Autologous stem-cell transHematopoietic cellHSCTStem cellSolid Organ TransplantationBoneMultiple myelomaDonorEngraftmentPost-transplantationMarrow transplantationOutcomesImmunosuppressionLiverSurvivalCord blood transplantationOrganIslet2023TherapyAcuteHaploidenticalDiagnosisOutcomeClinicalGVHDComplicationsPatient'sTissueTherapeuticSevereInfectionRenalRefractoryLymphomaAllogeneic stemMethodsSickle cell anImmunePeripheral blood stemPancreaticAlloHCTImmunologyMortalityProgenitorGraftCentersTherapiesPatient
Autologous stem-cell trans9
- Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. (haematologica.org)
- High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
- OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
- High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
- High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
- Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
- In the prospective Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a phase 3 comparison of autologous HSCT with 12 successive monthly intravenous pulses of cyclophosphamide in 156 patients with early diffuse cutaneous systemic sclerosis, HCST was associated with higher treatment-related mortality than in the first year after treatment. (medscape.com)
- An autologous stem cell transplantation uses your own blood stem cells. (clevelandclinic.org)
- We conducted a nationwide, multicenter, prospective registry study for newly diagnosed patients with peripheral T-cell lymphoma (PTCL) to better define the clinical characteristics, treatment patterns, survival outcomes, and the role of upfront autologous stem cell transplantation (ASCT) in these patients. (e-crt.org)
Hematopoietic cell12
- Hyperammonemia following hematopoietic cell transplantation (HCT) has been characterized as idiopathic and is associated with a very high mortality. (arizona.edu)
- Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
- An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
- Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
- This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
- Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
- Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
- Outcomes of Allogeneic Hematopoietic Cell Transplantation (Allo-HCT) in Patients with CALR-Mutated Myelofibrosis compared to those patients with a JAK2-mutation. (ebmt.org)
- We aim to address the unmet need to improve high relapse rate in patients with ALL undergoing hematopoietic cell transplantation (HCT) from a matched or mismatched unrelated/related donors. (lls.org)
- Disease relapse is the most frequent cause of treatment failure and mortality after hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL). (lls.org)
- Hematopoietic cell transplantation has become a cornerstone in the management of patients with lymphoma. (bloodline.net)
- Although allogeneic hematopoietic cell transplantation (alloHCT) is the treatment of choice, patient eligibility criteria and optimal conditioning regimen remain under study. (confex.com)
HSCT29
- Allogeneic hematopoietic stem cell transplantation (HSCT) in thalassemia remains a challenge. (nih.gov)
- Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
- Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
- The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
- This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
- Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
- Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
- Several groups are conducting trials to determine whether cellular therapy could be the treatment of choice for poor graft function after HSCT. (drugdiscoverynews.com)
- Other groups are also working on cell therapies for the treatment of poor graft function after HSCT. (drugdiscoverynews.com)
- Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
- Hematopoietic stem cell transplantation (HSCT) has been shown to be effective. (medscape.com)
- In ASTIS during the first year, 13 events, including 8 treatment-related deaths, occurred in the HSCT group and 8 events with no treatment-related deaths occurred in the control group (16.5% vs. 10.4%, respectively). (medscape.com)
- Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
- The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
- Despite prophylactic treatment of the patients with immunosuppressive drugs after allo-HSCT, GvHD is still associated with non-relapse mortality (NRM) and contributes around 25% of NRM. (frontiersin.org)
- Non-myeloablative autologous hemopoietic stem-cell transplantation (HSCT) shows some promise in treating scleroderma. (mountsinai.org)
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the optimal treatment for pediatric patients with high-risk or intermediate-acute myeloid leukemia. (blood-genomics.com)
- There was no difference in transplantation-related toxicity (TRT) in terms of infection, hepatic dysfunction, oral mucositis, and engraftment syndrome between the haploidentical HSCT and HLA-matched HSCT groups. (blood-genomics.com)
- Here, we present a case of an over 60-years old male patient with AML, and the possibility for him to receive an allogeneic hematopoietic stem cell transplantation (allo-HSCT). (pensoft.net)
- As an additional consideration, we will also discuss whether allo-HSCT is transplantable when AA is performed during the treatment of AML. (pensoft.net)
- Immune-related adverse event AA presenting before allo-HSCT during the nivolumab treatment for AML could be an indication of relapse after HSCT. (pensoft.net)
- In recent years, prospective studies have been conducted to assess the role of prophylaxis and treatment of invasive fungal diseases (IFD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). (unicatt.it)
