AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
AmikacinKanamycinAnti-Bacterial AgentsAminoglycosidesGentamicinsNetilmicinTobramycinMicrobial Sensitivity TestsCapreomycinCeftazidimeDrug Resistance, MicrobialSisomicinPseudomonas aeruginosaDibekacinLabyrinthine FluidsPiperacillinImipenemKanamycin KinaseEnterobacteriaceaeTicarcillinAcinetobacterCarbenicillinDrug Therapy, CombinationPerilymphCephalothinPseudomonas InfectionsThienamycinsAztreonamClofazimineSerratiaGram-Negative Bacterial Infections
KanamycinFluoroquinolonesLiposome inhalation suspensionGentamicinRegimenTobramycinAntibioticsLiposomal amikacinDisruption of the bacterial cell wallInhalationAntibiotic treatmentCross the placentaIntravenousArikayceConcentrationsRegimensBacterialAminoglycosidesInfectionsCeftazidimeSalmonellaTuberculosisPiperacillinSerumEfficacy and safetyClinicalSystemicInfectionEmpirical treatmentPharmacokineticsOtotoxicityStaphylococcusTherapeuticInjectionAntituberculosisImipenemPatientsDosageMoxifloxacinDoseRifampinDosesTherapyMultidrugDebrisAntimicrobialEthambutolMonotherapySusceptibleEmpiric treatmentPregnantAcute kidneyPneumoniaPreventionMedicationDrugsFailureDrugLung
Kanamycin7
  • aminoglycoside antibiotics such as amikacin, gentamicin, kanamycin etc. (mydr.com.au)
  • Pre-Extensively Drug-resistant TB (pre-XDR TB) is a type of MDR TB caused by TB bacteria that are resistant to isoniazid, rifampin, and a fluroquinolone OR by TB bacteria that are resistant to isoniazid, rifampin, and a second-line injectable (amikacin, capreomycin, and kanamycin). (cdc.gov)
  • Extensively drug-resistant TB (XDR TB) is a rare type of MDR TB that is resistant to isoniazid and rifampin, plus any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin). (cdc.gov)
  • However, the following antituberculosis drugs are contraindicated in pregnant women - Streptomycin, Kanamycin, Amikacin, Capreomycin and Fluoroquinolones (Ciprofloxacin / Ofloxacin). (ndtv.com)
  • MDR-TB that is also resistant to any one of the fluoroquinolones and to at least one of three injectable second-line medicines (amikacin, capreomycin or kanamycin).6 MDR-TB and XDR-TB are principally a result of inadequate or poorly administered treatment regimens. (who.int)
  • The latest evidence from individual patient data meta-analyses of 50 observational studies published since 2009 indicates that kanamycin and capreomycin are inferior and should be replaced by amikacin (or streptomycin, if susceptible) or, even better, by oral agents such as bedaquiline [ 13 , 14 ]. (ersjournals.com)
  • Extensively drug resistant-tuberculosis is defined as multidrug-resistant tuberculosis that is also resistant to any one of the fluoroquinolones and to at least one of three injectable second-line antibiotics (amikacin, capreomycin or kanamycin). (who.int)
Fluoroquinolones1
  • [ 14 ] The penetration of oxacillin and cefotaxime (β-lactams), and vancomycin and teicoplanin (glycopeptides) is significantly reduced through Staphylococcus aureus biofilms, whereas that of amikacin (aminoglycoside), and rifampicin and ciprofloxacin (fluoroquinolones) was unaffected. (medscape.com)
Liposome inhalation suspension5
  • Amikacin liposome inhalation suspension is the first drug approved under the US limited population pathway for antibacterial and antifungal drugs (LPAD pathway). (wikipedia.org)
  • The US Food and Drug Administration (FDA) granted the application for amikacin liposome inhalation suspension fast track, breakthrough therapy, priority review, and qualified infectious disease product (QIDP) designations. (wikipedia.org)
  • The FDA granted approval of Arikayce to Insmed, Inc. The safety and efficacy of amikacin liposome inhalation suspension, an inhaled treatment taken through a nebulizer, was demonstrated in a randomized, controlled clinical trial where patients were assigned to one of two treatment groups. (wikipedia.org)
  • One group of patients received amikacin liposome inhalation suspension plus a background multi-drug antibacterial regimen, while the other treatment group received a background multi-drug antibacterial regimen alone. (wikipedia.org)
  • By the sixth month of treatment, 29 percent of patients treated with amikacin liposome inhalation suspension had no growth of mycobacteria in their sputum cultures for three consecutive months compared to 9 percent of patients who were not treated with amikacin liposome inhalation suspension. (wikipedia.org)
Gentamicin7
  • Amikacin and gentamicin are the most commonly used in veterinary medicine. (wedgewoodpharmacy.com)
  • Amikacin has a broader spectrum of activity than some of the other members of this group and is often used for bacterial infections resistant to gentamicin. (wedgewoodpharmacy.com)
  • Amikacin is generally preferred over gentamicin for systemic use in neonatal foals. (wedgewoodpharmacy.com)
  • The isolates were sensitive to gentamicin and amikacin, showing minimum inhibitory concentrations 0.01-4 g/mL and 0.005-3.5 g/mL respectively. (who.int)
  • Aminoglycoside antibiotics such as gentamicin and amikacin may thus be introduced as a treatment regimen for typhoid fever. (who.int)
