MyeloidPatientsChemotherapyLymphoblasticRefractoryArsenic trioxideMyelogenousSurvivalMultiple myelomaCancersRetinoic acidHighly curableComplicationsMyelocytic leukemiaSubtypeAdultsTranslocation2018APMLGenesAbstractRARALymphomaProtocolsSubtypesDiagnosis and TreatmentDifferentiationCancerPeripheralTherapyRemissionRespiratorySigns and symptomsTretinoinGeneticSymptomsMyelofibrosisNewlyMonocyticTypeFunctioning leukemia cellsHematologicAnthracyclineSevereOncologyAggressiveProvenClinical trialsRecurrenceVitroSupportive
Myeloid25
- Acute promyelocytic leukemia (APL) is a distinct variant of acute myeloid leukemia (AML). (medscape.com)
- Investigators in Australia and the U.K. have found that expression of HOXA9 could be used as a marker to support diagnosis and selection of treatment pathways in patients with acute myeloid leukemia and myeloproliferative neoplasms. (medpagetoday.com)
- APL is a subtype of an acute form of leukemia called acute myeloid leukemia (AML) . (healthline.com)
- Acute promyelocytic leukemia (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells. (wikipedia.org)
- See also Acute Myeloid Leukemia Treatment Protocols . (medscape.com)
- Acute myeloid leukemia (AML) and related neoplasms. (oncolink.org)
- Myeloid leukemia associated with Down syndrome. (oncolink.org)
- The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and efficacy of ASTX660 when given alone and in combination with ASTX727 in participants with relapsed/refractory (R/R) acute myeloid leukemia (AML). (mayo.edu)
- Doctors may also refer to it as acute myeloid leukemia , acute nonlymphocytic leukemia, acute myelocytic leukemia, or acute granulocytic leukemia. (medicalnewstoday.com)
- We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. (hindawi.com)
- As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
- There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
- APL accounts for 5% to 10% of acute myeloid leukemia diagnoses in children and adolescents. (themedicaldispatch.com)
- Acute promyelocytic leukemia (APL) is a special type of acute myeloid leukemia (AML), accounting for about 5% to 10% of children with AML. (neoplasiaresearch.com)
- Taga T, Tomizawa D, Takahashi H, Adachi S. Acute myeloid leukemia in children: Current status and future directions. (neoplasiaresearch.com)
- Acute promyelocytic leukemia (APL) is one of the subtypes of acute myeloid leukemia (AML). (shmabstracts.org)
- BACKGROUND: Acute myeloid leukemia (AML) presents ongoing therapeutic challenges due to its intricate molecular pathogenesis. (bvsalud.org)
- The expansion of acute myeloid leukemia (AML) blasts not only suppresses normal hematopoiesis, but also alters the microenvironment. (bvsalud.org)
- Acute myeloid leukemia (AML) is a cancer of certain types of white blood cells. (msdmanuals.com)
- Acute" means this type of myeloid leukemia spreads very quickly and needs immediate treatment. (msdmanuals.com)
- Comprehensive genetic diagnosis of acute myeloid leukemia by next generation sequencing. (cdc.gov)
- Incidence, Survival, and Risk Factors for Adults with Acute Myeloid Leukemia Not Otherwise Specified and Acute Myeloid Leukemia with Recurrent Genetic Abnormalities: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database, 2001-2013. (cdc.gov)
- However, recent studies have shown that the mutational complexity of acute myeloid leukemia (AML) precludes the translation of molecular targeting into clinical success. (lu.se)
- The responding samples to H4, displayed increased expression of myeloid markers, a clear decrease in the nuclear-cytoplasmic ratio and the potential of re-activation of the monocytic transcriptional program reducing leukemia propagation in vivo. (lu.se)
- Acute myeloid leukemia (AML) is a disease with diverse genetic features of the leukemic cells and with variable outcome. (cancercentrum.se)
Patients43
- The overall success rate following APL treatment is 80 percent which is higher in low-risk patients. (yashfiin.com)
- Patients with AML are best treated at a center whose staff has significant experience in the treatment of leukemia. (medscape.com)
- Patients should be transferred to an appropriate (generally tertiary care) hospital if they are admitted to hospitals without appropriate blood product support, leukapheresis capabilities, or physicians and nurses familiar with the treatment of leukemia patients. (medscape.com)
