AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
Drug ResistanceDrug Resistance, MicrobialDrug Resistance, BacterialDrug Resistance, NeoplasmDrug Resistance, MultipleDisease ResistanceVascular ResistanceDrug Resistance, ViralDrug Resistance, Multiple, BacterialAnti-Bacterial AgentsMicrobial Sensitivity TestsTetracycline ResistanceMutationPlant DiseasesPenicillin ResistanceDrug Resistance, FungalAirway ResistanceMolecular Sequence Databeta-Lactam ResistanceBacterial ProteinsResistance TrainingR FactorsImmunity, InnateDNA, BacterialP-GlycoproteinEscherichia coliAmpicillin ResistanceChloramphenicol ResistancePhenotypeTetracyclinePlasmidsGenes, BacterialConjugation, GeneticMethicillin ResistanceBase SequenceGenotypeInsulinSequence Analysis, DNACephalosporin ResistanceErythromycinStreptomycinMultidrug Resistance-Associated ProteinsKanamycin ResistanceAmino Acid SequenceHerbicide ResistanceVancomycin ResistanceDrug Resistance, Multiple, ViralAntineoplastic AgentsCell Line, TumorPolymerase Chain ReactionAnti-Infective Agentsbeta-LactamasesMacrolidesStaphylococcus aureusATP-Binding Cassette TransportersTime FactorsGenes, MDRSignal TransductionDNA GyraseDrug Resistance, Multiple, FungalFluoroquinolonesBlood GlucosePlants, Genetically ModifiedKanamycinAminoglycosidesAntitubercular AgentsApoptosisObesityInsecticidesCiprofloxacinAntimalarialsDNA Transposable ElementsGenes, PlantMembrane Transport ProteinsReverse Transcriptase Polymerase Chain ReactionRifampinStreptococcus pneumoniaeCloning, MolecularHIV-1Salicylic AcidPseudomonas aeruginosaAnti-HIV AgentsCell LineDose-Response Relationship, DrugTumor Cells, CulturedChloroquineMuscle, SkeletalEnterobacteriaceaePlant ProteinsPlant ImmunityMice, Inbred C57BLStaphylococcusMycobacterium tuberculosisPyrethrinsGene Expression Regulation, BacterialPlant LeavesChromosome MappingCell SurvivalDoxorubicinChloramphenicol
AntimicrobialAntibiotic resistanceChemotherapyWastewater treatment plantsTherapiesDiagnosisInsulin ResistanceAntibioticsMutationDevelopment of resistancePredictorsBacterialDrugEfficacy2022InhibitorsAntimicrobialsMelanoma resistanceViralMutationsClinicalMalariaPathways2018Isolates showedVitroFindingsRegimenPatientsGeneticTherapeutic resistanceResearchersGenePathogensAntiretroviralGenesTumorAntidepressantsEvidence-based treatmentsMethodsMechanisms of resistanceStages of treatmentSignificantlyResistantMajor DepressiTargetsEndocrineProteinDevelopsSelectiveHeterogeneityHigh resistanceCurrent treatmentsIneffectiveStudySpecializesMolecularSusceptibility
Antimicrobial14
  • It is a truism that antimicrobial drugs select for resistance, but explaining pathogen- and population-specific variation in patterns of resistance remains an open problem. (nih.gov)
  • The rise in antimicrobial resistance (AMR), and increase in treatment-refractory AMR infections, generates an urgent need to accelerate the discovery and development of novel anti-infectives. (frontiersin.org)
  • The "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) project is part of the European Innovative Medicines Initiative (IMI) Antimicrobial Resistance (AMR) Accelerator. (frontiersin.org)
  • have been implicated as indicator bacteria species for the detection of antimicrobial resistance. (vin.com)
  • 1 Urbanization and habitat encroachment have led to an increase in human and wildlife interaction, and antimicrobial resistance is a point of concern in both human and animal medicine. (vin.com)
  • 6,7 This study evaluated the genotypic variability and the level of antimicrobial resistance of Enterococcus spp. (vin.com)
  • This study also investigated the effect of therapeutic antimicrobial treatment on the resistance patterns of three raptors (two Buteo jamaicensis and one Bubo virginianus ). (vin.com)
  • Wild raptor isolates showed similar patterns of antimicrobial resistance when compared with isolates recovered from the captive raptor controls. (vin.com)
  • Antimicrobial resistance has been a focus point for many researchers at the University of Groningen. (rug.nl)
  • De Vos: 'We need to understand how ecological and evolutionary interactions shape antimicrobial resistance. (rug.nl)
  • Drug-resistant TB is the largest single source of antimicrobial resistance in the world," says Mel Spigelman, president of the TB Alliance, a non-profit research group in New York City that developed the latest therapy. (scientificamerican.com)
  • To address this knowledge gap, we investigated the occurrence, concentration, and antimicrobial resistance patterns of VRE and vancomycin-susceptible enterococci at three U.S. spray irrigation sites that use reclaimed water. (cdc.gov)
  • however, resistance to other antimicrobial classes is more prevalent, particularly among non-E. faecalis isolates. (cdc.gov)
  • Made a commitment to the Antimicrobial Resistance (AMR) Challenge , which was the U.S. government's yearlong effort to accelerate the fight against antimicrobial resistance across the globe. (cdc.gov)
Antibiotic resistance15
  • The spread of antibiotic resistance is currently a major threat to health that humanity is facing today. (frontiersin.org)
  • Focus to limit the spread of antibiotic resistance by reducing the usage of antibiotics in health care, veterinary applications, and meat production, have been implemented, limiting the exposure of pathogens to antibiotics, thus lowering the selection of resistant strains. (frontiersin.org)
  • Here we examine the current literature in the role of WWTPs as reservoirs and hotspots of antibiotic resistance with a specific focus on bacteriophages as mediators of genetic exchange. (frontiersin.org)
  • In this review, we will focus on horizontal gene-transfer of antibiotic resistance. (frontiersin.org)
  • Since then, conjugation has been demonstrated in many environments, and between many different bacteria, stressing its relevance in the spread of antibiotic resistance ( Davies, 1994 ). (frontiersin.org)
