• Centers for Disease Control and Prevention. (cdc.gov)
  • About 5.7 million people in the U.S. have heart failure, and about half of people diagnosed will die within five years, according to the U.S. Centers for Disease Control and Prevention. (hopkinsmedicine.org)
  • I'm Commander Ibad Khan, and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
  • The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • It's been a rewarding progression in my career, going from studying single cells in culture to animal models to translational and clinical studies. (asbmb.org)
  • Empagliflozin, a sodium-glucose co-transporter 2 inhibitor developed, has been shown to reduce cardiovascular events in patients with type 2 diabetes and established cardiovascular disease. (nature.com)
  • By collaborating with HeartBeat.bio, we'll equip more researchers with the physiologically-relevant cell models, automated bioimaging technology, and reproducible workflows needed to drive development of novel heart disease treatments and reduce cardiovascular safety risk of drugs entering clinical trials," said Susan Murphy, President of Molecular Devices. (moleculardevices.com)
  • 2020 Cardiovascular Diagnosis and Therapy. (nih.gov)
  • Atherosclerotic cardiovascular disease (ASCVD), which mostly involves heart attacks and strokes caused by atherosclerosis, is one of the main causes of death worldwide [ 1 ]. (biomedcentral.com)
  • Cardiovascular diseases are closely linked to atherosclerotic plaque development and rupture. (techscience.com)
  • Assessment of plaque vulnerability is of fundamental significance to cardiovascular research and disease diagnosis, prevention, treatment and management. (techscience.com)
  • Cardiovascular disease (CVD) refers to a group of cardiovascular disorders and is currently the first leading cause of death worldwide. (biomedcentral.com)
  • We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
  • Patients with rheumatoid arthritis (RA) and other inflammatory joint disorders (IJD) have increased cardiovascular disease (CVD) risk compared with the general population. (bmj.com)
  • Therefore, patients with cardiovascular diseases would fail to achieve the desired outcomes by using these mitochondrial-targeted drugs ( 5 ). (frontiersin.org)
  • In the EMPA-REG OUTCOME trial, a large randomized controlled clinical trial, the highly selective SGLT2 inhibitor empagliflozin significantly reduced the risk of three-point major adverse CV events, cardiovascular death, heart failure hospitalization and composite renal outcomes in patients with type 2 diabetes (T2D) with established cardiovascular disease 2 . (nature.com)
  • Early recognition of potentially terrible outcomes is important in the emergency department (ED). Efficient prognosis of the disease is conducive to reducing the financial burden and providing appropriate care for patients. (signavitae.com)
  • As it happens, Bornfeldt became interested as a graduate student in how diabetes predisposes patients to heart disease. (asbmb.org)
  • She continues to probe the links between the two diseases as the deputy director of, and director of the diabetes complications research program at, the University of Washington's Diabetes Institute. (asbmb.org)
  • Before my graduate studies, I had not heard of women having heart attacks in their 30s, and it made me realize that the connection between diabetes and early heart disease was something that we urgently needed to understand and find treatments for. (asbmb.org)
  • At that time there weren't any good animal models to study diabetes-accelerated atherosclerosis, the process that leads to cardiovascular disease. (asbmb.org)
  • After my postdoc period, I set up my own lab here at the University of Washington, and that's when I had the opportunity to really focus on cardiovascular complications of diabetes by generating a mouse model of that disease. (asbmb.org)
  • we generated a new mouse model that we still use a lot to study mechanisms whereby diabetes promotes atherosclerosis. (asbmb.org)
  • We're now basing our research on data from human studies to be sure that we're studying the most important drivers of cardiovascular disease risk in diabetes in humans. (asbmb.org)
  • Diabetes mellitus (DM) , to assess the possibility of the safe use of new diagnostic measures and treatments in the aviation environment to alleviate fitness requirements for pilots/air traffic controllers with Diabetes mellitus. (europa.eu)
  • This study provides valuable information about the problems of patient education for adults with cardiovascular disease. (biomedcentral.com)
  • pulmonary heart disease. (nih.gov)
  • The software and repository are used to simulate cardiovascular and pulmonary solid and fluid mechanics and to provide spatially and temporally resolved benchmark solutions that are used by academic, government, and industry researchers to verify their computational methods. (stanfordchildrens.org)
  • They were divided into two groups according to their respiratory pathology: chronic obstructive pulmonary disease (COPD) and diffuse interstitial pulmonary disease (ILD). (bvsalud.org)
  • With ageing populations, increasing life expectancies and more sedentary lifestyles, today non-communicable chronic diseases are major disabling conditions for people in both developed and developing countries. (benthamscience.com)
  • and the extent to which chronic diseases impact on life expectancies. (benthamscience.com)
  • For example, rapid rises in child and adult obesity - and the related chronic diseases - are now major health issues which federal and State governments find difficult to constrain. (benthamscience.com)
