• If treatment is initiated early, thiamine deficiency can be prevented. (wikipedia.org)
  • Megaloblastic anemia is an uncommon problem in childhood that is most frequently associated with vitamin deficiency or gastrointestinal disease. (medscape.com)
  • The 2 most common causes of megaloblastic anemia are vitamin B-12 (cobalamin) deficiency and folic acid deficiency. (medscape.com)
  • Pernicious anemia, a common cause of vitamin B-12 deficiency in adults, is rare in childhood. (medscape.com)
  • Deficiency causes megaloblastic anemia, damage. (msdmanuals.com)
  • Deficiency causes megaloblastic anemia (indistinguishable from that due to vitamin. (msdmanuals.com)
  • Nonmegaloblastic macrocytosis is suspected in patients with macrocytic anemias when testing excludes vitamin B12 deficiency or folate deficiency. (msdmanuals.com)
  • Myelodysplasia and Iron-Transport Deficiency Anemia In myelodysplastic syndrome, anemia is commonly prominent. (msdmanuals.com)
  • Causes of megaloblastic anemia include vitamin B 12 (cobalamin) or folate (vitamin B 9 ) deficiency and specific drugs. (arupconsult.com)
  • Vitamin B 12 deficiency and associated megaloblastic anemia may be caused by pernicious anemia, in which a lack of intrinsic factor (IF) prevents sufficient absorption of vitamin B 12 . (arupconsult.com)
  • Additional testing for vitamin B 12 and/or folate deficiency and antibody testing for pernicious anemia may be performed based on the results of these initial tests. (arupconsult.com)
  • Patients with megaloblastic anemia due to vitamin B 12 deficiency may also present with symptoms of peripheral neuropathy, such as dysesthesia and hypoesthesia. (arupconsult.com)
  • However, some patients may be asymptomatic, and certain laboratory features of megaloblastic anemia may be masked by concurrent iron deficiency or microcytic anemia . (arupconsult.com)
  • Causes of megaloblastic anemia include vitamin B 12 or folate deficiency (as a result of decreased intake, decreased absorption, or increased demand), specific drugs, inborn errors of metabolism, myelodysplastic syndromes , and problems with DNA synthesis (eg, from chemotherapy). (arupconsult.com)
  • Because vitamin deficiency is a major cause of megaloblastic anemia, older individuals, persons who are malnourished, those with alcohol use disorder , and individuals who consume a vegetarian or vegan diet are at increased risk for megaloblastic anemia. (arupconsult.com)
  • Folate-deficiency anemia is the lack of folic acid in the blood. (massgeneral.org)
  • Who is at risk for folate-deficiency anemia? (massgeneral.org)
  • What are the symptoms of folate-deficiency anemia? (massgeneral.org)
  • The symptoms of folate-deficiency anemia may look like other blood conditions or health problems. (massgeneral.org)
  • How is folate-deficiency anemia diagnosed? (massgeneral.org)
  • What are possible complications of folate-deficiency anemia? (massgeneral.org)
  • Folate-deficiency anemia during pregnancy may cause a neural tube defect in the baby. (massgeneral.org)
  • Women are at risk of iron-deficiency anemia because of blood loss from their periods and higher blood supply demands during pregnancy . (webmd.com)
  • Iron-deficiency anemia, as the name suggests, is when the body doesn't produce enough iron. (webmd.com)
  • Folate deficiency anemia occurs when a person has a low level of folate, or vitamin B-9, in their body. (medicalnewstoday.com)
  • In this article, we explore the causes, symptoms, and complications relating to folate deficiency anemia. (medicalnewstoday.com)
  • Folate deficiency anemia is one of many different types of anemia. (medicalnewstoday.com)
  • Getting enough folate through the diet and supplements is the best way to prevent folate deficiency anemia. (medicalnewstoday.com)
  • Megaloblastic anemia due to folate deficiency. (empr.com)
  • People who already have folate-deficiency anemia may need to increase their dietary intake of folic acid , whether it's through their actual diet or supplementation. (naturalnews.com)
