Treatment gata3 transcription factor. Medical search. Frequent questions

Hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome, also known as Barakat syndrome, is a rare autosomal dominant disease characterized by the triad of hypoparathyroidism (H), deafness (D) and renal abnormalities (R). Its genetic cause is known to be the haploinsufficiency of the zinc finger transcription factor GATA3. (endocrine-abstracts.org)
This immunosuppressive helper T cell phenotype can be further induced by the zinc-finger transcription factor GATA3, which regulates Th2 cytokine expression [ 9 ] . (encyclopedia.pub)

Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) promoters in. (oncotarget.com)
In A549 cells, interleukin-1ß (IL1B) and tumor necrosis factor α (TNF) induced BIRC3 mRNA (~20-50-fold), with maximal protein expression from 6-24 h. (bvsalud.org)
GATA-binding protein 3 (GATA3) is a transcription factor that is crucial to mammary gland morphogenesis and differentiation of progenitor cells, and has been suggested to have a tumor suppressor function. (eur.nl)
Gene expression levels of T-box transcription factor (T-bet, TBX21), GATA binding protein 3 (GATA3), Retinoic acid-related orphan receptor C (RORC) and Forkhead box P3 (FOXP3) were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR). (openscience.si)
Western blot analysis was used to estimate the protein expression levels of specific transcription factors for T helper cells (Th1, Th2 and Th17) and key molecules of the Janus-activated kinase (Jak)/signal transducer and activator of transcription (Stat3) signaling pathway. (researcher-app.com)
The number of studies that have used protein interaction discovery approaches for identification of associated factors is overwhelming. (aacrjournals.org)
We do not aim to provide an exhaustive analysis of all available techniques, but instead will highlight some of the most widely used methods for protein-protein assessment and will describe some recent advances in global protein-protein analyses that are enabling non-experts to identify interactomes of their favorite factor. (aacrjournals.org)
The validity of co-IP approaches can quickly deteriorate when forced expression of tagged proteins are used to investigate possible interactions, yet this approach, particularly when endogenous factors are assessed, can provide useful information about potential protein associations. (aacrjournals.org)
We examined a panel of prolactin-induced tumors for characteristics relevant to clinical tumors: histotype, ERα/progesterone receptor (PR) expression and estrogen responsiveness, Activating Protein 1 (AP-1) components, and phosphorylation of signal transducer and activator of transcription 5 (Stat5), extracellular signal regulated kinase (ERK) 1/2 and AKT. (biomedcentral.com)
Surface receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and nuclear transcription factors attenuate T cell responses, where CTLA-4 competes with CD28 for binding to CD80/86, resulting in inhibitory downstream signalling [ 6 ] . (encyclopedia.pub)
Another study that compared a pair of twins with discordant HIV infection status showed that several other genes are also differentially methylated, including insulin-like growth factor binding protein 6 ( IGFBP6 ) [ 19 ]. (biomedcentral.com)

Each distinct CD4 + T-cell subset has a specific function and can mainly be distinguished by its cytokine profile, the expression pattern of cell surface molecules, and the activation of specific transcription factors 8 . (nature.com)
We have previously shown that administration of tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 T cell (Th2) cytokine transcription factor GATA-3. (listlabs.com)
The subsets of innate lymphoid cells have different property of cytokine production and usage of transcription factor. (tmu.edu.tw)
Several studies have clearly demonstrated that distinct cytokine activated signalling and transcription factors regulate the commitment of a naïve T cell along the Th1 or T helper cell type 2 (Th2) phenotype, as well as maintenance of the polarised phenotype. (bmj.com)
For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)
Various types of ILCs can be discriminated based on the expression of distinct transcription factors controlling the expression of a distinct set of cytokine genes endowing the various ILC subsets with a specific range of effector functions. (iisymposium.nl)