  • A total of 464 S. enterica serovar Typhi rovar Typhi isolates showing resistance to isolates were tested for susceptibility to ciprofloxacin and the 3rd-generation cepha- gentamicin and amikacin by the agar dilu- losporins is a cause of concern for physi- tion as well as the disk diffusion method, cians in developing countries [ 5-7 ]. (who.int)
  • showed that the strains of MDR the antibiotic doses of both gentamicin and S. enterica serovar Typhi involved in an amikacin were 10 g/disk. (who.int)
Regimen13
  • A 6-mo regimen consisting of isoniazid, rifampin, and pyrazinamide given for 2 mo followed by isoniazid and rifampin for 4 mo is the preferred treatment for patients with fully susceptible organisms who adhere to treatment. (cdc.gov)
  • The major determinant of the outcome of treatment is patient adherence to the drug regimen. (cdc.gov)
  • Although the drugs used in the initial treatment regimen for TB cross the placenta, they do not appear to have harmful effects on the fetus. (cdc.gov)
  • The 3-month weekly INH and rifapentine (3HP) regimen is not recommended for pregnant women or women expecting to become pregnant during the treatment period because its safety during pregnancy has not been studied. (cdc.gov)
  • The preferred initial treatment regimen is INH, rifampin (RIF), and ethambutol (EMB) daily for 2 months, followed by INH and RIF daily, or twice weekly for 7 months (for a total of 9 months of treatment). (cdc.gov)
  • The treatment of choice should be based on local resistance data, and the drug regimen should be tailored according to susceptibility results. (medscape.com)
  • Ideally, the management of TB among HIV-infected patients taking antiretroviral drugs requires a) directly observed therapy, b) availability of experienced and coordinated TB/HIV care givers, and in most situations, c) use of a TB treatment regimen that includes rifabutin instead of rifampin. (cdc.gov)
  • Group I received SDD regimen in the form of amikacin, miconazole, and colistin sulphate. (medbc.com)
  • Subsequently, these results were replicated in observational studies in many countries [ 7 , 8 ], followed by the first-ever full-length, multinational randomised controlled treatment trial for MDR-TB (STREAM Stage 1, ClinicalTrials.gov NCT02409290 ), comparing the WHO-recommended standardised shorter regimen with standardised longer regimens based on WHO recommendations in effect at that time [ 9 , 10 ]. (ersjournals.com)
  • The second study involved a 4-month treatment regimen in which moxifloxacin was substituted for isoniazid for 2 months, followed by moxifloxacin and rifapentine twice weekly for 2 months. (medscape.com)
  • This shorter regimen was inferior to both a 6-month regimen with moxifloxacin and to a standard 6-month treatment regimen. (medscape.com)
  • Administer the drug for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible TB. (medscape.com)
  • 4. Refractory MAC lung infection, defined as having positive MAC cultures while being treated with a multidrug mycobacterial antibiotic treatment regimen for a minimum of 6 consecutive months and no documented successful treatment, defined as negative sputum culture for MAC and cessation of treatment. (who.int)
Tobramycin1
Antibiotics14
  • Treatment of hospitalized patients with nursing home-acquired pneumonia requires broad-spectrum antibiotics with coverage of many gram-negative and gram-positive organisms, including methicillin-resistant S. aureus . (aafp.org)
  • A study of a hospital program promoting aminoglycosides as empiric treatment of pyelonephritis found that first-line use of aminoglycosides was associated with higher rates of in vitro activity and lower overall mortality compared with non-aminoglycoside antibiotics, and with a comparable rate of acute kidney injury. (medscape.com)
  • There are some gram-positive Staphyloccus that are sensitive to amikacin although generally the aminoglycosides are combined with other antibiotics when both gram-negative and gram-positive bacteria are present. (wedgewoodpharmacy.com)
  • Amikacin may be combined with other antibiotics to provide coverage for gram positive bacteria. (wedgewoodpharmacy.com)
  • Systemic use of amikacin and other aminoglycoside antibiotics are usually reserved for serious illnesses because of the risk of nephrotoxicity and ototoxicity. (wedgewoodpharmacy.com)
  • When using amikacin or other aminoglycoside antibiotics, monitoring of renal function and peak trough drug concentrations can be very useful to decrease the risks of nephrotoxicity. (wedgewoodpharmacy.com)
  • In the treatment of severe lung infections, such as those found in individuals with cystic fibrosis or bronchiectasis, the use of antibiotics can often lead to drug resistance and serious side effects. (aboutmanukahoney.com)
  • Susceptibility to the different antibiotics varied but none of the isolates from chicken was resistant to amikacin. (who.int)
  • In vitro, when bacterially laden SynF is diluted, akin to the dilution achieved clinically with lavage and local injection of antibiotics, amikacin and ultrasound application result in increased bacterial metabolism, aggregate permeabilization, and a 4-5 log decrease in colony forming units, independent of microbubble destruction. (jefferson.edu)
