Treating patients with relapsed patients with relapsed. Medical search. Frequent questions

Genetic tests look at the unique genetic material (genes) of patients' tumor cells. (memorialcare.org)
To demonstrate safety and feasibility of ipilimumab and nivolumab at the standard doses of drug in solid tumor and relapsed refractory HIV-classical Hodgkin lymphoma (cHL) participants with human immunodeficiency virus (HIV) infection given the possibility of increased toxicity based on immune activation, co-morbidity, or interference with highly active antiretroviral therapy (HAART) therapy. (ucsd.edu)
PURPOSE: This is a 2-part study of pembrolizumab (MK-3475) in pediatric participants who have either advanced melanoma or a programmed cell death ligand 1 (PD-L1)-positive advanced, relapsed or refractory solid tumor or lymphoma. (cincinnatichildrens.org)
Investigators report that bendamustine/rituximab debulking appears to decrease tumor lysis syndrome risk in patients with previously untreated chronic lymphocytic leukemia. (cancernetwork.com)
There were 17 odontogenic keratocyst tumor treated in the period of 10 years. (bvsalud.org)
Circulating tumor DNA predicts response in Chinese patients with relapsed or refractory classical hodgkin lymphoma treated with sintilimab. (cdc.gov)

Approximately 15-25% of patients respond to conservative therapy, which allows for the reconstitution of normal colonic flora and reduces the risk of relapse. (medscape.com)
A recent study shows that metacognitive therapy significantly reduces the risk of relapse. (eurekalert.org)

So it makes sense to use rituximab along with pentostatin as a comparator to bendamustine and rituximab for patients with multiply relapsed or refractory disease. (cancer.gov)

This randomized phase I/II trial studies the side effects and best dose of pomalidomide and ixazomib when given together with dexamethasone and to see how well pomalidomide and dexamethasone with or without ixazomib works in treating patients with multiple myeloma that has come back. (clinicaltrialsgps.com)
It is not yet known whether pomalidomide and dexamethasone are more effective with or without ixazomib in treating multiple myeloma. (clinicaltrialsgps.com)
What Is the Life Expectancy for Relapsed Multiple Myeloma? (healthline.com)
It's possible to live for many years following a relapse of multiple myeloma. (healthline.com)
Relapse is common with multiple myeloma. (healthline.com)
Many people with multiple myeloma experience several periods of remission, followed by relapse. (healthline.com)
This article will discuss the life expectancy for people with multiple myeloma after relapse. (healthline.com)
How long can you live after a relapse in multiple myeloma? (healthline.com)
You can live for many years after a relapse of multiple myeloma. (healthline.com)
In a 2016 study that included 511 people with multiple myeloma, the median time to first relapse was 26.9 months. (healthline.com)
But research shows that some people diagnosed with multiple myeloma survive for over 20 years without experiencing a relapse. (healthline.com)
In another retrospective study published in 2020, which included 300 people with multiple myeloma after first relapse, the median overall survival was 44.8 months. (healthline.com)
What happens when multiple myeloma relapses? (healthline.com)
To officially diagnose a relapse, doctors will rely on the results of several imaging, urine, and blood tests to see whether you meet the criteria from the International Myeloma Working Group. (healthline.com)
How many times can myeloma relapse? (healthline.com)
According to the International Myeloma Foundation , an early relapse refers to the first, second, or third time the myeloma progresses after a period of remission. (healthline.com)
CHICAGO and RARITAN, NJ, June 4, 2017 - Janssen Research & Development, LLC today announced new data from updated analyses of the pivotal Phase 3 CASTOR and POLLUX clinical studies, demonstrating that DARZALEX ® (daratumumab) in combination with bortezomib and dexamethasone, or lenalidomide and dexamethasone, improved progression-free survival (PFS) and the overall response rate (ORR) for previously-treated patients with multiple myeloma, regardless of cytogenetic risk. (jnj.com)
Additionally, data from the Phase 1b MMY1001 study will show the potential of daratumumab in combination with carfilzomib, lenalidomide and dexamethasone (KRd) for newly diagnosed patients with multiple myeloma. (jnj.com)
3 After initial therapy, it is common for individuals with multiple myeloma to become less responsive to therapy or eventually experience a relapse, when the cancer returns. (novartis.com)
Some patients also become refractory, which means they stop responding to treatment and still have myeloma cells in their bone marrow. (novartis.com)
3 Approximately 75,000 patients around the world are living with relapsed or refractory multiple myeloma. (novartis.com)
Throughout the multiple myeloma journey, a treatment team works with the patient to introduce different therapy combinations to address treatment resistance and/or disease progression. (novartis.com)
Proteasome inhibitors represented by bortezomib (BTZ) have been the main treatment for patients with newly diagnosed and relapsed or refractory myeloma in nearly two decades. (bvsalud.org)