The purpose of this study was to investigate whether an aberrant DNA methylation of transcriptional and inflammatory factors, including TBX21, GATA3, RORγt, FOXP3, IFN-γ, IL-4, IL-17A and TGF-β , in CD4 + T confers risk to BD. (oncotarget.com)
TBX21 (Th1) , GATA3 (Th2) , RORγt (Th17) and FOXP3 (Treg) are the primary subset-specific transcription factors of these CD4 + T cell subsets and can regulate T cell differentiation. (oncotarget.com)
An earlier study found that the ratio of Th1/Th17 cells was decreased in BD patients with uveitis [ 5 ], and another study reported an increase in the ratios of RORC / FOXP3 and TBX21 / GATA3 in neuro-Behçet's disease, suggesting a dysregulation of Th1, Th2, Th17 and Tregs in this disease [ 6 ]. (oncotarget.com)
More recently, the role of Th1 and Th17 CD4 + cells in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model for human MS, has been challenged, and it has been demonstrated that the transcription factor T-bet (also known as Tbx21 ) is critical for controlling Th1/Th17-mediated autoimmunity 12 . (nature.com)

Haploinsufficiency for the trans-acting T-cell-specific transcription factor GATA-3 (encoded by the GATA3 gene, and mapped to the 10p14-pter region) is responsible for this phenotype. (orpha.net)
T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper cell type 2 (Th2) cell polarisation, were examined in duodenal biopsies by western blotting. (bmj.com)
Group 2 ILCs (ILC2s), are characterized by the transcription factor GATA-3 and the IL-33 specific receptor ST-2. (elifesciences.org)

We found that the promoter methylation level of GATA3, IL-4 and TGF-β was significantly up-regulated in active BD patients and negatively correlated with the corresponding mRNA expression. (oncotarget.com)
The mRNA expression of GATA3 and TGF-β was markedly down-regulated in active BD patients compared to healthy individuals. (oncotarget.com)
Our results suggest that an aberrant DNA methylation of GATA3 and TGF-β is associated with their mRNA expression and participates in the pathogenesis of BD. (oncotarget.com)
Treatment with VIP or PACAP prior to in vitro LC Ag presentation to CD4+ T cells enhanced IL-17A, IL-6, and IL-4 production, decreased interferon (IFN)-γ and interleukin (IL)-22 release, and increased RORγt and Gata3 mRNA expression while decreasing T-bet expression. (syksignaling.com)

Given the importance of CD4 + Th cells in the disease process, this review will focus on how Th cells differentiate in the inflamed intestinal tract during IBD and how the Th lineage-specific cytokines and transcription factors (TFs) contribute to disease. (frontiersin.org)
Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
RESULTS: In UC mice model, Bud Lip-Gel showed inflammation was alleviated significantly, and the treatment was highly associated with lower DAI, less macroscopic and microscopic colonic damage and downregulation of pro-inflammatory cytokines TNF-α, IL-6 and MPO. (bvsalud.org)
Innate lymphoid cells (ILCs) lack antigen receptors but are equipped with receptors for cytokines, hormones, and paracrine signals enabling them to sense their environment and respond quickly by producing factors that influence parenchymal cells and other resident immune cells. (elifesciences.org)
Conclusions These findings are of prominence as CD3/CD28/CpG treatment can induce the anti-inflammatory cytokines IL-10 and IL-30 and the activation or inhibition of the CD40/CD154 functions as molecular rheostat of the expression of IL-10 or IL-30. (bioerc-iend.org)
The hierarchy of T-cell dysfunction from peripheral blood to inflamed joint suggests that these defects are acquired through prolonged exposure to proinflammatory cytokines such as tumour necrosis factor (TNF)-α. (biomedcentral.com)
These cells secrete immune inhibitory growth factors and cytokines, including vascular endothelial growth factor (VEGF), which is primarily produced by microglia, myeloid-derived suppressor cells (MDSCs) and tumour-associated macrophages (TAMs). (encyclopedia.pub)
Group 3 ILCs developmentally depend on the transcription factor RORgt and produce the cytokines IL-22, IL-17A and IL-17F. (iisymposium.nl)

Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
Prevention was associated with the downregulation of signal transducer and activator of transcription 3 (STAT3)-activating and Foxp3-counteracting interleukin-6 (IL-6), lower numbers of phospho-STAT3-containing lymphocytes, and higher Foxp3 + T-cell counts in the colon. (nature.com)

In addition, it was recently shown that Th17 cells that were generated with transforming growth factor (TGF)-β and IL-6 were not pathogenic and did not induce EAE without exposure to IL-23 (ref. 23 ). (nature.com)
however in Th2 cells GATA3 Jun BMS-582664 and MAF are specific transcription factors for IL-10 expression while STAT3 or STAT1 are the important factors for IL10 in Th17 expression [11-14]. (bioerc-iend.org)

