AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentGeographicals
PraziquantelAnthelminticsSchistosomicidesParasite Egg CountSchistosomiasis mansoniSchistosoma haematobiumSchistosomiasis haematobiaSchistosoma mansoniClonorchiasisOxamniquineSchistosomiasisAlbendazoleTrematode InfectionsPlatyhelminthsSchistosomiasis japonicaSchistosoma japonicumSchistosomaMethopreneAntiparasitic AgentsCestode InfectionsClonorchis sinensisAnticestodal AgentsParagonimiasisDiphyllobothriumIvermectinDiphyllobothriasisParagonimusHeterophyidaeOpisthorchiasisAntibodies, HelminthEchinococcosisCysticercosisCestodaAntigens, HelminthOpisthorchisEchinostomiasisFecesParasitic Diseases, AnimalCat DiseasesTrematodaTaeniaToxascariasisZimbabweToxascarisLaosArtemisininsTaeniasisHelminthiasisMetastrongyloideaIntestinal Diseases, ParasiticEchinococcus granulosusUgandaHymenolepiasisEchinostomaNeuroschistosomiasisHycanthoneCote d'IvoireTaenia solium
SchistosomiasisSchistosomaBiltricideDoseActivity of praziquantelAnthelminticTapewormsParasitesDosageInfectionsNeurocysticercosisDiagnosis and treatmentPatientsWormerClinicalWorld Health OrganTapeworm treatmentMorbidity2001ParasiteNiclosamideTopicalEfficacyDrugPreventivePlasma concentrationsInflammationRegimensStoolCystsInfectionLesionsFormulationTabletsHumansOralPreventionEchinococcusPregnant womenPyrantelInteractionsAdequateDiseasesPregnancyImprovesLiverAdultsAdverseAccumulationExperimentalCompoundsCestodes
Schistosomiasis16
  • Schistosomiasis is a chronic severe illness with estimates from the World Health Organization (WHO) showing that at least 290.8 million people required preventive treatment in 2018, in which more than 97.2 million people were reported to have been treated [ 1 ]. (hindawi.com)
  • Praziquantel can exacerbate central nervous system pathology due to schistosomiasis. (drugs.com)
  • Schistosomiasis caused by trematodes of the genus Schistosoma: As of 2005, praziquantel is the primary treatment for human schistosomiasis, for which it is usually effective in a single dose. (wikipedia.org)
  • Praziquantel is effective in reducing schistosomiasis during pregnancy. (wikipedia.org)
  • The recommended dosage of Biltricide for the treatment of schistosomiasis is 20 mg/kg three times a day as a one day treatment, at intervals of 4 to 6 hours. (rxlist.com)
  • No previous study has examined whether praziquantel treatment at 12-16 weeks gestation improves pregnancy outcomes or whether the use of a higher dose of praziquantel recommended to treat Asian schistosomiasis can be safely administered without adverse newborn or maternal outcomes. (freshinechem.com)
  • Praziquantel is the only drug recommended by the World Health Organization to treat both urogenital and intestinal schistosomiasis. (biomedcentral.com)
  • This systematic review was conducted to identify gaps and recent progress on the efficacy of different regimens of praziquantel in treating schistosomiasis among children in sub-Saharan Africa where Schistosoma mansoni and S. haematobium are endemic. (biomedcentral.com)
  • The review indicates that further investigations are necessary to conclusively determine efficacy of praziquantel on coinfection of S. haematobium and S. mansoni to formulate concrete guidelines on the use of repeated doses at 40 or 60 mg/kg for treating schistosomiasis. (biomedcentral.com)
  • In sub-Saharan Africa, studies have shown that praziquantel drastically reduces morbidity and transmission of schistosomiasis. (biomedcentral.com)
  • For quite a long time, praziquantel (PZQ) was widely used for the treatment of schistosomiasis and has shown benefit in treating liver fibrosis. (nih.gov)
  • In this review, we present a balanced and comprehensive view of the role of miRNAs in the pathogenesis, grading, and treatment of schistosomiasis-associated hepatic fibrosis. (nih.gov)
  • A newly established international public-private partnership (PPP) between TI Pharma, Merck KGaA (Darmstadt, Germany), Astellas Pharma Inc. and the Swiss Tropical and Public Health Institute ("Swiss TPH") has been launched to develop a new pediatric formulation of praziquantel to combat schistosomiasis - commonly known as bilharzia - in preschool children. (astellas.com)
  • Currently, infants and very young children who are infected with schistosomiasis cannot receive adequate treatment. (astellas.com)
  • Morbidity patterns and treatment effects in human schistosomiasis mansoni in two areas of Machakos and Makueni districts, Kenya / by Gabriel Gathingu Mbugua. (who.int)
  • Report of a meeting to review the results of studies on the treatment of schistosomiasis in preschool-age children. (who.int)