  • B12 [ vitamin b12 (liver-stomach concentrate with intrinsic factor)] is an anti- anemia preparation used to treat anemias that respond to oral hematinics, including pernicious anemia and other megaloblastic anemia and also iron-deficiency anemia. (rxlist.com)
  • Hematinic concentrate with intrinsic factor is a multifactor preparation effective in the treatment of anemias that respond to oral hematinics, including pernicious anemia and other megaloblastic anemias and also iron-deficiency anemia . (rxlist.com)
  • Folic acid alone is unwarranted in the treatment of proof vitamin B12 (liver-stomach concentrate with intrinsic factor) deficiency states, such as pernicious anemia. (rxlist.com)
  • Megaloblastic anemia is a type of anemia that occurs when the body is unable to produce enough healthy red blood cells due to a deficiency in folic acid or vitamin B12. (onlinebluepills.su)
  • If a deficiency is detected, further testing may be required to identify the underlying cause and determine the appropriate course of treatment. (onlinebluepills.su)
  • The primary treatment for megaloblastic anemia is supplementation with folic acid and/or vitamin B12, depending on the underlying cause of the deficiency. (onlinebluepills.su)
  • While supplementation with folic acid can help to manage megaloblastic anemia in patients with diabetes, it is important to address any underlying causes of the deficiency. (onlinebluepills.su)
  • A deficiency in folic acid results in megaloblastic anemia. (nih.gov)
  • Picinni and Ricciotti suggested in 1982, that "the therapeutic effectiveness of Polysaccharide Iron Complex when compared with iron fumarate in the treatment of iron deficiency anemia, appears to be as active as the iron fumarate and as well tolerated, however, it exerted a greater influence on the level of hemoglobin and on the number of red cells. (nih.gov)
  • It is indicated for the reduction of cytotoxicity when used in combination with 5-fluorouracil in the treatment of colorectal cancer and for the treatment of megaloblastic anemia due to folic acid deficiency when folic acid cannot be replaced orally. (janusinfo.se)
  • Administration of Seromycin and other antituberculosis drugs has been associated in a few instances with vitamin B 12 and/or folic-acid deficiency, megaloblastic anemia, and sideroblastic anemia. (nih.gov)
  • Most people who eat animal products are not likely to develop vitamin B12 deficiency anemia unless their bodies can't absorb it from food. (healthlinkbc.ca)
  • Check for vitamin B12 deficiency anemia. (healthlinkbc.ca)
  • See if vitamin B12 deficiency anemia is present after a person has been diagnosed with atrophic gastritis . (healthlinkbc.ca)
  • Low levels of vitamin B12 may mean you have vitamin B12 deficiency anemia , which might be caused by problems with the absorption of the vitamin (such as pernicious anemia ). (healthlinkbc.ca)
  • Describe the causes and treatment of cobalamin deficiency. (mhmedical.com)
  • The main cause of megaloblastic anemias is deficiency of either cobalamin (vitamin B 12 ) or folic acid, vitamins that are essential for DNA replication and repair. (mhmedical.com)
  • This could be because of iron deficiency, which is the most common form of anaemia. (bupa.co.uk)
  • Some health conditions, such as Crohn's disease , coeliac disease or pernicious anaemia might lead to a deficiency in some nutrients. (bupa.co.uk)
  • The most common anemia is iron deficiency anemia , caused by iron deficiency. (hickeysolution.com)
  • It is estimated that more than 90% of anemias are caused by deficiency of this nutrient. (hickeysolution.com)
  • In addition to iron deficiency, anemia can also occur due to low intake of vitamin B12 and B9. (hickeysolution.com)
  • Chronic anemia, therefore, can be considered a type of hereditary or acquired anemia , as it also occurs due to nutritional insufficiency, iron deficiency, pregnancy and vitamin B12 and B9 deficiency. (hickeysolution.com)
  • Iron deficiency anemia is caused by the lack of iron in the body, a fundamental nutrient for the performance of several basic functions of the body. (hickeysolution.com)
