com)
  • The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis. (biomedcentral.com)
  • Neuronal loss in the hippocampus, regarded as one of the basic pathological mechanisms underlying cognitive impairment, can result from Focal cerebral ischemia-reperfusion. (medindia.net)
  • Studies have shown that puerarin reduced cerebral edema in rats with cerebral ischemia-reperfusion injury, removed lipid peroxidation products, enhanced antioxidant capacity, improved antioxidant activity of the brain tissue, and reduced the degree of focal cerebral ischemic injury [ 2 - 4 ]. (hindawi.com)
  • Cerebral ischemia-reperfusion injury (CIRI) refers to the phenomenon that the ischemic injury of brain leads to the injury of brain cells, and ischemic injury is further aggravated after the recovery of blood reperfusion. (sciencegate.app)
  • However, the P2X7R/P2Y1R related EA treatment with the development of cerebral ischemic injury is complex and unclear. (biomedcentral.com)
  • Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury. (biomedcentral.com)
  • These data demonstrate that the σ 1 -receptor ligand PPBP attenuates ischemic injury when administration is initiated 60 min after the onset of focal ischemia but that prolonged continuous treatment with PPBP beyond 24 h provides no neuroprotection. (utmb.edu)
  • Along with the observation that migraine mutants had an elevated minimum cerebral blood flow threshold required for tissue survival and developed larger infarcts, these findings directly support the hypothesis that brain tissue in migraineurs is more susceptible to ischemic injury. (medscape.com)
  • Both pre- and post-treatment with BW-B 70C reduced infarctions and improved neurological deficit scores. (biomedcentral.com)
  • Therefore, promoting the mitochondrial structural repair and functional recovery is the crucial for the amelioration of the neurological damage after cerebral ischemia. (biomedcentral.com)
  • Celastrol is a bioactive compound that has been found to exhibit neuroprotective effects in cerebral ischemia, while whether it can protect against cerebral I/R injury by regulating glycolysis remains unclear. (sciencegate.app)
  • Water electrolysis-derived hydrogen inhalation had neuroprotective effects on cerebral ischemia/reperfusion injury in rats with the effect of suppressing oxidative stress and inflammation, and it is a possible new hydrogen resource to electrolyze water at the bedside clinically. (molecularhydrogenstudies.com)
  • We hypothesized that an imbalance of Ca2+/calmodulin dependent protein phosphorylation-dephosphorylation may be involved in delayed neuronal death after ischemia. (nih.gov)
  • Apoptosis is an important way of neuronal death after cerebral ischemia-reperfusion injury. (crimsonpublishers.com)
  • We tested the hypothesis that prolonged, continuous administration of PPBP would provide further neuroprotection in a rat model of transient focal ischemia and reperfusion. (utmb.edu)
  • The original phenolic hydroxyl in the puerarin molecules was substituted in order to change the blood-brain barrier permeability and thus enhance the efficacy for preventing cerebral ischemia/reperfusion injury. (hindawi.com)
  • The results showed that puerarin derivative P1-EA and P2-EA were resulting in an increased lipophilicity that enabled the derivatives to pass more efficiently through the blood-brain barrier, thus, improving the protective effects against cerebral ischemia/reperfusion injury. (hindawi.com)
  • In addition, we tested the anticerebral ischemia-reperfusion injury activity of these puerarin derivatives in order to determine their permeability through the blood-brain barrier and pharmacological activity. (hindawi.com)
  • TPA-associated hemorrhagic transformation (HT) often occurs as a result of catastrophic failure of the blood brain barrier (BBB), wherein the affected cerebral capillaries can no longer hold blood constituents. (nih.gov)
  • These symptoms can present independently or as sequelae of cerebral edema and/or symptomatic intracerebral hemorrhage (sICH). (medscape.com)
  • A sudden drop in systemic blood pressure could lead to cerebral ischemia, while, on the other hand, a sudden rise in systemic blood pressure could lead to edema or hemorrhage. (medscape.com)
