Systemic sclerosisRaynaudDystrophic calcinosis cutis MetastaticDiagnosisResult in calcinosis cutisUniversalisDepositionTumoralCircumscriptaDermatomyositisIatrogenicScrotal calcinosisIdiopathic calcinosisConnective tissueEtiologyCalcificationCushing'sPathogenesisOccursCutaneousSurgicalSodiumPrevalenceSymptomsDysfunctionSkinDogsTherapiesRefractoryPreventionLupusPatientsOccurElbowsFibroblastDiseaseUlcersCommonOptionsTraumaSteroidsPatientAdequately
Systemic sclerosis3
- In addition, calcinosis is seen in Limited Cutaneous Systemic Sclerosis, also known as CREST syndrome (the "C" in CREST). (wikipedia.org)
- Calcinosis may result from a variety of causes such as: Trauma to the region Inflammation (bug bites, acne) Varicose veins Infections Tumors (malignant or benign) Diseases of connective tissue Hypercalcemia Hyperphosphatemia Calcinosis cutis is associated with systemic sclerosis. (wikipedia.org)
- PURPOSE OF REVIEW: The aim of this study was to provide updated information on the prevalence, pathogenesis, diagnostics and therapeutics of calcinosis cutis associated with systemic sclerosis (SSc). (bvsalud.org)
Raynaud3
- A 34-year-old woman with history of scleroderma (CREST variety-ie, calcinosis cutis, Raynaud phenomenon, esophageal motility disorder, sclerodactyly, and telangiectasia) developed dyspnea that worsened upon exertion. (medscape.com)
- Vascular ectasias also occur in association with a number of systemic diseases (eg, renal failure, aortic stenosis, cirrhosis, CREST syndrome [calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias]) and after radiation to the bowel. (merckmanuals.com)
- Scleroderma / CREST syndrome (calcinosis cutis, Raynaud phenomena, esophageal dysfunction, sclerodactyly, and telangiectasia) is the most common overlap syndrome resulting in sclerodermatomyositis. (medpagetoday.com)
Dystrophic calcinosis cutis Metastatic1
- 527-530 Dystrophic calcinosis cutis Metastatic calcinosis cutis Iatrogenic calcinosis cutis Traumatic calcinosis cutis Idiopathic calcinosis cutis Idiopathic scrotal calcinosis Subepidermal calcified nodule Tumoral calcinosis Osteoma cutis Intralesional corticosteroids may be beneficial. (wikipedia.org)
Diagnosis7
- Therefore, the diagnosis and treatment of a patient with GM still remains a challenge for the clinician as well as for the patient who often has to suffer a protracted disease course with a significant impact on quality of life. (karger.com)
- In this article, we discuss the etiology, clinical presentation, and diagnosis of GM as well as up-to-date treatment options to give an overview of the current data. (karger.com)
- The diagnosis and evaluation of patients with calcinosis cutis is discussed separately. (medilib.ir)
- Plain radiography can help with diagnosis and quantifying the calcinosis burden. (bvsalud.org)
- Since itchiness is a uncomfortable symptom of many different conditions, dog owners should have their dogs examined by a veterinarian for diagnosis and treatment. (barkleyandpaws.com)
- If you are not able to agree to this procedure, for whatever reasons, then if you have vet who will work with you then he or she may be willing to treat speculatively by giving an immunosuppressive shot of dexamethasone, and if there is remarkable improvement then a presumptive diagnosis can be made and a complete course of immunosuppressive treatment can be started within 2-3 days. (cimda.co.uk)
- Complications due to Cushing's disease and its treatment are common, but with careful diagnosis and management, many dogs with Cushing's disease can survive for as long as two to three years or more, depending on a number of factors. (dermvetolympia.com)
Result in calcinosis cutis2
- Some infectious granulomas produce 1,25-vitamin D. Infections that may result in calcinosis cutis include onchocerciasis, cysticercosis, histoplasmosis, cryptococcosis, and intrauterine herpes simplex. (medscape.com)
- Do not administer Ceftriaxone simultaneously with Calcium Gluconate Injection via Y-site in any age group.5.3 Tissue Necrosis and CalcinosisIntravenous administration of Calcium Gluconate Injection and local trauma may result in calcinosis cutis due to transient increase in local calcium concentration. (drugcentral.org)