  • CONCLUSIONS: The LDUST has a solid ability to predict complications in cirrhosis outpatients with CSPH, and its integration with Child and MELD models enhances their predictive power. (bvsalud.org)
  • Describe cardiovascular symptoms and complications associated with post-COVID conditions. (cdc.gov)
  • Today I'll present an overview of post-COVID conditions as an introduction of the main presentation on evaluating and supporting patients with cardiovascular symptoms and complications following COVID-19. (cdc.gov)
  • In addition, several studies have demonstrated the beneficial effects of empagliflozin on myocardial infarction (MI) in diabetic animal models 10 , 11 , prompting us to investigate the real-time ATP change in cardiac energy production in an ischemic-reperfusion model of MI. (nature.com)
  • These subjects didn't have any cardiovascular disease when the plasma samples were collected, but they were followed over time so that we knew who developed a myocardial infarction later on. (asbmb.org)
  • The technology platform is built on self-organizing, highly scalable cardiac organoids which recapitulate the human heart physiology and enable modeling of diseases such as drug-induced and genetic cardiomyopathies as well as myocardial infarction, heart remodeling and regeneration. (moleculardevices.com)
  • Interestingly, green tea has already been demonstrated to curb the incidence of cardiovascular disease as well as improve cognitive impairment in Alzheimer's models, though the mechanism for such action is unclear," says Agnetti. (hopkinsmedicine.org)
  • Personalised treatment for cognitive impairment in dementia: development and validation of an artificial intelligence model. (cdc.gov)
  • By computationally sifting through public databases of genomic information, Stanford University researchers have matched 53 human diseases, including cancers, Crohn's disease and cardiovascular conditions, to existing drugs that might work as treatments for them. (livescience.com)
  • Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)
  • As Cardioids represent better predictive models than cardiomyocytes or engineered spheroid models, this collaboration has the potential to considerably improve preclinical drug profiling and significantly increase the efficiency of pharmaceutical drug development," Murphy concluded. (moleculardevices.com)
  • For better prevention and intervention, relevant guidelines recommend using predictive models for early detection of ASCVD high-risk groups. (biomedcentral.com)
  • Different models' discrimination and calibration degrees were compared to find the optimal prediction model for this population according to different genders and further analyze the risk factors of ASCVD. (biomedcentral.com)
  • In our institution, when we adjusted the data for temporo- spatial factors, patient characteristics, and hospital events, treatment with third-generation cephalosporins, metronidazole, and fluoroquinolones was identified as a risk factor for VRE. (cdc.gov)
  • The effect of antecedent treatment with various antibiotic ducted at high-incidence units and their small sample size agents as a risk factor for nosocomial VRE has been explored made it difficult to control for multiple confounding (7,19,21). (cdc.gov)
  • The Framingham risk score is a robust algorithm to predict cardiovascular disease (CVD) risk based on demographic and clinical factors among European Americans. (cdc.gov)
  • The association between peripheral arterial disease and risk for hip fractures in elderly men is not explained by low hip bone mineral density. (lu.se)
  • Introduction: To examine if peripheral arterial disease (PAD) is associated with an increased risk for hip fracture in men independent of hip BMD. (lu.se)
  • The risk for hip fractures was calculated using Cox proportional hazard models. (lu.se)
  • Prediction models containing several features to estimate the risk of patients with confirmed infection could help clinicians give appropriate treatment when health care resources are limited. (signavitae.com)
  • Thirty-four articles were included in the review, and relevant data were extracted from the risk prognosis model. (signavitae.com)
  • This systematic review compared different types of models for predicting the prognosis of influenza infection, informing us of risk factors for the predictive model in predicting the prognosis of influenza in the early stage. (signavitae.com)
  • OBJECTIVES: to evaluate differences in bone mineral density, risk of fractures and bone remodeling markers in patients with terminal lung disease, at the time they are evaluated for lung transplantation, comparing two types of pathologies. (bvsalud.org)
  • Disease-related malnutrition (DRM) affects approximately a third of hospitalized patients and is associated with an increased risk of morbimortality. (bvsalud.org)
  • External validation of AIBx, an artificial intelligence model for risk stratification, in thyroid nodules. (cdc.gov)
  • Heart Failure: The Alzheimer's Disease of The Heart? (hopkinsmedicine.org)
  • Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure, according to a team led by Johns Hopkins University researchers. (hopkinsmedicine.org)
  • They used a fluorescent antibody commonly used in Alzheimer's disease research and a new fluorescent stain for amyloid developed by Agnetti to visualize and quantify the desmin protein clumps. (hopkinsmedicine.org)
  • Fully automated discrimination of Alzheimer's disease using resting-state electroencephalography signals. (cdc.gov)