  • Our data suggest that UTMD + antibiotics may serve as an important adjunct for the treatment of septic arthritis. (jefferson.edu)
  • Comparison of meropenem with amikacin plus ceftazidime in the empirical treatment of febrile neutropenia: a prospective randomised multicentre trial in patients without previous prophylactic antibiotics. (druglib.com)
  • Mycobacterium abscessus is] currently treated with a 13-month treatment course that involves some very aggressive antibiotics. (rnz.co.nz)
  • And one of those antibiotics is called amikacin and we deliver it into the patients through nebulisation, where it's aerosolised into their lungs. (rnz.co.nz)
  • The story of drug resistance in TB is paralleled in many other bacteria over use and improper use of antibiotics stimulates drug resistance, which makes treatment of bacterial infections more difficult. (cdc.gov)
Liposomal amikacin2
Disruption of the bacterial cell wall1
  • The mechanism of action for amikacin is through disruption of the bacterial cell wall, irreversible binding of the 30S ribosomal subunit, and inhibition of bacterial protein synthesis. (wedgewoodpharmacy.com)
Inhalation1
  • AVAIL is a pivotal Phase 3 clinical study evaluating AeroVanc, vancomycin hydrochloride inhalation powder, for the treatment of Methicillin-resistant Staphylococcus aureus (MRSA) lung infection in people living with cystic fibrosis (CF). With 143 people currently enrolled, out of a target of 200, Savara is updating its guidance for enrollment completion. (globenewswire.com)
Antibiotic treatment5
  • Antibiotic treatment was given according to the result of the drug sensitivity test of P. aeruginosa . (vin.com)
  • On the fifth day from the beginning of the antibiotic treatment, the amikacin volume of distribution and clearance estimated by applying the population pharmacokinetic equations and taking into account the CrCl were 0.25 (0.07) L/kg and 0.04 (0.01) mL · min -1 · kg -1 , respectively. (aacc.org)
  • If the time required for an antibiotic to penetrate biofilms is longer than the duration of antibiotic treatment, the slower penetration will explain the antibiotic resistance. (medscape.com)
  • Biofilms contain a small reversible subpopulation of so-called persister cells that adopt a slow- or nongrowing lifestyle through the emergence of small colony variants and are highly tolerant to extracellular stresses, such as antibiotic treatment. (medscape.com)
  • [ 16 ] After antibiotic treatment, only persister cells may survive, creating the reservoirs of surviving cells that may regrow to cause a relapsing chronic infection, which has been clearly described for cystic fibrosis-associated lung infections caused by P. aeruginosa [ 17 ] and for candidiasis by C. albicans . (medscape.com)
Cross the placenta1
  • While it is known to cross the placenta, amikacin is only partially secreted in breast milk. (wikipedia.org)
Intravenous5
  • Before treatment of enterococcal infections, all suspected intravenous lines, intra-arterial catheters, and urinary catheters should be removed, if possible, and abscesses drained. (medscape.com)
  • A 78-year-old man with prostate cancer needed intravenous treatment with amikacin for a suspected gram-negative bacillary respiratory infection. (aacc.org)
  • Predose and peak concentrations (obtained 0.5 h after completion of the intravenous dose of amikacin) were measured by a homogeneous immunoassay (Cobas Integra®, Roche) to confirm that the dosage was correct. (aacc.org)
  • Evaluation of the efficacy and safety of intravenous ciprofloxacin versus meropenem in the treatment of postoperative infection. (druglib.com)
  • Initial treatment by intravenous tazocilline-amikacin was changed to intravenous amoxicillin-clavulanic acid (2 g/200 mg). (cdc.gov)
Arikayce1
Concentrations5
  • The final pharmacokinetic model analysed 358 amikacin concentrations. (nih.gov)
  • Following the logistic regression analysis of treatment failure, new amikacin target concentrations were estimated and used in development of an alternative dosing strategy. (nih.gov)
  • The bactericidal properties of amikacin are concentration dependent and there is significant bactericidal activity even after drug concentrations are below the minimum inhibitory concentration (MIC). (wedgewoodpharmacy.com)
  • Fig. 1 shows amikacin concentrations determined in our patient as well as the dosage regimens. (aacc.org)
  • To evaluate the performance of the Bayesian estimation, the measured amikacin concentrations were compared with the predicted ones, generated on the basis of the estimates of the CrCl and that estimated by the CKD-EPI Cys equation. (aacc.org)
Regimens7
  • Bactericidal with the highest EBA  Rifampicin (R) - bactericidal with high EBA and a key sterilizing drug in short-course treatment regimens of TB  Pyrazinamide (Z) - high sterilizing agent. (slideshare.net)
  •  Recommended treatment regimens for children in each TB diagnostic category. (slideshare.net)
  • The use of rifabutin-containing antituberculosis regimens should always include an assessment of the patient's response to treatment to decide the appropriate duration of therapy (i.e., 6 months or 9 months). (cdc.gov)