Universalis4
- These include calcinosis cutis circumscripta, calcinosis cutis universalis, tumoral calcinosis, and transplant-associated calcinosis cutis. (medscape.com)
- Calcinosis cutis universalis occurs in the second decade of life. (medscape.com)
- Calcinosis cutis universalis with joint contractures complicating juvenile dermatomyositis. (medscape.com)
- Tristano AG, Villarroel JL, Rodriguez MA, Millan A. Calcinosis cutis universalis in a patient with systemic lupus erythematosus. (medscape.com)
Deposition6
- Calcinosis cutis consists of deposition of calcium salts within the skin. (medicaljournals.se)
- Calcinosis circumscripta, a more localized form of calcium deposition in the skin, can occur on pressure points such as the paws and elbows, at suture sites, and on the tongue, but has different underlying causes than calcinosis cutis. (dermvetolympia.com)
- Calcinosis cutis is an uncommon disorder characterized deposition of crystals of calsium phosphate (hydroxyapatite) in the skin in various areas of the body. (biomedcentral.com)
- Calcinosis cutis is an uncommon disorder which results in progressive deposition of insoluble calsium salts (crystals of calcium phosphate, hydroxyapatite) in the skin. (biomedcentral.com)
- INTRODUCTION - The term "calcinosis cutis" describes the deposition of insoluble calcium salts in the skin and subcutaneous tissue. (medilib.ir)
- SUMMARY: Calcinosis cutis is the deposition of insoluble calcium in the skin and subcutaneous tissues. (bvsalud.org)
Tumoral2
- Tumoral calcinosis is more common in blacks of South African heritage. (medscape.com)
- Tumoral calcinosis usually arises in the first or second decade of life. (medscape.com)
Circumscripta1
- Calcinosis cutis circumscripta tends to arise in the second half of life. (medscape.com)
Dermatomyositis3
- In the setting of dermatomyositis, calcinosis cutis is associated with longer disease duration, fingertip ulcers, and NXP-2 autoantibodies. (medscape.com)
- Calcinosis cutis complicating adult-onset dermatomyositis. (medscape.com)
- Valenzuela A, Chung L, Casciola-Rosen L, Fiorentino D. Identification of clinical features and autoantibodies associated with calcinosis in dermatomyositis. (medscape.com)
Iatrogenic2
- Calcinosis cutis is classified into 4 major types according to etiology: dystrophic, metastatic, iatrogenic, and idiopathic. (medscape.com)
- Calcinosis cutis is a group of idiopathic skin calcifications that are classified into four major types according to aetiology: idiopathic, metastatic, iatrogenic, or injury and dystrophic calcinosis. (biomedres.info)
Scrotal calcinosis6
- Idiopathic scrotal calcinosis is a rare benign disease which presents with multiple asymptomatic various sized nodules on the scrotal skin wall. (biomedres.info)
- Idiopathic scrotal calcinosis, Management, Surgery. (biomedres.info)
- Idiopathic scrotal calcinosis is the most common type which was first reported by Lewiuski [ 3 ]. (biomedres.info)
- Idiopathic scrotal calcinosis usually occurs in males between 20 to 40 years of age. (biomedres.info)
- Idiopathic scrotal calcinosis is a rare metabolic disorder and commonly presents as a solitary skin lesion. (biomedres.info)
- The pathogenesis of idiopathic scrotal calcinosis remains controversial. (biomedres.info)
Idiopathic calcinosis3
- Solitary milialike idiopathic calcinosis cutis: a case unassociated with Down syndrome. (medscape.com)
- Sais G, Jucglà A, Moreno A, Peyrí J. Milia-like idiopathic calcinosis cutis and multiple connective tissue nevi in a patient with Down syndrome. (medscape.com)
- Calcification of idiopathic calcinosis is usually localized to a specific area such as the genital area or chest [ 1 , 2 ]. (biomedres.info)
Connective tissue2
- Treatment principles - The treatment of dystrophic calcinosis cutis associated with autoimmune connective tissue disease is often difficult. (medilib.ir)
