Treatment antineoplastic agents. Medical search. Frequent questions

These publications spurred rapid advancement in the previously non-existent field of cancer chemotherapy, and a wealth of new alkylating agents with therapeutic effect were discovered over the following two decades. (wikipedia.org)
In the Anatomical Therapeutic Chemical Classification System, alkylating agents are classified under L01A. (wikipedia.org)
Phase I and II clinical trials have indicated that these agents have antitumor activity as single agents and enhance the development of antitumor T-cell responses when used as therapeutic vaccine adjuvants. (nih.gov)
The activity and safety of these novel anticancer agents are being explored in a wide range of tumor types as part of a variety of therapeutic strategies with the goal of harnessing the immune response to fight cancer. (nih.gov)
Radiation therapy remains a primary therapeutic modality for the treatment of spinal metastasis, because nearly 95% of patients who are ambulatory at the start of radiation therapy remain so. (medscape.com)
Together, these findings suggest that autophagy inhibitors may enhance the therapeutic effects of TKIs in the treatment of CML. (lu.se)
Therapeutic response has been beneficial and resulted in successful treatment of these diseases. (oncologynurseadvisor.com)
This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

As a group, antineoplastic agents interfere with the production of eosinophils, but they may also cause toxicity to normal tissues, especially the bone marrow. (medscape.com)

An antimetabolite antineoplastic agent, cytarabine is converted intracellularly to the active compound cytarabine-5'-triphosphate, which inhibits DNA polymerase. (medscape.com)

Used both as single agent and in multiagent regimens for the treatment of malignant GTN. (medscape.com)
Use as single agent or as part of multiagent regimen for treatment of malignant GTN. (medscape.com)
Effective antineoplastic used in patients with chemotherapy-resistant malignant GTN. (medscape.com)
Pemetrexed injection is also in combination with another chemotherapy medication as a first treatment for malignant pleural mesothelioma (a type of cancer that affects the inside lining of the chest cavity) in people who cannot be treated with surgery. (medlineplus.gov)
When administered into the pleural cavity in the treatment of malignant pleural effusion, bleomycin acts as a sclerosing agent. (nih.gov)
1 HSCT is most commonly used as a treatment option for malignant conditions. (oncologynurseadvisor.com)

the third presentation will consider exposures to healthcare workers, especially in the context of antineoplastic drugs. (cdc.gov)
The presence of antineoplastic drugs and their metabolites in the urine of nurses and other healthcare professionals confirms exposure. (cdc.gov)
The TAPUR Study aims to describe the safety and efficacy of Food and Drug Administration (FDA)-approved, targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has a potentially actionable genomic alteration. (facingourrisk.org)
availability of drugs in the treatment of noncommunicable diseases (NCDs) ( 2 ). (who.int)
Because embryonic tissues grow rapidly and have a high DNA turnover rate, they resemble cancer tissues and are thus very vulnerable to antineoplastic drugs. (msdmanuals.com)
In honor of these nurses and all who work with hazardous drugs (many of which are used in the treatment of cancer) we are posting this blog on how to safely prepare, administer or otherwise handle these drugs. (cdc.gov)
Hazardous drugs can include those used for cancer therapy, some antiviral drugs, hormone agents, and bioengineered drugs. (cdc.gov)
Despite the prevention efforts to date, workplace contamination has been well documented by research on a small percentage of antineoplastic, or cancer-killing drugs. (cdc.gov)
Reproductive health is one of the most vulnerable end points because many hazardous drugs used for cancer treatment target rapidly dividing cells in the same way teratogens target rapidly dividing embryonic cells. (cdc.gov)
Some classes of drugs are more hazardous than others and, as a group, antineoplastic drugs have been shown in animal studies to be some of the most potent teratogenic agents known, at doses typically used in cancer treatment. (cdc.gov)
In addition, there are numerous new drugs that have been approved for cancer treatment. (cdc.gov)

Selpercatinib (Retevmo, Retsevmo) is a potent antineoplastic agent. (globaldata.com)
Arsenic trioxide (As 2 O 3 ) is an environmental toxicant and a potent antineoplastic agent. (springer.com)

Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)
Treatments targeted various genomic findings including EGFR alterations, mTOR activation, cell cycle targets and FGFR1 mutations. (nih.gov)

Thus, 2-chloro-2΄-deoxy- β -D-adenosine can be distinguished from other chemotherapeutic agents affecting purine metabolism in that it is cytotoxic to both actively dividing and quiescent lymphocytes and monocytes, inhibiting both DNA synthesis and repair. (nih.gov)