  • But there is a growing problem of antibiotic resistance. (medlineplus.gov)
  • Antibiotic resistance can cause problems. (medlineplus.gov)
  • What Can Be Done about Antibiotic Resistance? (medlineplus.gov)
  • What Is Antibiotic Resistance? (medlineplus.gov)
  • The Urgent Care Association (UCA) and its members are concerned about the looming antibiotic resistance crisis. (cdc.gov)
  • Since 2016, UCA teamed up with the Antibiotic Resistance Action Center (ARAC) at George Washington University's Milken Institute of Public Health to better understand challenges and opportunities within the urgent care delivery system. (cdc.gov)
  • Participated in or convened four antibiotic stewardship symposia with representatives from industry, the payer community, CDC, ARAC, and other key stakeholders concerned about antibiotic resistance and the role urgent care centers can play in effecting change. (cdc.gov)
  • Studies have shown that even low concentrations of antibiotics in the environment may contribute to antibiotic resistance and therefore measures should be taken to ensure that as little as possible ends up in our environment. (janusinfo.se)
  • Concentrations in Swedish wastewater treatment plants are at risk of selecting antibiotic resistance. (janusinfo.se)
  • This also takes into account the risk of antibiotic resistance selection and environmental interaction between other macrolide antibiotics. (janusinfo.se)
Chemotherapy6
  • Whilst oligodendrogliomas are relatively rare, with only 40 new cases every year, and respond well to standard radiotherapy and chemotherapy treatments, astrocytomas are highly invasive and difficult to treat. (sciencedaily.com)
  • The two drugs address molecular pathways that cause cell growth and survival, abnormal blood vessel growth, and resistance to chemotherapy and radiation. (mdanderson.org)
  • The generation of cellular models of drug resistance has been pivotal in unravelling the main effectors of resistance to traditional chemotherapy at the molecular level (i.e. intracellular drug inactivation, detoxifying systems, defects in DNA repair, apoptosis evasion, membrane transporters and cell adhesion). (nature.com)
  • Since then, chemotherapy has been one of the main therapeutic strategies in cancer treatment, but, to paraphrase Paul Ehrlich, resistance has followed as a faithful shadow. (nature.com)
  • 5 Metastatic EAC is typically managed with chemotherapy and immunotherapy, but many patients eventually develop resistance to these therapies, leading to poor outcomes. (onclive.com)
  • 8 Moreover, the resistance to cytotoxic chemotherapy caused by stress can be reversed by using propranolol. (onclive.com)
Wastewater treatment plants2
  • A recent area of focus has been to limit the spread of resistance through wastewater treatment plants (WWTPs), serving as huge reservoirs of microbes and resistance genes. (frontiersin.org)
  • We collected 48 reclaimed water samples from one Mid-Atlantic and two Midwest spray irrigation sites, as well as their respective wastewater treatment plants, in 2009 and 2010. (cdc.gov)
Therapies14
  • Gupta added that with a more advanced portfolio of genetic and epigenetic biomarkers to screen for potential BRAFi resistance development in patients, more personalized therapies with enhanced prevention of melanoma recurrence can be developed in the future. (yaledailynews.com)
  • The development of targeted therapies has also been followed by resistance, reminiscent of an evolutionary arms race, as exemplified by imatinib and other BCR-ABL inhibitors for the treatment of chronic myelogenous leukaemia. (nature.com)
  • In addition, the novel cancer stem cell paradigm raises the prospect of cell-targeted therapies instead of treatment directed against the whole tumour. (nature.com)
  • The findings point to multiple resistance mechanisms working together in the disease and highlight the need for combination therapies. (genomeweb.com)
  • Additionally, the findings demonstrate a stunning ability to restore therapeutic sensitivity to current tyrosine kinase inhibitor (TKI) therapies after resistance sets in, including the third-generation TKI, Osimertinib (marketed as Tagrisso by AstraZeneca) . (yahoo.com)
  • This lung cancer can be effectively treated with current third-generation tyrosine kinase inhibitor (TKI) therapies for about 9-18 months, but virtually all patients eventually develop therapeutic resistance. (yahoo.com)
  • Standard treatments for brain tumors are both highly toxic and nonspecific, and after treatment for brain tumors, patients can still suffer from the damage caused by these very aggressive therapies," said Flores, the principal investigator of the Hematopoietic Stem Cell Engineering Laboratory within the UF Brain Tumor Immunotherapy Program. (technologynetworks.com)
  • However, after initial responses, about 20%-40% of patients experience a relapse as the cancer develops resistance to the therapies. (uclahealth.org)
  • The grant will allow Lo and his team to investigate how this diversity occurs in response to targeted therapies and immune-based treatments, so they can find ways to prevent resistance. (uclahealth.org)
  • By understanding the genomic instability mechanisms behind early seeds of resistance, we hope to develop new therapies that can stop cancer cells from becoming resistant and reduce the need for additional treatments to control the cancer. (uclahealth.org)
  • In a study published March 29 in the journal Science Signaling, the team demonstrates their use of network-scale proteomic experiments and mathematical analyses to build a "system-wide" view of how signaling mutations cause leukemia and to identify points of susceptibility that can be targeted by "cocktail" therapies to prevent drug resistance. (uclahealth.org)
  • Understanding this complex network of events is critical to designing new molecularly targeted anti-cancer therapies to simultaneously target the primary mutation while preventing the development of secondary, resistance-conferring mutations, and we now have additional tools to do this. (uclahealth.org)