- Treatment of calcinosis - Treatment of calcinosis cutis associated with autoimmune connective tissue diseases involves careful consideration of the need for treatment and the selection of an appropriate treatment regimen. (medilib.ir)
Etiology2
- See "Calcinosis cutis: Etiology and patient evaluation" . (medilib.ir)
- Further studies should then be performed to assess for the etiology of the pulmonary hypertension, as the etiology determines treatment options and prognosis. (medscape.com)
Calcification2
- Therefore, for many patients, the primary goal of treatment is to minimize symptoms and alleviate functional limitations rather than the complete resolution of cutaneous calcification [ 1 ]. (medilib.ir)
- Treatment of underlying disease - Suppression of activity of the associated autoimmune disease is suggested based upon the theory that autoimmune disease-related tissue injury contributes to risk for cutaneous calcification ( algorithm 1 ) [ 2 ]. (medilib.ir)
Cushing's4
- Additionally, dogs that are suffering from Cushing's Disease can develop calcinosis cutis if their disease is not well controlled. (dermvetolympia.com)
- When Cushing's disease is suspected, there are confirmatory tests to diagnose this disease before beginning treatment, such as an ACTH stimulation test or Low Dose Dexamethasone Suppression Test and an abdominal ultrasound. (dermvetolympia.com)
- If the patient has been diagnosed with Cushing's disease, then treatment for this disease will be started as soon as possible. (dermvetolympia.com)
- Calcinosis cutis is a condition commonly seen in dogs with Cushing's disease that causes the mineralization of the skin. (barkleyandpaws.com)
Pathogenesis2
- The pathogenesis of calcinosis cutis is not completely understood and a variety of factors allow for different clinical scenarios to occur. (medscape.com)
- The role of inflammatory cytokines in the pathogenesis of systemic lupus erythematosus-related atherosclerosis: a novel target for treatment? (jrheum.org)
Occurs3
- Calcinosis cutis occurs when calcium crystals are abnormally deposited in the skin. (dermvetolympia.com)
- Tissue necrosis, ulceration, and secondary infection are the most serious complications.If extravasation occurs or clinical manifestations of calcinosis cutis are noted, immediately discontinue intravenous administration at that site and treat as needed.5.4 Hypotension, Bradycardia, and Cardiac Arrhythmias with Rapid AdministrationRapid injection of Calcium Gluconate Injection may cause vasodilation, decreased blood pressure, bradycardia, cardiac arrhythmias, syncope and cardiac arrest. (drugcentral.org)
- If extravasation occurs or clinical manifestations of calcinosis cutis are noted, immediately discontinue intravenous administration at that site and treat as needed. (drugcentral.org)
Cutaneous2
- He is Co-Study Chair of a multi-disciplinary NIH initiative aimed at the study and treatment of cGVHD (04-C-0281) and Principal Investigator of a therapeutic study of topical ruxolitinib for cutaneous cGVHD (18-AR-0035). (nih.gov)
- This is a training, natural history of disease, and screening protocol for the evaluation, treatment and follow-up of patients with dermatologic diseases and systemic diseases with cutaneous manifestations. (nih.gov)
Surgical5
- Medical and surgical treatments are options to cure calcinosis cutis. (biomedcentral.com)
- Potential interventions include treatment for an underlying disease, medication to reduce calcium deposits or associated inflammation, and surgical removal of calcium deposits. (medilib.ir)
- Surgery - Surgical removal of calcinosis may be useful for patients with discrete, symptomatic areas of calcinosis cutis as the primary treatment or as an adjunct to medical therapy. (medilib.ir)
- Although early reports documenting poor wound healing and sinus track formation led to the historical avoidance of surgical procedures for dystrophic calcinosis cutis, subsequent reports suggest that surgery can be effective for some patients. (medilib.ir)
- Surgical treatment remains the most effective therapy when feasible. (bvsalud.org)
Sodium1
- The efficacy of other treatments, such as magnesium or aluminum antacids, sodium etidronate, diphosphonates and diltiazem is unclear, but they have been reported to be serviceable in refractory calcinosis. (wikipedia.org)