  • Therefore, whenever the body's iron stores are very low, iron deficiency anemia or iron deficiency anemia develops. (hickeysolution.com)
  • Impairment of thymidylate synthesis in patients with folic acid deficiency is thought to account for the defective deoxyribonucleic acid (DNA) synthesis that leads to megaloblast formation and megaloblastic and macrocytic anemias. (pillsync.com)
  • Anemia due to hematinic deficiencies - iron deficiency anaemia, megaloblastic anemia. (apollohospitals.com)
  • This means that this is one of the fruits that can help treat anemia when it is generated by a deficiency of this mineral in the body and that, in addition, it can be very healthy for many people. (fastlyheal.com)
  • Vitamin B12 deficiency is a cause of megaloblastic anemia, in which red blood cells are larger than normal and the ratio of nucleus size to cell cytoplasm is increased. (naturalmedicinejournal.com)
  • There are other potential causes of megaloblastic anemia, including folate deficiency or various inborn metabolic disorders. (naturalmedicinejournal.com)
  • Pernicious anemia is a type of megaloblastic anemia caused by vitamin B12 deficiency, and it should be treated with vitamin B12. (naturalmedicinejournal.com)
  • People at risk for vitamin B12 deficiency include strict vegetarians, elderly people, breastfed infants, and people with increased vitamin B12 requirements associated with pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, or liver or kidney disease. (naturalmedicinejournal.com)
  • There are two different types of anemias linked to vitamin B12 deficiency. (draxe.com)
  • Megaloblastic anaemia due to vitamin B12 deficiency caused by small intestinal bacterial overgrowth: possible role of vitamin B12 analogues. (ox.ac.uk)
  • However, there was evidence of vitamin B12 deficiency as shown by an abnormal deoxyuridine suppression test and by the response to treatment with physiological doses of vitamin B12. (ox.ac.uk)
  • A deficiency of folic acid may lead to anemia, in which there is decreased production of red blood cells. (encyclopedia.com)
  • Pernicious anemia, a serious type of anemia that is due to vitamin B12 deficiency and is found mostly in older people. (nutrawiki.org)
  • Treatment and prevention of vitamin B12 deficiency, and diseases caused by low vitamin B12 levels. (nutrawiki.org)
  • The treatment of vitamin B12 deficiency can unmask the symptoms of polycythemia vera. (nutrawiki.org)
  • 7. Folicil deficiency/megaloblastic anaemia associated with haemolytic anaemia e.g. (pillintrip.com)
  • Patients with malignant disease, unless megaloblastic anaemia due to Folicil deficiency. (pillintrip.com)
  • Thirty-four patients were enrolled with vitamin B12 deficiency, non-regenerative macrocytic anemia, a positive anti-intrinsic factor antibody and anti-parietal cell antibody and a histological diagnosis of atrophic gastritis in the presence or not of Helicobacter pylori. (bvsalud.org)
  • Pernicious anemia is caused by an intrinsic factor deficiency or autoantibodies against intrinsic factor. (bvsalud.org)
  • It shall not be used in presence of pernicious and megaloblastic anemia due to Vit B12 deficiency. (pharmacyexam.com)
  • Vitamin B12 (cobalamin) and/or folic This was a population-based cross-sectional acid deficiency can cause a characteristic study with cluster random sampling on megalo blastic anaemia. (who.int)
  • 12 deficiency is important because inappropriate treatment with folic acid will lected from all regions of Shiraz. (who.int)
  • It is the role of vitamin B-12 in the reduction of folic acid derivatives that results in the megaloblastic changes seen clinically. (medscape.com)
  • Folic acid may obscure pernicious anemia in that the blood picture may revert to normal while neurological manifestations remain progressive. (rxlist.com)
  • One of the key factors in the management of megaloblastic anemia is folic acid, a B-vitamin that plays a crucial role in the production of healthy red blood cells. (onlinebluepills.su)
  • In this article, we will discuss the role of folic acid in the management of megaloblastic anemia in patients with diabetes and explore various aspects related to this topic. (onlinebluepills.su)