- In a similar study in patients 60 years of age or older by Lowenberg et al, 813 patients received either conventional-dose treatment (daunorubicin 45 mg/m 2 /d for 3 d) or escalated-dose treatment (daunorubicin 90 mg/m 2 /d for 3 d), both administered over 3 hours on days 1, 2, and 3. (medscape.com)
- Cure of APL patients, however, is also dependent on peculiar aspects related to the management and supportive measures that are crucial to counteract life-threatening complications associated with the disease biology and molecularly targeted treatment. (nih.gov)
- some patients will need ongoing maintenance therapy depending on how much consolidation treatment they have received, as well as if they had a stem cell transplant. (oncolink.org)
- Tretinoin should be given only under the supervision of a doctor who has experience in treating people who have leukemia (cancer of the white blood cells) and in a hospital where patients can be monitored for severe side effects and treated if these side effects occur. (medlineplus.gov)
- This trial also provides physicians more information for managing patients - from treatment initiation, to assessing response and management post disease remission. (biospace.com)
- Today's news continues the progress of bringing more treatment options to patients with this devastating disease," said Lee Greenberger , Ph.D., chief scientific officer of The Leukemia & Lymphoma Society. (biospace.com)
- With increasingly effective treatments, early death (ED) has become the predominant reason for therapeutic failure in patients with acute promyelocytic leukemia (APL). (lu.se)
- Patients with acute promyelocytic leukemia (APL) are at high risk in general and can have severe adverse reactions to VESANOID (tretinoin). (rxlist.com)
- VESANOID (tretinoin) should therefore be administered only to patients with APL under the strict supervision of a physician who is experienced in the management of patients with acute leukemia and in a facility with laboratory and supportive services sufficient to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity, including respiratory compromise. (rxlist.com)
- About 25% of patients with APL treated with VESANOID (tretinoin) have experienced a syndrome called the retinoic acid-APL ( RA -APL) syndrome characterized by fever, dyspnea , acute respiratory distress, weight gain, radiographic pulmonary infiltrates, pleural and pericardial effusions, edema, and hepatic, renal, and multi- organ failure . (rxlist.com)
- Recently, a randomized prospective study showed that the addition of ATO to "ATRA + chemotherapy" treatment protocol had a significantly higher EFS in patients with APL than those treated with "ATRA + chemotherapy" protocol. (druglib.com)
- van Hout MSE, Wekking EM, Berg IJ, Deelman BG: Psychological treatment of patients with chronic toxic encephalopathy: Lessons from studies of chronic fatigue and whiplash. (karger.com)
- In their article "Liver Transplantation for the Treatment of Hepatocellular Carcinoma,' Drs. Hanish and Knechtle provide a cogent review of many of the issues surrounding the management of hepatocellular carcinoma (HCC) in patients with cirrhosis. (cancernetwork.com)
- In their scholarly article, Dr. Park and Dr. Tallman review the important clinical trials for treating patients with APL reported over the last two decades and argue the case for further reduction and perhaps elimination of conventional cytotoxic chemotherapy in the frontline treatment of this disease. (cancernetwork.com)
- The LLS mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of patients and their families. (schoolandyouth.org)
- The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
- It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
- See Clues on the Skin: Acute Poisonings , a Critical Images slideshow, to help diagnose patients based on their dermatologic presentations. (medscape.com)
- A significant portion of patients with acute myelogenous leukemia (AML) can now be cured with chemotherapy. (hematology.org)
- As with acute lymphoblastic leukemia, the successful management of patients with AML requires a therapeutic strategy determined by careful assessment of individual prognosis, aggressive supportive therapy, and early recognition and treatment of complications. (hematology.org)