Twenty-four patients were enrolled prospectively and were treated with unlabeled rituximab 70 mg and a therapeutic activity (median 7.3 GBq) of 131 I-rituximab. (karger.com)
Within the subgroups of patients with node-positive disease or who were treated with L, the hazard of relapse was significantly greater for patients with GGI at or above the median. (biomedcentral.com)
The SADAL study evaluated single-agent oral selinexor in patients with RR DLBCL and demonstrated an overall response rate (ORR) of 29.1% with median duration of response (DOR) of 9.3 months. (biomedcentral.com)
Among patients with or without prior ASCT, the median OS was 10.9 and 7.8 months, respectively. (biomedcentral.com)
Among patients with disease refractory to the most recent DLBCL treatment regimen, the median OS was 7.0 months compared with 11.1 months for disease not refractory to the most recent treatment. (biomedcentral.com)
Increased median OS observed in patients responding to selinexor was consistent across subgroups regardless of age, prior ASCT therapy, or refractory status. (biomedcentral.com)
In the same 2016 study, the median overall survival in patients who received a stem cell transplant and relapsed within 12 months was 23.1 months, compared to 122.2 months in those who relapsed after 12 months. (healthline.com)
At 15 months median follow-up, there were four cases of clinical CHF during treatment (1.7%), including one patient during TH and three after receiving the AC regimen. (cancernetwork.com)
In a publication on 225 patients, primarily with Hb SS disease, data shows that even though 60% of patients were taking hydroxyurea, the median survival age was only 48 years. (nih.gov)
Median age of patients was 38 years (range = 1-91 years). (cdc.gov)
The median age of patients with elevated amylase was 65 years. (bvsalud.org)

It was the aim of this paper to identify prognostic factors in patients with relapsed or refractory B-cell non-Hodgkin's lymphomas, treated by radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab ( 131 I-rituximab). (karger.com)
In this interview, we discuss the results of the phase III MURANO trial, which tested the combination of venetoclax with rituximab in relapsed/refractory CLL. (cancernetwork.com)
Randomized Phase II Trial of Rituximab with Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia (NCI-10-C-0025). (cancer.gov)
Moreover, rituximab has been used successfully to treat some patients with hairy cell leukemia who have relapsed or not responded to previous chemotherapy. (cancer.gov)
Although the hairy cells that remain after cladribine or pentostatin treatment are essentially always CD20 positive, only a minority of patients respond to rituximab therapy alone. (cancer.gov)
However, combinations of rituximab and either cladribine or pentostatin seem to be highly effective in nearly all patients. (cancer.gov)
Dr. Kreitman is currently directing a randomized clinical trial of rituximab with cladribine in newly diagnosed (untreated) patients and patients who have had only one prior course of cladribine, but no prospective trial has yet evaluated rituximab with pentostatin in patients with hairy cell leukemia. (cancer.gov)
NCI researchers think that combining bendamustine and rituximab may prove effective in treating patients with multiply relapsed or refractory hairy cell leukemia. (cancer.gov)
In this trial, patients with hairy cell leukemia who have not responded to initial chemotherapy followed by second-line treatment with rituximab, or who have relapsed following two courses of chemotherapy, will be randomly assigned to receive rituximab combined with either pentostatin or bendamustine. (cancer.gov)

Clinical-stage biopharmaceutical company Nkarta has treated its first patient in the first-in-human Phase I clinical trial of NKX101, an investigational immunotherapy designed to treat relapsed/refractory acute myeloid leukemia (AML) or higher-risk myelodysplastic syndromes (MDS). (biospace.com)
In the Phase 1b clinical trial on 84 patients with non-Hodgkin's lymphoma and acute lymphocytic leukemia, the use of azer-cel has demonstrated "clinically-meaningful results" with an acceptable safety profile. (smallcaps.com.au)
Adults with relapsed or refractory B-precursor acute lymphoblastic leukaemia have an unfavourable prognosis. (nih.gov)
Single-agent blinatumomab showed antileukaemia activity in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia characterised by negative prognostic factors. (nih.gov)
This phase II trial studies how well inotuzumab ozogamicin works in treating younger patients with B-lymphoblastic lymphoma or CD22 positive B acute lymphoblastic leukemia that has come back (relapsed) or does not respond to treatment (refractory). (luriechildrens.org)
Objective: To investigate the effect of evobrutinib on immune responses in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinated patients with RMS from a Phase II trial (NCT02975349). (uab.cat)
If not treated promptly, malaria may progress to severe disease, a life-threatening stage, in which mental status changes, seizures, renal failure, acute respiratory distress syndrome, and coma may occur. (cdc.gov)
Acute GvHD contributes significantly to non-relapse morbidity and mortality (NRM), thus prevention or control of this severe complication is necessary. (frontiersin.org)
Eight patients from the first NGFR-HSV-TK-studies developed acute ( n = 6) or chronic GvHD ( n = 2), which resolved after treatment with GCV alone in seven of eight patients. (frontiersin.org)
patients experience unilateral onset of acute orbital pain and ophthalmoparesis, and the disorder may threaten sight if untreated inflammation extends beyond the cavernous sinus to affect the optic nerve. (medscape.com)