  • Spigelman hopes that pretomanid will be included in treatments faster than the other therapies because the TB Alliance tested pretomanid in combination with other TB drugs from the start. (scientificamerican.com)
  • There is currently no evidence that additional treatment is needed with Paxlovid or other anti-SARS-CoV-2 therapies in cases where COVID-19 rebound is suspected. (cdc.gov)
Diagnosis5
  • Serum MDR1 and NPY levels exhibited a high predictive value for early epilepsy diagnosis, treatment efficacy assessment, and prognostication in children with epilepsy treated with LEV plus OXC combination. (usp.br)
  • Partner diagnosis and treatment is important to prevent reinfection and complications. (medscape.com)
  • After assessing your symptoms, a blood test to measure leptin levels can help your healthcare provider to confirm a diagnosis of leptin resistance. (weight-loss-medical.com)
  • How Does the History of Chronic Myeloid Leukemia Inform the Future of Diagnosis, Treatment, Resistance, and Cure? (medscape.com)
  • In that regard, one thing that has really come to the fore is not only do we start treatment regardless of CD4 count, but we also often start as soon as a patient is ready to start, as soon as they want to start - sometimes even on the same day or in the same few days after diagnosis, as long as you can line up the insurance. (medscape.com)
Insulin Resistance22
Antibiotics6
  • Moreover, we find that the selective pressure from antibiotics arises not so much from the rate of antibiotic use per se but from the frequency of treatment: frequent antibiotic therapy disproportionately impacts the fitness of sensitive strains. (nih.gov)
  • Resistance to antibiotics in clinical bacteria has been documented for several decades ( Davies and Davies, 2010 ). (frontiersin.org)
  • This rapid development of resistance even to newly developed antibiotics indicates that we are fighting a losing battle. (frontiersin.org)
  • While resistance genes for antibiotics exist in small environmental microbial populations even before the clinical usage of those antibiotics, the spread of resistance among human pathogens is not commenced until a selective pressure (e.g., usage of antibiotics) is added - triggering a development and selection for resistant bacteria ( Davies and Davies, 2010 ). (frontiersin.org)
  • Since 2007, the Centers for Disease Control and Prevention (CDC) has not recommended fluoroquinolone antibiotics for the treatment of gonorrhea in the United States because of bacterial resistance. (medscape.com)
  • You don't want to prescribe antibiotics for a cold and treatments can sometimes be stopped when there are no longer any symptoms,' explains De Vos. (rug.nl)
Mutation4
  • The only specific treatment available for patients with genetic disorders causing GH resistance with growth failure due to GHRD, STAT5b mutations, ALS mutations, or IGF1 gene mutation is rhIGF-I. (medscape.com)
  • Of the patients exposed to HAART for at least 6 months and who experienced viral rebound, information was available on resistance for 26 (21.5% of the total deaths) and 19 of those tested had at least one resistance mutation (median 5, range, 1-16). (nih.gov)
  • Detection of an Arg292Lys mutation (N2 numbering) in the virus neuraminidase (NA) gene within 2 days of initiating oseltamivir treatment, in the first reported human infection by avian A(H7N9) influenza virus, 1 raised concern about emergence of resistance during treatment with neuraminidase inhibitors. (flutrackers.com)
  • This is important because a Ser31Asn resistance mutation in the M2 protein of A(H7N9) viruses, also present in A(H1N1)pdm09 and seasonal A(H3N2) viruses, abrogates effectiveness of available M2 inhibitors (amantadine and rimantadine). (flutrackers.com)
Development of resistance2
  • What is the effect of compliance on the development of resistance to these agents? (treatmentactiongroup.org)
  • Comparison of pre- and post-treatment paired tumor biopsies from patients treated with fulvestrant revealed an upregulation of cyclin E2 upon development of resistance. (lu.se)
Predictors2
  • How have predictors, moderators, mediators, treatment response, remission and resistance been defined and measured in randomised controlled trials for adolescent depression? (bmj.com)
  • Epidemiologic and viral predictors of antiretroviral drug resistance among persons living with HIV in a large treatment program in Nigeria. (bvsalud.org)
Bacterial3
  • The Innovative Medicines Initiative-funded "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) consortium is establishing a validated and globally harmonized preclinical model to increase reproducibility and more reliably translate results from animals to humans. (frontiersin.org)
  • The explosion of multidrug and pandrug resistant strains of a diversity of important bacterial pathogens, including ESBL (extended spectrum beta-lactamase), methicillin/vancomycin resistant Staphylococcus aureus (MRSA/VRSA), and pandrug resistant Acinetobacter baumannii ( Fair and Tor, 2014 ), seen over the last decade is a further indication that our current attempts to dampen the spread of resistance is not as efficient as needed. (frontiersin.org)
  • For example, by reducing the stress response in bacteria, you might be able to reduce horizontal gene transfer, the exchange of genes between bacterial species, which could reduce the spread of resistance genes. (rug.nl)
Drug27
  • CDC recommends that all cases of malaria diagnosed in the United States should be evaluated for drug resistance. (cdc.gov)
  • All specimens submitted for drug resistance testing will first undergo molecular testing by polymerase chain reaction (PCR) for species confirmation. (cdc.gov)
  • Depending on the species, the age of the specimen, and the previous receipt of antimalaria medicines, different testing methods may be employed to assess for the presence of drug resistance. (cdc.gov)