- Although results of these studies have been encouraging, they have been unable to generate a consensus for optimal prophylaxis and treatment of IFD in the complex scenario of allo-HSCT. (unicatt.it)
- The definition of the level of risk for IFD associated with the various types and phases of transplantation and the implementation of surveillance and diagnostic strategies are the critical determinants of the antifungal prophylactic and therapeutic approach for allo-HSCT recipients. (unicatt.it)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Stem cell72
- Introduction To observe the short-term and long-term effects of extensive fascial resection combined with autologous limbal stem cell sharing transplantation for pterygium. (researchsquare.com)
- Methods A retrospective case series analysis was performed with 403 patients (420 eyes) who underwent extensive fascial resection combined with autologous limbal stem cell sharing transplantation in the Department of Ophthalmology, Second People's Hospital of Yunnan Province from January 2017 to June 2018. (researchsquare.com)
- Discussion and conclusion Extensive fascial resection combined with autologous limbal stem cell sharing transplantation for the treatment of pterygium, the patient's appearance satisfaction is higher, and the recurrence probability is lower than the average recurrence rate of limbal stem cell transplantation. (researchsquare.com)
- Pterygium excision combined with autologous conjunctival flap transposition, pterygium excision combined with amniotic membrane transplantation, pterygium excision combined with autologous limbal stem cell transplantation and so on [12] . (researchsquare.com)
- Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
- Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
- Hastening the return of the body's white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation. (fda.gov)
- Stem cell transplantation is a common treatment for blood cancers. (fda.gov)
- We investigated the safety and efficacy of immune suppression and autologous haemopoietic stem-cell infusion to treat such patients. (northwestern.edu)
- Patients underwent dose-intense immune suppression and autologous haemopoietic stem-cell (CD34) infusion. (northwestern.edu)
- Results: Nine patients underwent stem-cell mobilisation but two were excluded before transplantation because of infection. (northwestern.edu)
- The remaining seven received high-dose chemotherapy and stem-cell infusion. (northwestern.edu)
- Because of their multi-potent capabilities, mesenchymal stem cell (MSC) lineages have been used successfully in animal models to regenerate articular cartilage and in human models to regenerate bone. (wikipedia.org)
- The adult stem cell fraction is present in the nucleated cells of the marrow. (wikipedia.org)
- Stem cell transplantation may be an option in cases of severe recalcitrant ALPS. (medscape.com)
- OBJECTIVES: I. Determine whether mixed or full donor chimerism can be safely established in older patients with acute myeloid leukemia (AML) treated with nonmyeloablative conditioning comprised of low dose total body irradiation, followed by allogeneic peripheral blood stem cell transplantation, followed by unrelated donor lymphocyte infusion (DLI). (knowcancer.com)
- Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
- OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
- Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
- This is a big deal for the bone marrow transplantation field," said Dr. Geoffrey Hill, the paper's senior co-author and director of Hematopoietic Stem Cell Transplantation at Fred Hutchinson Cancer Research Center. (sciencedaily.com)
- Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
- To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)
- Allogeneic stem cell transplantation uses donor stem cells to treat and sometimes cure certain blood disorders and blood cancers. (clevelandclinic.org)
- Healthcare providers typically recommend stem cell transplantation if initial treatments don't work or if conditions have come back. (clevelandclinic.org)
- About 50% of people who need stem cell transplantation use stem cells donated by someone who's not a family member. (clevelandclinic.org)
- Providers may recommend allogeneic stem cell transplantation if initial treatments didn't work or treatments worked but the condition has come back. (clevelandclinic.org)
- In allogeneic stem cell transplantation, healthcare providers replace unhealthy stem cells with donated healthy stem cells. (clevelandclinic.org)
- What's the difference between allogeneic and autologous stem cell transplantations? (clevelandclinic.org)
- Allogeneic stem cell transplantation uses donated stem cells. (clevelandclinic.org)
- While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
- What cancers are treated with allogeneic stem cell transplantation? (clevelandclinic.org)
- People in remission from AML may be candidates for allogeneic stem cell transplantation. (clevelandclinic.org)
- Healthcare providers may recommend allogeneic stem cell transplantation for severe forms of aplastic anemia. (clevelandclinic.org)
- Providers may use allogeneic stem cell transplantation to treat severe forms of thalassemia. (clevelandclinic.org)
- Providers may use allogeneic stem cell transplantation if other treatments aren't successful. (clevelandclinic.org)
- Allogeneic stem cell transplantation may cure some blood disorders FA causes. (clevelandclinic.org)
- Allogeneic stem cell transplantation replaces damaged white blood cells. (clevelandclinic.org)
- Allogeneic stem cell transplantation treats the recurring and life-threatening infections this condition causes. (clevelandclinic.org)
- Who is a candidate for allogeneic stem cell transplantation? (clevelandclinic.org)