- Compare and contrast AML and ALL in terms of age of patients, central nervous system involvement, treatment, and outcome. (hematology.org)
- For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy, and whose APL is characterized by the presence of the t(15;17) translocation or PML/RARA gene expression. (lls.org)
- These data suggest that use of resveratrol as postremission therapy for acute promyelocytic leukemia as well as adjunctive therapy in patients with exposure to arsenic may decrease arsenic nephrotoxicity. (springer.com)
- Patients with acute promyelocytic leukemia (APL) treated with Trisenox have experienced symptoms of differentiation syndrome, which may be life-threatening or fatal. (centerwatch.com)
- HOUSTON (AP) - Following his leukemia diagnosis, Houston Texans receiver John Metchie and other patients at MD Anderson Cancer Center would sit in an observatory gazing out the windows while hooked up to IVs that delivered their treatment. (ozarksfirst.com)
- Adult patients with high-risk APL also receive some chemotherapy, as well as maintenance therapy (further treatment to prevent the leukemia from coming back). (themedicaldispatch.com)
- Some of the patients with high-risk APL developed mouth sores from the idarubicin treatment. (themedicaldispatch.com)
- Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
- Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
- A chemotherapeutic agent used in the treatment of refractory or relapsed acute promyelocytic leukemia in patients with prior retinoid and anthracycline chemotherapy. (drugbank.com)
- The correct diagnosis and treatment of these patients depend on the knowledge of normal hemostasis mechanisms and the results of laboratory tests that evaluate these mechanisms. (bvsalud.org)
- Among 899 patients with acute leukemia diagnosed at two large children's hospitals, a priori lab-based definitions of high disease burden, infection risk, renal dysfunction, and coagulopathy were applied to electronic health record data. (bvsalud.org)
- Black patients with acute lymphoblastic leukemia demonstrated increased prevalence of coagulopathy. (bvsalud.org)
- Characterization of therapy-related acute leukemia in hereditary breast-ovarian carcinoma patients: role of BRCA1 mutation and topoisomerase II-directed therapy. (cdc.gov)
- Combination treatment has proven effective for patients with acute promyelocytic leukemia, exemplifying the importance of therapy targeting multiple components of oncogenic regulation for a successful outcome. (lu.se)
- Elderly patients with secondary AML, high-risk genetics or significant co-morbidites should rather receive treatment with hypomethylating agents such as azacitidine, with or without venetoclax. (cancercentrum.se)
- In all patients that might become considered for intensive treatment, the AML diagnosis should be based on morphologic and immunophenotypic features of bone marrow aspirates as well as on genetic characteristics of the leukemic blasts. (cancercentrum.se)
- However, the aim of treatment may be dependent on the genetic risk and comorbidity, and some patients may need supportive care for infection before being eligible for treatment decision. (cancercentrum.se)
- Patients with acute promyelocytic leukemia (APL) are treated according to a separate protocol (included in the care program) based on all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). (cancercentrum.se)
- Non-small Cell Lung Cancer The ADAURA trial confirmed that in patients with early-stage (stage II to IIIA) NSCLC, adjuvant treatment with osimertinib after surgical resection of the tumor significantly improved overall survival. (medscape.com)
Chemotherapy13
- Depending on the degree of severity, APL treatment may include non-chemo drugs, all-trans-retinoic acid (ATRA) along with chemotherapy, transfusion of platelets, and other blood products. (yashfiin.com)
- before 2013 the standard of treatment was anthracycline (e.g. daunorubicin, doxorubicin, idarubicin or mitoxantrone)-based chemotherapy. (wikipedia.org)
- Several treatment strategies using these agents, usually in combination with chemotherapy, but also without or with minimal use of cytotoxic agents, have provided excellent therapeutic results. (nih.gov)