  • Laboratory methods for testing for malaria drug resistance include in vitro tests, molecular characterization, determination of drug levels, and animal models. (cdc.gov)
  • Determining the drug level in the blood can help distinguish between drug non-adherence and drug resistance. (cdc.gov)
  • Definitions of resistance in multidrug-resistant tuberculo- tients need prolonged treatment courses, which are sis (MDR TB) and extensively drug-resistant tuberculosis burdened by frequent drug-related adverse events. (cdc.gov)
  • Researchers theorized that combining the drugs would help stave off onset of drug resistance, a common occurrence and major obstacle in cancer treatment. (mdanderson.org)
  • Although traditionally associated with the last stages of the disease, recent findings with minimally transformed pretumorigenic primary human cells indicate that the ability to generate drug resistance arises early during the tumorigenic process, before the full transformation. (nature.com)
  • Two main groups of factors contribute to the development of drug resistance. (nature.com)
  • The cytochrome P 450 enzymes, a multigene family of constitutive and inducible haem-containing oxidative enzymes from the liver, play an important role in the metabolism of a diverse range of xenobiotics and are often overexpressed in a variety of solid tumours in which they can contribute to drug resistance. (nature.com)
  • Drug analogues of DNA precursors such as 5-fluorouracil and cytosine arabinoside require metabolic activation, and resistance can arise from modification of these activation pathways. (nature.com)
  • ABSTRACT Patterns of drug resistance in recurrent cases of tuberculosis may be different than in those without a history of treatment. (who.int)
  • In this retrospective study, the drug resistance pattern and outcome of treatment with DOTS category I (CAT I) regimen was compared in 63 recurrent cases and 872 new cases of pulmonary tuberculosis from April 2003 to January 2008 at the National Research Institute of Tuberculosis and Lung Disease in Tehran, Islamic Republic of Iran. (who.int)
  • Resistance to isoniazid and ethambutol was significantly more common in recurrent cases, but there were no differences in rates of resistance to rifampin, pyrazinamide, streptomycin or the rate of multi-drug resistant strains. (who.int)
  • Due to the low frequency of multi-drug resistance in the recurrent cases, a CAT I regimen may be suitable for empirical therapy before drug sensitivity results become available. (who.int)
  • Preventions and Treatments of Alcohol and Drug Abuse. (mellenpress.com)
  • Clinical tools to predict both drug resistance and possible treatment combination approaches to overcome it are lacking. (lu.se)
  • Now, a multidisciplinary team of researchers at UCLA has developed a "roadmap" of the complex signaling processes involved in cancer that could lead to new methods for diagnosing and overcoming such drug resistance. (uclahealth.org)
  • In many cases, drug resistance results from secondary mutations replacing or amplifying the original cancer-promoting signal targeted by the drug. (uclahealth.org)
  • These new approaches for sorting out the complexities of cancer cells involve building a wiring diagram of the interconnections or "crosstalk" in cancer cells that will help scientists overcome drug resistances. (uclahealth.org)
  • 16th European Meeting on HIV & Hepatitis - Treatment Strategies & Antiviral Drug Resistance is organized by Virology Education B.V and will be held during May 30 - Jun 01, 2018 at Events Rome Trevi Fountain, Rome, Lazio, Italy. (emedevents.com)
  • Nearly 90% of people infected with extensively drug-resistant (XDR) TB who took this treatment during a clinical trial recovered in 6 months. (scientificamerican.com)
  • But tackling drug resistance is possible if researchers have sufficient funding to develop treatments, he says. (scientificamerican.com)
  • Doctors treat TB with drug cocktails to reduce the chances that the bacterium that causes the illness will evolve resistance to a particular therapy. (scientificamerican.com)
  • Determining factors associated with drug resistance can inform patient management and healthcare policies , particularly in resource-limited settings where drug resistance testing is not routine. (bvsalud.org)
  • Cases PLWH receiving cART who developed acquired drug resistance (ADR) and controls were those without ADR between 2004 and 2011. (bvsalud.org)
  • Evidence on the distribution of pre-treatment HIV-1 drug resistance (HIVDR) among risk groups is limited in Africa. (lu.se)
Efficacy5
  • However, melanoma treatment efficacy is limited by acquired resistance to these BRAFi treatments. (yaledailynews.com)
  • The study's identification of the loss of Block of Proliferation 1, or BOP1, function as the cause of BRAFi resistance brings new insights to melanoma treatment and suggests an additional biological target to enhance treatment efficacy. (yaledailynews.com)
  • Perceived stress and the chronotropic effect of exercise will be correlated with clinical outcomes to determine the efficacy of the study treatment combination. (onclive.com)
  • The aim of the present study was to investigate the usefulness of multidrug resistance protein 1 (MDR1) and neuropeptide Y (NPY) levels in predicting the efficacy of levetiracetam (LEV) plus oxcarbazepine (OXC) treatment administered to children with epilepsy and to determine their prognosis. (usp.br)
  • The 500-mg IM dose of ceftriaxone is recommended over previous dosing, given concern for resistance, prior lower-dose ceftriaxone dose failures, and seemingly improved efficacy in pharyngeal infections. (medscape.com)
20221
  • In 2022, AstraZeneca's top pharmaceutical product by revenue was Tagrisso, a medication used in the treatment of non-small-cell lung carcinomas. (yahoo.com)