Additionally, this research has demonstrated clinical responses in patients with relapsed/refractory AML who received non-engineered allogeneic NK cells as a treatment in some single-center studies. (biospace.com)
With its amplified NKG2D targeting and enhanced NK cell engineering," added Dr. Rajangam, "NKX101 has the potential to improve upon this earlier clinical experience with non-engineered NK cells and to activate a deep and robust immune response in AML patients. (biospace.com)
We have previously shown that the Gene expression Grade Index (GGI) was able to identify two subtypes of estrogen receptor (ER)-positive tumors that were associated with statistically distinct clinical outcomes in both untreated and tamoxifen-treated patients. (biomedcentral.com)
The licence grants Imugene the potential to start a registration-enabling clinical study in 2024 for patients with third and fourth line diffuse large B cell lymphoma and other blood cancer indications. (smallcaps.com.au)
Background: Evobrutinib is an oral, central nervous system (CNS)-penetrant and highly selective covalent Bruton's tyrosine kinase inhibitor under clinical development for patients with relapsing multiple sclerosis (RMS). (uab.cat)
My particular clinical interests include integration of comprehensive leukemia genetic data with therapy selection for children with high risk newly-diagnosed and relapsed ALL and AML with a focus on precision medicine treatment approaches. (upenn.edu)
I am a primary clinical mentor in Hematologic Malignancies for first, second, third, and fourth year pediatric hematology-oncology fellows and closely supervise their patient care in the inpatient and outpatient clinical settings. (upenn.edu)
I am an experienced early-phase clinical trialist and current serve as a steering member of the COG ALL committee, the COG Myeloid Diseases Vice-Chair of Relapse, the LLS PedAL Clinical Trials Leader, and the COG Developmental Therapeutics committee Vice-Chair of Biology for Hematologic Malignancies. (upenn.edu)
The sNDA is supported by the landmark P aliperidone Palmitate R esearch I n D emonstrating E ffectiveness study (PRIDE), which is the first prospective, randomized clinical trial to evaluate schizophrenia treatments within the context of many "real world" issues faced by patients in their daily lives, including one of the most challenging circumstances - recent incarceration. (jnj.com)
This draft decision from NICE is hugely disappointing for patients and the clinical community as we are at risk of losing access to a highly effective treatment that has rapidly become standard of care in relapsed or refractory Hodgkin lymphoma. (hospitalhealthcare.com)
I would urge Takeda and the clinical community to work with NICE during this consultation period, to both ensure that all eligible patients in England continue to have access to brentuximab vedotin and that the whole of the UK remains at the forefront of the management and research of Hodgkin lymphoma. (hospitalhealthcare.com)
The characteristic clinical feature of TBRF is the occurrence of febrile episodes lasting 3‒5 days, with relapses after 5 to 7 days of apparent recovery. (cdc.gov)
7] there primary breast tumors could be used to predict disease is an evident correlation between clinical outcome for the recurrence better than currently available clinical and patients and ER- status of the tumors. (lu.se)
Clinical outcome for the patients is represented by M+ (distant recurrences within 6 years) and M- (no recurrences within a follow-up vised clustering was into two groups based on ER- period of at least 5 years). (lu.se)
This prospective study was conducted to ascertain the degree of elevated amylase, its clinical utility, and implications in MM patients. (bvsalud.org)

Determine the time to progression and overall survival of patients treated with this drug. (knowcancer.com)
This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival. (memorialcare.org)
The analyses described here evaluated a number of subpopulations in order to understand how response correlates with survival outcomes in order to identify patients who could most optimally benefit from selinexor treatment. (biomedcentral.com)
My overarching career goal as an academic pediatric oncologist and translational physician-scientist is to develop successful precision medicine therapies for children with high-risk leukemias aimed at decreasing relapse risk, minimizing toxicity, and improving long-term survival. (upenn.edu)
In another paper, the cumulative survival in 150 adults was followed from 2003 to 2016 and patients were screened for heart, lung, and kidney disease. (nih.gov)
It is also concerning that this decision could potentially deny patients at high risk of relapse post-ASCT access to a valuable new treatment approach that has been shown to improve progression free survival in this patient population. (hospitalhealthcare.com)
Limitations were slow recruitment, lack of enrolling patients without radical local treatment, and too short follow-up for evaluation of overall survival in patients with PSA relapse. (lu.se)
Confirmatory studies of the efficacy of docetaxel in the setting of PSA-only relapse in addition to endocrine therapies may be justified if longer follow-up will show increased metastatic-free survival. (lu.se)
Higher mortality (29.4% versus 17%) and shorter mean survival of (30.2 ± 3.3 months versus 51.7 + 4.9 months) were recorded in patients with elevated amylase levels in comparison to those with normal levels. (bvsalud.org)