- a type of cancer in which there are too many immature blood cells in the blood and bone marrow) in people who have not been helped by other types of chemotherapy or whose condition has improved but then worsened following treatment with other types of chemotherapy. (medlineplus.gov)
- For far too long, people with AML had very few treatment options, aside from very intense chemotherapy. (biospace.com)
- One treatment option is induction chemotherapy, which involves several drugs. (medicalnewstoday.com)
- Consolidation chemotherapy can follow induction chemotherapy to treat any remaining leukemia cells that are not visible in the blood or bone marrow. (medicalnewstoday.com)
- Research suggests that while treatments such as intensive chemotherapy and allogeneic stem cell transplantation may be curative for younger people, they are less likely to be effective in older individuals. (medicalnewstoday.com)
- Treatment with ATRA and anthracycline-based chemotherapy (ATRA + chemotherapy) decreases relapses of the disease as well as early hemorrhagic deaths. (druglib.com)
- However, there is no report comparing treatment outcomes of "ATO + ATRA + chemotherapy" and "RIF + ATRA + chemotherapy" protocols in children with APL so far. (druglib.com)
- This patient had an excellent response to chemotherapy, suggesting that this mutation will not affect the treatment and prognosis of APL. (neoplasiaresearch.com)
- Leukemia stem cells (LSC) are thought to be the basis of leukemia progression since they are highly resistant to conventional chemotherapy. (bvsalud.org)
- Previous first-line treatment for intermediate, high, very high risk myelodysplastic syndromes (based on IPSS-R) or CMML with any antineoplastic agents including for example chemotherapy, lenalidomide and hypomethylating agents (HMAs) such as decitibine and azacitidine. (who.int)
Lymphoblastic2
- B-cell acute lymphoblastic leukemia with a mutation called the Philadelphia chromosome is a particularly aggressive cancer with poor outcomes, said Ravi Majeti, M.D., Ph.D., an assistant professor of medicine and senior author of the paper. (labroots.com)
- Congratulations to the international group of researchers led by HemaSphere Editor-in-Chief Prof. Jan Cools of the VIB-KU Leuven Center for Cancer Biology who have made a breakthrough in understanding the development of acute lymphoblastic leukemia, an aggressive cancer of the blood. (ehaweb.org)
Refractory3
- Dr. Lai, of the University of Pennsylvania, describes the difference between refractory vs relapse, and the implications these have on treatment. (medpagetoday.com)
- Treatment recommendations include general recommendations, which take into account patient age and performance status, as well as recommendations for relapsed or refractory disease and acute promyelocytic leukemia (APL). (medscape.com)
- relapsed after or refractory to treatment with molecularly targeted and/or low-intensity chemotherapeutic regimens. (mayo.edu)
Arsenic trioxide16
- The introduction of all-trans retinoic acid (ATRA) and, more recently, arsenic trioxide (ATO) into the therapy of acute promyelocytic leukemia (APL) has revolutionized the management and outcome of this disease. (nih.gov)
- In the 1990s, research showed that an arsenic compound, arsenic trioxide , was effective in the treatment of acute promyelocytic leukemia. (cancer.gov)
- In this excellent review of acute promyelocytic leukemia (APL) treatment, the authors highlight opportunities offered by incorporating arsenic trioxide (ATO) into the therapeutic armamentarium. (cancernetwork.com)
- In the treatment of acute promyelocytic leukemia, arsenic trioxide has been known to display strong anti-tumor effects with few toxic effects. (medindia.net)
- In 2005, arsenic trioxide was obtained from the treatment of nonferrous ores or concentrates in 14 countries. (cdc.gov)
- Arsenic trioxide for years has been used to fend off a rare subtype of blood cancer known as acute promyelocytic leukemia (APL). (tgen.org)
- But as Drs. Dhruv and Bell drilled down into the studies, they discovered that a specific subtype of GBM cells were more responsive to the arsenic trioxide treatment. (tgen.org)
- Northwestern was involved in one of the clinical trials, which tested the efficacy of arsenic trioxide in combination with temozolomide (TMZ) and radiation in treatment of GBM. (tgen.org)
- Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro . (centerwatch.com)