Inhibitors4
  • Published in the journal PNAS on Feb. 19, the study found that one form of resistance to these inhibitors is caused by the loss of a protein called Block of Proliferation 1. (yaledailynews.com)
  • CONCLUSIONS: These data highlight the complexity of estrogen receptor positive breast cancer and suggest that the development of diverse resistance mechanisms dictate levels of ER independence and potentially cross-resistance to CDK inhibitors. (lu.se)
  • This treatment has been shown to be effective in treating many types of cancer, but many cancers, including brain tumors, have yet to demonstrate significant response to immune checkpoint inhibitors. (technologynetworks.com)
  • This is a totally novel mechanism of overcoming resistance to checkpoint inhibitors that's been shown to work in multiple resistant brain tumor models. (technologynetworks.com)
Antimicrobials2
  • Treatment with antimicrobials produces a selection pressure towards resistance. (rug.nl)
  • Another approach is to develop new antimicrobials that evade resistance. (rug.nl)
Melanoma resistance3
  • Drawing from these findings, we would ideally try to directly engage with patients who develop melanoma resistance," said Romi Gupta, first author and pathology researcher at the Yale School of Medicine. (yaledailynews.com)
  • In the study, a large-scale RNA screen was conducted to pinpoint epigenetic regulators - which alter gene activity and expression but are not part of the DNA sequence - involved in melanoma resistance. (yaledailynews.com)
  • According to Gupta, a library of 363 known epigenetic regulators served as potential candidates for melanoma resistance, and the one seen most often in melanoma resistance was BOP1. (yaledailynews.com)
Viral3
  • In this study of [ viral load ] failure on lopinavir monotherapy, we found that patients often failed without PI mutations, but that resistance accumulated with longer time on the failing regimen," the researchers wrote. (infectiousdiseaseadvisor.com)
  • Paxlovid treatment and had subsequent positive viral antigen and/or reverse transcriptase polymerase chain reaction (RT-PCR) testing. (cdc.gov)
  • There was no increased occurrence of hospitalization or death, and there was no evidence that the rebound in detectable viral RNA was the result of SARS-CoV-2 resistance to Paxlovid (5). (cdc.gov)
Mutations5
  • More than 50 percent of melanomas contain mutations in the BRAF gene, making BRAF the primary target of melanoma treatment. (yaledailynews.com)
  • Pre-treatment reverse transcriptase inhibitor (RTI), PI and integrase inhibitor (INSTI) mutations were assessed using the Stanford HIVDR database. (lu.se)
  • Additionally, 32 clusters with shared pre-treatment HIVDR mutations were identified. (lu.se)
  • Introduction of INSTIs after 2017 may have abrogated the increase in pre-treatment RTI mutations, albeit in the HET population only. (lu.se)
  • Treatment reference Mutations of factor V make it resistant to its normal cleavage and inactivation by activated protein C, and they also predispose to venous thrombosis. (msdmanuals.com)
Clinical12
  • As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
  • Lead researcher Aung Naing, M.D., assistant professor in MD Anderson's Department of Investigational Cancer Therapeutics, says that prior to the Phase I clinical trial, patients were heavily treated and resisted most other treatments. (mdanderson.org)
  • Challenging resistance to treatment has now become crucial in psychiatric clinical practice also because of the relevance of this topic from a public health standpoint. (springer.com)
  • The study will assess the impact of clinical variables on genetic finding, and develop a genomic profile for TRD which can be used to guide treatment in patients. (europa.eu)
  • 64 Careful evaluation of the patient, any underlying clinical conditions, and surgical treatment rendered is necessary to optimize decision-making for antibiotic use and limit promiscuous prescribing practices. (dentalcare.com)
  • BACKGROUND: Resistance to endocrine treatment in metastatic breast cancer is a major clinical challenge. (lu.se)
  • If successful in a clinical setting, this approach would have potential to transform treatment for the proportion of patients who do not currently benefit from this remarkable class of immunotherapeutic treatment. (technologynetworks.com)
  • Wang J, Liang C. Clinical effect and influence on congnitive reaction of single use of valproate, oxcarbazepine, and levetiracetam in treatment of children epilepsy. (usp.br)
  • A comprehensive review in the journal Cell provides an in-depth look at the biology, clinical outcomes, and treatment options for menopause, including the effects of hormonal changes on metabolic and cognitive functions. (news-medical.net)
  • The European Meeting on HIV & Hepatitis is the premier European platform for clinicians, allied healthcare providers, researchers and clinical virologists to discuss the latest developments in antiviral therapy for HIV, HCV, and HBV and for translating them into new treatment strategies to further improve clinical care. (emedevents.com)
  • Founded sixteen years ago as the European HIV resistance workshop, the meeting evolved to embrace all aspects of clinical care of people living with HIV in Europe. (emedevents.com)
  • Particular emphasis is put on optimal treatment strategies, clinical virology, molecular epidemiology and public health aspects of HIV, HBV and HCV infections throughout Europe. (emedevents.com)
Malaria1
  • Culturing malaria parasites will be attempted only for pre-treatment specimens that arrive within 72 hours of collection. (cdc.gov)
Pathways1
  • They find globally increased ITH, including heterogeneous expression of therapeutic targets and potential resistance pathways, between cellular subpopulations following treatment resistance. (genomeweb.com)
20181
  • MDR TB with additional resistance to fluoroquinolones, and XDR TB, with additional resistance to bedaquiline or in 2018 ( 1 ). (cdc.gov)