  • The most notable changes in these guidelines reflect both the recent advances in the use of antiretroviral therapy and the findings of clinical trials that evaluated new drug regimens for the treatment and prevention of TB among HIV-infected persons. (cdc.gov)
  • New pediatric formulations continue to advance to market, and consensus has begun to form around the need for efficacy studies of simplified multidrug-resistant TB (MDR-TB) treatment regimens in children. (treatmentactiongroup.org)
  • 1, 2 Clinical drug resistance is becoming of increasing importance worldwide and is attributed to factors including patient non-adherence to treatment, inappropriate treatment regimens, drug malabsorption, and a poor health infrastructure needed for the effective delivery of treatment. (bmj.com)
  • In three phase III trials, shorter TB treatment regimens were not as effective as standard 6-month regimens. (medscape.com)
Bacterial5
Aminoglycosides4
  • Amikacin and other aminoglycosides are eliminated via the kidney and can be nephrotoxic. (wedgewoodpharmacy.com)
  • Amikacin and other aminoglycosides are commonly used in ophthalmic preparations to treat corneal ulcers. (wedgewoodpharmacy.com)
  • Amikacin, like other aminoglycosides, can be given in multiple daily doses (conventional) or once-daily dose (pulse). (medscape.com)
  • This increase poses several problems, including a) the lack of available antimicrobials for therapy of infections caused by VRE, because most VRE are also resistant to multiple other drugs (e.g., aminoglycosides and ampicillin) previously used for the treatment of infections due to these organisms, and b) the possibility that the vancomycin resistance genes present in VRE may be transferred to other gram-positive microorganisms such as Staphylococcus aureus. (cdc.gov)
Infections16
  • Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection. (wikipedia.org)
  • For more information please review the Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents . (cdc.gov)
  • Systemic amikacin is used to treat serious gram-negative infections. (wedgewoodpharmacy.com)
  • Foscarnet injection is also used to treat herpes simplex virus (HSV) infections of the skin and mucus membranes (mouth, anus) in people whose immune system is not working normally and when treatment with acyclovir did not help. (medlineplus.gov)
  • Therefore, there is a need for better treatment outcomes for individuals with these pulmonary infections. (aboutmanukahoney.com)
  • The use of manuka honey in combination with amikacin could have significant benefits for individuals with pulmonary infections. (aboutmanukahoney.com)
  • If proven to be successful, this therapy could revolutionize the treatment of pulmonary infections, offering a more effective and less harmful alternative to current treatment methods. (aboutmanukahoney.com)
  • In conclusion, the combination of amikacin and manuka honey shows great promise as a potential treatment for pulmonary infections in individuals with cystic fibrosis and bronchiectasis. (aboutmanukahoney.com)
  • Nevertheless, this study offers hope for individuals with pulmonary infections and opens new avenues for the development of more effective and less harmful treatment options. (aboutmanukahoney.com)
  • Treatment failure in joint infections is associated with fibrinous, antibiotic-resistant, floating and tissue-associated Staphylococcus aureus aggregates formed in synovial fluid (SynF). (jefferson.edu)
  • Comparison of probability of target attainment calculated by Monte Carlo simulation with meropenem clinical and microbiological response for the treatment of complicated skin and skin structure infections. (druglib.com)
  • Meropenem versus imipenem-cilastatin for the treatment of hospitalized patients with complicated skin and skin structure infections: results of a multicenter, randomized, double-blind comparative study. (druglib.com)
  • in group A, after 3 months of treatment, infections in the vertebral body and intervertebral space were not significantly absorbed, and the infection gradually absorbed after 6 months. (scirp.org)
  • Healthcare providers treating VIM-GES-CRPA infections should consult with a specialist knowledgeable in the treatment of antibiotic-resistant bacteria to determine the best treatment option. (cdc.gov)
  • The increasing rates of multidrug-resistant (MDR) infections with few novel treatment options available has spurred the recent interest in fosfomycin. (bvsalud.org)
  • [ 6 ] In critically ill patients with serious gram-negative infections, higher loading doses and closer monitoring of amikacin levels are required to achieve a peak-to-MIC ratio of greater than 8-10. (medscape.com)
Ceftazidime4
Salmonella1
  • RÉSUMÉ L'apparition d'isolats de Salmonella enterica serovar Typhi montrant une résistance à la ciprofloxacine et aux céphalosporines de 3e génération inquiète les médecins des pays en développement. (who.int)
Tuberculosis18
  • It is also used for the treatment of multidrug-resistant tuberculosis. (wikipedia.org)
  • This Statement is one of a series of four Statements on diagnosis, treatment, and control of tuberculosis. (cdc.gov)