- the use of arsenic trioxide vials as a treatment for a rare form of leukemia called acute promyelocytic leukemia (APL), highlighting their effectiveness and potential side effects. (imedix.com)
- Arsenic trioxide is used to treat a type of leukemia (acute promyelocytic leukemia-APL). (imedix.com)
- Read the Patient Information Leaflet if available from your pharmacist before you start using arsenic trioxide and each time you get a treatment. (imedix.com)
- A clinical trial has found that the combination of all-trans retinoic acid, which is a metabolite of vitamin A, and arsenic trioxide is highly effective in children with standard- and high-risk acute promyelocytic leukemia, or APL. (themedicaldispatch.com)
- By comparison, all-trans retinoic acid and arsenic trioxide have fewer acute or long-term side effects. (themedicaldispatch.com)
- The combination of all-trans retinoic acid and arsenic trioxide is currently the preferred initial treatment for adults with standard-risk APL. (themedicaldispatch.com)
- He founded PolaRx Biopharmaceuticals, Inc., in 1997, where he also served as Chief Scientific Officer until 1999, and on the team responsible for bringing Trisenox (Arsenic Trioxide for the treatment of Acute Promyelocytic Leukemia) to NDA completion, now marketed and sold worldwide by Teva. (bignewsnetwork.com)
Myelogenous3
- Acute myelogenous leukemia (AML) is a blood cancer that affects white blood cells, red blood cells, and/or platelets. (oncolink.org)
- BCR-ABL-positive leukemia (chronic myelogenous leukemia in blast crisis). (mayo.edu)
- Acute myelogenous leukemia (AML) is a type of cancer that involves the bone marrow. (medicalnewstoday.com)
Survival6
- Acute promyelocytic leukemia was first characterized in 1957 by French and Norwegian physicians as a hyperacute fatal illness, with a median survival time of less than a week. (wikipedia.org)
- However, of the forms of acute leukemia that affect adults, AML currently has the shortest length of survival. (medicalnewstoday.com)
- The last decade has seen major changes in the treatment of chronic lymphocytic leukemia (CLL), with randomized trials now demonstrating improved survival with the use of chemoimmunotherapy. (cancernetwork.com)
- The 10-year survival rate for acute promyelocytic leukemia is 80 to 90 percent. (copingmag.com)
- Event-free survival is the length of time after primary treatment that the patient remains free of worsening disease, relapse, or death. (themedicaldispatch.com)
- APL is an aggressive malignancy, and without treatment, the median survival is less than 1 month. (shmabstracts.org)
Multiple myeloma1
- A resurgence of interest in arsenic as a medicinal agent for the treatment of acute promyelocytic leukemias, multiple myeloma, myelodysplastic syndromes, and assorted resistant solid tumors may potentially contribute to increases in arsenic exposure. (medscape.com)
Cancers7
- Leukemia is a group of cancers that develop in the cells that produce blood cells. (healthline.com)
- These include your age, your AML subtype, if you have had treatment for other cancers in the past, your overall health, and testing results. (oncolink.org)
- Leukemia is an umbrella term for cancers affecting the blood-forming cells in the body. (medicalnewstoday.com)
- Many cancers re-emerge after treatment, despite the sensitivity of the bulk of tumor cells to treatments. (mdpi.com)
- It doesn't seem all that long ago when most cancers were death sentences, but now the majority of cancers have strong treatment options. (onedayonejob.com)
- Medscape Cancer Treatment, Staging, and Guideline Syntheses provide the essential information clinicians need to accurately stage and treat most cancers using the latest recommendations and guidelines. (medscape.com)
- 1995). in Five Continents, Vol. I to VIII IARC CancerBase No. 7, Lyon, [Current treatment of cancers of the anal canal]. (who.int)
Retinoic acid3
- Outcome of acute promyelocytic leukemia (APL) has greatly improved since the introduction of all-trans-retinoic acid (ATRA). (druglib.com)
- Describe the unique features of acute promyelocytic leukemia (AML M3), including the morphologic appearance of the promyelocyte, hemorrhagic complications, chromosomal abnormality, and treatment with induction therapy and all trans retinoic acid. (hematology.org)