- Healthcare providers consider several factors before recommending allogeneic stem cell transplantation to treat blood disorders or cancer. (clevelandclinic.org)
- For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
- Not all cancers or blood diseases respond to stem cell transplantation, including allogeneic stem cell transplantation. (clevelandclinic.org)
- What makes a good match for an allogeneic stem cell transplantation? (clevelandclinic.org)
- Leipzig University Hospital is one of the few centers in Germany where the disease can be treated with the benefit of interdisciplinary collaboration, including by using stem cell transplantation (SCT) and other modern therapeutic techniques. (leipzig-for-lifechangers.com)
- We transplant two or three children every year in this way (and as many as four last year), and thus do about two thirds of all transplants throughout Germany," says Dr. Kühl, head of pediatric stem cell transplantation at the Department of Pediatric Oncology, Hematology and Hemostaseology at Leipzig University Hospital. (leipzig-for-lifechangers.com)
- Bone marrow or stem cell transplantation, which can cure SCD. (medlineplus.gov)
- The stem cell treatment at Aarhus University Hospital is first class. (auh.dk)
- The hospital is now accredited by JACIE - the international accreditation organisation for stem cell transplantation. (auh.dk)
- Aarhus University Hospital has just obtained the international accreditation by JACIE, a joint American-European organisation working to promote quality of stem cell transplantation therapy. (auh.dk)
- At Aarhus University Hospital, patients with e.g. leukaemia receive a stem cell transplantation - also called a bone marrow transplantation - as a part of their treatment. (auh.dk)
- In stem cell transplantation it is important to maintain a high quality in all steps of the processes - both concerning donors of stem cells, during the transplantation and finally concerning the patients. (auh.dk)
- Our quality is high and we are in control of all working procedures and have a good collaboration with all the departments involved in stem cell treatment, says Betina Samuelsen Sørensen, consultant at Department of Clinical Immunology at Aarhus University Hospital. (auh.dk)
- From March 1 2017, Department of Hematology has been approved by the Danish Health Authority as an independent centre for allogeneic stem cell transplantation from a sibling or a donor from a registry. (auh.dk)
- This will benefit patients in the western part of Denmark who need an allogeneic stem cell transplantation, says Jan Maxwell Nørgaard, Head Consultant at Department of Haematology. (auh.dk)
- Home » Frequently asked Questions on Health » What is stem cell transplantation? (ndtv.com)
- I came to know that it could be treated by stem cell plantation. (ndtv.com)
- The stem cell transplantation is the treatment to cure sickle cell anaemia. (ndtv.com)
- First and the most important requirement for stem cell transplantation in sickle cell anaemia is a HLA match sibling donor. (ndtv.com)
- Transplantation of pancreatic islets or stem cell derived insulin secreting cells is an attractive treatment strategy for diabetes. (nih.gov)
- Autologous hematopoietic stem cell transplantation (aHSCT) is a well-established treatment for hematologic malignancies such as multiple myeloma (MM) and non-Hodgkin lymphoma (NHL). (bloodline.net)
- Various changes in the field over the past decade, including the frequent use of tandem aHSCT in MM, the advent of novel therapies for the treatment of MM and NHL, plus the addition of new stem cell mobilization techniques, have led to the need to reassess current stem cell mobilization strategies. (bloodline.net)
- Correction of NK cell defects in CHS should improve the outcome of hematopoietic stem-cell transplantation, proposed as therapy. (torvergata.it)
- Allogeneic hematopoietic stem cell transplantation is the only potentially curative treatment for myelofibrosis. (ascopost.com)
- Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
- Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)
- Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
- To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (cdc.gov)
- Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
- Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
- The stem cell mobilization result was poor. (cdc.gov)
- Stem cell transplantation is necessary for survival and may cure the disorder. (msdmanuals.com)
- About 75% of people die by age 10, and all die by age 40 unless stem cell transplantation is done. (msdmanuals.com)
Solid Organ Transplantation2
- Kidney Transplantation Kidney transplantation is the most common type of solid organ transplantation. (merckmanuals.com)
- Thirteen patients received either one or two islet transplantation alone (ITA), while five patients received islet transplantation after previous solid organ transplantation. (lu.se)
Bone22
- This abnormal cell growth often begins in the bone marrow, which is made up of stem cells that form into different types of blood cells with specific functions in the body. (fda.gov)
- Similar to all approved umbilical cord products , the label carries a Boxed Warning for infusion reactions, graft versus host disease (GvHD - a condition that occurs when donor bone marrow or stem cells attack the graft recipient), engraftment syndrome (characterized by a noninfectious fever and rash), and graft failure (occurs when new cells do not produce white blood cells, red blood cells and platelets). (fda.gov)
- Mesenchymal stem cells (MSCs) are multipotent cells found in multiple human adult tissues, including bone marrow, synovial tissues, and adipose tissues. (wikipedia.org)
- Mesenchymal stem cells were originally discovered and studied as fibroblast-colony-forming cells in guinea-pig bone marrow and spleen cells by Friedenstein in the 1970s. (wikipedia.org)