In eosinophilic CRSwNP, we confirmed the type 2 inflammation by elevated GATA3 gene expression level. (openscience.si)
Angelicae Sinensis , Radix Astragali and Rhizoma Coptidis are all herbs of modified Danggui Buxue Tang (DGBX) and are extensively applied herbs in traditional Chinese medicine for the treatment of anemia and inflammation. (researcher-app.com)
Curcumin inhibits the powerful inflammation transcription factor NF-κB and is associated with reduced levels of inflammation. (geresdengle.com)
The molecular mechanisms underlying HIV-induced inflammation, which persists even during effective long-term treatment, remain incompletely defined. (biomedcentral.com)
Our study identified key genes differentially methylated already in primary infection and in tissues that could contribute to the persisting metabolic disorders and inflammation in HIV-infected individuals despite effective treatment. (biomedcentral.com)
Under efficient anti-retroviral treatment (ART), residual inflammation persists in most individuals, increasing the risk of non-AIDS comorbidity and mortality [ 9 ]. (biomedcentral.com)

Although pre-clinical and phase II trials in IBD support the use of oligonucleotide-based therapies for treating the pathogenic process occurring in the gut of patients with these disorders, further work is needed to establish whether and which patients can benefit from specific ASOs and identify biomarkers that could help optimize treatment. (gihealthfoundation.org)

Many important questions remain however regarding factors which induce and maintain Th1 cell polarisation in CD. (bmj.com)
We found that primary human astrocytes are unable to induce GATA3 after injury. (frontiersin.org)
Lentivirus-mediated overexpression of GATA3 significantly increased the number of GFAP/SOX2 double positive astrocytes and expression of pro-neural factor ASCL1, but failed to induce neurogenesis, suggesting that GATA3 is required for enhancing the neurogenic potential of primary human astrocytes and is not sufficient to induce neurogenesis alone. (frontiersin.org)
Primary human astrocytes do not induce GATA3 after injury. (frontiersin.org)

Eosinophilic CRSwNP was characterized by higher level of GATA3 gene expression compared to noneosinophilic CRSwNP, whereas there was no difference in T-bet, RORC and FOXP3 between eosinophilic and noneosinophilic CRSwNP. (openscience.si)

Critical factors in the differentiation of effector Th cells during inflammatory bowel disease (IBD). (frontiersin.org)
CONCLUSION: Novel Bud liposomes complex in thermosensitive Gel effectively mitigated symptoms, alleviated macroscopic and microscopic colon damage, and reduced inflammatory reaction in UC mice, which might be a potential strategy for UC treatment. (bvsalud.org)
Roles for the baculoviral inhibitor of apoptosis repeat-containing (BIRC) genes, BIRC2 and BIRC3, may include signaling to the inflammatory transcription factor, nuclear factor-κB (NF-κB) and protection from cell death. (bvsalud.org)
This paradigm proposes that genetic and environmental factors shape a complex series of molecular and cellular interactions leading to a chronic inflammatory response. (biomedcentral.com)

We show that NAD + regulates CD4 + T-cell differentiation through tryptophan hydroxylase-1 ( Tph1 ), independently of well-established transcription factors. (nature.com)

Treatment with corticosteroids and cyclosporine (CsA) resulted in a decrease of the methylation level of GATA3 and TGF-β in inactive BD patients. (oncotarget.com)

When metastasis is detected in the left supraclavicular node in patients with head and neck carcinoma, locating the primary cancer remains a difficult and time-consuming challenge despite the dramatic development of screening technologies and treatment methods. (biomedcentral.com)
Cost-effectiveness in the diagnosis and treatment of carcinoma of unknown primary origin. (medscape.com)

Our findings unravel a new pathway orchestrating CD4 + T-cell differentiation and demonstrate that NAD + may serve as a powerful therapeutic agent for the treatment of autoimmune and other diseases. (nature.com)
Taken together, our findings demonstrate that tuftsin decreases the proinflammatory environment of EAE and may represent a therapeutic opportunity for treatment of MS. (listlabs.com)
The regulation of the innate lymphoid cells will provide the more effective and novel therapeutic strategy treatments in human diseases. (tmu.edu.tw)
Conclusions Our study successfully discovered many key noncoding RNA molecules related to pathogenesis of asthma and relevant treatment, which may provide novel biomarkers and therapeutic targets for asthmatic diagnose and therapy. (researchsquare.com)