  • Without sufficient folic acid, the production of red blood cells becomes impaired, leading to the development of megaloblastic anemia. (onlinebluepills.su)
  • Ensuring adequate intake of folic acid is crucial for preventing and managing megaloblastic anemia in patients with diabetes. (onlinebluepills.su)
  • In order to diagnose megaloblastic anemia, healthcare providers usually order blood tests to assess red blood cell size, shape, and count, as well as levels of folic acid and vitamin B12. (onlinebluepills.su)
  • WARNING: Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemia where vitamin B12 is deficient. (drugs.com)
  • Folic acid may mask the symptoms of pernicious anemia in that hematologic remission may occur while neurological manifestations progressive. (drugs.com)
  • Pernicious anemia should be excluded before using this product since folic acid may mask the symptoms of pernicious anemia. (drugs.com)
  • Folic acid measurements are used in the diagnosis and treatment of megaloblastic anemia, which is characterized by the presence of megaloblasts (an abnormal red blood cell series) in the bone marrow. (fda.gov)
  • Vitamin B12 is usually measured at the same time as a folic acid test, because a lack of either one or both can lead to a form of anemia called megaloblastic anemia . (healthlinkbc.ca)
  • Folic acid is usually indicated in the treatment of megaloblastic anemias of pregnancy. (pillsync.com)
  • Folic acid acts on megaloblastic bone marrow to produce a normoblastic marrow. (pillsync.com)
  • Keep in mind that anemia can also be caused by lack of iron and folate/folic acid, so consuming and absorbing all of these nutrients is crucial. (draxe.com)
  • Thiamine responsive megaloblastic anemia syndrome (also known as Rogers Syndrome) is a very rare autosomal recessive genetic disorder affecting a thiamine transporter, which is characterized by megaloblastic anemia, diabetes mellitus, and hearing loss. (wikipedia.org)
  • Thiamine responsive megaloblastic anemia syndrome is associated with progressive sensorineural hearing loss. (wikipedia.org)
  • Thiamine-responsive megaloblastic anemia syndrome is a rare condition characterized by hearing loss, diabetes, and a blood disorder called megaloblastic anemia. (medlineplus.gov)
  • Individuals with thiamine-responsive megaloblastic anemia syndrome begin to show symptoms of megaloblastic anemia between infancy and adolescence. (medlineplus.gov)
  • Some individuals with thiamine-responsive megaloblastic anemia syndrome develop optic atrophy, which is the degeneration (atrophy) of the nerves that carry information from the eyes to the brain . (medlineplus.gov)
  • Thiamine-responsive megaloblastic anemia syndrome has been reported in approximately 30 families worldwide. (medlineplus.gov)
  • Mutations in the SLC19A2 gene cause thiamine-responsive megaloblastic anemia syndrome. (medlineplus.gov)
  • Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome. (medlineplus.gov)
  • Folicil should not be administered for treatment of pernicious anaemia or undiagnosed megaloblastic anaemia without sufficient amounts of cyanocobalamin (vitamin B 12 ) as Folicil alone will not prevent and may precipitate development of subacute combined degeneration of the spinal cord. (pillintrip.com)
  • Inclusion cri- consumption of a strictly vegetarian diet, teria were being healthy and aged 20-80 pernicious anaemia and malabsorption syn- years. (who.int)
  • Megaloblastic maturation of erythroid precursors is shown. (medscape.com)
  • Macrocytic RBCs occur in a variety of clinical circumstances, many unrelated to megaloblastic maturation. (msdmanuals.com)
  • 5. Mecobalamin promotes nucleic acid synthesis in the bone marrow and promotes the maturation and division of erythroblasts thereby improving anemia, thus increasing erythrocyte production. (avenzor.ae)
  • Another rare type is pernicious anemia (or "vitamin B12 anemia"), which is the official term describing vitamin B12 malabsorption, in which a person cannot properly absorb vitamin B12. (draxe.com)