The GGI was significantly and linearly related to risk of relapse: each 10-unit increase in GGI resulted in an increase of approximately 11% in the hazard rate (p = 0.02). (biomedcentral.com)
The FTC also alleged that their safety claim for Spontane-ES was unsubstantiated, because yohimbine creates safety risks by significantly raising blood pressure and interacting adversely with certain medications, such as beta-blockers that are used to treat heart disease. (consumeraffairs.com)
Data from a systematic review highlight a significantly higher risk of any bleeding and major bleeding in patients with treatment-naïve chronic lymphocytic leukemia treated with a second generation Bruton tyrosine kinase inhibitors. (cancernetwork.com)

Susan M. O'Brien, MD, highlights ongoing trials from 2021 examining combination therapies for patients with chronic lymphocytic leukemia. (cancernetwork.com)
Therefore, doctors are interested in finding new treatments or new combinations of existing treatments for patients with hairy cell leukemia who have relapsed or not responded to previous therapies. (cancer.gov)
Metastatic melanoma is one of the most difficult cancers to cure and recent advances in the development of targeted therapies have improved patient outcome. (edu.au)
7 Over 500 patients have since had access to brentuximab vedotin via the nCDF for the treatment of R/R HL following an ASCT or following at least two previous therapies when ASCT or multi-agent chemotherapy is not a treatment option and access will remain until the completion of this NICE appraisal. (hospitalhealthcare.com)

The primary outcome measures include the incidence of treatment-emergent adverse events and the proportion of patients experiencing dose-limiting toxicities of the therapy. (biospace.com)
Patients with AML who relapse following front-line therapy are at high risk of experiencing poor outcomes, despite recent breakthroughs in treatment research, according to a statement made by Carlos Bachier, M.D., Director of Cellular Therapy Research, Sarah Cannon Research Institute and Program Director for Sarah Cannon Center for Blood Cancer at TriStar Centennial Medical Center in Nashville, Tennessee. (biospace.com)
Patients with genetic changes or abnormalities (mutations) may benefit more from treatment which targets their tumor's particular genetic mutation, and may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas. (memorialcare.org)
All relapses (cases) were identified from patients randomized to receive monotherapy or from the switching treatment arms for whom relapse occurred before the switch. (biomedcentral.com)
To assess time to next treatment (TNT) for patients taking pomalidomide/dexamethasone/ixazomib compared to those on pomalidomide/dexamethasone. (clinicaltrialsgps.com)
After completion of study treatment, patients are followed up every 4 weeks until disease progression and then every 3 months for 3 years. (clinicaltrialsgps.com)
To preliminarily assess objective response rates associated with treatment for commonly represented solid tumors (Kaposi sarcoma, anal cancer , and lung cancer ) and relapsed refractory HIV-cHL. (ucsd.edu)
In very mild cases (ie, patients without fever, abdominal pain, or leukocytosis), in patients who do not have other comorbidities, cessation of causative antibiotics may be the only treatment necessary. (medscape.com)
Whereas metronidazole is the recommended first-line treatment for mild to moderate disease without complications, vancomycin is recommended first-line therapy for severe infection or for patients with risk factors for adverse outcomes, such as advanced age, critical illness, overall debility, or inflammatory bowel disease (IBD). (medscape.com)
In another study, a review of 11 trials (1463 adult patients total) comparing metronidazole with vancomycin or another agent, combined agents, or placebo, neither vancomycin nor fidaxomicin were clearly superior for the initial treatment of CDI. (medscape.com)
All patients have received treatment and are improving. (cdc.gov)
Research findings show that one and a half years after the end of treatment, only about 30 per cent of patients are still healthy. (eurekalert.org)
We found that about 67 to 73 per cent of patients, depending on how you measure it, were still classified recovered one year after the end of treatment. (eurekalert.org)
The researchers reported that participants in the study had a lower rate of relapse than what is found with other treatment methods. (eurekalert.org)
Between 67 and 73 per cent were still healthy one year following treatment, according to patient questionnaire responses. (eurekalert.org)
In Multiple Sclerosis Interferonb has been used as a first line treatment regimen for the past 15 years and many patients have shown therapeutic benefit and continue to do so from this 'natural' immune modulator. (hrb.ie)