The family consists of T-bet+INFγ+ group 1 innate lymphoid cells, GATA3+IL5+IL13+ group 2 innate lymphoid cells, and RORγt+IL17+ and/or IL22+ group 3 innate lymphoid cells. (tmu.edu.tw)

STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment. (openscience.si)
Further data on transcription factors expression rates in CRS phenotypes are needed. (openscience.si)
STNM01, a double-stranded RNA oligonucleotide silencing carbohydrate sulfotransferase, an enzyme involved in fibrogenic processes, and hgd40, a specific DNAzyme inhibiting expression of the transcription factor GATA3. (gihealthfoundation.org)
To analyse expression of transcription factors which control the Th1 cell commitment in CD. (bmj.com)
Interferon γ (IFN-γ) and interleukin (IL)-4 RNA expression was examined in T lamina propria lymphocytes by quantitative reverse transcription-polymerase chain reaction. (bmj.com)
The interstitial stroma, another subcompartment of the metanephric nephron, is characterized by the expression of the transcription factor forkhead box D1 ( Foxd1 ). (j-organoid.org)
Results The essential transcription factor(s) or pathway(s) that activates IL-10 expression is dependent on the type of both the cell and stimuli [11 15 While many studies have attempted to understand the regulation of IL-10 in a specific cell type through a specific stimulus the role of cell-to-cell communication or conversation in the induction of IL-10 is largely unknown. (bioerc-iend.org)
On the other hand, environmental factors have been reported to modulate epigenetic modifications and thereby affect gene expression and phenotype [ 11 , 12 ]. (researchsquare.com)

Our data demonstrate a previously unknown aspect of tumor heterogeneity relevant for neuroblastoma treatment strategies. (nih.gov)
These cells primarily produce interferon (IFN)-γ and tumor necrosis factor (TNF) that, respectively, activate macrophages and direct cytotoxic CD8 + T cell responses, that in turn promote elimination of intracellular pathogens such as viruses and bacteria ( 8 ). (frontiersin.org)
Treatment protocols, including clinical trials, are the mainstay treatment for children with hematological and solid tumor malignancies. (biomedcentral.com)
The paucity of murine models of this "luminal" tumor subtype has hindered studies of factors that promote their pathogenesis and modulate responsiveness to estrogen-directed therapeutics. (biomedcentral.com)
These tumors were distinct from mouse mammary tumor virus (MMTV)-neu tumors, and contained elevated transcripts for factors associated with luminal/alveolar expansion and differentiation, suggesting that they arose from physiologic targets of prolactin. (biomedcentral.com)
Our studies demonstrate that prolactin can promote diverse carcinomas in mice, many of which resemble luminal breast cancers, providing a novel experimental model to examine the pathogenesis, progression and treatment responsiveness of this tumor subtype. (biomedcentral.com)

This binding initiates a cascade of events that culminates in differentiation into Th1 cells, by increasing the transcription factor T-bet 12 . (bvsalud.org)
Th2 cells have a differentiation process which is dependent on IL-4, which causes the activation of the transcription factor STAT 6 . (bvsalud.org)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Moreover, we identified and classified more than 100 transcription factors that showed significant changes during differentiation, and found novel transcription factors that were not reported to be related to preadipoctye differentiation. (biomedcentral.com)

This factor promotes the growth and branching of the ureteric bud. (j-organoid.org)
GATA3 promotes neural progenitor state but not neurogenesis. (frontiersin.org)

Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)
The comprehensive transcriptome analysis from KPNA3 knockdown cells indicated that KPNA3 is involved in the regulation of numerous EMT-related genes, including the downregulation of GATA3 and E-cadherin and the up-regulation of HAS2. (bmbreports.org)

Consequently, it is critical that we understand the cellular and molecular immune factors that regulate the uterine environment. (elifesciences.org)

Although the pathogenesis of BD is still not clear, numerous studies have suggested that environmental factors, infection triggers, abnormal autoimmune regulation and genetic susceptibility are closely associated with BD [ 3 ]. (oncotarget.com)