- This study proved that the colony-forming units of bone marrow-derived stem cells were able to form cartilage once they were transplanted into a diffusion chamber. (wikipedia.org)
- Most of the adult bone marrow consists of blood cells in various stages of differentiation. (wikipedia.org)
- Most of these cells are CD34+ heme progenitors (destined to differentiate into blood components), while very few are actually MSC's capable of differentiating into bone, cartilage, or muscle. (wikipedia.org)
- Despite this low number of MSC's, isolated bone marrow nucleated cells implanted into degenerated human peripheral joints have shown some promise for joint repair. (wikipedia.org)
- As the number of MSC's that can be isolated from bone marrow is fairly limited, most research in cartilage regeneration has focused on the use of culture-expanded cells. (wikipedia.org)
- Characterize the time to recovery of normal bone marrow function after transplantation in these patients. (knowcancer.com)
- Fred Hutchinson Cancer Research Center bone marrow transplantation program, in partnership with the Seattle Cancer Care Alliance (SCCA), is the largest program in the world. (dnatube.com)
- Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
- The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
- Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
- High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
- High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
- A new study challenges long-held theories of why a common virus -- cytomegalovirus, or CMV -- can reactivate and become a life-threatening infection in people with a compromised immune system, including blood cancer patients undergoing bone marrow transplantation. (sciencedaily.com)
- CMV infection is the most common complication of bone marrow transplantation. (sciencedaily.com)
- AML is a type of blood cancer with excess immature white blood cells in bone marrow. (pensoft.net)
- On day 138, the 11th dose of nivolumab was administered, and patient's platelet count was 53×109/L. However, immediately after the 11th dose, there was a sudden decrease in platelet count to 32×109/L. As the following 12th dose of nivolumab was served, the patient's platelet counts gradually dropped to 5×109/L. This result may reveal bone marrow damage, and it was possibly attributed to the nivolumab treatment. (pensoft.net)
- Aplastic anemia (AA), the myelodysplastic syndromes (MDS), and paroxysmal nocturnal hemoglobinuria (PNH) are rare diseases that all result in bone marrow failure-the ineffective formation of circulating blood cells-leading to anemia, bleeding, infection, and death in many cases, even with modern therapies. (bloodline.net)
- Effects of invivo CXCR4 blockade and proteasome inhibition on bone marrow plasma cells in HLA-sensitized kidney transplant candidates. (cincinnatichildrens.org)
Multiple myeloma2
- [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
Donor8
- Today, the U.S. Food and Drug Administration approved Omisirge (omidubicel-onlv), a substantially modified allogeneic (donor) cord blood-based cell therapy to quicken the recovery of neutrophils (a subset of white blood cells) in the body and reduce the risk of infection. (fda.gov)
- Each dose is patient-specific, containing healthy stem cells from an allogeneic pre-screened donor, meaning it comes from a different individual rather than using the patient's own cells. (fda.gov)
- Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
- Nonmobilized donor lymphocytes are harvested from the same HLA identical related donor on day 95 after PBSC transplantation. (knowcancer.com)
- However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. (nature.com)
- Donor-T-cells were transduced with the replication-deficient retrovirus SFCMM-3, expressing HSV-TK and the truncated ΔLNGFR for selection of transduced cells. (frontiersin.org)
- Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
- Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
Engraftment5
- Once these MSCs are ready for re-implantation, they are usually transferred with growth factors to allow for continued cell growth and engraftment to the damaged tissue. (wikipedia.org)
- Incomplete engraftment (poor graft function) requires the patient to undergo more transfusions of red cells or platelets. (drugdiscoverynews.com)
- One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
- To overcome these limitations, here we present a novel 3D printed and functionalized encapsulation system for subcutaneous engraftment of islets or islet like cells. (nih.gov)
- Moreover after the transplant, although the successful engraftment, NK cell cytotoxicity resulted still partially impaired at one year, almost normal at ten years and, anyhow, fully recovered by in vitro IL-2 treatment. (torvergata.it)
Post-transplantation1
- At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)
Marrow transplantation3
- Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients. (nature.com)
- Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
- The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
Outcomes3
- Simultaneous islet cell-kidney transplantation may be desirable in the future after the outcomes have improved. (merckmanuals.com)
- Much of the current confusion and controversy in MDS treatment stems from the lack of consensus on which therapies to use in which patients, and what realistic outcomes might be. (bloodline.net)
- Secondary or treatment-related acute myeloid leukemia (sAML) is associated with poor outcomes. (confex.com)
Immunosuppression5
- Encapsulation of pancreatic islet cells allows for transplantation in the absence of immunosuppression. (scialert.net)