- Dr. Zhu Chen, Dr. Anne Dejean and Dr. Hugues de Thé will be awarded the Sjöberg Prize 2018 for their work on how acute promyelocytic leukemia (APL) could be cured based on arsenic and retinoic acid. (ehaweb.org)
Highly curable1
- One type, called acute promyelocytic leukemia, is now highly curable. (msdmanuals.com)
Complications5
- Together with providing current indications on genetic diagnosis, modern risk-adapted front-line therapy and salvage treatment, the review contains specific recommendations for the identification and management of most important complications such as the bleeding disorder, APL differentiation syndrome, QT prolongation and other ATRA- and ATO-related toxicities, as well as for molecular assessment of response to treatment. (nih.gov)
- APL is characterized by excessive production of promyelocytic blasts, which are responsible for hemorrhagic complications. (shmabstracts.org)
- Thrombotic complications occur less frequently in APL, mainly seen during the course of treatment. (shmabstracts.org)
- In APL, thrombosis related complications include acute myocardial infarction, cerebrovascular accidents, and DVT/pulmonary embolism among others. (shmabstracts.org)
- Allo-hSCT is estimated to reduce the risk of leukemia relapse to half, but with significant risk for treatment-related complications. (cancercentrum.se)
Myelocytic leukemia1
- AML may also be called acute myelocytic leukemia, acute granulocytic leukemia, or acute non-lymphocytic leukemia. (oncolink.org)
Subtype1
- The subtype of AML and the individual's overall health may determine the treatment options. (medicalnewstoday.com)
Adults2
- AML is the most common type of acute leukemia in adults, and it happens when the bone marrow begins making myeloblasts, also called blasts. (medicalnewstoday.com)
- In combination with tretinoin for the treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia (APL) whose APL is characterized by the presence of the t(15;17) translocation or the PML/RARA gene expression. (lls.org)
Translocation3
- In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). (wikipedia.org)
- Although the chromosomal translocation involving RARA is believed to be the initiating event, additional mutations are required for the development of leukemia. (wikipedia.org)
- We report the case of a child with acute promyelocytic leukemia (APL) who had characteristic chromosome translocation t(15;17) and rare PML-RARA gene mutation. (neoplasiaresearch.com)
20182
- I have been in remission for three years and my doctor has hopes that I will be cured of leukemia by 2018. (schoolandyouth.org)
- Specification for the Diagnosis and Treatment of Acute Promyelocytic Leukemia in Children (2018 Edition). (neoplasiaresearch.com)
Genes2
- Eight other rare gene rearrangements have been described in APL fusing RARA to promyelocytic leukemia zinc finger (PLZF), nucleophosmin, nuclear matrix associated, signal transducer and activator of transcription 5b (STAT5B), protein kinase A regulatory subunit 1α (PRKAR1A), factor interacting with PAPOLA and CPSF1 (FIP1L1), BCL-6 corepressor or oligonucleotide/oligosaccharide-binding fold containing 2A (NABP1) genes. (wikipedia.org)
- De Braekeleer E, Douet-Guilbert N, De Braekeleer M. RARA fusion genes in acute promyelocytic leukemia: a review. (neoplasiaresearch.com)
Abstract1
- ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
RARA3
- Induction therapy should not be modified based on the presence of leukemia cell characteristics that have variably been considered to predict a poorer prognosis (eg, secondary chromosomal abnormalities, FLT3 mutations, CD56 expression, BCR3 PML-RARA isoform). (medscape.com)
- Microgranular variant of acute promyelocytic leukemia with normal conventional cytogene-tics, negative PML/RARA FISH and positive PML/RARA transcripts by RT-PCR. (neoplasiaresearch.com)
- Avgerinou G, Katsibardi Κ, Filippidou M, Tzanoudaki M, Papadhimitriou SI, Kattamis A. Cytogenetically cryptic and fish negative PML/RARA rearrangement in acute promyelocytic leukemia detected by RT-PCR. (neoplasiaresearch.com)
Lymphoma2
- The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against cancer. (schoolandyouth.org)
- The Leukemia & Lymphoma Society is a 501(c)(3) organization, and all monetary donations are tax deductible to the fullest extent allowed by tax laws. (schoolandyouth.org)