Schistosoma5
Biltricide6
  • Biltricide (praziquantel). (drugs.com)
  • Praziquantel (PZQ), sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections in mammals, birds, amphibians, reptiles, and fish. (wikipedia.org)
  • Our Biltricide (praziquantel) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • BILTRICIDE® (praziquantel) is a trematodicide provided in tablet form for the oral treatment of schistosome infections and infections due to liver fluke. (rxlist.com)
  • BILTRICIDE tablets contain 600 mg of praziquantel. (rxlist.com)
  • Praziquantel ( Biltricide ) is an anthelmintic effective against flatworms . (curecrowd.com)
Dose9
  • The recommended dose for clonorchiasis and opisthorchiasis is 25 mg/kg three times a day as a one day treatment, at intervals of 4 to 6 hours. (rxlist.com)
  • Nursing mothers should stop breastfeeding on the day of treatment and for 72 hours after taking the last dose. (rxlist.com)
  • A single standard dose of 40 mg/kg body weight was the most used regimen (9) followed by the repeated single standard dose assessed for efficacy at 3-4 weeks post-treatment. (biomedcentral.com)
  • Praziquantel administrated at 60 mg/kg was slightly more efficacious than the 40 mg/kg standard dose. (biomedcentral.com)
  • However, failure/resistant cases have been reported after the use of a single standard dose of praziquantel at 40 mg/kg body weight. (biomedcentral.com)
  • Treatment of echinococcosis for patients weighing more than 60 kg is albendazole administered PO with meals in a dose of 400 mg twice daily for 28 days. (medscape.com)
  • Individual suffering and the global burden of disease due to these infections can be significantly reduced through adequate and easy treatment with single-dose drugs. (who.int)
  • 3 women were treated with praziquantel, single dose, 40 mg/kg body weight. (who.int)
  • Trois autres femmes ont été traitées au praziquantel en dose unique de 40 mg/kg de poids corporel. (who.int)
Activity of praziquantel2
  • The anthelminthic activity of praziquantel was discovered in 1972 in the laboratories of Bayer AG and was followed up at the German pharmaceutical manufacturer E. Merck. (vin.com)
  • The woman is taking a drug which decreases the activity of praziquantel metabolizing enzymes (P450 inhibitors) the last two weeks before the enrollment, for example cimetidine, ketoconazole, itraconazole, erythromycin. (who.int)
Anthelmintic3
  • Praziquantel is in the anthelmintic class of medications. (wikipedia.org)
  • Since praziquantel was first introduced as a broadspectrum anthelmintic in 1975, innumerable articles describing its successful use in the treatment of the majority of human-infecting trematodes and cestodes have been published. (qxmd.com)
  • 10 Marketed under the tradename Profender®, this preparation is a unique combination of two active substances, emodepside and praziquantel: emodepside comes from a new class of active anthelmintic substances, while praziquantel, a convenient spot-on formulation for cats, controls cestodes. (vin.com)
Tapeworms2
  • Praziquantel paralyzes the tapeworms forcing them to release themselves from the digestive tract thus allowing your pet to digest them with just one treatment. (fda.gov)
  • Seth O'Neal] Well, the risk of presumptive treatment for adult intestinal tapeworms comes from the fact that one of the drugs, praziquantel, can potentially damage any larvae that might be in the brain. (cdc.gov)
Parasites5
  • Praziquantel is known to be one of the safest most effective pond fish medications available for treating a vast array of external and internal parasites. (macarthurwatergardens.com)
  • A new treatment for internal parasites was shown to be safe and effective when administrated to a wide range of reptile species. (vin.com)
  • Virbantel Chewable Tablets for Small Dogs and Puppies, 50 Tablets is an effective dewormer for the treatment and control of certain internal parasites in dogs and puppies at least 12 weeks old. (vetdepot.com)
  • Consult your veterinarian for assistance in the diagnosis, treatment and control of parasites. (chewy.com)
  • The control of human visceral leishmaniasis (VL) is hard since there are no vaccines available as well as the treatment is hampered by toxicity and resistant parasites. (bvsalud.org)
Dosage1
  • This letter concerns your firm's marketing of veterinary products under the Queen City Animals brand name for the "treatment" of disease in dogs and cats, including all dosage forms of the following Queen City Animals products: Liquid Vanilla Flavored Wormer (Pyrantal Pamoate), Praziquantel Tapeworm Dewormer Capsules, Nitenpyram Flea Killing Capsules, and Lufenuron Flea Controlling Capsules. (fda.gov)