Despite prophylactic treatment of the patients with immunosuppressive drugs after allo-HSCT, GvHD is still associated with non-relapse mortality (NRM) and contributes around 25% of NRM. (frontiersin.org)
Patients with chronic lymphocytic leukemia and small lymphocytic lymphoma can now receive treatment with pirtobrutinib. (cancernetwork.com)
Data from the phase 1/2 TRANSCEND CLL 004 study support an application for liso-cel as a treatment for patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. (cancernetwork.com)
Because the longer elimination half-life of etretinate would increase the duration of teratogenic potential for female patients, ethanol must not be ingested by female patients of childbearing potential either during treatment with SORIATANE or for 2 months after cessation of therapy. (nih.gov)
Lack of consistent treatment, when and where people with schizophrenia need it, can put patients at risk for relapse, possibly leading to disability, homelessness, incarceration and other serious consequences," said Michelle Kramer, Vice President, U.S. Neuroscience Medical Affairs, Janssen. (jnj.com)
PRIDE assessed as its primary endpoint time to treatment failure, which is a subset of relapse. (jnj.com)
Patients were randomized to paclitaxel 175 mg/m² every 3 weeks for 4 weeks plus trastuzumab for 10 weeks followed by AC (60/600 mg/m²) every 3 weeks for 4 weeks, or to the same treatment with trastuzumab given for 52 weeks. (cancernetwork.com)
Exercise plus the antisense treatment provides more benefit for patients with myotonic dystrophy. (medindia.net)
Is Stem Cell Therapy Safe for Relapsing-Remitting Multiple Sclerosis Treatment? (medindia.net)
Groundbreaking gene therapy for genetic beta thalassemia is now accessible as a treatment to a patient post-FDA approval. (medindia.net)
However, most patients and doctors prefer cladribine because the typical course of treatment lasts 5-7 days as opposed to 3-6 months or longer with pentostatin. (cancer.gov)
Should this decision be made final within the Final Appraisal Determination (FAD) expected in January 2017, it would mean that patients in England would be denied access to a medicine that has transformed treatment paradigms and given many patients the opportunity to achieve a potential cure with or without a stem cell transplant. (hospitalhealthcare.com)
Brentuximab vedotin is being reviewed by NICE for the initial launch indications and also for a new indication, granted marketing authorisation by the European Commission in June 2016, for the treatment of patients with CD30+ HL at increased risk of relapse or progression following ASCT. (hospitalhealthcare.com)
The decision means patients will be denied access to a treatment option that has been successful for a number of patients and, consequently, will limit positive outcomes for this group of patients some of whom could be cured. (hospitalhealthcare.com)
Background: Historically, endocrine therapy was used in a range of scenarios in patients with rising PSA, both as a treatment for locally advanced non-metastatic prostate cancer and PSA recurrence following curative intended therapy. (lu.se)
315 patients had PSA relapse after radical treatment, 33 patients had no prior local therapy. (lu.se)
Even when coinfected patients receive proper treatment, they relapse repeatedly and the outcome frequently is fatal. (who.int)
10. As a rule, patients have to overcome major logistic problems in order to access treatment: long distances to the treatment centre, lack of transport, treatment is unaffordable, or its costs pose a serious financial burden. (who.int)
For these reasons, patients may not comply with treatment (if they began) and drug resistance may emerge. (who.int)
Gimenez-Roldan et al have reported that relapses may occur as long as 13 years after initial diagnosis and treatment. (medscape.com)
Patients should have an idea of the differential diagnosis of Tolosa-Hunt syndrome and report any new symptoms or side effects from treatment to the physician. (medscape.com)
Gene expression profiling of tumors using DNA microarrays is a promising method for predicting prognosis and treatment response in cancer patients. (lu.se)
We conclude that the idealization of abstinence objective is inseparable from the constant threat of relapse represented as any psychoactive substance consumption during or after treatment. (bvsalud.org)
In one side, there is the crack user and peculiarities of the addict individuals, and, on the other hand, the need for complex multiprofessional and interdisciplinary treatment, with actions on relapse process and management for any lapses. (bvsalud.org)
Standard treatment between dogmatisme and judgement patients with malaria cases at [French]. (cdc.gov)
Among the cases, 10 relapsed (58.8%) after primary treatment. (bvsalud.org)