Isolates showed1
  • Gram negative isolates showed high resistance rate of 73.1% to ampicillin and 65.4% to amoxicillin-clavulanic acid while Gram-positive isolates showed high resistant rate of 94.1% to penicillin. (who.int)
Vitro3
  • Infectivity and in vitro miltefosine susceptibility of L. infantum isolates collected before treatment for cured and failed patients. (ajtmh.org)
  • METHODS: To study the complexity of the mechanisms involved in the resistance to the selective estrogen receptor degrader (SERD) fulvestrant, we performed comprehensive biomarker analyses using several in vitro models that recapitulate the heterogeneity of developed resistance. (lu.se)
  • RESULTS: We found that different in vitro models of fulvestrant resistance show variable stability in their phenotypes, which corresponded with distinct genomic alterations. (lu.se)
Findings3
  • In the framework of resistance to treatments in EDs, the psychodynamic model suggested in the past by A. Adler, H. Kohut, and D. W. Winnicott seems to be reconceptualized by recent findings, with the EDs emerging in the present articles as disorders of the development of the Self, as already theorized [ 13 , 14 ]. (springer.com)
  • These findings may really open the door to successful immunotherapy treatment of malignant brain tumors," said Mitchell, co-leader of the Cancer Therapeutics and Host Response research program at the UF Health Cancer Center and a member of the Evelyn F. and William L. McKnight Brain Institute of the University of Florida. (technologynetworks.com)
  • The findings suggest that specific lipid subclasses are crucial indicators and potential targets for treatment in human health and various diseases. (news-medical.net)
Regimen2
  • In David's final talk entitled, "How Long Should Treatment Be Given If We Had An Antiretroviral Regimen That Completely Blocks HIV Replication? (treatmentactiongroup.org)
  • Because of resistance with oral cephalosporins, only one regimen, treatment with ceftriaxone IM, is recommended as first-line for treatment of gonorrhea in the United States. (medscape.com)
Patients28
  • By combining two drugs, researchers shrank tumors in some patients with treatment-resistant Ewing's sarcoma, a cancer that primarily affects the bones and most often occurs in teens and young adults. (mdanderson.org)
  • We're encouraged that five of 17 patients with Ewing's sarcoma - about 29% - responded to the treatment," Naing says. (mdanderson.org)
  • By combining drugs in a scientifically rational way, we may be able to overcome resistance to single agents and provide benefit to patients with advanced Ewing's sarcoma," says study senior author Razelle Kurzrock, M.D., professor and chair of the Department of Investigational Cancer Therapeutics. (mdanderson.org)
  • For those with secondary forms of GH resistance, other than that due to GH inactivating antibodies in rhGH-treated patients with GH1 gene deletion who require rhIGF-I treatment, the underlying cause (eg, malnutrition, liver disease) should be identified and treated appropriately. (medscape.com)
  • Some of the aspects contributing to denial and resistance to treatments can be automatic and unmotivated whilst others are consciously generated by patients who actively oppose to treatment, also on the basis of the biological vulnerability of altered reward and inhibition underlying these disorders [ 7 , 8 ]. (springer.com)
  • This predictive power of BOP1 as a biomarker for BRAFi resistance could serve as indicators for changes in dosage or more thorough controls for recurrence in patients with BOP1. (yaledailynews.com)
  • Albumin is a cost-effective predictor of intravenous immunoglobulin-resistance in young patients with Kawasaki disease. (pharmacytimes.com)
  • Patients with resistance had a higher risk of developing cardiac complications, such as coronary artery lesions (CALs). (pharmacytimes.com)
  • However, 10%-20% of KD patients are resistant to IVIG treatment which puts those patients at high risk of [CALs]," the study authors wrote. (pharmacytimes.com)
  • Therefore, it is important to predict whether patients will be resistant to IVIG before the treatment. (pharmacytimes.com)
  • They added that early prediction of IVIG resistance is a pivotal topic of interest for researcers investigating KD because patients with IVIG resistance may improve on an early-intensified therapy. (pharmacytimes.com)
  • Investigators conducted the retrospective study on a cohort of 907 patients with KD from southwestern China to identify the risk factors leading to IVIG resistance. (pharmacytimes.com)
  • If these patients were able to avoid initial IVIG treatment, they advanced toward other therapeutic alternatives more quickly. (pharmacytimes.com)
  • But among young patients with KD, those facing treatment resistance were generally older (average age 32.5 months) and had longer hospitalizations than responders. (pharmacytimes.com)
  • Investigators, who collected a blood sample of patients prior to initial IVIG infusion also compared white blood cell count, percentage of neutrophils, C-reaction protein (CRP), and CRP/albumin ratio, which calculates CAR, between patients with and without treatment resistance. (pharmacytimes.com)
  • Treatment challenges arise from the different biological dysfunctions implicated in different patients and the lack of biomarkers available to guide the choice of anti-depressants. (europa.eu)
  • The role of rare variants has not been well studied and few studies have investigated the genetics of TRD (patients with two or more failed treatments). (europa.eu)
  • This project will combine exome sequencing and genome-wide genotyping in the unique GSRD sample of 1346 MDD patients characterized for stages of treatment resistance (number of failed treatments). (europa.eu)