  • According to the Linus Pauling Institute at Oregon State University , pernicious anemia and B12 malabsorption are associated with a chronic inflammatory disease in the stomach, referred to as atrophic gastritis ( low stomach acid ). (draxe.com)
  • Megaloblastic anaemia due to bacterial overgrowth of the small intestine is due to vitamin B12 malabsorption. (ox.ac.uk)
  • This report describes a patient with bacterial overgrowth of the small intestine who had megaloblastic anaemia and malabsorption of vitamin B12, but persistently normal levels of serum vitamin B12 and normal serum and red cell folate levels. (ox.ac.uk)
  • In congenital folate malabsorption, oral treatment may not be effective and parental folate may therefore be required. (pillintrip.com)
  • Introduction: pernicious anemia is an autoimmune disease characterized by atrophic gastritis due to malabsorption of vitamin B12. (bvsalud.org)
  • Some genetic conditions that could contribute to this include sickle cell and some hemolytic anemias being passed down. (webmd.com)
  • Two forms of cold antibody autoimmune hemolytic anemias are generally recognized: Donath-Landsteiner hemolytic anemia (DLHA) and cold agglutinin disease. (medscape.com)
  • Symptoms of anemia - like fatigue or shortness of breath - happen because your organs aren't getting what they need to work the way they should. (webmd.com)
  • Common symptoms of megaloblastic anemia include fatigue, weakness, pale skin, and shortness of breath. (onlinebluepills.su)
  • Anaemia can cause symptoms such as tiredness, weakness, or shortness of breath. (bupa.co.uk)
  • This is called haemolytic anaemia. (bupa.co.uk)
  • Haemolytic anaemia can be triggered by an underlying health condition or by using medicines such as penicillin and non-steroidal anti-inflammatory drugs (NSAIDs). (bupa.co.uk)
  • Megaloblastic anemia is an aregenerative macrocytic anemia with nuclear dysmaturity, where the nucleus appears immature relative to the cytoplasm because of impaired DNA synthesis (see the image below). (medscape.com)
  • In the megaloblastic anemias, DNA synthesis is impaired, leading to slowing or arrest of cellular division during the DNA synthesis phase of the cell cycle (S phase). (mhmedical.com)
  • Understanding the pathophysiology of the megaloblastic anemias requires knowledge of the absorption, transport, and utilization of folate and cobalamin as well as familiarity with the key chemical reactions in which these vitamins are essential cofactors. (mhmedical.com)
  • This type of anemia also occurs in people with cancer. (massgeneral.org)
  • Your healthcare provider may think you have this type of anemia after taking your health history and doing a physical exam. (massgeneral.org)
  • With this type of anemia, your body may not create enough blood cells, or they may not work the way they should. (webmd.com)
  • in this type of anemia, red blood cells do not show changes in size, a sudden loss of blood being characteristic of this condition, as in hemorrhages, for example. (hickeysolution.com)
  • In pregnant women, due to the increase in the amount of iron needed during this period, this type of anemia can also occur. (hickeysolution.com)
  • For this type of anemia to occur, 2 defective genes are needed. (hickeysolution.com)
  • Megaloblastic anemia occurs when a person has a low number of red blood cells (anemia), and the remaining red blood cells are larger than normal (megaloblastic). (medlineplus.gov)
  • Because RBC membrane molding occurs in the spleen after cell release from the marrow, RBCs may be slightly macrocytic after splenectomy, although these changes are not associated with anemia. (msdmanuals.com)
  • If resistance occurs, parenteral therapy, or oral therapy with so-called massive doses of VITAMIN B12 (liver-stomach concentrate with intrinsic factor) may be necessary for adequate treatment of the patient. (rxlist.com)
  • A form of hemolytic anemia that occurs in repeated episodes. (nih.gov)