PURPOSE: This phase II trial is studying how well lenalidomide works in treating patients with relapsed mycosis fungoides/Sezary syndrome. (stanford.edu)

In the broader group of patients with relapsed/refractory non-Hodgkin's lymphoma, azer-cel showed a 58% overall response rate and 41% complete response rate across all doses and lymphodepletion (chemotherapy) regimens. (smallcaps.com.au)
Hairy cell leukemia is usually treated with a chemotherapy drug called cladribine when signs or symptoms of the disease develop, such as low blood cell counts, recurrent infections, or a swollen spleen. (cancer.gov)

The Medical Research Charities Group (MRCG) is the national organization of 35 patient groups and foundations which promote an improved environment for medical research in general and for charities in particular, obtain funding for research projects, bring together organizations working in the field and disseminate the outcomes. (hrb.ie)

ABSTRACT A longitudinal study was done in a leishmaniasis-endemic region in eastern Sudan during the period November 2001-February 2003 to determine the incidence of failure of sodium stibogluconate treat- ment. (who.int)
All were treated with sodium stibogluconate, 20 mg/kg body weight for at least 28 days. (who.int)

In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia. (nih.gov)
But if the signs and symptoms of your cancer reappear after a period of remission, your cancer is considered relapsed. (healthline.com)
Once you enter remission, your doctor will monitor your blood work regularly to check for signs of a relapse. (healthline.com)
Every time you relapse, however, it can become more difficult to achieve remission. (healthline.com)
Patients usually respond to corticosteroids, and spontaneous remission can occur, although permanent ocular motor deficits may remain. (medscape.com)
patients who have experienced spontaneous remission appear to have as much risk of reoccurrence as those treated with medication. (medscape.com)

In this interview we discuss prognostic models that may be able to predict disease progression in patients with chronic lymphocytic leukemia treated with the targeted agent ibrutinib. (cancernetwork.com)

A relapse is also known as a recurrence. (healthline.com)
One study in the review, however, showed CDI recurrence in only 15% of patients treated with fidaxomicin, compared with 25% of patients treated with vancomycin. (medscape.com)

This phase I trial studies the side effects and the best dose of wild-type reovirus (viral therapy) when given with sargramostim in treating younger patients with high grade brain tumors that have come back or that have not responded to standard therapy. (mayo.edu)
Most breast cancer patients whose tumors express the estrogen receptor (ER) receive endocrine therapy. (biomedcentral.com)
Giving ipilimumab with nivolumab may work better in treating patients with HIV associated classical Hodgkin lymphoma or solid tumors compared to ipilimumab with nivolumab alone. (ucsd.edu)
A Phase 3 study of active surveillance for low risk and a randomized trial of carboplatin vs.cisplatin for standard risk pediatric and adult patients with germ cell tumors. (nebraskamed.com)

To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)

Here, we aim to investigate the ability of the GGI to predict relapses in postmenopausal women who were treated with tamoxifen (T) or letrozole (L) within the BIG 1-98 trial. (biomedcentral.com)
Must have selected and have committed to use 2 effective forms of contraception (birth control) simultaneously, at least 1 of which must be a primary form, unless absolute abstinence is the chosen method, or the patient has undergone a hysterectomy or is clearly postmenopausal. (nih.gov)

Current control of visceral leishmania- is associated with high morbidity and mor- sis is based on case detection and treat- tality of untreated patients. (who.int)

Your outlook depends on a number of factors, including the length of time since your last relapse and which treatments you have tried. (healthline.com)
The main aim of this project is to develop a symptom management self care tool for patient with relapsed MM. MM is incurable and as a result of all novel treatments available patients live longer but not always with a exceptional QOL due to symptom burden. (hrb.ie)
We would urge Takeda, NICE and clinicians to work together to reassess the decision and find a cost-effective solution that would ensure patients in England have access to the best possible treatments available and to avoid a postcode lottery across the UK. (hospitalhealthcare.com)
Treatments for BRCA mutation-positive hormone-relapsed meta. (bvsalud.org)

All participants in the trial are adults living with relapsed/refractory AML or higher-risk MDS. (biospace.com)
To determine whether administration of eflornithine (DFMO) in combination with dinutuximab, irinotecan hydrochloride (irinotecan) and temozolomide results in an improved response rate compared to dinutuximab, irinotecan and temozolomide in patients with relapsed or refractory neuroblastoma and therefore is a therapeutic regimen worthy of further testing in patients with newly-diagnosed high-risk neuroblastoma. (arnoldpalmerhospital.com)
These compelling findings from the Phase 3 CASTOR and POLLUX trials show daratumumab delivered deep and durable responses for previously-treated patients, regardless of cytogenetic risk," said Dr. Katja Weisel, Associate Professor, Department of Hematology and Oncology, University Hospital of Tuebingen, Tuebingen, Germany. (jnj.com)
p=0.0053) in patients with high risk cytogenetics (n=44) compared to Vd alone. (jnj.com)
The second aim of this study is to sequence the TCR receptors of participating patients and identify TCR motifs that may indicate a predisposition to (or protection from) severe SARS-CoV-2, leading to possible risk stratification of such patients, and whether or not age, gender or ethnicity has any contribution to said risk. (mayoclinic.org)
CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
Family history of venous thromboembolism and risk of hospitalized thromboembolism in cancer patients: A nationwide family study. (cdc.gov)
Familial Risk in Patients With Carcinoma of Unknown Primary. (cdc.gov)

Application of state of the art raman chemical imaging and chemometrics to accelerate and improve patient prostate biopsy assessment for cancer. (hrb.ie)
ECOG 2198 examined the cardiac effects of paclitaxel plus trastuzumab (TH) given prior to doxorubicin plus cyclophosphamide (AC) in 234 HER-2-positive (2+ or 3+) stage II breast cancer patients. (cancernetwork.com)
Treating Multiply Relapsed or Refractory Hairy Cell Leukemia was originally published by the National Cancer Institute. (cancer.gov)
The news that Hodgkin lymphoma patients could lose access to a drug that has been available for some time through the former Cancer Drugs Fund is of concern. (hospitalhealthcare.com)
This evaluation uses new cost-effectiveness estimates to update olaparib for previously treated BRCA mutation-positive hormone-relapsed metastatic prostate cancer (NICE technology appraisal guidance TA831). (bvsalud.org)
Evidence-based recommendations on olaparib (Lynparza) for previously treated BRCA mutation-positive hormone-relapsed metastatic prostate cancer in adults. (bvsalud.org)