  • Multiple-drug-resistant tuberculosis (i.e., resistance to at least isoniazid and rifampin) presents difficult treatment problems. (cdc.gov)
  • Untreated tuberculosis (TB) disease represents a greater hazard to a pregnant woman and her fetus than does its treatment. (cdc.gov)
  • Treatment of tuberculosis in children - special considerations. (slideshare.net)
  • Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis. (cdc.gov)
  • Therapeutic drug management: is it the future of multidrug-resistant tuberculosis treatment? (ersjournals.com)
  • These guidelines update previous CDC recommendations for the diagnosis, treatment, and prevention of tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) in the United States. (cdc.gov)
  • Early diagnosis and effective treatment of TB among HIV-infected patients are critical for curing TB, minimizing the negative effects of TB on the course of HIV, and interrupting the transmission of Mycobacterium tuberculosis to other persons in the community. (cdc.gov)
  • The net effect of this pattern of treatment was to separate the study of tuberculosis from mainstream medicine. (encyclopedia.com)
  • One team of public health experts in North Carolina maintains that treatment for tuberculosis is the most pressing health care need of recent immigrants to the United States. (encyclopedia.com)
  • The roster of enrolling and planned pediatric tuberculosis (TB) treatment studies is growing. (treatmentactiongroup.org)
  • My friend is suffering from lymph node tuberculosis and is under treatment. (ndtv.com)
  • Regional Committee for Africa adopted a resolution on scaling up AIDS, tuberculosis and malaria interventions.1 The resolution recognized that both access to and adequate utilization of effective treatment with quality-assured medicines are crucial for reducing the disease burden. (who.int)
  • This study aimed to describe the clinical, microbiological, molecular epidemiology and treatment of multidrug resistant tuberculosis (MDRTB) cases in the UK and to determine factors associated with survival. (bmj.com)
  • With three new and three recently repurposed drugs, treatment of multidrug-resistant tuberculosis (MDR-TB) is more hopeful today than at any time since it emerged in the 1980s and 1990s [ 1 - 3 ]. (ersjournals.com)
  • This optimism contrasts starkly with dismal global treatment success rates of 48-56% as reported by the World Health Organization (WHO) in its annual Global Tuberculosis Reports from 2014 to 2019 [ 4 , 5 ]. (ersjournals.com)
  • Emergence and spread of multidrug- and extensively drug-resistant tuberculosis are facilitated by inadequate case detection and inappropriate treatment. (who.int)
Piperacillin2
  • Amikacin, fosfomycin, imipenem, and tazobactam/piperacillin were found to be the effective treatment options. (ijp-online.com)
  • Monotherapy with meropenem versus combination therapy with piperacillin plus amikacin as empiric therapy for neutropenic fever in children with lymphoma and solid tumors. (druglib.com)
Serum3
  • Prediction of amikacin serum concentration was more accurate when the estimation was carried out by entering the CKD-EPI Cys ( r 2 , 3.2835 vs 1.6009). (aacc.org)
  • Immunoassay techniques are the preferred methods of measurement of serum amikacin levels and produce comparable results with other testing techniques such as gas chromatography and microbiological assays. (medscape.com)
  • Serum amikacin levels are used to guide therapy to ensure adequate but not excessive levels. (medscape.com)
Efficacy and safety2
  • A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome. (cdc.gov)
  • To investigate the efficacy and safety of bedaquiline as part of treatment schemes for rapidly growing mycobacteria. (bvsalud.org)
Clinical9
  • Identifying patients with NTM and clinical deterioration is difficult, but important, as these are the once most likely to benefit from antimycobacterial treatment. (springer.com)
  • NKTR-171, a wholly-owned new sodium channel blocker being developed as an oral therapy for the treatment of peripheral neuropathic pain, is in Phase 1 clinical development. (prnewswire.com)
  • IMPALA is a pivotal Phase 3 clinical study evaluating Molgradex, an inhaled formulation of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF), for the treatment of autoimmune pulmonary alveolar proteinosis (aPAP). (globenewswire.com)
  • Objective -To determine clinical history, structures involved, treatment, and outcome of lacerations of the heel bulb and proximal phalangeal region (pastern) in horses. (avma.org)
  • Objective -To determine history, clinical and radiographic abnormalities, and outcome in horses with signs of navicular area pain unresponsive to corrective shoeing and systemic nonsteroidal anti-inflammatory drug administration that were treated with an injection of corticosteroids, sodium hyaluronate, and amikacin into the navicular bursa. (avma.org)
  • To explore senile brucellosis spondylitis clinical features and diagnostic criteria, in order to improve the diagnosis rate and evaluate the clinical effects of treatment strategies. (scirp.org)
  • Familiar with the clinical features of BS and the diagnosis and treatment plan can play a positive role in the prevention and treatment of the disease. (scirp.org)