  • Approximately one half of deaths (45.5%) were from AIDS-related causes and 74 deaths (61.2%) occurred in individuals who had received HAART: patients had been exposed to a median of seven (range 2-14) antiretroviral drugs and two-fifths had started treatment in the pre-HAART era. (nih.gov)
  • Another 15 patients had received only non-HAART treatment regimens prior to death. (nih.gov)
  • Plasma levels of interleukin (IL)‐12/ IL‐23p40, IL‐15, IL‐16, IL‐17A, IL‐1α, IL‐7, tumor necrosis factorβ and vascular endothelial growth factor were compared in 48 patients suffering from major depression before, after one and after six weeks of antidepressive treatment in relation to therapy response. (uni-regensburg.de)
  • Counsel patients to abstain from sexual activity until after full treatment and testing and treatment of partners is complete. (medscape.com)
  • The aim of this study was to assess the effects of resistance exercise and stretching on sleep, mood, and quality of life in chronic insomnia patients. (scielo.br)
  • Moderate-intensity resistance exercise and stretching led to similar improvements in objective and subjective sleep in patients with chronic insomnia. (scielo.br)
  • People with COVID-19 rebound should fol ow CDC recommendations regarding isolation of infected patients regardless of treatment with an antiviral agent and/or previous isolation after the initial infection. (cdc.gov)
  • Treatment with TKIs significantly decreases the mortality rate in patients with CML. (medscape.com)
  • In the DASISION (DASatinib versus Imatinib Study In treatment-Naive CML patients) trial, final 5-year analysis showed significantly higher MMR and molecular response with ≥4.5 log reduction of BCR-ABL on the International Scale (MR4.5) in patients with newly diagnosed CP-CML who received dasatinib, 100 mg once daily (n = 259), than in those who received imatinib, 400 mg once daily (n = 260). (medscape.com)
  • In patients with homozygous or heterozygous factor V Leiden resistance , the prolongation of the clotting time is significantly reduced because their factor V is resistant to cleavage by activated protein C. (msdmanuals.com)
Genetic4
  • Genetic counseling regarding mode of transmission, the contribution of consanguinity, and the risk of future offspring having conditions causing GH resistance is an important aspect of education and prevention. (medscape.com)
  • In addition, Gupta said that most previous studies on BRAFi resistance have focused on genetic factors. (yaledailynews.com)
  • Preliminary evidence suggests that genetic variants may be useful in making treatment choices, but further work to identify relevant variants is needed. (europa.eu)
  • While being able to quite efficiently reduce the presence of resistant bacteria entering any of the final products of WWTPs (e.g., effluent water and sludge), the presence of resistance genes in other formats (mobile genetic elements, bacteriophages) has mainly been ignored. (frontiersin.org)
Therapeutic resistance1
  • Exploring and targeting the underlying mechanisms of therapeutic resistance are critical for improving the outlook for esophageal cancer. (onclive.com)
Researchers5
  • One reason for this resistance could be their ability to form a communication network, say researchers. (sciencedaily.com)
  • The Special Issue "Treatment resistance in Eating Disorders" gathers together the contributions provided by several experienced groups of researchers in the field of Eating Disorders (EDs). (springer.com)
  • A collaboration between researchers at Yale, the University of Massachusetts Medical School and the Vanderbilt Medical Center has determined a new cause of melanoma treatment resistance. (yaledailynews.com)
  • Using single-cell RNA sequencing, a group led by researchers from the University of Texas MD Anderson Cancer Center find that treatment resistance in small cell lung cancer (SCLC) is followed by increased intratumoral heterogeneity (ITH). (genomeweb.com)
  • In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)
Gene2
  • Chen M, Hou C, Huo D, Bao J, Fa H, Shen C. An electrochemical DNA biosensor based on nitrogen-doped graphene/Au nanoparticles for human multidrug resistance gene detection. (usp.br)
  • Cefoxitin (30g) was used as surrogate to determine phenotypic methicillin resistance in staphylococcus isolates, and the methicillin resistance ( mec A) gene was detected by conventional PCR assay. (who.int)
Pathogens1
  • We need to understand how these species interact and contribute to the spread of resistance genes or to the increased growth of pathogens. (rug.nl)
Antiretroviral1
  • The first order of business seems to make sure we adequately study these new combinations and treatment strategies before mounting an antiretroviral Marshall Plan. (treatmentactiongroup.org)
Genes2
  • What roles do different species play within the ecosystem and how are resistance genes transferred? (rug.nl)
  • This allows us to find ways to reduce selection pressure towards resistance or the transfer of resistance genes. (rug.nl)
Tumor1
  • Where resistance had been a barrier, an intravenous infusion of hematopoietic stem and progenitor cells led to a robust response to immunotherapy treatment in aggressive brain tumor models, the investigators found. (technologynetworks.com)
Antidepressants1
  • In summary, our study provides valuable evidence that this cytokine might serve as a marker of therapy resistance to antidepressants. (uni-regensburg.de)
Evidence-based treatments1
  • This personalised medicine study should facilitate the development of new evidence-based treatments and substantially reduce the time to identify the best treatment strategy in MDD. (europa.eu)
Methods2
  • Two alternative methods of eliciting systemic resistance, seed treatment and root drench, were evaluated. (gla.ac.uk)
  • Overall, 193 children with epilepsy admitted to the hospital were enrolled and randomly divided into two groups according to different treatment methods: group A (n = 106, treated with LEV plus OXC combination) and group B (n = 87, treated with OXC only). (usp.br)