Parasites were isolated from lymph node aspirates from 22 participants identified as relapsed patients. (who.int)
Les parasites ont été isolés dans les échantillons prélevés par aspiration dans les ganglions lymphatiques de 22 participants identifiés comme patients ayant rechuté. (who.int)

Azer-cel continues to demonstrate promising results in diffuse large B cell lymphoma patients who relapsed following CAR T, and high overall response rates with molecular remissions in this patient setting are encouraging," Ms Chong said. (smallcaps.com.au)
Most people will experience several remissions and relapses throughout their disease course. (healthline.com)

Endoscopic findings may be normal in patients with mild disease or may demonstrate nonspecific colitis in moderate cases. (medscape.com)
Oral metronidazole and oral vancomycin have similar efficacy rates in treating diarrhea caused by C difficile in mild to moderate infection but not in severe disease. (medscape.com)
The Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) recommend a regimen of metronidazole (500 mg PO TID for 10-14 days) as first-line therapy for mild to moderate disease without complications (lower cost and similar efficacy to PO vancomycin in these patients). (medscape.com)
The course of schizophrenia is varied for some patients, often fluctuating between a series of relapses, or return of disease after partial recovery. (jnj.com)
This study provides preliminary answers to at least two questions: How effective should scientists expect gene therapy for this disease will be in actual patients? (medindia.net)
The majority of these patients will have received only cladribine, but because pentostatin works differently, some patients with disease that is refractory to cladribine may be sensitive to pentostatin. (cancer.gov)
Conclusion: Docetaxel improved PFS in patients starting bicalutamide due to PSA relapse after local therapy or localized disease without local therapy. (lu.se)

Determine the frequency and duration of complete and partial response rates for patients with relapsed or refractory indolent lymphoproliferative disorders treated with ixabepilone. (knowcancer.com)
The initial diagnostic evaluation of patients with any lymphoproliferative malignancy should include a careful history and physical examination, with close attention paid to the presence of systemic B symptoms, lymph node involvement, organomegaly, and evidence of cutaneous involvement. (medscape.com)

In addition to routinely considering malaria as a cause of febrile illness among patients with a history of international travel to areas where malaria is transmitted , clinicians should consider a malaria diagnosis in any person with a fever of unknown origin regardless of their travel history. (cdc.gov)
Tickborne relapsing fever (TBRF) is a zoonosis caused by spirochetes of the genus Borrelia and transmitted to humans by ticks of the genus Ornithodoros . (cdc.gov)
One event of neutropenic infection/fever occurred in 27% of the patients receiving docetaxel. (lu.se)

Conclusion: These results suggest evobrutinib, an investigational drug with therapeutic potential for patients with RMS, acts as an immunomodulator, that is, it inhibits aberrant immune cell responses in patients with RMS, while responsiveness to foreign de novo and recall antigens is maintained. (uab.cat)

She subsequently relapsed and was placed on trastuzumab, an ACE inhibitor, and a diuretic. (cancernetwork.com)

PROJECTED ACCRUAL: A total of 35 patients will be accrued for this study within 1-1.5 years. (knowcancer.com)
44.8% of patients were ≥ 70 years of age. (biomedcentral.com)
70 years had an OS of 11.1 months compared with 7.8 months in patients ≥ 70 years. (biomedcentral.com)
In CLARIFY-MS (NCT03369665), patients with highly active relapsing MS were assigned to receive CladT 3.5 mg/kg cumulative dose over 2 years. (pairscongress.com)
Of the 482 patients treated with CladT, 70.1% were female and the mean age was 37.4 years. (pairscongress.com)
Ten years down the road, what are we going to see in these patients? (abcactionnews.com)
Although responses to cladribine and pentostatin can last years or even decades, these drugs do not appear to cure most patients. (cancer.gov)

Azer-cel is being marketed as a potential first-in-class allogeneic CD19 CAR T candidate for a growing population of CAR T-relapsed patients with diffuse large B cell lymphoma. (smallcaps.com.au)
Notably, the azer-cel data was stronger in patients with diffuse large B cell lymphoma who had relapsed. (smallcaps.com.au)
For patient education information, see Lymphoma . (medscape.com)
Takeda UK Ltd has announced that brentuximab vedotin (Adcetris ® ), a medicine that has rapidly become standard of care for patients with relapsed/refractory Hodgkin's lymphoma (R/R HL), 1 has received a negative recommendation within draft guidance from the National Institute for Health and Care Excellence (NICE). (hospitalhealthcare.com)
Brentuximab vedotin has been a game changer in the management of relapsed or refractory Hodgkin lymphoma and is the only licensed medicine in this setting. (hospitalhealthcare.com)

Determine the toxicity of this drug in these patients. (knowcancer.com)