Is lack of response to single-agent chemotherapy in gestational trophoblastic disease associated with dose scheduling or chemotherapy resistance? (medscape.com)
Your doctor may change your dose of pemetrexed injection, delay treatment, or permanently stop your treatment based on the results of the blood tests. (medlineplus.gov)
If you are a female who can become pregnant, you will need to have a pregnancy test before you begin treatment, and you should use a reliable method of birth control while receiving pemetrexed injection and for at least 6 months after the final dose. (medlineplus.gov)
You should not breastfeed during your treatment with pemetrexed injection and for 1 week after the final dose. (medlineplus.gov)
Detoxifying agents used in connection with high dose treatment of antineoplastic agents are classified in V03AF (e.g. calcium folinate). (whocc.no)
Prevention: Calcium folinate should be administered every day during treatment with trimetrexate and for 72 hours after the last dose of trimetrexate. (janusinfo.se)
In case of high dose pyrimethamine or prolonged treatment with low doses, calcium folinate 5 to 50 mg/day should be simultaneously administered, based on the results of the peripheral blood counts. (janusinfo.se)
Treatment started with the recommended dose, but this dose was later reduced or treatment interrupted for a few days in some dogs. (europa.eu)
In case of side effects, the veterinarian might decide to lower the dose of Palladia or to stop treatment, either temporarily or permanently. (europa.eu)
Acute nephrotoxicity has been observed with high doses of LEUSTATIN (4 to 9 times the recommended dose for Hairy Cell Leukemia), especially when given concomitantly with other nephrotoxic agents/therapies. (nih.gov)
Treatment may be interrupted or stopped, or the dose modified, if serious side effects occur or certain other medicines have to be taken. (europa.eu)
These findings urge further investigations to avoid the potential risks in current empiric continuous low-dose chemotherapy regimens with antineoplastic agents. (researchsquare.com)
This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges can promote tumorigenesis and tumor progression in vitro and in vivo , through stimulation of tumor cell functions directly as well as enhancement of tumor angiogenesis by BMDCs recruitment indirectly. (researchsquare.com)
However, the conventional chemotherapy with antineoplastic agents at the maximum tolerated dose (MTD) is typically administrated in short cycles, obligatorily separated by long treatment breaks (e.g., 3 weeks), and unfortunately accompanied by serious toxic side effects. (researchsquare.com)

Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic tumor and is associated with poor prognosis and treatment response. (stanford.edu)

It is recommended that bleomycin be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (nih.gov)
Treatment with bleomycin sulfate. (dentalcare.com)
Bleomycin sulfate is an antineoplastic agent used for the treatment of lymphomas, testicular tumors, and squamous cell carcinoma. (dentalcare.com)
Treatment with Aramchol resulted in statistically significant fibrosis improvement in a validated bleomycin model of lung fibrosis (IPF), comparable to Pirfenidone which is the gold standard treatment. (prnewswire.com)
Bleomycin, an anti-neoplastic agent that causes lung fibrosis in human patients, has been used extensively in rodent models to mimic IPF and serves as the standard agent for induction of experimental pulmonary fibrosis in animals. (prnewswire.com)

Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)
What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
Goodman, Gilman, and others began studying nitrogen mustards at Yale in 1942, and, following the sometimes dramatic but highly variable responses of experimental tumors in mice to treatment, these agents were first tested in humans late that year. (wikipedia.org)

Chemotherapeutic agents may be used in patients whose conditions are refractory to steroid treatment. (medscape.com)

Ezharmia is indicated for the treatment of patients with relapsed or refractory adult T-cell leukemia/lymphoma. (pharmaceutical-technology.com)
Jaypirca is indicated for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy, including a Bruton's tyrosine kinase (BTK) inhibitor. (pharmaceutical-technology.com)

Pemetrexed injection is used in combination with other chemotherapy medications as a first treatment for a certain type of non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body. (medlineplus.gov)
Pemetrexed injection is also used alone to treat NSCLC as ongoing treatment in people who have already received certain chemotherapy medications and whose cancer has not worsened and in people who could not be treated successfully with other chemotherapy medications. (medlineplus.gov)
Pemetrexed is in a class of medications called antifolate antineoplastic agents. (medlineplus.gov)
Fludara is usually given after other cancer medications have been tried without successful response to treatment. (rxlist.com)

Agents in this class halt the cell cycle at the G1 phase in tumor cells. (medscape.com)
Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. (medscape.com)
Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. (medscape.com)
There are indications that certain antineoplastic agents at low dosages may exhibit abnormal pharmacological actions, such as promoting tumor growth. (researchsquare.com)