They also discussed the diagnostic value of transcription factors T-bet/GATA3 ratio in predicting AMR, which may be of value in diagnosis of C4d-negative AMR. (hindawi.com)
GATA3 staining aided in the diagnosis of urothelial bladder cancer with left supraclavicular node metastasis. (biomedcentral.com)
Pathological diagnosis on the basis of immunohistochemistry and specific diagnosis methods such as radiological and serological assessments are important for providing rapid diagnosis and appropriate treatment. (biomedcentral.com)
Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. (medscape.com)
No lower limit of blast percentage is required to establish the diagnosis, but most treatment protocols define ALL by the presence of greater than or equal to 25% blasts. (biomedcentral.com)

Treatment of the mixed type with chemotherapeutic agents resulted in enrichment of NCC-like cells. (nih.gov)
this suggests that the novel independent signaling pathways KPNA3-TGF-β-GATA3-HAS2/E-cadherin and KPNA3-AKT-HAS2/E-cadherin are involved in the EMT-mediated progress of TNBC MDA-MB-231 cells. (bmbreports.org)
however treatment of cells with either CD3/CD28 or CpG alone induced a relatively small increase in IL-10 production (Physique? (bioerc-iend.org)
GATA3 increases the GFAP/SOX2-positive cells and ASCL1 after injury in 3D. (frontiersin.org)

An immunohistochemical investigation of the gingival tissue was performed to detect the presence of the Th2 specific transcription factor (GATA3). (bvsalud.org)
There is no specific treatment available, although corticosteroids help in disappearing its symptoms. (ijpsr.com)
Although an ELISA-based method was used, the readout reflects the activity rather than the binding of the transcription factors because the primary antibody provided with this kit is specific for an epitope on the bound and active form of the transcription factor. (syksignaling.com)

X-linked hypophosphatemia (XLH), representing about 80% of hypophosphatemic rickets, is an X-linked dominant disease due to inactivating mutations in the PHEX gene (located at Xp22.1) resulting in an excessive secretion of the phosphaturic hormone fibroblast growth factor 23 (FGF23). (endocrine-abstracts.org)
Meanwhile, the ureteric bud secretes Wnt-9b and fibroblast growth factor 9 (FGF9), which differentiate the metanephric mesenchyme into pretubular aggregates. (j-organoid.org)

The last decade has witnessed great advances in our understanding of the genetic and biological basis of childhood acute lymphoblastic leukemia (ALL), the development of experimental models to probe mechanisms and evaluate new therapies, and the development of more efficacious treatment stratification. (haematologica.org)
Genetic classification of B-ALL is paramount for risk stratification and in treatment evaluation, especially within the context of clinical trial enrollment. (biomedcentral.com)
Uncovering the prognostic significance of these genetic aberrations is fundamental for risk stratification and ultimately individualized treatment. (biomedcentral.com)

PURPOSE: A novel formulation for Ulcerative Colitis (UC) treatment by rectal administration with budesonide liposomes (Bud Lip) and thermosensitive gel (Gel) was developed for future clinical use. (bvsalud.org)
The current review enlightens the pathogenesis of the disease, clinical indications, diagnostic evaluation, and various therapies for the treatment. (ijpsr.com)
The care of an individual who has developed a related tumour or cancer should be individualised based on their clinical situation, their family history and the monitoring they need as part of their treatment and post-treatment follow-up. (eviq.org.au)

The rs570613 single nucleotide polymorphism (SNP) in intron 4 of GATA3 was previously found to be associated with a reduction in breast cancer risk in the Cancer Genetic Markers of Susceptibility project and in pooled analysis of two case-control studies from Norway and Poland (P (trend) = 0.004), with some evidence for a stronger association with estrogen receptor (ER) negative tumours [Garcia-Closas M et al. (eur.nl)
While treatments directed against this receptor have successfully lowered mortality rates, many primary tumors initially or later exhibit resistance. (biomedcentral.com)
More importantly, there is no full cure is available up to now despite majority of children with asthma can alleviate the asthmatic symptoms and obtain adequate asthma control via avoidance of triggering factors, rational management and/or medication, such as short-acting inhaled β2-receptor agonists [ 4 , 5 ]. (researchsquare.com)