  • Date of diagnosis was determined and data were collated on key demographic factors, clinical, radiological and treatment details. (bmj.com)
  • The goals of TB treatment are to shorten the clinical course of TB, prevent complications, prevent the development of latency and/or subsequent recurrences, and decrease the likelihood of TB transmission. (medscape.com)
Systemic3
  • Systemic treatment may be more useful in suppurative otitis externa and/or otitis media where there is an inflammatory discharge with concurrent tissue infection. (vin.com)
  • Systemic treatment is indicated when the ear canal cannot be treated topically (e.g., stenosis, compliance problems or topical adverse reactions) and in otitis media. (vin.com)
  • Systemic antibiotic administration and nebulizing treatment had been conducted for almost 3 months. (vin.com)
Infection6
  • For most pregnant women, treatment for latent TB infection can be delayed until 2-3 months post-partum to avoid administering unnecessary medication during pregnancy. (cdc.gov)
  • For women who are at high risk for progression from latent TB infection to TB disease, especially those who are a recent contact of someone with infectious TB disease, treatment for latent TB infection should not be delayed on the basis of pregnancy alone, even during the first trimester. (cdc.gov)
  • For the same reason, drugs in breast milk are not an effective treatment for TB disease or latent TB infection in a nursing infant. (cdc.gov)
  • As shown by the number of pulmonary exacerbations just prior to randomization, people with MRSA lung infection have a strong need for improved treatment options. (globenewswire.com)
  • What we found we can use mānuka honey for is we can reduce the concentration, the amount of amikacin that you need to nebulise into people's lungs to sterilise this infection. (rnz.co.nz)
  • Nonetheless, the number of patients presenting with NTM infection that requires treatment appears to be increasing. (msdmanuals.com)
Empirical treatment1
  • These findings confirm recommendations in international guidelines that advocate fosfomycin trometamol for empirical treatment of uncomplicated cystitis in women. (bvsalud.org)
Pharmacokinetics1
  • To examine the pharmacokinetics of amikacin and its pharmacokinetic pharmacodynamic (PKPD) relationship in neonates. (nih.gov)
Ototoxicity1
  • Amikacin trough levels of more than 10 mcg/mL have been associated with significant ototoxicity and nephrotoxicity. (medscape.com)
Staphylococcus1
  • The only Gram-positive bacteria that amikacin strongly affects are Staphylococcus and Nocardia. (wikipedia.org)
Therapeutic1
  • In hemophilia, ADYNOVATE™ [Antihemophilic Factor (Recombinant)], a longer-acting PEGylated Factor VIII therapeutic has been filed for approval in the U.S. by partner Baxalta Inc. In anti-infectives, Amikacin Inhale is in Phase 3 studies conducted by Bayer Healthcare as an adjunctive treatment for intubated and mechanically ventilated patients with Gram-negative pneumonia. (prnewswire.com)
Injection1
  • Your doctor will probably check the level of calcium in your blood before you receive foscarnet injection and during treatment. (medlineplus.gov)
Antituberculosis2
  • All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
  • Because alternatives to the use of rifampin for antituberculosis treatment are now available, the previously recommended practice of stopping protease inhibitor therapy to allow the use of rifampin for TB treatment is no longer recommended for patients with HIV-related TB. (cdc.gov)
Imipenem1
  • Meropenem versus imipenem/cilastatin in the treatment of sepsis in Chinese patients. (druglib.com)
Patients16
  • Nonhospitalized nursing home patients requiring treatment for pneumonia should be treated with an antipneumococcal fluoroquinolone, or either a high-dose beta-lactam/beta-lactamase inhibitor or a second- or third-generation cephalosporin, in combination with azithromycin (Zithromax). (aafp.org)
  • Physicians and patients also should be aware that paradoxical reactions might occur during the course of TB treatment when antiretroviral therapy restores immune function. (cdc.gov)
  • Some studies find that monotherapy is adequate treatment in many patients with enterococcal bacteremia without evidence of endocarditis. (medscape.com)
  • Meropenem +/- granulocyte colony stimulating factor in the treatment of febrile neutropenic patients with cancer: prospective randomized study. (druglib.com)
  • With no treatment, over 60% of patients with the most common type of vertigo (caused by debris in the inner ear) recover within four weeks. (lifeextension.com)
  • In the area of pain, Nektar has an exclusive worldwide license agreement with AstraZeneca for MOVANTIK™ (naloxegol), the first FDA-approved once-daily oral peripherally-acting mu-opioid receptor antagonist (PAMORA) medication for the treatment of opioid-induced constipation (OIC), in adult patients with chronic, non-cancer pain. (prnewswire.com)
  • Because XDR TB is resistant to the most potent TB drugs, patients are left with treatment options that are much less effective. (cdc.gov)