- We mobilised autologous haemopoietic stem cells with 2·0 g/m 2 cyclophosphamide and 10 μg/kg granulocyte colony stimulating factor daily, enriched with CD34-positive selection, and reinfused after immunosuppression with 200 mg/kg cyclophosphamide, 1 g methylprednisolone, and 90 mg/kg equine antithymocyte globulin. (northwestern.edu)
- Research and Development of new and improved transplant, cell therapy and immunosuppression procedures. (ebmt.org)
- Immunosuppression must be continued lifelong or until islet cell function ceases. (merckmanuals.com)
- However, islet transplantation is associated with several challenges including function-loss associated with dispersion and limited vascularization as well as the need for continuous immunosuppression. (nih.gov)
Liver7
- This Special Issue of the Viruses journal is dedicated to the diagnostic and therapeutic advancements of viral liver diseases with the aim of giving a complete update not only on the treatments currently available and future developments, but also on the still unmet needs in the management of special patient populations. (mdpi.com)
- T-cell infiltrate intensity is associated with delayed response to treatment in late acute cellular rejection in pediatric liver transplant recipients. (cincinnatichildrens.org)
- Aim: To evaluate the invasive dental procedures for removing dental foci performed in patients scheduled for liver transplantation and its accompanying complications. (bvsalud.org)
- This research aimed at evaluating invasive dental procedures for removing dental foci in patients scheduled for liver transplantation along with any accompanying complications. (bvsalud.org)
- After approval by the Research Ethics Committee for the Santa Casa de Misericórdia de São Paulo, this study evaluated 33 prospective patients who were candidates for liver transplants and had been receiving treatment in a dentistry department for patients with special needs, during 3 years, according to the indication/medical records maintained by the liver transplant team. (bvsalud.org)
- Liver transplantation is the most effective treatment option for patients with acute or chronic liver failure. (bvsalud.org)
- An alternative approach is liver cell transplantation. (bvsalud.org)
Survival4
- Despite the fact that most follicular lymphomas are advanced at the time of diagnosis, many patients may not require treatment for prolonged periods of time, and the median survival of patients with follicular lymphomas has historically been approximately 8-10 years. (medscape.com)
- We hypothesized that patients transplanted with FluTreo would have a long-term survival advantage over other treatment alternatives. (confex.com)
- The following factors were studied in the whole cohort: age, type of disease (treatment-related or post myelodysplastic syndrome/MDS), previous intensive chemotherapy cycles, cytogenetic risk, overall (OS) and disease-free survival (DFS). (confex.com)
- For patients with advanced non-small cell lung cancer (NSCLC) harboring the ALK gene rearrangement, ceritinib (Zykadia) provided longer progression-free survival than chemotherapy in patients previously treated with chemotherapy and crizotinib (Xalkori), but gastrointestinal toxicity was. (ascopost.com)
Cord blood transplantation3
- The product is intended for use in adults and pediatric patients 12 years and older with blood cancers planned for umbilical cord blood transplantation following a myeloablative conditioning regimen (treatment such as radiation or chemotherapy). (fda.gov)
- Eighty-seven percent of subjects who were randomized to receive Omisirge achieved neutrophil recovery with a median of 12 days following treatment with the product, compared to 83% of subjects who were randomized to receive umbilical cord blood transplantation and who achieved neutrophil recovery with a median of 22 days. (fda.gov)
- We investigated NK cell functions in a CHS patient before and after cord-blood transplantation, and the ability of in vitro IL-2 treatment to restore them. (torvergata.it)
Organ6
- Systemic lupus erythematosus (SLE) is a debilitating multi-organ autoimmune disease that has no cure and limited treatment options 1 . (nature.com)
- Yet, in contrast to organ donation, there's no shortage of donated stem cells in Germany. (leipzig-for-lifechangers.com)
- An important factor in interstitial aggression is the appearance of autoreactive clones of plasma cells, dissemination of virusinfected leucocytes throughout the body with the involvement of various organs and systems, which exacerbates multiple organ failure. (genescells.ru)
- The lab also is developing and evaluating novel therapeutic approaches to eliminate T and B cells causing autoimmunity and solid organ transplant rejection. (cincinnatichildrens.org)
- These preparatory interregional and interdisciplinary meetings focused on the following areas: cloning and human reproductive health, biologicals, organ transplantation, research, and medical genetics. (who.int)
- Although no evidence-based guidelines for dental septic focal treatment exist, patients should be advised to have dental foci removed before undergoing organ transplants in order to avoid post-transplant systemic and local oral complications. (bvsalud.org)
Islet11
- Induction of experimental diabetes mellitus is indeed, the first step in the process of purification of pancreatic Langerhans islet cells of normal rats for transplantation under the testis subcutaneous of experimentally induced diabetic rats. (scialert.net)
- Biopsy of pancreas tissue of diabetic and normal rats showed that the Langerhans islet beta cells of diabetic rats have been clearly degenerated. (scialert.net)
- employing enzymes like DNase and trypsine, so the islet cells were changed into single cells and these cells were assayed by flow cytometry. (scialert.net)