  • It is important for patients with diabetes to work closely with their healthcare team to determine the appropriate dosage and frequency of supplementation, as well as to monitor their response to treatment. (onlinebluepills.su)
  • If the patient's anemia does not improve with supplementation, the healthcare provider may need to adjust the dosage, frequency, or method of administration. (onlinebluepills.su)
  • A treatment with vitamin B12 supplementation was started, after which gradual improvement of the symptoms was seen. (bvsalud.org)
  • Some forms - like the mild anemia that happens during pregnancy - aren't a major concern. (webmd.com)
  • MA145 trade name] is indicated for intermittent preventive treatment of malaria as part of antenatal care for women in pregnancy in malaria-endemic areas. (who.int)
  • The signs and symptoms are sometimes non-specific with tiredness being the Effects of Anaemia on Pregnancy most typical. (ehd.org)
  • this results in low hemoglobin levels and microcytic anemia characterized by small red blood cells (RBCs). (rupahealth.com)
  • Lab work will reflect no changes to RBCs or mild microcytic anemia. (rupahealth.com)
  • Moderate-to-severe microcytic anemia with increased destruction (hemolysis) of RBCs and spleen enlargement is the result. (rupahealth.com)
  • mild microcytic anemia presents on lab work, but commonly the patient is asymptomatic. (rupahealth.com)
  • There are several risk factors for this anemia, such as those who have had stomach or intestinal surgery, small intestine problems, or people with a family history of this anemia. (healthlinkbc.ca)
  • Older adults have a greater risk of anemia because they are more likely to have kidney disease or other chronic medical conditions. (webmd.com)
  • Susceptible infections including UTIs (not for initial uncomplicated episodes), shigellosis, prophylaxis and treatment of Pneumocystis jiroveci pneumonia (PJP), travelers' diarrhea or acute exacerbations of chronic bronchitis in adults, acute otitis media in children. (empr.com)
  • Chronic kidney disease can affect the production of your red blood cells and lead to anaemia. (bupa.co.uk)
  • On the other hand, anemias that settle in a slow and gradual (chronic) manner, in which there is a low production of hemoglobin over weeks or months, tend to be asymptomatic until well advanced stages. (hickeysolution.com)
  • In these cases, due to the adaptability of red blood cells (red blood cells), patients with chronic anemia generally do not show symptoms up to levels of 8g / dL or 9g / dL of hemoglobin. (hickeysolution.com)
  • The key to treating pernicious anemia is to reduce chronic inflammation in the body. (draxe.com)
  • African-American kid with, abdominal pain, chronic hemolytic anemia and abnormal RBC shape. (medicosplexus.com)
  • Hematology (from the Greek word 'haima', meaning blood) is the branch of internal medicine that deals with the physiology, pathology, etiology, diagnosis, treatment, prognosis and prevention of blood-related disorders. (apollohospitals.com)
  • Treatment consists of high doses of oral thiamine. (wikipedia.org)
  • This syndrome is called "thiamine-responsive" because the anemia can be treated with high doses of vitamin B1 (thiamine). (medlineplus.gov)
  • After several parenteral doses treatment can be switched over to the oral form. (janusinfo.se)
  • In case of high dose pyrimethamine or prolonged treatment with low doses, calcium folinate 5 to 50 mg/day should be simultaneously administered, based on the results of the peripheral blood counts. (janusinfo.se)
  • Megaloblastic anemia is a condition characterized by the production of unusually large, abnormal red blood cells that do not function properly. (onlinebluepills.su)
  • Pernicious anemia can be caused by an autoimmune disorder that damages the stomach lining. (draxe.com)
  • Sedative-hypnotic drugs are the primary agents for treatment of alcohol withdrawal syndrome because they are cross-tolerant drugs that modulate GABA functions. (medscape.com)
  • Certain oral manifestations, such as Hunter´s glossitis and burning mouth syndrome, may precede the onset of this anemia. (bvsalud.org)
