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  • Clinical
  • Drugs that suppress FOXM1 in combination with the standard treatment, such as ixazomib, should result in better outcomes, but clinical trials will ultimately be needed to prove this theory. (news-medical.net)
  • Treatment failure can be categorized as virologic failure, immunologic failure, clinical failure, or some combination of the three. (nih.gov)
  • Clinical failure is defined as the occurrence of new opportunistic infections and/or other clinical evidence of HIV disease progression during therapy. (nih.gov)
  • Treatment solely on the basis of clinical suspicion should only be considered when a parasitological diagnosis is not accessible. (wikipedia.org)
  • Despite many distinguishing features, the clinical spectrums of following diseases may overlap with chancroid: Primary syphilis Genital herpes Practical clinical approach for this STI as Genital Ulcer Disease is to rule out top differential diagnosis of Syphilis and Herpes and consider empirical treatment for Chancroid as testing is not commonly done for the latter. (wikipedia.org)
  • contributes
  • The study, which appears Oct. 24, 2011 in the online journal PLoS ONE , suggests that this early-stage dormancy phenomenon contributes to the failure of artesunate alone, or even combined with other drugs, to eliminate the mosquito-borne disease. (medicalxpress.com)
  • relapse
  • It has also been noted that D2 receptors may return to the level existing prior to drug exposure during long periods of abstinence, a fact which may have implications in relapse treatment. (wikipedia.org)
  • commonly
  • In mice engineered to overproduce FOXM1 that were caused to develop leukemia, following treatment with cytarabine, a drug commonly used to treat AML, the mice had more residual disease compared to control mice with AML and normal levels of FOXM1. (news-medical.net)
  • doses
  • In patients with high cholesterol levels, aspirin in in normal doses has hardly any anti-clotting effects, whereas treatment with a statin (inhibitor of cholesterol) significantly reduces blood clotting. (innovations-report.com)
  • First, can dopamine supersensitivity be observed during ongoing treatment with therapeutically relevant doses and modes of antipsychotic administration? (jneurosci.org)
  • Drugs
  • Just adding one of the new drugs, Avastin, to a treatment regimen will increase costs to the patient of $8,000 per month. (positivearticles.com)
  • A priority review designation is assigned to drugs that are deemed by the FDA to have the potential to provide an important advancement in treatment or provide a treatment for which there is no adequate therapy available. (bio-medicine.org)
  • We interviewed 119 people with treatment failure and an equal number of cured cases [controls] and their families regarding sociodemographic characteristics, information about TB, information about drugs, treatment compliance, family support and patient-family interaction. (who.int)
  • Any evidence of treatment failure, despite full treatment, and no vomiting, is an indication to treat with second line drugs without further delay. (malariasite.com)
  • invasive
  • Since exosome-derived factors can be detected in standard blood samples, these results suggest this chemoresistance-associated factor, or others like it, could serve as a "minimally invasive predictive biomarker for pancreatic cancer treatment response. (medicalxpress.com)
  • This would be a major advance since standard methods used to assess cancer treatment responses are highly invasive, and their accuracy may depend heavily upon the region captured in the tissue biopsy. (medicalxpress.com)
  • Caspofungin is used in the treatment of febrile neutropenia and as salvage therapy for the treatment of invasive aspergillosis. (wikipedia.org)
  • viral load
  • The goal of therapy following treatment failure is to achieve and maintain virologic suppression, as measured by a plasma viral load below the limits of detection using the most sensitive assay (AI*) . (nih.gov)
  • Virologic failure is defined as a repeated plasma viral load ≥200 copies/mL after 6 months of therapy. (nih.gov)
  • Because infants with high plasma viral loads at initiation of therapy occasionally take longer than 6 months to achieve virologic suppression, some experts continue the treatment regimen for infants receiving ritonavir-boosted (LPV/r) -based therapy if viral load is declining but is still ≥200 copies/mL at 6 months and monitor closely for continued decline to virologic suppression soon thereafter. (nih.gov)