- A secondary advantage is that islet cell transplantation appears to help maintain normoglycemia in patients who require total pancreatectomy for pain due to chronic pancreatitis. (merckmanuals.com)
- Its disadvantages are that transplanted glucagon -secreting alpha cells are nonfunctional (possibly complicating hypoglycemia) and several pancreata are usually required for a single islet cell recipient (exacerbating disparities between graft supply and demand and limiting use of the procedure). (merckmanuals.com)
- A purified islet cell fraction is infused percutaneously into the portal vein by direct puncture of that vein or via a branch of the mesenteric vein. (merckmanuals.com)
- Islet transplantation is a minimally invasive β-cell replacement strategy. (lu.se)
- Islet transplantation is a reimbursed treatment in Norway. (lu.se)
- Here, we summarize the cost and clinical outcome of 31 islet transplantations performed at Oslo University Hospital (OUS) from January 2010 to June 2015. (lu.se)
- For all groups combined, we estimate that 44% of the patients have a 50% reduction in insulin requirement 4 years after the initial islet transplantation. (lu.se)
- We hereby add to the common pool of growing experience with islet transplantation and also describe the cost of the treatment at our center. (lu.se)
20231
- Apoptotic cell death in disease-Current understanding of the NCCD 2023. (cincinnatichildrens.org)
Therapy15
- In patients with severe or complicated CDI, oral vancomycin is recommended as first-line therapy due to faster symptom resolution and fewer treatment failures than when metronidazole is used. (medscape.com)
- [ 50 , 51 ] A 2018 systematic review and meta-analysis comprising 7 studies with 543 patients with recurrent CDI that compared FMT to standard-of-care management found FMT to hold promise as a treatment modality in this setting relative to medical therapy alone. (medscape.com)
- Today's approval is an important advance in cell therapy treatment in patients with blood cancers," said Peter Marks, M.D., Ph.D., director of the FDA's Center for Biologics Evaluation and Research. (fda.gov)
- This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
- Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
- If transplantation is done early enough following the onset of the disease, it's been proven to be an effective therapy with a very good outcome for patients, he says. (leipzig-for-lifechangers.com)
- However, the full potential of CAR T therapy is hampered by the lack of long-term persistence of the engineered T cells in patients. (lls.org)
- It is also expected to provide critical information to further develop this immune cell-based therapy for treatment of multiple other malignancies. (lls.org)
- A poor prognosis for patients, the likelihood of developing pulmonary fibrosis after infection, according to several researchers, can be corrected by cell therapy. (genescells.ru)
- The combined efforts of many research groups can lead to reliable information on the cell therapy benefit and the need to include it in the standards of treatment of patients with this extremely severe pathology. (genescells.ru)
- Radiation therapy uses high-energy rays to kill or shrink cancer cells. (hopkinsmedicine.org)
- It is a leader in the latest investigational strategies, including pharmacologic and device therapy, mechanical circulatory support, and heart transplantation, many of which are only available in select institutions across the nation. (uhhospitals.org)
- The mainstay of adjuvant treatment for early-stage, hormone receptor-positive breast cancer has been endocrine therapy, either with tamoxifen and. (ascopost.com)
- Although not yet scientifically proven, evaluation and dental treatment during the pre-transplantation period is recommended in order to prevent infections and resultant odontogenic-origin sepsis during the post-transplant period, when patients receive immunosuppressive therapy. (bvsalud.org)
- A study by Tang et al has determined that long-term TKI therapy may reduce the abundance of leukemic stem cells in select patients. (medscape.com)
Acute2
- Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). (nature.com)
- Eight patients from the first NGFR-HSV-TK-studies developed acute ( n = 6) or chronic GvHD ( n = 2), which resolved after treatment with GCV alone in seven of eight patients. (frontiersin.org)
Haploidentical2
- Transduced cells were transfused either after day +60 (matched donors) or on day +42 (haploidentical donors). (frontiersin.org)
- 2002 until 2007), two were included in TK007 (2005-2009) and six serves as a control group for outcome after haploidentical transplantation without HSV-TK-transduced DLI. (frontiersin.org)
Diagnosis1
- knowcancer.com is intended to be solely for informational purposes and should not be a substitute for professional medical advice, diagnosis or treatment. (knowcancer.com)
Outcome2
- The aim of this study was to analyse the long-term outcome of rectal cancer patients who submitted to preoperative chemoradiation with consecutive intensive follow-up and aggressive surgical treatment of recurrent disease. (researchgate.net)
- Outcome data are in line with previously reported studies, especially the data for salvage treatment and BEAM conditioning in DLBCL patients confirmed the outcome reported recently in a phase III study. (smw.ch)
Clinical7
- Surgical excision is the main treatment of pterygium, but the postoperative recurrence rate is high, the appearance of the eye is not ideal, postoperative foreign body feeling has been a difficult problem of clinical treatment. (researchsquare.com)
- Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
- Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