  • Due to its direct contribution to edema and HT, reperfusion-associated BBB damage has been extensively studied, while BBB damage that occurs within the thrombolytic time window is largely neglected. (nih.gov)
  • The purpose of this study was to review the pathophysiology mechanisms and clinical features of arterial and venous thrombosis and to provide guidance for further research on the pathophysiological mechanism, clinical diagnosis, and treatment of venous thrombosis. (frontiersin.org)
  • The mechanism for localized hypercoaguability in granulomatous sarcoidosis may be due to the localized increase in Tumor Necrosis Factor alpha (TNF alpha) and interleukin-6 (IL-6) which can cause " microvascular damage leading to thrombosis ," and " ischemia . (transcendingsquare.com)
  • In order to improve the early diagnosis, prevention and treatment of SD in clinical practice, the book also provides extensive data on its pathophysiological mechanism, epidemiology and etiology, together with detailed analyses. (nshealth.ca)
  • Progress in Pathophysiological Mechanism of Global Cerebral Ischemia-Reperfusion Injury -- 5. (nshealth.ca)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • Thirty-four male rats were randomly divided into four groups: the normal group and the sham-operation group without any treatment, the I/R group with only intragastric administration of normal saline, and the intervention group, which received intragastric administration of 10 mg/kg atorvastatin at different times. (geneticsmr.com)
  • Sixty minutes after the onset of ischemia, rats were randomly assigned to six treatment groups to receive a continuous IV infusion of PPBP (1 μmol · kg -1 · h -1 ) for 1, 2, 3, or 4 days or saline for 1 or 4 days. (utmb.edu)
  • Therefore, derivatives of puerarin may serve as promising approach to improve neuron function in ischemia-reperfusion brain injury-related disorders. (hindawi.com)
  • These visual defects are associated with cerebral neuron immaturity especially in the primary visual cortex. (shengsci.com)
  • Dioscorea has great medicinal and therapeutic capabilities and is a potential source of bioactive substances for the prevention and treatment of many diseases. (mdpi.com)
  • Prolonged treatment with a potent σ-ligand is associated with loss of therapeutic efficacy for this compound. (utmb.edu)
  • In addition, the present study indicated that treatment with GP suppressed the I/R-induced increase in the pro-apoptotic protein levels of Bax and cytochrome c and the activity of caspase-3/8, as well as the I/R-induced decrease in the levels of anti-apoptotic protein Bcl‑2. (spandidos-publications.com)
  • Several studies showed that α-MSH has protective effects against ischemia/reperfusion (I/R) induced organ damages. (hku.hk)
  • 2. Zhang X, Zhang B-Z, Yang X-P, Zhang W-W. Protective effects of nicotinic acid on disturbance of memory retrial induced by cerebral ischemia-reperfusion in rats. (life-enhancement.com)
  • This article describes the pathophysiology of, and treatment strategy for, cerebral ischemia. (nih.gov)
  • Reperfusion plays an important role in the pathophysiology of cerebral ischemia. (nih.gov)
  • The development of effective neuroprotection methods and the establishment of reliable imaging modalities for an early and accurate diagnosis of the extent and degree of the ischemia are imperative. (nih.gov)
  • This book summarizes the occurrence of SD, especially in specific groups (such as women, young and middle-aged groups), its causes, predisposing factors, lifestyle, morbidity, point of care testing, and advanced treatment methods including extra-corporeal membrane oxygenation, cardiopulmonary resuscitation and hypothermia treatment. (nshealth.ca)
  • Specifically, they used a calcium-sensitive contrast agent as a biomarker, which enabled the changes in calcium concentration to be traced and thus correlated with the spatiotemporal dynamics of cerebral ischemia. (compamed-tradefair.com)
  • Cerebral autoregulation protects the brain against sudden changes in systemic blood pressure. (medscape.com)
  • Another new study from China suggests that nicotinic acid protects memory function caused by the disruption of oxygen (cerebral ischemia) and the restoration of blood flow (reperfusion) into the brains of rats following disruption. (life-enhancement.com)