In addition to calcium folinate administration, measures to ensure the prompt excretion of methotrexate (maintenance of high urine output and alkalinisation of urine) are integral parts of the calcium folinate rescue treatment. (janusinfo.se)

PDQ Adult Treatment Editorial Board. (medscape.com)
Adult Non-Hodgkin Lymphoma Treatment (PDQ®): Health Professional Version. (medscape.com)
To date, no standard treatment is established for GVHD and no therapies are FDA approved for this indication in pediatric or adult patients. (oncologynurseadvisor.com)
The versatile drug is now also approved for the treatment of B-cell Hodgkin lymphoma, non-Hodgkin lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis in the adult population. (oncologynurseadvisor.com)

As alkylating agent, mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. (medscape.com)

If the systemic cause of EM can be identified, treatment should be initiated to treat the cause. (uspharmacist.com)

An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to DNA. (wikipedia.org)
Before their use in chemotherapy, alkylating agents were better known for their use as sulfur mustard, ("mustard gas") and related chemical weapons in World War I. The nitrogen mustards were the first alkylating agents used medically, as well as the first modern cancer chemotherapies. (wikipedia.org)
A common myth holds that Goodman and Gilman were prompted to study nitrogen mustards as a potential treatment for cancer following a 1943 incident in Bari, Italy, where survivors exposed to mustard gas became leukopenic. (wikipedia.org)
Although still early in clinical development, agonists of Toll-like receptor 9 (TLR9) have demonstrated potential for the treatment of cancer. (nih.gov)
We performed capture-based next generation sequencing (NGS) genomic analysis assay of 236/315 cancer-associated genes, with average depth of over 1000 fold, to guide treatment in HGG patients. (nih.gov)
It is an antineoplastic agent (cancer medicine). (mayoclinic.org)
Radiopharmaceuticals used in the treatment of cancer are classified in V10X. (whocc.no)
Monoclonal antibodies mainly indicated for the treatment of cancer are classified in this group. (whocc.no)
It is indicated for the reduction of cytotoxicity when used in combination with 5-fluorouracil in the treatment of colorectal cancer and for the treatment of megaloblastic anemia due to folic acid deficiency when folic acid cannot be replaced orally. (janusinfo.se)
The following regimens have been used in adults and elderly in the treatment of advanced or metastatic colorectal cancer and are given as examples. (janusinfo.se)
anti-neoplastic properties, which make it a potentially beneficial agent for use in cancer prevention. (natmedtalk.com)
Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. (facingourrisk.org)
Scholars@Duke publication: Challenges after curative treatment for childhood cancer and long-term follow up of survivors. (duke.edu)
In patients who have not had previous treatment for the condition, Calquence may be used on its own or combined with another cancer medicine, obinutuzumab. (europa.eu)
Calquence can only be obtained with a prescription and treatment should be started and supervised by a doctor with experience in the use of cancer medicines. (europa.eu)
One of the studies, involving 535 patients who had not had previous treatment for CLL, compared Calquence or its combination with obinutuzumab versus a combination of obinutuzumab with another cancer medicine, chlorambucil. (europa.eu)
A second main study involving 310 patients compared Calquence alone with a combination of other cancer medicines (rituximab and either idelalisib or bendamustine) in patients whose CLL had come back or not responded with previous treatment. (europa.eu)
Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
Pharmacologic principles of cancer treatment / Bruce Chabner. (who.int)
WHO handbook for reporting results of cancer treatment. (who.int)
Acute care hospitals continue to specialize in the treatment of many patients with cancer who are at increased risk for infection (e.g., hematopoietic stem cell transplant recipients, patients with febrile neutropenia), with programs and policies that promote adherence to infection control standards. (cdc.gov)
The study of the clinical characteristics of patients with metastatic prostate cancer who are infected with COVID-19 provides observations from a small sample of patients with prostate cancer in South Italy that seem to align with results from other regions of the world in relation to COVID-19 treatment, hormone levels, and options for the management of patients with prostate cancer who are positive for COVID-19. (who.int)
Pregnancy should not delay treatment of cancer. (msdmanuals.com)
Although pregnancy often concludes successfully despite cancer treatment, risk of fetal injury due to treatment leads some women to choose pregnancy termination. (msdmanuals.com)
If invasive cancer is diagnosed after 20 weeks and if the woman accepts the unquantified increase in risk, treatment can be deferred until into the 3rd trimester (eg, 32 weeks) to maximize fetal maturity but not delay treatment too long. (msdmanuals.com)
la prise en charge du cancer col métastatique s'est enrichie depuis 2017 par la disponibilité des thérapies ciblées dans notre pays. (bvsalud.org)
Cette étude avait pour objectifs de déterminer les caractéristiques épidémiologiques, cliniques et thérapeutiques des patientes prises en charge pour cancer du col métastatique dans notre structure. (bvsalud.org)