- The accumulated experience of preclinical experiments made it possible to urgently proceed to conduct clinical trials of the safety of their use in patients with ARDS and to search for optimal indications to obtain maximum benefits for patients after transplantation. (genescells.ru)
- At Aarhus University Hospital, Department of Clinical Immunology is responsible for the contact to donors and the quality of the stem cells. (auh.dk)
- In this phase one clinical trial, the efficacy of these cells for the treatment of refractory lupus nephritis (LN) was verified. (sscb-stembiotech.com)
- More clinical studies are needed to be able to draw proper conclusions about the possible effects of the two treatments. (lu.se)
GVHD1
- In transplant recipients, we also recorded HCT-comorbidity index/CI score, cumulative incidence (CI) of graft-versus-host disease (GVHD), and treatment-related mortality (TRM). (confex.com)
Complications3
- There are complications of serial transfusions of either of these cell types, and a patient needs intense prophylactic treatments to protect from infections if his or her white counts are low. (drugdiscoverynews.com)
- Current treatment of systemic sclerosis is directed toward managing complications and providing symptomatic relief. (medscape.com)
- CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
Patient's3
- The method entails isolating patient's immune cells (T cells) and genetically engineering them to recognize and kill cancer cells using a Chimeric Antigen Receptor (CAR). (lls.org)
- After the first week of treatment, the patient's WBC count fell to 36×109/L with a significant decrease in blast cell count. (pensoft.net)
- On the day of the treatment, a sample of the patient's blood is drawn which is then centrifuged. (lu.se)
Tissue10
- The loose connective tissue under the epithelium contains a large number of fibroblasts and abundant capillaries, which indicates that the pterygium epithelial cells have a strong ability to proliferate and migrate. (researchsquare.com)
- As a result, many researchers have focused on adult stem cells, or stem cells isolated from adult humans that can be transplanted into damaged tissue. (wikipedia.org)
- At some point, a signal is introduced (either in culture or after transplant to the damaged tissue) for the cells to differentiate into the end tissue Until recently, the use of cultured mesenchymal stem cells to regenerate cartilage has been primarily in research with animal models. (wikipedia.org)
- Disease-modifying treatment aims at inhibiting tissue fibrosis and vascular and immune system alterations, which are the three crucial components of disease pathogenesis. (medscape.com)
- Specifically, 9 patients received systemic infusion of mesenchymal stem cells derived from adipose tissue and followed up for a 12-month follow-up period. (sscb-stembiotech.com)
- As reported by the researchers, allogeneic transplantation of mesenchymal stem cells from adipose tissue was shown to be safe and able to reduce proteinuria and disease activity. (sscb-stembiotech.com)
- For this reason, multiple infusions of adipose tissue mesenchymal stem cells over time are necessary to maintain long-term remission of refractory lupus nephritis. (sscb-stembiotech.com)
- Tumors are abnormal masses of tissue that form when cells begin to reproduce at an increased rate. (hopkinsmedicine.org)
- For the first time, a randomized trial has provided good evidence to support the use of neoadjuvant chemotherapy for treatment of high-risk soft-tissue sarcoma of the extremities or trunk wall. (ascopost.com)
- as well as diagnostic techniques, drug development and tissue transplantation. (who.int)
Therapeutic4
- PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
- Allogeneic multipotent mesenchymal stromal cells (mesenchymal stem cells) are considered as first-line therapeutic cells. (genescells.ru)
- Plasma cell biology: Foundations for targeted therapeutic development in transplantation. (cincinnatichildrens.org)
- 5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
Severe3
- As a result, a frequent and serious risk of this treatment is the occurrence of severe and sometimes deadly infections. (fda.gov)
- Treatment with Omisirge has the potential to cause severe side effects, which must be considered in assessing the risks and benefits of using this product. (fda.gov)
- NK cell cytotoxicity in Chédiak-Higashi syndrome (CHS) is strongly impaired as lytic granules are not released upon NK-target cell contact, contributing to several defects typical of this severe immunodeficiency. (torvergata.it)
Infection4
- Likewise, in asplenic ALPS patients with, stress the infection risks, including the pneumococcal sepsis associated with asplenia (which may be compounded by lack of memory B cells and autoimmune neutropenia). (medscape.com)
- This is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. (clevelandclinic.org)
- X-linked lymphoproliferative syndrome is an immunodeficiency disorder that results from an abnormality in T cells and natural killer cells and results in an abnormal response to Epstein-Barr virus infection. (msdmanuals.com)
- Deficiency or malfunction of T cells increases the risk of serious infection. (msdmanuals.com)
Renal5
- Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
- Treatment led to statistically significant reductions in proteinuria and serum creatinine and preserved renal architecture. (nature.com)
- The primary indication for kidney transplantation is End-stage renal failure. (merckmanuals.com)
- During the first three months after treatment, a complete and partial renal response was observed in 33.3% and 44.4% of patients, respectively. (sscb-stembiotech.com)
- Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality. (cincinnatichildrens.org)
Refractory1
