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  • approved allogeneic stem
  • A key aspect of the strategic rationale for the acquisition of the culture-expanded MSC assets was the potential for early and significant revenue streams using Prochymal®, the world's first approved allogeneic stem cell therapeutic and the only allogeneic stem cell therapeutic designated by the United States Food and Drug Administration (FDA) as both an Orphan Drug and Fast Track product. (cnbc.com)
  • Mesenchymal Stem
  • In this study, an intralesional injection was performed with allogeneic tenogenically induced mesenchymal stem cells and platelet-rich plasma 5-6 days after diagnosis of suspensory ligament (SL) ( n = 68) or superficial digital flexor tendon (SDFT) ( n = 36) lesion. (frontiersin.org)
  • The aim of this study was to investigate regenerative effects of ultrasound- (US-) guided injection with human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) and/or polydeoxyribonucleotide (PDRN) injection in a chronic traumatic full-thickness rotator cuff tendon tear (FTRCTT) in a rabbit model. (hindawi.com)
  • Mesenchymal stem cells (MSCs) have been proposed as an attractive alternative to overcome the limitations of the current treatments [ 4 ]. (hindawi.com)
  • phase
  • Allogeneic stem cell transplantation for myeloproliferative neoplasm in blast phase. (healthtap.com)
  • It has been hypothesized that the most indicated moment for treatment is the transition between the inflammatory phase and the subacute reparative phase ( 3 , 4 ), which is characterized by scar tissue production and collagen type III deposition by the fibroblasts. (frontiersin.org)
  • OLDSMAR, FL (January 8, 2013) - (OTC:CCEL) Cryo-Cell International Chief Scientific Officer Linda L. Kelley , PhD, expressed optimism that an effective treatment for cerebral palsy (CP) using cord blood stem cells may be on the horizon now that the first results of a Phase 2 study have been published. (cryo-cell.com)
  • A recently-completed internal review of the Crohn's Disease program reinforced Mesoblast's intention to complete the ongoing Phase 3 trial in adult patients with Crohn's Disease refractory to treatment with steroids, classic immunosuppressives and biologic therapy. (cnbc.com)
  • tissue
  • HIV infection and viral reservoir - Cell-associated total HIV-1 DNA in CD4 T cells from peripheral blood and from gut-associated lymphoid tissue (GALT): Expressed in copies per million cells. (clinicaltrials.gov)
  • To prepare for baby, one important decision to make is whether saving baby's umbilical cord blood, placental blood or cord blood tissue is right for your family. (hubpages.com)
  • They have also demonstrated an ability to provide these benefits when administered peripherally and within 24-48 h post-stroke, which immensely expands the current treatment window of 3-4 h for tissue plasminogen activator. (springer.com)
  • Cryo-Cell operates in a facility that is compliant with Good Manufacturing Practice and Good Tissue Practice (cGMP/cGTP), and is ISO 9001:2008 certified and accredited by the American Association of Blood Banks. (cryo-cell.com)
  • Of the various MSCs, human umbilical cord blood-derived MSCs (UCB-MSC) have a greater therapeutic potential than MSCs derived from other tissues because of attributes that include the ability to home in on injured tissue, low immunogenicity, multidirectional differentiation, and extensive secretion profiles [ 5 ]. (hindawi.com)
  • Such 'allogeneic tissue networks', formed by linking international registries, are scientifically and ethically easier to justify than private UCB banks that store autologous stem cells for exclusive use by the donor or a close relative. (scielo.org.za)
  • therapeutic
  • A multidisciplinary team, including nurse navigators, provides personalized care in the 49-bed inpatient unit and outpatient Cancer and Therapeutic Blood Treatment Center. (dana-farber.org)
  • This chapter highlights the current research with UCB cells in the development of a novel treatment for stroke and demonstrates the great therapeutic potential of these cells. (springer.com)
  • lymphomas
  • To determine the tolerability of pembrolizumab treatment in the setting of relapsed myeloid malignancies and mature B cell lymphomas following alloSCT. (clinicaltrials.gov)
  • outcomes
  • Because the outcomes using chemotherapy and HCT treatments have been changing over time, regular comparisons between these approaches should be performed to continually redefine optimal therapy for a given patient. (nkch.org)
  • The data consistently revealed superior outcomes in the group that received cord blood compared to the other two groups. (cryo-cell.com)
  • ischemic
  • The evidence presented suggests that the UCB cells have a great deal of potential as a future treatment for stroke, both ischemic and hemorrhagic, in young and adult alike. (springer.com)
  • approaches
  • However, higher-risk approaches such as haploidentical transplantation are becoming safer and more efficacious and are increasingly being used interchangeably with fully matched allogeneic approaches. (nkch.org)
  • Condition
  • Their reason is that conditions that require stem cells as a treatment would need to be treated using donor stem cells since the genetics of that condition are already part of the cord blood at birth. (hubpages.com)
  • Dr. Kelley commented, "Results from those studies should greatly extend our knowledge of the usefulness of cord blood for the treatment of a devastating condition for which there is currently no known treatment. (cryo-cell.com)
  • efficacy
  • The paper by Dr. Min Young Kim and colleagues is the first to demonstrate efficacy using umbilical cord blood as therapy in a large, placebo-controlled, double-blind study in South Korea. (cryo-cell.com)