Infections11
  • The search included studies published from 2008 to 2017 (August) with emphasis on the efficacy of praziquantel on S. haematobium and S. mansoni infections among preschool and school children. (biomedcentral.com)
  • Praziquantel treatment in trematode and cestode infections: an update. (qxmd.com)
  • Status and emerging issues in the use of praziquantel for treatment of human trematode and cestode infections are briefly reviewed. (qxmd.com)
  • However, Fasciola hepatica and Fasciola gigantica infections are refractory to praziquantel, for which triclabendazole, an alternative drug, is necessary. (qxmd.com)
  • In addition, larval cestode infections, particularly hydatid disease and sparganosis, are not successfully treated by praziquantel. (qxmd.com)
  • Current and future trends in the preven- latum infections in this region, which atic at interview but both were report- tion, treatment and control of rabies. (cdc.gov)
  • The drug of choice for tapeworm infections is praziquantel. (medlineplus.gov)
  • In this article, we detail the different types of parasitic infections in humans, their symptoms and treatments, and tips to prevent them. (medicalnewstoday.com)
  • The treatment for parasite infections depends on the particular type of parasite. (medicalnewstoday.com)
  • Treatments for larval cyst infections may include anti-parasitic drugs and surgery to remove the cyst. (sparrow.org)
  • Praziquantel can also be used against other helminth infections, such as most foodborne trematodes and cestodes. (who.int)
Neurocysticercosis2
  • Treatment of neurocysticercosis is much more complicated, though, and can require long-term medications and surgery. (cdc.gov)
  • Controlling this inflammation is an important part of treatment of neurocysticercosis. (cdc.gov)
Diagnosis and treatment7
  • E granulosus is discussed separately from the other 3 species, notably Echinococcus multilocularis, which causes alveolar echinococcosis, because of marked differences in epidemiology, clinical features, diagnosis, and treatment. (medscape.com)
  • Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. (medscape.com)
  • Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. (vetdepot.com)
  • Clinical cases should at all times and in all places find adequate diagnosis and treatment and, if necessary referral, in the primary health care system. (who.int)
  • Early diagnosis and treatment are important in prevention of tuberculosis (TB) infection. (academicjournals.org)
  • There are many controversies regarding nonbacterial cystitis, including possible etiologic agents, methods of diagnosis, and treatment, especially for noninfectious causes. (medscape.com)
  • The diagnosis and treatment are readily available, the treatment course outcome were assessed by wet preparation is short, resistance has not been recorded microscopy and culture methods [ 3 ]. (who.int)
Patients10
  • Patients suffering from cardiac irregularities such as arrhythmias should be monitored during treatment with praziquantel. (drugs.com)
  • Caution should be exercised when administering praziquantel at the usual recommended doses in patients with moderate to severe liver impairment (Child Pugh class B and C). Reduced metabolism of praziquantel may lead to considerably higher and longer lasting plasma concentrations of the unmetabolized drug. (drugs.com)
  • All patients with cerebral cysticercosis are strongly recommended to be hospitalized during treatment. (wikipedia.org)
  • For individual patients in clinical settings, the risk of treatment in pregnant women who are known to have an infection needs to be balanced with the risk of disease progression in the absence of treatment. (cdc.gov)
  • For individual patients in clinical settings, praziquantel should be used in breast-feeding women only when the risk to the infant is outweighed by the risk of disease progress in the mother in the absence of treatment. (cdc.gov)
  • This was a single-centre, randomized, single-blind, vehicle-controlled pilot study in adult patients (n = 46) with 4 weeks of treatment and 4 weeks of follow-up. (qxmd.com)
  • Deferring treatment only exacerbates the morbidity of the patients. (freshinechem.com)
  • All of the patients were treated with praziquantel. (unboundmedicine.com)
  • Patients diagnosed with Katayama syndrome received praziquantel and dexamethasone for 3 days, with the praziquantel treatment being repeated at 3-4 weeks. (unboundmedicine.com)