LEUSTATIN (cladribine) Injection (also commonly known as 2-chloro-2΄-deoxy- β -D-adenosine) is a synthetic antineoplastic agent for continuous intravenous infusion. (nih.gov)
The literature review describes potential preferred treatments for COVID-19 and their interactions with the most commonly used antineoplastic agents. (who.int)

Metabolism of these agents may be slowed significantly, causing prolonged effects. (medscape.com)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)

In a clinical investigation, 17 patients with Hairy Cell Leukemia and normal renal function were treated for 7 days with the recommended treatment regimen of LEUSTATIN Injection (0.09 mg/kg/day) by continuous intravenous infusion. (nih.gov)
Comment: Palifermin should not be administered within 24 hrbefore, during infusion of, or within 24 hr after administration of antineoplastic agents. (medscape.com)

Combination products are classified in L01XY - Combinations of antineoplastic agents. (whocc.no)
All combinations of antineoplastic agents in L01 - Antineoplastic agents are classified in this group. (whocc.no)
Combinations of antineoplastic agents with hyaluronidase are classified at the same 5th level as the combinations of antineoplastic agents without hyaluronidase. (whocc.no)

This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. (elsevierhealth.com)
5 Combining rituximab, a monoclonal antibody targeting the CD20 antigen on B cells, with standard chemotherapy has improved NHL treatment outcomes. (haematologica.org)
The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)

Anticancer agents based on natural product models / edited by John M. Cassady, John D. Douros. (who.int)

Risk of additive immune system effects with etrasimod has not been studied in combination with antineoplastic, immune-modulating, or noncorticosteroid immunosuppressive therapies. (medscape.com)

If myxedema coma is suspected on clinical impression, start IV thyroid hormone treatment. (medscape.com)

and 3) Unmet needs (pathology, patient, treatment and management). (bvsalud.org)

Despite the fact that most follicular lymphomas are advanced at the time of diagnosis, many patients may not require treatment for prolonged periods of time, and the median survival of patients with follicular lymphomas has historically been approximately 8-10 years. (medscape.com)
Rituximab was developed in 1986 and received FDA approval for the treatment of B cell non-Hodgkin lymphomas in 1997. (oncologynurseadvisor.com)

Treatment options differ for acute and chronic lesions. (uspharmacist.com)
1 This article reviews the conditions and treatment of common acute dermatosis lesions. (uspharmacist.com)
It was under development for the treatment of relapsed or refractory acute myelocytic leukemia and acute lymphocytic leukemia. (pharmaceutical-technology.com)

This group comprises preparations used in the treatment of neoplastic diseases, and immunomodulating agents. (whocc.no)

8 Despite high response rates to rituximab-based regimens, many patients become resistant to treatment or relapse after initially achieving a response. (haematologica.org)
however, severe neurological toxicity has been reported rarely following treatment with standard cladribine dosing regimens. (nih.gov)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)

E ditor ,-Hydroxyurea is an antineoplastic agent used in the treatment of various myelproliferative conditions and severe psoriasis. (bmj.com)
The rapid resolution of the condition on stopping hydroxyurea treatment should alert ophthalmologists to this possible link in any patients who develop lid problems which do not respond to usual management strategies while on such treatment. (bmj.com)
Marrow suppression is less common than with hydroxyurea, but occurrence of neurologic toxicity may limit treatment and closely resemble the neurologic symptoms of hypereosinophilic syndrome. (medscape.com)
Primary alkylating agent used in cases in which prednisone fails and in those patients who cannot tolerate hydroxyurea or vincristine. (medscape.com)
However, previous treatment with hydroxyurea or leukopheresis to reduce WBC count is allowed prior to randomization. (who.int)

Idiopathic pulmonary fibrosis (IPF) is a severe, chronic, progressive, fibrotic interstitial disease of unknown etiology, which remains an unmet need despite approved treatments which are limited by side effects. (prnewswire.com)

Nitrogen mustards Cyclophosphamide - the most widely used alkylating agent of modern times. (wikipedia.org)

in each of these three exposure scenarios, pharmaceutical agents can cause genotoxic and/or mutagenic damage. (cdc.gov)

BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)

Idelalisib is used in combination with rituximab to treat chronic lymphocytic leukemia (CLL) that has come back after other treatment. (mayoclinic.org)
Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. (medscape.com)
Prior therapy with alkylating agents either alone or in combination. (pocketdrugguide.com)