  • The autoantibody responsible for Donath-Landsteiner hemolytic anemia (DLHA) is a cold-reacting immunoglobulin known as the D-L autoantibody. (medscape.com)
  • Donath-Landsteiner hemolytic anemia (DLHA) may be either idiopathic or secondary to an identifiable cause. (medscape.com)
  • Anemia in thalassemia results from ineffective RBC formation and increased hemolysis of the RBCs in circulation. (rupahealth.com)
  • Researchers have reported that these symptoms may occur when vitamin B12 levels are just slightly lower than normal and are considerably above the levels normally associated with anemia. (naturalmedicinejournal.com)
  • Overview of Decreased Erythropoiesis Anemia, a decrease in the number of red blood cells (RBCs), hemoglobin (Hb) content, or hematocrit (Hct), can result from decreased RBC production (erythropoiesis), increased RBC destruction. (msdmanuals.com)
  • The large oval RBCs (macro-ovalocytes) on peripheral smear and the increased RBC distribution width that are typical of classic megaloblastic anemia may be absent. (msdmanuals.com)
  • Megaloblastic anemia, a group of diseases characterized by large red blood cells (RBCs), is a form of macrocytic anemia . (arupconsult.com)
  • Anemia is a condition in which you have too few RBCs. (healthline.com)
  • Anemia can deprive your tissues of oxygen it needs because RBCs carry the oxygen. (healthline.com)
  • Anemia, proteinuria, and hematuria continued after infusion of washed red blood cells (RBCs), methylprednisolone administration, and anti-infection treatment after hospital admission. (biomedcentral.com)
  • Certain forms of anemia are passed down through your genes, and infants may have it from birth. (webmd.com)
  • Patients with megaloblastic anemia may present with symptoms of anemia such as pale skin and fatigue. (arupconsult.com)
  • When a person does not have enough folate , they develop anemia , the symptoms of which include fatigue , weakness, and pale skin. (medicalnewstoday.com)
  • Megaloblastic anemias result most often from deficiencies of vitamin B12 and folate. (msdmanuals.com)
  • Folate-responsive megaloblastic anemia (MEGAF) is an autosomal recessive metabolic disorder characterized by megaloblastic anemia resulting from decreased folate transport into erythrocytes. (nih.gov)
  • Moderate-to-severe anemia develops, along with other thalassemia-related health complications. (rupahealth.com)
  • There were no effects on haematology, blood chemistry, urine analysis and neuromuscular function that were associated with treatment. (europa.eu)
  • In addition to calcium folinate administration, measures to ensure the prompt excretion of methotrexate (maintenance of high urine output and alkalinisation of urine) are integral parts of the calcium folinate rescue treatment. (janusinfo.se)
  • Megaloblastic changes affect all 3 hematopoietic cell lines. (medscape.com)
  • Women, young children, and people with long-term diseases are more likely to have anemia. (webmd.com)
  • Vitamin-responsive neurogenetic diseases represent a group of rare conditions that are probably underdiagnosed in adults and may have a dramatic response to treatment when started early in the course of the disease. (cdc.gov)
  • This article provides a brief and updated systematic review on the epidemiology, diagnosis and treatment of this neglected disease. (degruyter.com)
  • In a routine blood test, anemia is reported as a low hemoglobin or hematocrit. (webmd.com)
  • If you have anemia, your hemoglobin level will be low, too. (webmd.com)
  • Anemia is a symptom caused by the impairment of hemoglobin, a protein present in red blood cells, blood cells responsible for the transport of oxygen in the body. (hickeysolution.com)
  • Red blood cells live shorter and don't function properly without sufficient hemoglobin, causing anemia. (rupahealth.com)
  • He underwent laboratory examination for macrocytic anemia (hemoglobin, 58 g/L), proteinuria (2+) and hematuria (103/HP). (biomedcentral.com)
  • Only later a decreased hemoglobin and vitamin B12 value was seen in the context of a pernicious anemia. (bvsalud.org)