Mechanisms of resistance2
  • This discovery gives us profound insights into the mechanisms of resistance to immunotherapy drugs, and it may offer a roadmap to use immunotherapy to effectively treat many forms of cancer. (technologynetworks.com)
  • For years, Catherine Flores, Ph.D., an assistant professor in the UF College of Medicine's Lillian S. Wells Department of Neurosurgery, has been studying mechanisms of resistance to a type of immunotherapy called "PD-1 checkpoint blockade" in rodent models of glioblastoma and medulloblastoma. (technologynetworks.com)
Stages of treatment1
  • By diagnosing BOP1 levels in early stages of treatment, oncologists may now be able to more accurately predict whether a patient would undergo resistance to BRAFi in the future and alter the treatment plan accordingly, the study noted. (yaledailynews.com)
Significantly4
  • Despite these attempts, the global resistance has increased significantly. (frontiersin.org)
  • After treatment, compared with group B, group A exhibited a remarkably higher total effective rate and a significantly lower total adverse reaction rate. (usp.br)
  • Interestingly, the level of IL‐17A turned out to rise significantly in the non‐responder group compared to responder during antidepressive treatment. (uni-regensburg.de)
  • Studies show that symptoms of ADHD caused by UARS significantly improve or remit with treatment in surgically treated children. (wikipedia.org)
Resistant3
  • This network favours the spread of tumour cells, cell division and makes astrocytomas more resistant to treatment. (sciencedaily.com)
  • This project will address the emerging healthcare problem of Treatment Resistant Depression (TRD). (europa.eu)
  • Dr. Roger Lo, professor of medicine, dermatology and molecular & medical pharmacology at the David Geffen School of Medicine at UCLA, received an $800,000 grant from the V Foundation to study new ways to defeat malignant melanoma, an aggressive type of skin cancer that often becomes resistant to current cancer treatments. (uclahealth.org)
Major Depressi1
  • The cytokine IL‐17A as a marker of treatment resistance in major depressive disorder? (uni-regensburg.de)
Targets1
  • One treatment targets the mitogen-activated protein kinase cancer pathway that sustains the growth of many types of cancer. (uclahealth.org)
Endocrine1
  • These factors can damage your endocrine system and metabolic function, leading to leptin resistance. (weight-loss-medical.com)
Protein2
  • Nutritional consultation may be needed for children with inadequate intake, and to promote the high-protein, low-fat diet that appears to enhance response to IGF-I and reduce the common development of obesity with rhIGF-I treatment. (medscape.com)
  • The activated protein C resistance assay is a screening test for the presence of factor V Leiden. (msdmanuals.com)
Develops3
  • Unfortunately, in people who are overweight, leptin resistance often develops. (weight-loss-medical.com)
  • When leptin resistance develops, leptin signaling is interrupted, so that no matter how much leptin is produced, the brain does not get the message. (weight-loss-medical.com)
  • Leptin resistance usually develops over time due to three primary factors: (1) too little sleep, (2) too much stress and (3) too much of the wrong foods. (weight-loss-medical.com)
Selective1
  • We modelled the dynamics of competing strains of S. pneumoniae to investigate the impact of transmission dynamics and treatment-induced selective pressures on the probability of stable coexistence. (nih.gov)
Heterogeneity1
  • This unmet need is mainly due to the heterogeneity underlying both the mechanisms involved in resistance development and breast cancer itself. (lu.se)
High resistance1
  • Overall, 107 participants experienced virologic failure, with 20% (n=21) having intermediate/high resistance to lopinavir. (infectiousdiseaseadvisor.com)
Current treatments2
  • Until now it has not been understood why astrocytomas respond so poorly to current treatments compared with other gliomas. (sciencedaily.com)
  • He also said, "We are even more amazed to see how it works in combination with current treatments like Osimertinib, especially its ability to restore therapeutic effectiveness in cells that have developed Osimertinib resistance. (yahoo.com)
Ineffective1
  • Areas under the curve for MDR1 and NPY for predicting ineffective treatment were 0.867 and 0.834, whereas those for predicting epilepsy recurrence were 0.916 and 0.829, respectively. (usp.br)
Study5
  • Low albumin levels (hypoalbuminemia) may be an independent risk factor associated with intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD), according to retrospective study results published in the Italian Journal of Pediatrics . (pharmacytimes.com)
  • This study aims to identify both rare and common variants associated with stages of resistance, the first such study to be performed. (europa.eu)
  • This in-depth study of a juvenile institution in Alaska explores the issues of power, resistance, treatment, and culture. (mellenpress.com)
  • The study is part of a journal issue focused on resistance mechanisms in cancer. (uclahealth.org)
  • A case-control study was conducted using data captured from an electronic medical record in a large treatment program in Nigeria . (bvsalud.org)
Specializes1
  • To schedule a consultation with a qualified healthcare provider in Washington who specializes in leptin resistance, call (703) 822-5003 or contact Dr. Lynese Lawson online . (weight-loss-medical.com)
Molecular1
  • For some drugs (chloroquine, sulfadoxine-pyrimethamine and similar drugs, atovaquone), molecular markers have been identified that confer resistance. (cdc.gov)
Susceptibility1
  • Because of cefixime's lower susceptibility, new guidelines were issued that no longer recommend oral cephalosporins for first-line gonococcal infection treatment. (medscape.com)