  • In 2001, he left McKinsey & Company and co-founded, with Dr. Lan Bo Chen of the Dana-Farber Cancer Institute, the Boston-based biotech company Synta Pharmaceuticals, which specialized in new drugs to treat cancer and chronic inflammatory diseases. (wikipedia.org)
  • Dosimetric impact of deep learning-based CT auto-segmentation on radiation therapy treatment planning for prostate cancer. (cdc.gov)
  • Flowchart showing the possible mechanisms linking oral/dental infections to systemic diseases. (medscape.com)
  • [ 5 , 7 ] Although the underlying mechanisms are complex, the chronic inflammatory state and microbial burden in people with periodontal disease may predispose them to cardiovascular diseases in ways proposed for other infections. (medscape.com)
  • infections have declined by 41% since 2000 and more than 11 million people living with HIV are receiving HIV treatment which has contributed to a reduction of up to 48% in deaths due to HIV since 2005. (who.int)
  • This qualitative study involved 30 adult patients with cardiovascular disease who were hospitalized or had a history of hospitalization. (biomedcentral.com)
  • In this regard, an extensive body of research supports the use of the andragogy model in patient education. (biomedcentral.com)
  • The overall objectives of my research are to develop clinically translatable tissue regeneration and drug delivery strategies, and three-dimensional, in vitro human disease models using biologically-derived biomaterials. (wpi.edu)
  • We will utilize techniques from engineering, chemistry and biology to address these research areas, including chemical modifications to alter drug-material interactions, small molecule and macromolecule conjugates to direct cell fate, and multi-cellular tissue/disease systems for paracrine signaling and direct cell-cell interactions. (wpi.edu)
  • When initiating new pre-clinical or basic research studies it is key to choose the right animal model to ensure successful translation to the clinical setting. (nih.gov)
  • Horizons in World Cardiovascular Research. (novapublishers.com)
  • I thought better animal models would be needed in order to understand mechanisms and move the research area forward. (asbmb.org)
  • Research on the relationship between oral health and systemic diseases gained rapid acceleration after the death of President Theodore Roosevelt in 1919 from odontogenic sepsis. (medscape.com)
  • In experiments described in the May 11 issue of the journal Circulation Research , the investigators report identifying in diseased hearts the form of the protein that tends to clump, and visualizing it in the heart using a noninvasive positron emission tomography (PET) scan could, they say, lead to advances in monitoring disease progression and testing new therapies. (hopkinsmedicine.org)
  • Research related to congenital heart disease includes exploring the ability to grow hypoplastic hearts. (stanfordchildrens.org)
  • To test whether computer models could identify which drugs were likely to produce adverse side effects, pharmaceutical chemists at the University of California, San Francisco, teamed up with toxicologists at Novartis Institutes for BioMedical Research. (livescience.com)
  • In addition to its role in cardiac diseases research, the application for cardiac safety is of great importance as cardiovascular safety concerns remain a leading cause of failure in clinical trials, which can be attributed in part to reliance on models that are limited in predictivity. (moleculardevices.com)
  • Health services research and value-based care that addresses disaster-related injury and illness for chronic disease. (cdc.gov)
  • The Research-to-Care Logic Model is used by the WTC Health Program to evaluate the effectiveness of the WTC research program. (cdc.gov)
  • In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Preventing Chronic Disease . (cdc.gov)
  • www.cdc.gov/pcd/issues/2022/21_0385.htm Preventing Chronic Disease. (cdc.gov)
  • The performance of the ASCVD prediction model based on the RSF algorithm is better than that based on Cox regression, Lasso-Cox, and the traditional ASCVD prediction model in the rural population of Xinjiang. (biomedcentral.com)
  • Traditional ASCVD prediction models (Framingham and China-PAR models) were constructed in the test set. (biomedcentral.com)
  • Cardiovascular disease and central nervous symptoms play an important role in prognostic models of influenza. (signavitae.com)
  • Determine which clinical assessments and tests are needed for a patient with cardiovascular symptoms. (cdc.gov)
  • Agnes E.G. Walker, James R.G. Butler, Stephen Colagiuri , " Health Policy in Ageing Populations: Economic Modeling of Chronic Disease Policy Options in Australia ", Bentham Science Publishers (2013). (benthamscience.com)
  • The Marsden Lab at Stanford Engineering develops fundamental computational methods for the study of cardiovascular disease progression, surgical methods, treatment planning, and medical devices. (stanfordchildrens.org)
  • MATERIAL AND METHODS: fifty-nine subjects, proposed to receive a lung transplant due to advanced lung disease, were included in this study. (bvsalud.org)
  • The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. (frontiersin.org)
  • Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
  • In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. (frontiersin.org)
  • We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases. (frontiersin.org)
  • To address this issue, we used a mouse model that enabled direct measurement of cytosolic and mitochondrial ATP levels. (nature.com)