Prevalence2
- RECENT FINDINGS: Observational studies show ethnic and geographical differences in the prevalence of calcinosis. (bvsalud.org)
- Prevalence of calcinosis cutis in the United States using the All of Us research database. (cdc.gov)
Symptoms2
- Do the signs and symptoms of calcinosis cutis warrant treatment? (medilib.ir)
- Decision to treat - Consideration of the severity of the signs and symptoms of calcinosis cutis is important because the response to treatment is variable and unpredictable, and there is risk for treatment-related adverse effects. (medilib.ir)
Dysfunction2
- Long disease duration, features of vascular dysfunction and osteoporosis have been associated with calcinosis. (bvsalud.org)
- Excluding left-sided heart disease, including diastolic dysfunction, is especially important in these patients because of major treatment implications. (medscape.com)
Skin8
- Calcinosis cutis is a term used to describe a group of disorders in which calcium deposits form in the skin. (medscape.com)
- In all cases of calcinosis cutis, insoluble compounds of calcium are deposited within the skin due to local and/or systemic factors. (medscape.com)
- Calcinosis cutis is a type of calcinosis wherein calcium deposits form in the skin. (wikipedia.org)
- Calcinosis cutis lesions commonly appear on the skin as bumps or flat raised areas (papules or plaques) with gritty yellow, white, or grey granules. (dermvetolympia.com)
- The lesions are commonly surrounded by reddened skin, because calcinosis cutis often causes inflammation. (dermvetolympia.com)
- Histological presentations of skin calcinosis in various locations were substantially similar, showing calcium deposits of varying sizes that stained dark blue with Hematoxylin and Eosin (HE) staining and black with von Kossa staining ( Figure 1D ). (biomedres.info)
- a) For the purposes of this section, systemic therapy is treatment that is administered through any route (orally, injection, suppository, intranasally) other than the skin, and topical therapy is treatment that is administered through the skin. (cornell.edu)
- Calcinosis Cutis in the Setting of Chronic Skin Graft-Versus-Host Disease. (nih.gov)
Dogs2
- In dogs, calcinosis cutis is found in young, large breed dogs and is thought to occur after a traumatic injury[citation needed]. (wikipedia.org)
- I have known numerous dogs with SRMA and although it is extremely painful, it can be brought under control very soon after starting immunosuppressive treatment. (cimda.co.uk)
Therapies3
- A better understanding of the process of calcinosis cutis will lead to therapies to improve patient morbidity. (biomedcentral.com)
- Although responses to a wide variety of therapies are documented in the literature, data are insufficient for determining the most effective treatment pathway. (medilib.ir)
- Duration of therapy - Patients who respond to systemic pharmacologic therapies for calcinosis cutis are often maintained on continuous or intermittent treatment for months to years in an attempt to reduce risk for recurrence of disease. (medilib.ir)
Refractory1
- Pancreatic adenocarcinoma (PDAC) is highly refractory to treatment. (bvsalud.org)
Prevention2
- Direct oral anticoagulants (DOACs) are widely prescribed for the prevention and treatment of stroke, systemic embolism and venous thromboembolism.1 Their mechanism of action involves. (annals.edu.sg)
- There was once good reason based on sound scientific reasoning and in vitro studies to think that oral supplementation of these chemicals would be useful in the prevention or treatment of arthritis. (skeptvet.com)
Lupus4
- Marzano AV, Kolesnikova LV, Gasparini G, Alessi E. Dystrophic calcinosis cutis in subacute lupus. (medscape.com)
- Miteva L, Pramatarov K, Vassileva S. Calcinosis cutis in childhood systemic lupus erythematosus. (medscape.com)
- Extensive calcinosis cutis with systemic lupus erythematosus. (medscape.com)
- Bullous systemic lupus erythematosus with milia and calcinosis. (medscape.com)
Patients3