  • In our study, eosinophilia, recurrence, and complications were seen at a higher rate in paediatric patients with multiorgan involvement, who required repetitive surgeries and long-term medical treatment. (bvsalud.org)
Wormer2
  • Nobody wants their dog to suffer from worms, so the Bayer Tapeworm Dog De-Wormer provides effective at-home treatment. (southernstates.com)
  • It is advised that you repeat the dog wormer treatment at least every six months. (chewy.com)
Clinical2
  • Authored by Jennifer F. Friedman, M.D., Ph.D., MPH, director of clinical studies for the Center for International Health Research at Rhode Island Hospital, the study found that praziquantel does not lead to adverse events for the pregnant woman or her newborn. (freshinechem.com)
  • While species identification on gross morphologic appearance is difficult, it may not have much clinical relevance as treatment of Diphyllobothriasis is the same regardless of the species. (medscape.com)
World Health Organ2
  • In mass prevention campaigns for which the World Health Organization (WHO) has determined that the benefit of treatment outweighs the risk, WHO encourages the use of praziquantel in any stage of pregnancy. (cdc.gov)
  • Despite World Health Organization recommendations to offer pregnant women treatment with praziquantel, many nations continue to withhold treatment, awaiting safety and efficacy data from controlled drug trials such as this one. (freshinechem.com)
Tapeworm treatment1
  • The pet travel scheme rules state that animals imported to the UK must have a rabies vaccine and tapeworm treatment, but this does not take account of the fact that the animal may be developing another disease for which vaccination would have little or no effect. (vethelpdirect.com)
Morbidity1
  • The reduction in the cytokine levels can be directly related to the influence of the drug praziquantel, modulating the cytokine response by elimination of adult worms, decline in parasitic load, and reduction of morbidity. (hindawi.com)
20011
  • The chemotherapeutic trial presented in This study was carried out in the first 6 this study is the first attempt in Iraq to try months of 2001 in Basra Maternity Hospitt to identify alternatives to metronidazole, tal, the main centre for gynaecology and obt the only currently available treatment for stetrics in the city. (who.int)
Parasite1
Niclosamide1
Topical2
  • Topical praziquantel as a new treatment for perioral dermatitis: results of a randomized vehicle-controlled pilot study. (qxmd.com)
  • Recently, a combination of emodepside and praziquantel (Profender®, Bayer Health Care group, Leverkusen, Germany) for topical application may be a promising alternative treatment option for the veterinarian. (vin.com)
Efficacy2
  • To evaluate the safety, efficacy and tolerability of praziquantel 3% ointment as monotherapy. (qxmd.com)
  • We recommend the use of the egg reduction rate (ERR) formula recommended by the WHO for assessing praziquantel efficacy in order for the results to be comparable for different regions. (biomedcentral.com)
Drug6
  • There are 100 drug interactions with praziquantel. (drugs.com)
  • The drug cimetidine heightens praziquantel bioavailability. (wikipedia.org)
  • Use of the Combination Emodepside/Praziquantel in Reptiles: A New Drug for Endoparasite Management? (vin.com)
  • Drug treatment has not been well studied in cats. (vethelpdirect.com)
  • The possibility of finding these candidates is empowered by the significant impact (effect size) of drug response phenotypes such as adverse drug reactions and treatment outcomes, in contrast to other complex traits such as disease susceptibility and health [ Reference Maranville and Cox 2 ]. (cambridge.org)
  • Further, there are concerns about the extent to which populations are either under treated or over treated with donated praziquantel where data are not adequate or appropriately used to determine focal endemic areas for mass drug administration (MDA) targeting. (who.int)
Preventive2
  • In 2012, at least 249 million people required preventive treatment and only 42.1 million were reported to have been treated [ 2 ]. (biomedcentral.com)
  • The prevalence of lymphatic filariasis has been reduced in some countries,4 thanks to regular provision of preventive chemotherapy for more than 53 million people through the community- directed treatment strategy. (who.int)
Plasma concentrations1
Inflammation2
  • Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation. (greenmedinfo.com)
  • Early treatment is essential, as chronic bladder inflammation can lead to squamous metaplasia and squamous cell carcinoma. (appliedradiology.com)
Regimens1