  • Empagliflozin treatment significantly increased cytosolic and mitochondrial ATP levels in the hearts of db/db mice. (nature.com)
  • In this model, the aorta - the main artery coming from the heart - is surgically constricted, which noticeably raises pressure and stress, and causes heart failure. (hopkinsmedicine.org)
  • To elucidate mechanisms underlying this early stenosis, we used a data-informed, computational model to perform in silico parametric studies of TEVG development. (stanford.edu)
  • 2 Center for Congenital Heart Diseases, University Medical Center Groningen, Groningen, The Netherlands. (nih.gov)
  • To understand the underlying pathophysiology of right heart failure and to aid in the development of new treatments we need solid animal models that mimic the pathophysiology of human disease. (nih.gov)
  • In this review we provide an overview of the available animal models of acute and chronic right heart failure and discuss the strengths and limitations of the different models. (nih.gov)
  • Once the heart fails to pump, the only treatment in the end is a heart transplant. (hopkinsmedicine.org)
  • The team used a common mouse model of heart failure to look for desmin clumps. (hopkinsmedicine.org)
  • The Stanford BASE program brings together experts from multiple specialties across the Stanford University campus and its hospitals-including computational modeling, tissue engineering, genetics, and molecular biology-to create bold new solutions for children with heart disease. (stanfordchildrens.org)
  • It focuses on patient-specific modeling in pediatric and congenital heart disease, as well as adult cardiovascular disease. (stanfordchildrens.org)
  • The Michael Ma Lab at the Stanford University School of Medicine studies congenital heart disease and its surgical therapies. (stanfordchildrens.org)
  • The design of airplanes, bridges and even heart stents starts with computer-generated models that not only detail what the products could look like, but how they'd work under different conditions. (livescience.com)
  • For instance, topiramate, an anticonvulsant used to treat epilepsy, emerged as a good match for inflammatory bowel disease. (livescience.com)
  • These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo . (hindawi.com)
  • and other respected institutions, provides a way to capture medical images and patient data to create specific blood flow simulation and analysis models. (stanfordchildrens.org)
  • MODEL-SI (Digital Transformation - Case Studies for Aviation Safety Standards - Modelling and Simulation) , to explore combinations of methodologies to deliver practical, reliable flight load envelopes and load distributions, for eVTOL (electric Vertical Take-Off and Landing) in support of airworthiness certification activities. (europa.eu)
  • Treating WTC-related health conditions for which there has been treatment uncertainty. (cdc.gov)
  • By comparing the discrimination and calibration degrees of each model, the RSF showed the best prediction performance in males and females (male: Area Under Curve (AUC) 0.791 (95%CI 0.767,0.813), C statistic 0.780 (95%CI 0.730,0.829), Brier Score (BS):0.060, female: AUC 0.759 (95%CI 0.734,0.783) C statistic was 0.737 (95%CI 0.702,0.771), BS:0.110). (biomedcentral.com)
  • Currently, the most commonly used survival analysis method is the Cox proportional hazards model, and most traditional ASCVD prediction models are constructed based on this model. (biomedcentral.com)
  • we're combining data that we get from large human cardiovascular outcome studies with the mechanistic mouse models that we have in the lab. (asbmb.org)
  • 3) the development of data models for enhancing the use of flight data for safety. (europa.eu)
  • In the present study, we crossed cytoATP-Tg or mitoATP-Tg mice with a mouse model of T2D and assessed the effects of empagliflozin on the cardiac energy status of those mice. (nature.com)
  • It describes actions to accelerate HIV prevention and treatment interventions in the African Region towards ending the AIDS epidemic. (who.int)
  • This document provides a framework for action to accelerate HIV prevention and treatment interventions in the WHO African Region, taking into account the Regional context. (who.int)
  • The microenvironment of the oral cavity may change according to the age of the patient, eruption or loss of teeth, or active other conditions (eg, caries, periodontal disease). (medscape.com)
  • New treatments and diagnostic measures for cardiovascular diseases (CaVD) , to study the impact of the use of new equipment and treatments in inflight conditions. (europa.eu)
  • The study aimed to explore the experiences of people with cardiovascular disease in patient education. (biomedcentral.com)
  • But by figuring out this mechanism, we may be able to devise better treatments and diagnostic tools. (hopkinsmedicine.org)
  • Then, the data were analyzed using directed content analysis and a preliminary framework based on six constructs of the andragogy model. (biomedcentral.com)
  • My laboratory aims to investigate the molecular and genetic basis of neural circuit function and dynamics, to develop bioinformatic tools for analysis of high-content neural data, and to design rapid cellular and whole-organism screens for therapeutic drugs and genetic modulators affecting neural disease. (wpi.edu)
  • Patient-specific vessel material properties were quantified using Cine MRI data for modeling use. (techscience.com)
  • The host response to this infection is an important factor in determining the extent and severity of the disease. (medscape.com)