  • Health care providers can help prevent drug-resistant TB by quickly diagnosing cases, following recommended treatment guidelines, monitoring patients' response to treatment, and making sure therapy is completed. (cdc.gov)
  • That can be quite unpleasant and distressing, so one of the things that we hope to achieve with this as we move this forward is to look to see whether or not we get the improvement of the nebulisation treatment, not just from an anti-microbial perspective, not just about killing the bacteria, but also, making the treatment a little more pleasant for the patients. (rnz.co.nz)
  • These drugs are safe, cheap and effective more than 95 percent of patients can be cured with these drugs, if they take the treatment as prescribed. (cdc.gov)
  • PETTS was a prospective observational study of patients with MDR TB in 9 countries, studying risk factors for, and the consequences of acquired drug resistance in the treatment of MDR TB. (cdc.gov)
  • One week, two weeks, one month, three months, six months and 12 months after treatment, the patients were evaluated and followed up at the monitoring sites. (scirp.org)
  • the remaining 38 patients (61.29%) were combined with varying degrees of neurological impairment, and surgical treatment was performed after 2 to 4 weeks of drug therapy without improvement (group B). The pain scores showed that there was a statistically significant difference between the two groups at the same time point (P (scirp.org)
  • Despite the statistical insignificance of the improved mortality rate, SDD treatment seems to be a useful tool in treating this group of highly critical patients. (medbc.com)
  • In patients receiving treatment for active TB, pyridoxine 25-50 mg orally once daily should be coadministered to prevent peripheral neuropathy. (medscape.com)
  • An estimated 37% of cases worldwide, however, remain un-notified, with patients receiving either no treatment or treatment that is unlikely to reach internationally recommended standards. (who.int)
Dosage4
  • However, a new study has found that combining the traditional drug amikacin with manuka honey can potentially reduce the dosage of the drug and improve treatment outcomes. (aboutmanukahoney.com)
  • This is a significant finding as it suggests that the use of manuka honey can potentially reduce the dosage of amikacin required for effective treatment. (aboutmanukahoney.com)
  • Amikacin is known to be a toxic drug, and reducing the dosage required for treatment can greatly improve the quality of life for individuals with cystic fibrosis. (aboutmanukahoney.com)
  • By reducing the dosage of amikacin required for effective treatment, this combination therapy can potentially improve treatment outcomes and reduce the occurrence of severe side effects. (aboutmanukahoney.com)
Moxifloxacin1
  • Favorable outcomes were seen in 85% and 80% of the two moxifloxacin groups, compared with 92% of the standard treatment group. (medscape.com)
Dose2
  • In the nursing home setting, treatment should consist of an antipneumococcal fluoroquinolone alone or either a high-dose beta-lactam/beta-lactamase inhibitor or a second- or third-generation cephalosporin, in combination with azithromycin. (aafp.org)
  • When the MIC is unknown or greater than 0.25 mg/L, high-dose daptomycin (10-12 mg/kg) in the treatment of enterococcal endocarditis appears to reduce the development of daptomycin-resistant strains. (medscape.com)
Rifampin1
  • Rifampin is used in combination with at least 1 other antituberculous drug for the treatment of active TB. (medscape.com)
Doses2
  • Amikacin should be used in smaller doses in the elderly, who often have age-related decreases in kidney function, and children, whose kidneys are not fully developed yet. (wikipedia.org)
  • No doses should be missed and treatment should not be stopped early. (cdc.gov)
Therapy8
  • Antibiotic therapy for nursing home-acquired pneumonia should target a broad range of organisms, and drug-resistant microbes should be considered when making treatment decisions. (aafp.org)
  • Researchers in a recent study combined the drug amikacin with manuka honey to determine if this combination therapy could improve treatment outcomes. (aboutmanukahoney.com)
  • One of the main advantages of this combination therapy is the potential to reduce the occurrence of amikacin-associated hearing loss. (aboutmanukahoney.com)
  • Additionally, the use of manuka honey in this therapy shows promise as a more natural and potentially less harmful alternative to traditional antibiotic treatments. (aboutmanukahoney.com)
  • The primary treatment for the most common type of vertigo, caused by debris in the inner ear, is repositioning therapy, which can relieve vertigo in a single session when performed by a trained clinician. (lifeextension.com)
  • Studies that are under way or starting soon will evaluate preventive therapy for children exposed to MDR-TB and treatment shortening for less severe forms of drug-sensitive TB (DS-TB) in children, as well as fill gaps in PK and safety data that are necessary to optimize treatment, including in HIV-positive children and children with MDR-TB. (treatmentactiongroup.org)