Therefore, in this report, we investigated how overexpression of GATA3 in primary human astrocytes would affect the neurogenic potential before and after injury in 2D and 3D cultures. (frontiersin.org)

There are many shreds of evidence that suggest that the extrinsic antigens, environmental conditions, and genetic factors play a crucial role in the development of sarcoidosis through an exaggerated immune response. (ijpsr.com)

Aim of the study is to evaluate if steroid treatment might be useful in improving thyrotoxicosis in subj. (endocrine-abstracts.org)

Activated JNK in turn phosphorylates c-jun in its N terminus, activating the c-jun-containing AP-1 complexes.34 Activation of AP-1 transcription factor eventually results in increased IL-2 transcription. (syksignaling.com)

Gata3 was previously found to be a mechanism that zebrafish brain uses to injury-dependent induction of neural progenitors. (frontiersin.org)

Historically, genetic factors identified by conventional karyotyping have been used to diagnose ALL and to risk-stratify children with the disease. (haematologica.org)

Results In the present study, we performed a systematic transcriptome analysis based on the deep RNA sequencing of ten asthmatic children before and after desensitization treatment. (researchsquare.com)

In neonates with bilateral renal agenesis, severe neonatal respiratory distress due to associated pulmonary hypoplasia, and spontaneous pneumothorax, further treatment may not be indicated. (medscape.com)
Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas. (medscape.com)

We genotyped GATA3 rs570613 in 6,388 cases and 4,995 controls from the Breast Cancer Association Consortium (BCAC) and 5,617 BRCA1 and BRCA2 carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). (eur.nl)
We conclude that there is no evidence that either GATA3 rs570613, or any variant in strong linkage disequilibrium with it, is associated with breast cancer risk in women. (eur.nl)
Breast Cancer Research and Treatment , 117 (2), 371-379. (eur.nl)
Since Virchow's time, the survival rates of cancer patients have improved because of dramatic research advances in the epidemiology of cancer and the development of screening technologies and treatment methods. (biomedcentral.com)
His work has served as the bedrock for the development of T cell therapies and CAR-T therapy, offering hope and new possibilities in the realm of cancer treatment. (cancerresearch.org)

The treatment of chronic ongoing AMR remains controversial. (hindawi.com)
The symptoms of the disease have a negative influence on patients' quality of life (QOL) which is an important consequence of treatment concerning chronic diseases 4 . (ijpsr.com)

Therefore, diverse cellular compartments orchestrated by multiple environment-driving factors make the mechanisms underlying asthma extraordinary complex and unclear, particularly with respect to long noncoding RNAs (lncRNAs). (researchsquare.com)

Organ transplantation is a well-accepted treatment for patients with end-stage organ failure. (hindawi.com)
While more than 50 percent of the patients don't require any treatment and illness goes on its own, only 10% require treatment in which severe symptoms developed and last long. (ijpsr.com)
Gene editing technologies are a game changer, enabling design of novel molecular-immunological treatments to be used in combination with chemoradiation, to achieve long lasting survival benefits for patients. (encyclopedia.pub)

Periodontal disease is the result of microbial aggression as well as metabolic and environmental factors and life-style habits influence the pathogenesis of this disease 1 . (bvsalud.org)

Diagnose and treatment for asthma, particularly in childhood asthma have always remained a great challenge because of its complex pathogenesis and multiple triggers, such as allergen, viral infection, tobacco smoke, dust, etc. (researchsquare.com)

Anatomy16

Organisms10

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes70

Disciplines and Occupations1

Information Science4

Zinc finger transcription factor2

Protein11

Cytokine6

TBX214

GATA3

MRNA expression4

Cytokines8

Signal transducer and activator of transcription2

Th172

Inflammation6

Pathogenic1

Induce4

RORC1

Inflammatory4

Regulates1

Methylation1

Carcinoma2

Therapeutic4

Innate1

Expression9

Tumor6

Differentiation4

Promotes2

Genes2

Regulate1

Autoimmune1

Diagnosis5

Cells4

Specific3

Fibroblast2

Stratification3

Clinical3

Receptor3

Primary1

Extrinsic1

Evaluate1

Activation1

Found1

Genetic factors1

Results1

Renal2

Cancer5

Chronic2

Cellular1

Patients3

Metabolic1

Diagnose1