  • Our previous studies have demonstrated that EA protects cerebral neural cells against inflammatory injury after cerebral ischemia, which appears at 24 h to 14 days after treatment. (biomedcentral.com)
  • [ 11 , 12 ] Hyperperfusion is defined as a major increase in ipsilateral cerebral blood flow (CBF) that is well above the metabolic demands of the brain tissue. (medscape.com)
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • Revealing immediate changes during reperfusion are essential for the appropriate treatment and subsequent recovery of brain tissues. (compamed-tradefair.com)
  • The extent of reperfusion injury likely depends on the extent of initial hypoperfusion, the time to collateral collapse, the volume of irreversible tissue damage, and the degree of autoregulatory and pro-inflammatory responses. (medscape.com)
  • Microglial cells are the first line immune cells that initiate inflammatory responses following cerebral ischemia/reperfusion(I/R) injury. (aging-us.com)
  • Research has been directed at developing treatments that modulate inflammatory responses and protect against cell death caused by cerebral I/R. Key among such treatments include mesenchymal stem cell (MSC) therapy. (aging-us.com)
  • In addition, certain pro-inflammatory chemokines and cytokines are key during the initial period of reperfusion, whereas the late period of hepatic injury is neutrophil-mediated ( 3 ). (spandidos-publications.com)
  • Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage. (scienceopen.com)
  • It is well-documented that extracellular ATP triggers surrounding glial purinergic receptors signaling pathway and pro-inflammatory cytokines release to aggravate neural injury in cerebral ischemia [ 8 , 9 ]. (biomedcentral.com)
  • Patients with occlusive lesions of all four cervical arteries usually have severe cerebral ischaemia and their distal runoff is usually unable to be visualized on angiography. (nih.gov)
  • Cerebral reperfusion syndrome presents with ipsilateral headache, contralateral focal neurologic deficits, and/or seizures, but a complete triad is not required for diagnosis. (medscape.com)
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
  • Always seek the advice of a qualified physician for medical diagnosis and treatment. (medindia.net)
  • Study aimed at defining patient groups based on molecular features rather than symptoms to allow for early diagnosis and development of disease-specific neuroprotective treatment for each molecular form. (uc.edu)
  • This book provides up-to-date guidance on the diagnosis and treatment of sudden death, including sudden cardiac and non-cardiac death. (nshealth.ca)
  • Progress in Diagnosis and Treatment of Sudden Death Caused by Respiratory Diseases -- 20. (nshealth.ca)
  • The commonly used imaging techniques for ischemia diagnosis, such as ultrasonography or computed tomography, often lack the necessary sensitivity to detect ischemia at an early stage," comments Goran Angelovski, the principal investigator of this study. (compamed-tradefair.com)
  • In view of the prevalence and severity of this complication in the perioperative period, the aim of this article is to provide a sound foundation whereby providers can more readily make a prompt diagnosis of perioperative MI (PMI) and institute an effective treatment plan. (medscape.com)
  • I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
  • In the normally perfused brain, cerebral blood flow remains constant despite changes in systemic blood pressure. (medscape.com)
  • Conversely, in the chronically hypoperfused brain, autoregulation is impaired, and cerebral blood pressure varies with changes in systemic blood pressure. (medscape.com)
  • This study uses an established animal model to research the recovery and the sequelae stages of brain ischemia. (jove.com)
  • Safflower injection can correct the imbalance of thromboxane (TXA2) HJNKM / prostacyclin (PGI2) and abnormal changes of the ultrastructure of brain tissue in circulating blood after cerebral ischemia-reperfusion, and reduce the injury of cerebral ischemia reperfusion. (crimsonpublishers.com)