Cyclophosphamide is an alkylating agent. (pocketdrugguide.com)
In another study, the efficacy of fludarabine/cyclophosphamide in a population of chronic lymphocytic leukemia patients was accurately determined by analyzing response rates according to the patients' treatment history. (pocketdrugguide.com)

The agent is widely distributed, including in the central nervous system and tears, after IV administration. (medscape.com)

A variety of second-line agents may be used for refractory cases. (medscape.com)

Hence, early treatments to prevent progression are needed. (bvsalud.org)

Although not a first-line treatment for GVHD, rituximab may offer an alternative treatment option for GVHD in pediatric patients. (oncologynurseadvisor.com)

For the management of long-bone metastatic disease accompanied by an impending or completed fracture, open internal fixation is usually the preferred method of treatment. (medscape.com)

The objective was to determine the cellular immune response early in the course of treatment in order to examine whether cell mediated immunity could be responsible for imiquimod mediated regression of BCC. (nih.gov)
None of the patients showed response to respective biologic treatments. (nih.gov)
The lack of response suggests that further study of mechanisms of resistance in HGG is warranted before routine use of biologically-targeted agents based on NGS results. (nih.gov)
The duration of treatment depends on the dog's response to treatment. (europa.eu)
The main measures of effectiveness were the 'objective response' (an evaluation by the veterinarian of the way the tumour changed during treatment) and the time taken until the tumour started to get worse. (europa.eu)
Dogs treated with Palladia had greater objective response rates (37%) than dogs treated with placebo (8%) after six weeks of treatment. (europa.eu)
Predicting in vivo response to antineoplastics remains an elusive challenge. (cdc.gov)
56did have a positive response to treatment. (bvsalud.org)

After several parenteral doses treatment can be switched over to the oral form. (janusinfo.se)

In this group of patients with HGG, NGS revealed a high frequency of GAs that lead to targeted treatment in 30 % of the patients. (nih.gov)
This group comprises antineoplastic preparations which cannot be classified in the preceding groups. (whocc.no)

Prior therapy with alkylating agents and fludarabine. (pocketdrugguide.com)
Patients relapsed after or were refractory to alkylating agents and failed to achieve a PR with their last fludarabine-based therapy. (pocketdrugguide.com)
Appropriate management of therapy and complications is possible only when adequate diagnostic and treatment facilities are readily available. (nih.gov)
LEUSTATIN (cladribine) Injection should be administered under the supervision of a qualified physician experienced in the use of antineoplastic therapy. (nih.gov)
As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)

As a result, the clinical development of metronomic chemotherapy has been impeded by numerous limitations, including the lack of its basic pharmacological data, ambiguity of its definition and the resulting empiric design of treatment protocols. (researchsquare.com)

These agents alkylate DNA bases, thereby producing "cross-links" that covalently link the two DNA strands and prevent cell replication. (pocketdrugguide.com)
LOXO-305 (RXC-005) is under development for the treatment of chronic lymphocytic leukemia (CLL), small lymphocytic leukemia (SLL), non-Hodgkin lymphoma including mantle cell lymphoma, marginal zone lymphoma, Waldenstrom macroglobulinemia, B-cell chronic lymphocytic leukemia (CLL) relapsed/refractory chronic lymphocytic leukemia (CLL) in patients resistant to ibrutinib, follicular lymphoma and diffuse large B-cell lymphoma. (pharmaceutical-technology.com)

PKD is a chronic disease, so treatment cannot include any toxic components. (concordia.ca)
Chronic leukemia showed higher treatment duration. (sld.cu)

This protocol, consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent. (scirp.org)

Anatomy6

Organisms5

Diseases15

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes24

Disciplines and Occupations1

Technology, Industry, Agriculture4

Named Groups5

Health Care17

Therapeutic9

Bone marrow1

Antimetabolite1

Malignant6

Drugs11

Potent2

MTOR2

Purine metabolism1

Dose14

Prognosis1

Bleomycin5

Tumors4

Chemotherapeutic agents1

Patients with relapsed or refractory2

Medications4

Tumor4

Calcium folinate1

Adult4

Interfere1

Systemic1

Cancer27

Commonly2

Metabolism2

Infusion2

Combinations3

Outcomes3

Anticancer1

Therapies1

Hormone1

Pathology1

Lymphomas2

Acute3

Diseases1

Regimens3

Hydroxyurea5

Severe1

Nitrogen mustards1

Exposure1

Cytotoxic1

Combination3

Cyclophosphamide2

Administration1

Refractory cases1

Progression1

Pediatric1

Metastatic1

Response8

Parenteral1

Group2

Therapy5

Clinical1

Cell2

Chronic2

Radiotherapy1