  • Following widespread resistance to chloroquine and sulphadoxine-pyrimethamine all malaria- endemic countries except two in the Region have changed the treatment policy to artemisinin-based combination therapy (ACT). (who.int)
  • Treatment lasts for 9 months if the patient's sputum culture result is still positive after 2 months of therapy. (medscape.com)
Multidrug1
  • Yet treatment is feasible and cost- effective if WHO guidelines are followed, with cure rates of up to 80% among multidrug-resistant cases and up to 60% among extensively drug-resistant cases in low-resource settings. (who.int)
Debris1
  • This protocol summarizes the types and causes of dizziness and vertigo and the different treatment strategies available, including repositioning techniques to remove debris from the inner ear either at home or at the doctor's office. (lifeextension.com)
Antimicrobial3
  • Mediolateral (A) and craniocaudal (B) radiographic views of the right stifle joint of a 5-year-old 43.0-kg (94.6-lb) castrated male Rottweiler that was evaluated for a 5-month history of 2 draining tracts following tibial plateau leveling osteotomy and subsequent implant removal and antimicrobial treatment. (avma.org)
  • Antimicrobial susceptibility tests do not predict the response to topical treatment. (vin.com)
  • this does not necessarily mean that the bacteria are resistant to the antimicrobial, as the high levels following topical treatment frequently exceed the MIC. (vin.com)
Ethambutol1
  • In the first study, ethambutol was replaced with gatifloxacin for 2 months of intensive treatment followed by a 2-month continuation phase. (medscape.com)
Monotherapy1
  • Efficacy of meropenem as monotherapy in the treatment of ventilator-associated pneumonia. (druglib.com)
Susceptible1
  • In most susceptible cases, the patient undergoes 6 months of treatment. (medscape.com)
Empiric treatment1
  • Ineffective empiric treatment of UTI is common when associated with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae . (ijp-online.com)
Pregnant2
  • A pregnant woman taking amikacin with another aminoglycoside has a possibility of causing congenital deafness in her child. (wikipedia.org)
  • Treatment of TB disease for pregnant women co-infected with HIV should be the same as for nonpregnant women, but with attention given to additional considerations. (cdc.gov)
Acute kidney1
  • An increase of Cr (1.3 g/dL) was observed 9 days after the end of the treatment with amikacin, which was compatible with the presence of acute kidney injury. (aacc.org)
Pneumonia1
  • It is hoped that these studies will lead to a better understanding of this organism and host-parasite interactions, which in turn will result in better means of prevention, diagnosis, and treatment of P. carinii pneumonia. (rochester.edu)
Prevention2
  • Table 1 provides an overview of ongoing and planned pediatric TB prevention and treatment studies. (treatmentactiongroup.org)
  • The continued and enhanced application of GIS to chronic disease surveillance, prevention, and treatment priorities can provide valuable benefits to both health departments and the communities they serve. (cdc.gov)
Medication2
  • Your doctor will order laboratory tests before and during your treatment to see if your kidneys are affected by this medication. (medlineplus.gov)
  • The length of your treatment depends on how you respond to the medication. (medlineplus.gov)
Drugs4
  • Treatment of TB in children How many drugs? (slideshare.net)
  • People receiving treatment for TB disease should tell their health care provider if they are having trouble taking the drugs. (cdc.gov)
  • These drugs constitute the mainstay of treatment and knowledge of resistance is likely to be of direct benefit to the individual patient and to public health TB programmes. (bmj.com)
  • Before 2010, treatment consisted of four to five drugs given for about 24 months, including daily injections for the first 6 to 8 months. (ersjournals.com)
Failure2
  • This will lead to treatment failure and resistance. (vin.com)
  • Immunocompromised status, failure to culture the bacterium in 30 days or to apply appropriate three drug treatment, and age were significant factors in mortality. (bmj.com)
Drug3
  • Flunarizine, a calcium channel blocker drug used for migraines in Europe but not approved in the United States, has shown promise as a potential treatment for migraine-associated vertigo. (lifeextension.com)
  • Standardized drug treatment has a good cure rate. (scirp.org)
  • However, efforts to improve access to treatment are hampered by development of HIV, TB and malaria drug resistance. (who.int)
Lung3
  • By using a lab-based lung model and a nebulizer, the combination of manuka honey and amikacin was administered through a fine spray of liquid. (aboutmanukahoney.com)
  • Demonstrating NTM biofilm growth in the human lung could also open up new treatment opportunities as biofilm disrupting targets could be systematically examined, something that has not previously been attempted for NTM. (springer.com)
  • Because NTM lung disease and bronchiectasis often co-exist, we can readily leverage our existing relationships with physician experts around the world who are eagerly awaiting new treatment options. (salesandmarketingnetwork.com)