  • cases
  • The aim of the study is to evaluate the possible role of MOTT in treatment failure cases of pulmonary TB. (ersjournals.com)
  • The median interval between symptom onset and treatment (with albendazole in 12 cases and ivermectin in one case) was 3.5 months. (curehunter.com)
  • Recent medical studies have suggested that the fear of "skin thinning" is in many cases unfounded and can lead to poor compliance and treatment failure as a result of unnecessary fear. (wikipedia.org)
  • behavioral
  • It is known, however, that withdrawal from chronic antipsychotic treatment induces behavioral dopaminergic supersensitivity in animals. (jneurosci.org)
  • typically
  • As a toxic organic compound of arsenic, melarsoprol is a dangerous treatment that is typically only administered by injection under the supervision of a licensed physician. (wikipedia.org)
  • People
  • But just because I recognize issues, discuss genuine, painful emotion and make loud an inner voice that among most people is strangled, doesn't mean my treatment has been a failure. (healthyplace.com)
  • Technological breakthroughs are changing the course of heart-failure treatment -- but doubts remain about how many people will benefit in the near future. (medicinenet.com)
  • The new system required court-supervised drug treatment which was cheaper than incarceration and helped people end their addiction and become productive members of society. (wikipedia.org)
  • About 1-5% of people die from adverse events related to melarsoprol treatment. (wikipedia.org)
  • made
  • Laboratory results must be confirmed with repeat testing before a final assessment of virologic treatment failure is made. (nih.gov)
  • Especially with session-by-session assessments, real-time scoring and report generation the data provides clinicians and patients with excellent feedback about the course of treatment and whether adjustments need to be made to the treatment plan. (wikipedia.org)
  • provide
  • Subjects whose GP AC2 at the enrollment treatment visit is positive for C. trachomatis will then be asked to provide a first-void urine sample for repeat chlamydia testing with GP AC2 at 28- and 67-days after study drug initiation [corresponding to the first follow-up visit (study visit 2) and second follow-up visit (study visit 3), respectively]. (bioportfolio.com)
  • WebMD does not provide medical advice, diagnosis or treatment. (webmd.com)
  • These findings provide a model and a mechanism for antipsychotic treatment failure and suggest new directions for the development of more effective antipsychotics. (jneurosci.org)
  • patient
  • With formal assessments of patient needs, the clinician can devise an individualized treatment plan that incorporates these needs and evidence-based practices and principals. (wikipedia.org)
  • Obviously, the most fundamental use of BHOM is to use the data to track treatment progress on a patient-by-patient basis. (wikipedia.org)
  • heart
  • Heart Failure? (webmd.com)
  • ORLANDO, Fla. -- The American College of Cardiology is launching a new initiative to reduce the number of patients who are readmitted to hospitals within 30 days of being discharged for congestive heart failure or a heart attack. (wsj.com)
  • But the last few years have witnessed a surge in both the types of devices being tested for heart-failure treatment, and in the optimism of experts about their usefulness. (medicinenet.com)
  • A lot of the big advances that we've had in treating heart failure in the last few years has been with devices," says Marvin A. Konstam, MD, chief of cardiology and director of cardiovascular development at Tufts-New England Medical Center. (medicinenet.com)
  • For instance, the dream of using machines for long-term supportive patients with end-stage heart failure is now a reality. (medicinenet.com)
  • But Rose, who led a study of one such implant used in heart-failure treatment -- the left ventricular assist device -- is temperate in his enthusiasm. (medicinenet.com)
  • Of course, there is a potential disadvantage to having an ICD for heart-failure treatment: If the experience of being shocked by a box in your chest doesn't sound pleasant, you're right. (medicinenet.com)
  • In some patients with heart failure, the electrical signals that coordinate pumping of the different heart chambers become erratic, making the heart unable to pump blood efficiently. (medicinenet.com)