Protocols1
- Diseases are different, treatment protocols are different, baseline health is different, mind frames are different, and so are prognoses. (copingmag.com)
Subtypes1
- It is different than other forms of leukemia because it has eight distinct subtypes, which develop from different types of cells. (medicalnewstoday.com)
Diagnosis and Treatment1
- Always seek the advice of a qualified physician for medical diagnosis and treatment. (medindia.net)
Differentiation4
- Treatment with ATRA should be continued until terminal differentiation of blasts and achievement of complete remission. (medscape.com)
- Therapy should not be modified on the basis of incomplete blast maturation (differentiation) detected up to 50 days or more after the start of treatment. (medscape.com)
- Dr. Lai, of the University of Pennsylvania, believes steroids are "very effective" for both the treatment and prevention of differentiation syndrome. (medpagetoday.com)
- tretinoin), the acid form of vitamin A. Treatment with ATRA dissociates the NCOR-HDAC complex from RAR and allows DNA transcription and differentiation of the immature leukemic promyelocytes into mature granulocytes by targeting the oncogenic transcription factor and its aberrant action. (wikipedia.org)
Cancer8
- I'd learned some about leukemia when dealing with magnetic fields associated with transmission lines, argued need for regulatory action before the appellate court 20 years ago, but no, earlier bad decision affirmed… And I've long known of cancer clusters, and the increases in childhood leukemia in certain scenarios. (legalectric.org)
- Tretinoin is used to produce remission (a decrease or disappearance of signs and symptoms of cancer) of APL, but other medications must be used after treatment with tretinoin to prevent the cancer from returning. (medlineplus.gov)
- It is an aggressive cancer, so it requires immediate treatment. (medicalnewstoday.com)
- Vesanoid (tretinoin) is a cancer medication used to treat acute promyelocytic leukemia (a type of blood cancer). (rxlist.com)
- So You've Got Acute Blood Cancer … Join The Club! (copingmag.com)
- Researchers at the Stanford University School of Medicine have discovered that when a certain aggressive leukemia is causing havoc in the body, the solution may be to force the cancer cells to grow up and behave. (labroots.com)
- The problem with cancer treatment is that its short-term effects are often worse than those of the disease. (onedayonejob.com)
- They have already had success with the treatment that they've helped develop for acute promyelocytic leukemia, and there hope is that their research will apply to treating many other forms of cancer too. (onedayonejob.com)
Peripheral3
- The presence of promyelocytes containing multiple Auer rods (termed faggot cells) on the peripheral blood smear is highly suggestive of acute promyelocytic leukemia. (wikipedia.org)
- Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
- Describe the predominant cell types seen in the peripheral blood and/or bone marrow in each of the four major categories of leukemia (AML, ALL, CML, CLL). (hematology.org)
Therapy5
- Treatment of APL includes induction therapy, consolidation therapy, and maintenance therapy. (medscape.com)
- In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. (mayo.edu)
- Nevertheless, their results suggest that cognitive behavioural therapy is more effective than providing no treatment. (karger.com)
- Dr. Kutny pointed out that because there was no need for maintenance therapy, the length of time the children were undergoing treatment was reduced from more than two years to approximately nine months. (themedicaldispatch.com)
- We evaluated disparities in disease burden, organ dysfunction, vital signs, and timing of therapy in children newly presenting with acute leukemia. (bvsalud.org)
Remission2
- after a remission, you will enter this second phase of treatment. (oncolink.org)
- Total remission was reached, on average, within two months after treatment with Trisenox began. (centerwatch.com)
Respiratory1
- A vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates. (drugbank.com)
Signs and symptoms1
- Read on to learn about how APL differs from other leukemias, how to spot signs and symptoms, the diagnostic process, and how it's treated. (healthline.com)
Tretinoin3