- An important aspect of caring for ALPS patients is medical treatment of the chronic and refractory autoimmune cytopenias that frequently cause morbidity and even mortality in these patients. (medscape.com)
Lymphoma7
- Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
- Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
- Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)
- Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. (medscape.com)
- The proposed strategy is design to enhance proliferation, lengthen persistence and augment the anti-lymphoma activity of adoptively transferred CMV-CD19 CAR T cells. (lls.org)
- According to experts who presented talks on high-throughput sequencing of T-cell receptors at the 3rd World Congress of Cutaneous Lymphoma. (ascopost.com)
- Immunotherapy with an anti-programmed cell death protein 1 (PD-1) inhibitor-pembrolizumab (Keytruda)-showed encouraging responses in patients with advanced cutaneous T-cell lymphoma (either mycosis fungoides or Sézary syndrome). (ascopost.com)
Allogeneic stem1
- Omisirge, administered as a single intravenous dose, is composed of human allogeneic stem cells from umbilical cord blood that are processed and cultured with nicotinamide (a form of vitamin B3). (fda.gov)
Methods1
- METHODS: Young and replication-induced senescent endothelial colony-forming cells (ECFCs) derived from human circulating EPCs were used to examine cellular activities and senescence-associated indicators after transfection of short interference RNA specific to Panx1 or lentivirus-mediated Panx1 overexpression. (bvsalud.org)
Sickle cell an1
- I am a 24 years old man suffering from sickle cell anaemia . (ndtv.com)
Immune8
- Previous research on CMV reactivation has focused on T cells, the celebrated disease fighters of the immune system. (sciencedaily.com)
- There had been occasional hints that antibodies produced by immune system B cells played some role against CMV, but it seemed to be a supporting role. (sciencedaily.com)
- But Hill and his research team found that strain-specific antibodies made from B cells are responsible for keeping CMV suppressed in mice, without the need for any other immune cells. (sciencedaily.com)
- In a series of experiments looking at the roles of different types of immune cells, the team found that B cells played a critical role in controlling CMV. (sciencedaily.com)
- Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
- Treatment involves a combination approach to treat the immune response, improve circulation, and stop the progression of skin symptoms. (mountsinai.org)
- Over-activated T-cells will cause immune-related adverse events such as Aplastic Anemia (AA). (pensoft.net)
- In hemophagocytic lymphohistiocytosis, too many blood cells in the immune system are activated. (msdmanuals.com)
Peripheral blood stem2
- OUTLINE: Conditioning: Patients undergo low dose total body irradiation followed by infusion of allogeneic peripheral blood stem cells (PBSC) on day 0. (knowcancer.com)
- In another trial, this group is evaluating whether peripheral blood stem cells combined with MSCs can treat poor graft function. (drugdiscoverynews.com)
Pancreatic1
- Pancreas Transplantation Pancreas transplantation is a form of pancreatic beta-cell replacement that can restore normoglycemia in diabetic patients. (merckmanuals.com)
AlloHCT1
- Conclusions: Among patients who underwent alloHCT and lived to 100 days, the majority did not report regretting their transplantation. (cdc.gov)
Immunology1
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Mortality1
- there is a significant risk for perioperative mortality with elevated serum lactate levels (5 mmol/L) and leukocytosis (50,000 cells/µL). (medscape.com)
Progenitor1
- BACKGROUND: We examined the role of Panxs (pannexins) in human endothelial progenitor cell (EPC) senescence. (bvsalud.org)
Graft2
- Oral beclomethasone dipropionate for treatment of human intestinal graft-versus-host disease. (nature.com)
- CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
Centers2
- In Germany, there are only a few specialized centers for ALD transplantation. (leipzig-for-lifechangers.com)
- Centers where SCT for sickle cell disease available in India are - Dr. B L Kapur Memorial Hospital - New Delhi, CMC - vellore, Apollo - Chennai, TMH - Mumbai, Narayn Hridyalaya - Banglore, Shayadri Hospital - Pune. (ndtv.com)
Therapies3
- Gene therapies to treat SCD in people who are 12 years and older and have had repeated sickle cell crises. (medlineplus.gov)
- These new therapies involve taking some of your blood stem cells and either adding new DNA to them or changing their existing DNA. (medlineplus.gov)
- Recent findings have revealed new targets for treatment that could lead to more efficient therapies. (medscape.com)
Patient5
- Generally, before receiving this kind of transplant, the patient will undergo a course of treatments to remove their own stem cells and prepare the body for the new stem cells. (fda.gov)
- By infusing these CAR T cells back into the patient, the engineered cells seek out and eliminate malignant cells. (lls.org)
- Laboratory investigations revealed white blood cell count (WBC) 44×109/L with 86% blasts, hemoglobin 8.1 g/dL and a platelet count of 37×109/L. After obtaining an informed consent, the patient was treated with an induction chemotherapy with IA regimen (cytarabine 1.5 g/m2 by vein daily on days 1-3, with idarubicin 12 mg/m2 by vein daily on days 1-3). (pensoft.net)
- Taken together, our results indicate that IL-2 had a wide capacity to restore NK cell effector functions, being able to reverse the altered cytotoxic activity, lytic granule pattern, and cytokine production observed in the CHS patient. (torvergata.it)
- The treatment method is also very expensive for the patient as it is not covered by medical insurance. (lu.se)