  • TB360 trade name] should not be used for intermittent treatment regimens. (who.int)
Stool1
  • Stool examination was are considered to be food delicacies repeated after treatment. (cdc.gov)
Cysts1
  • Mike Miller] Since this treatment you describe can be dangerous, is there an alternative for people with known brain cysts? (cdc.gov)
Infection3
  • With treatment, the tapeworm infection goes away. (medlineplus.gov)
  • Infection may recur despite treatment. (vethelpdirect.com)
  • Two months after infection, the animals received treatments, and after 15 days they were evaluated for the treatment effect. (bvsalud.org)
Lesions2
  • Integumental lesions are likely the result of the interaction of praziquantel with cutaneous phospholipids and proteins. (vin.com)
  • Curcumin treatment attenuates liver lesions induced by intestinal ischemia/reperfusion. (greenmedinfo.com)
Formulation3
  • A pediatric formulation is desperately needed to develop an adequate treatment for the most vulnerable age group. (astellas.com)
  • The objective of this partnership is to develop a formulation of praziquantel more suited to young children. (astellas.com)
  • Astellas Pharma Inc. contributes to the development of the first ever pediatric formulation of praziquantel by utilizing its innovative pharmaceutical technologies that help improve convenience of use and functionality through the removal of praziquantel's bitter taste. (astellas.com)
Tablets2
Humans1
  • In humans there are strict guidelines for rapid treatment known as Post Exposure Prophylaxis. (vethelpdirect.com)
Oral1
Prevention4
  • However, the available evidence suggests no difference in adverse birth outcomes in the children of women who were accidentally treated with praziquantel during mass prevention campaigns compared with those who were not. (cdc.gov)
  • According to WHO guidelines for mass prevention campaigns, the use of praziquantel during lactation is encouraged. (cdc.gov)
  • TB360 trade name] is indicated in children weighing less than 25 kg, for the prevention and treatment of tuberculosis caused by the bacterium Mycobacterium tuberculosis . (who.int)
  • With significant improvement in treatment and prevention of cardiovascular diseases, cancer has or will soon become the number. (academicjournals.org)
Echinococcus1
  • Praziquantel is also effective against Echinococcus multilocularis. (wikipedia.org)
Pregnant women1
  • Praziquantel is pregnancy category B. There are no adequate and well-controlled studies in pregnant women. (cdc.gov)
Pyrantel1
  • praziquantel is also often used in fixed combination with pyrantel embonate against the roundworms (ascarids): Toxocara cati and Toxascaris leonina. (wikipedia.org)
Interactions1
Adequate1
  • Globally, more than 200 million people are infected and would require treatment, mainly in developing countries with limited access to safe drinking water and adequate sanitation. (astellas.com)
Diseases1
Pregnancy2
  • Sensitivity reactions: Urticaria, rash, pruritus and eosinophilia in white blood cell counts Other locations/body as a whole: Lower back pain, myalgia, arthralgia, fever, sweating, various cardiac arrhythmias, and hypotension The WHO states praziquantel is safe during pregnancy. (wikipedia.org)
  • Millions of women, many of whom are in a multi-year, cyclical pattern of pregnancy and breast-feeding, are denied praziquantel," said Friedman. (freshinechem.com)
Improves1
  • Praziquantel ointment 3% effectively improves POD symptoms and QOL. (qxmd.com)
Liver1
  • Curcumin treatment attenuates lipopolysaccharide induced liver injury. (greenmedinfo.com)
Adults1
  • Treatment currently focuses on adults and school-aged children, but many preschool children are also infected. (astellas.com)
Adverse1
  • No serious treatment-related adverse events occurred in either group. (qxmd.com)
Accumulation1
  • The accumulation of evidence shows that commencement of this treatment after the first trimester does not adversely affect the mother or fetus. (freshinechem.com)
Experimental1
  • The drug's mode of action is not exactly known at present, but experimental evidence indicates praziquantel increases the permeability of the membranes of schistosome cells towards calcium ions. (wikipedia.org)
Compounds1
  • To cope with and overcome these problems, combined use of drugs, i.e., praziquantel and other newly introduced compounds such as triclabendazole, artemisinins, and tribendimidine, is being tried. (qxmd.com)
Cestodes1
  • The severe contractions observed in cestodes appear within seconds after exposure to praziquantel and this is soon followed by the loss of sucker concavity. (vin.com)