- If you have a very high number of white blood cells before you begin tretinoin treatment, or if you have an increase in the number of white blood cells during your treatment with tretinoin, expecially if you experience any of the symptoms of RA-APL syndrome, your doctor may prescribe one or more medications to treat or prevent the increase in white blood cells. (medlineplus.gov)
- If you can become pregnant, you will need to avoid pregnancy during your treatment with tretinoin. (medlineplus.gov)
- Tell your doctor immediately if you think you might be pregnant at any time during your treatment with tretinoin. (medlineplus.gov)
Genetic2
- An integrative approach reveals genetic complexity and epigenetic perturbation in acute Promyelocytic leukemia: a single institution experience. (cdc.gov)
- Here as a complement to genetic profiling, we used unbiased, combinatorial in vitro drug screening to identify pathways that drive AML and to develop personalized combinatorial treatments. (lu.se)
Symptoms3
- The symptoms of APL tend to be nonspecific and can resemble those of many other conditions or other types of leukemia. (healthline.com)
- You should consult a medical professional if you have any potential warning symptoms of APL, even if leukemia is unlikely to be the cause. (healthline.com)
- Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. (harvard.edu)
Myelofibrosis1
- Acute panmyelosis with myelofibrosis. (oncolink.org)
Newly1
- However, as a newly diagnosed leukemia survivor fighting for my life, that wasn't always the effect. (copingmag.com)
Monocytic1
- Acute monoblastic/monocytic leukemia. (oncolink.org)
Type1
- Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. (mayo.edu)
Functioning leukemia cells1
- The treatment is designed to wipe out the abnormally functioning leukemia cells. (oncolink.org)
Hematologic1
- Clinicians should be aware of possible underlying hematologic malignancy while dealing with a patient with an unprovoked acute DVT and pancytopenia. (shmabstracts.org)
Anthracycline1
- Children with high-risk APL also received four doses of the anthracycline idarubicin during the initial phase of treatment. (themedicaldispatch.com)
Severe4
- Activated charcoal is prescribed for the treatment of moderate to severe cases of poisoning where gastrointestinal decontamination (removal of toxin from gastrointestine) is needed. (medindia.net)
- Fewer than 10% of the children experienced severe side effects, which occurred only in the initial phase of treatment. (themedicaldispatch.com)
- Artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. (drugbank.com)
- Those with severe comorbidities may prefer primary palliative treatment, with or without cytoreductive medications. (cancercentrum.se)
Oncology1
- Gibson Oncology is developing a novel class of proprietary drug candidates currently in clinical trials for the treatment of difficult-to-treat tumors. (bignewsnetwork.com)
Aggressive1
- The acute leukemias are aggressive malignancies that originate in a hematopoietic stem cell and are rapidly fatal without immediate treatment. (hematology.org)
Proven1
- The treatment I was on, and the only proven treatment for a cure was not working for me. (schoolandyouth.org)
Clinical trials2
- These studies lay the conceptual and practical framework for clinical trials using ATRA in the treatment of a commonly lethal pediatric disease. (sciencedaily.com)
- Only clinical trials that compared the efficacy of a potential treatment for EHS against a control condition were included in the review. (karger.com)
Recurrence1
- It will be important to attend follow-up exams to check for a recurrence of leukemia and any possible treatment side effects. (medicalnewstoday.com)
Vitro1
- The xenograft model validated in vitro results, as E7070 treatment suppressed AML xenograft growth via RBM39-mediated PI3K/AKT pathway suppression. (bvsalud.org)
Supportive3
- Treatment of acute arsenic toxicity is supportive. (medscape.com)
- Though his family was very supportive from afar, he said it was difficult to be in Houston for treatment while they were in Canada, where he grew up. (ozarksfirst.com)
- The Swedish AML group (for participants, see www.svenskaamlgruppen.se) has published national care programs since 2005, including basic background and recommendations for diagnosis, treatment and supportive care. (cancercentrum.se)