- In December 2013, the FDA approved orally administered treprostinil (Orenitram) extended-release tablets for the treatment of pulmonary arterial hypertension in WHO group I patients to improve exercise capacity. (medscape.com)
- Long-term treatment improves the quality of life and survival rate in patients who are proven responders to calcium channel blockers (CCBs). (medscape.com)
- Object: The aim of this study was to examine the efficacy and the changes of amino acid sequences of the interferon sensitivity-determining region (ISDR) by prolonged interferon (IFN) treatment in patients who have serum hepatitis C virus (HCV)-genotype 1b and a high level of serum HCV-RNA. (go.jp)
Occur3
- Because calcinosis cutis are not always well defined, a recurrence of the lesions may occur. (biomedcentral.com)
- Calcinosis cutis can occur with or without extravasation of Calcium Gluconate Injection, is characterized by abnormal dermal deposits of calcium salts, and clinically manifests as papules, plaques, or nodules that may be associated with erythema, sweling, or induration. (drugcentral.org)
- 4, 5.2)Tissue Necrosis and Calcinosis: Calcinosis cutis can occur with or without extravasation of Calcium Gluconate Injection. (drugcentral.org)
Elbows1
- However, the presence of hard white scaly patches on the elbows and knees, known as calcinosis cutis, is rarely caused by other conditions. (sitstay.com)
Fibroblast1
- Altered levels of inorganic pyrophosphate and fibroblast growth factor-23 have been implicated in dysregulated phosphate metabolism that may lead to calcinosis in SSc. (bvsalud.org)
Disease1
- Efforts to distinguish which form of the disease is present are important, as this can influence treatment recommendations. (dermvetolympia.com)
Ulcers1
- Prior to widespread acceptance of H. pylori , conventional doctors blamed stress and hyperacidity, ignoring the most effective treatment against ulcers. (alive.com)
Common5
- As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
- Dystrophic calcinosis cutis is most common. (medscape.com)
- DYSTROPHIC CALCINOSIS CUTIS - Dystrophic calcinosis cutis, the most common form of calcinosis cutis, results from local tissue injury. (medilib.ir)
- Dear Editor, Cryotherapy is a cost-effective treatment that can be performed by non-dermatologists for viral warts, which are very common.1,2 The National University Hospital, Singapore. (annals.edu.sg)
- Pelodera dermatitis and calcinosis cutis are two less common conditions that can cause dog scratching. (barkleyandpaws.com)
Options4
- No consistently successful treatment options exist, but extracorporeal photopheresis may be the most promising therapy, and research is ongoing. (medscape.com)
- With this case, we aim to discuss the options of management and rationalize the decisions, in which the course of treatment of this patient has proceeded. (jbstjournal.com)
- Treatment options include surgery, radiation therapy, and chemotherapy, and the specific treatment will depend on the type and stage of the cancer, as well as the overall health of the dog. (thepet.info)
- When health issues arise, it is crucial to know what treatment options are available and. (softwavetrt.com)
Trauma1
- There are numerous triggering factors initiating the onset division of trigeminal nerve on right side after 1 month of of HZ such as trauma, malignancy of dorsal root ganglia, X-ray treatment. (sambuz.com)
Steroids1
- Avoiding overuse of oral and injectable steroids is important because they are known to induce calcinosis cutis with long term, high dose use. (dermvetolympia.com)
Patient2
- Clinical follow-up without intervention to reduce calcium deposits is a reasonable option for calcinosis cutis that is asymptomatic, nonprogressive, unassociated with internal involvement, and of minimal concern to the patient. (medilib.ir)
- The patient opted for conservative treatment with chemotherapy over hemipelvectomy. (jbstjournal.com)
Adequately1
- There are also plausible and potentially useful treatments that have not yet been adequately studied, such as physical therapy and some supplements. (skeptvet.com)