  • From the perspective of neural plasticity, Dr. Yun Xiang and co-workers from Sun Yat-sen University in China observed the effects of functional electrical stimulation treatment on endogenous neural precursor cell proliferation and expression of basic fibroblast growth factor and epidermal growth factor in the rat brain on the infarct side. (medindia.net)
  • After about 20 minutes, blood flow to the brain was restored (reperfusion). (life-enhancement.com)
  • Reperfusion of ischemic areas could exacerbate ischemic brain damage through the generation of reactive oxygen species. (biomedcentral.com)
  • Cerebral ischemia is characterized in conditions of a reduced blood supply to the brain tissue, causing a deprivation of oxygen and glucose delivery and a production failure of adenosine triphosphate (ATP), a key energy carrier. (compamed-tradefair.com)
  • Cerebral hyperexcitability in migraine experiencers might sensitize brain tissue to ischemia. (medscape.com)
  • We investigated whether a personal history of migraine is associated with vulnerability to brain ischemia in humans. (medscape.com)
  • In this review, we discussed the recent findings of spatio-temporal evolution of BBB injury in the early stages of cerebral ischemia and its association with intracerebral hemorrhage following tPA thrombolysis. (nih.gov)
  • The clinical presentation of cerebral reperfusion syndrome varies but generally includes components of the following triad: 1) ipsilateral headache, 2) contralateral focal neurologic deficits, and/or 3) seizures. (medscape.com)
  • Symptom severity is not necessarily proportional to degree of reperfusion - both reperfusion and hyperperfusion can result in cerebral injury with similar clinical presentations. (medscape.com)
  • Ischemia/reperfusion (I/R) is a predominant cause of hepatic injury, which is of clinical significance following liver surgery, hemorrhagic shock and liver transplantation ( 1 ). (spandidos-publications.com)
  • To evaluate the clinical efficacy of traditional Chinese medicine in the treatment of arrhythmia. (acupuncturetimes.com)
  • The researchers searched CNKI, VIP, WF, PubMed, Web of Science, and Cochrane Library with the set-up themes as randomized controlled trials (RCTs) on the clinical efficacy of traditional Chinese medicine in the treatment of arrhythmia. (acupuncturetimes.com)
  • Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats: a possible new hydrogen resource for clinical use. (molecularhydrogenstudies.com)
  • These findings provide an experimental basis for the clinical application of drugs in the treatment of OA. (bvsalud.org)
  • El Paso Nutrition and Healthy Weight Clinic of UTHealth Houston School of Public Health has opened its doors to help patients and providers in the Paso del Norte region with comprehensive clinical weight loss support through evidence-based medical treatments and training. (uth.edu)
  • Huang Y , Tan F , Zhuo Y , Liu J , He J , Duan D , Lu M , Hu Z , . Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α. (aging-us.com)
  • Taken together, these findings reveal that hypoxia-preconditioned OM-MSC inhibits pyroptotic and apoptotic death of microglial cell in response to cerebral ischemia/reperfusion insult by activating HIF-1α in vitro . (aging-us.com)
  • In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
  • During that same year, he directed the summer school of the International Society of Neurochemistry and the Journal of Neurochemistry under the theme of Cerebral Metabolism in Health and Disease. (wikipedia.org)
  • Cerebral ischemia/reperfusion (I/R) injury is closely related to dysfunctional glucose metabolism. (sciencegate.app)
  • Journal of cerebral blood flow and metabolism. (nottingham.ac.uk)
  • A traditional oxygen-glucose deprivation/reperfusion (OGD/R) model, analogous to I/R, was established. (aging-us.com)
  • The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model. (scienceopen.com)
  • To test the neuroprotective efficacy of 5-LOX inhibition in a rat model of focal cerebral IR, ischemic animals were either pre- or post-treated with a potent selective 5-LOX inhibitor, (N- [3-[3-(-fluorophenoxy) phenyl]-1-methyl-2-propenyl]- N -hydroxyurea (BW-B 70C). (biomedcentral.com)
  • In the present study, we used a 5-LOX inhibitor, N- [3-[3-(-fluorophenoxy) phenyl]-1-methyl-2-propenyl]- N -hydroxyurea (BW-B 70C), in a rat model of focal cerebral IR. (biomedcentral.com)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)