While some people tend to follow a abstinence/relapse dichotomous, i.e., the centrality of the phenomenon is the psychoactive substance. (bvsalud.org)
Therefore, dependence comprises the abstinence violation and will cause the previous pattern of psychoactive use, meaning the end of the relapse (3) . (bvsalud.org)
However, in individuals who experience a "lapse" or even a "relapse", violating abstinence, there is an affective component, that is related to feelings of shame, guilt, anger and hopelessness triggered by the discrepancy between their previous abstemious identity and their current lapse or relapse behavior (7-10) . (bvsalud.org)

Tyrosine depletion does not cause depressive relapse in antidepressant-treated patients. (ox.ac.uk)
Hjemdal thinks many patients find it difficult to revisit earlier depressive episodes. (eurekalert.org)

OnCARlytics can enhance the expression of CD19 on solid tumours [while] azer-cel is a supercharged allogeneic T cell designed to identify and kill malignant cells expressing the CD19 marker… we are thrilled about the potential benefit for patients from the combination of these two technologies. (smallcaps.com.au)
32 (40%) of patients who achieved CR/CRh underwent subsequent allogeneic HSCT. (nih.gov)

The first aim of this study is to verify that the TCR beta sequencing and curation platforms we will be using are able to identify patients with severe COVID-19 based on the TCR repertoires. (mayoclinic.org)
The patients who participated in the study received ten sessions of metacognitive therapy. (eurekalert.org)
This study, carried out by researchers at the Massachusetts General Hospital (MGH) and collaborators, has implications for patients who experience fatigue due to genetics-related musculoskeletal diseases as well as other types of illness-induced fatigue. (medindia.net)
Wheeler and his colleagues' study suggests that is not the case and that the effects of exercise could be beneficial to these patients and others with similar conditions. (medindia.net)
Stopping rules were built into the study so that if too many patients either rejected their grafts or developed moderate to severe GVHD, the study would move to the 2nd cohort. (nih.gov)
Based on the three patients losing their grafts, stopping rules were met and the study moved to the 2nd cohort where 1 dose of Cy was given at 50mg/kg on day 3 post-transplant. (nih.gov)
We randomly recruited 820 visceral sistance to amphotericin B and pentamidine leishmaniasis patients to the study from has been observed [ 5 ]. (who.int)
This study aimed to verify the relapse representations of crack addict, according to Moscovici's theory. (bvsalud.org)
The study excluded patients with elevated lipase, abnormal creatinine clearance, and evidence of intestinal obstruction or perforation. (bvsalud.org)
Patients with amylase value >100 U/L were designated to have "elevated amylase level" for the purpose of this study. (bvsalud.org)

You may not always experience symptoms if you have a relapse. (healthline.com)
Unfortunately, it is typical for patients with depression to experience relapses. (eurekalert.org)
Thus patients with SCD continue to experience early mortality (DeBaun M et al. (nih.gov)
Relapses may occur (30-40% of patients may experience relapse), and patients should know that the course of any relapse often follows the original event but may require additional testing. (medscape.com)

Despite ER status being one of the most reliable biomarkers used today to predict response to endocrine therapy, such as tamoxifen or an aromatase inhibitor, a significant proportion of women still relapse, which indicates the need for additional predictive markers. (biomedcentral.com)
A pathologists' task in assessing a prostate biopsy for cancerous tissue is of prime importance since failure to correctly identify tissue can lead to a failure to accurately diagnose the patient and predict their likely prognosis. (hrb.ie)

She says they're seeing cardiovascular damage in both patients with severe COVID-19 symptoms and those with mild to no symptoms at all. (abcactionnews.com)
This may be accomplished by testing and analyzing results between two cohorts: patients presenting acutely to MCF with mild COVID-19 and patients presenting with severe COVID-19. (mayoclinic.org)
The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)

Although BTZ has improved the prognosis of MM patients, MM remains incurable in most patients, mainly because MM cells become resistant to BTZ. (bvsalud.org)

Materials and Methods: In an 18-month period, all consenting patients with newly diagnosed or relapsed MM were tested for serum amylase levels. (bvsalud.org)

Evidence-based recommendations on alemtuzumab (Lemtrada) for treating highly active relapsing-remitting multiple sclerosis in adults. (nice.org.uk)
Later relapse (fourth, fifth, and beyond) means that multiple lines of therapy have already been tried. (healthline.com)
Relapsing-remitting multiple sclerosis has been successfully treated using autologous hematopoietic stem cell therapy. (medindia.net)

In low transmission areas, give a single dose of 0.25mg/kg · primaquine with ACT to patients with P. falciparum malaria to reduce transmission. (who.int)
Five patients had 1 malaria attack, and 4 patients had up to 3 relapses. (cdc.gov)
Malaria Relapses dents. (cdc.gov)

The diagnosis of C difficile colitis should be suspected in any patient with diarrhea who has received antibiotics within the previous 3 months, has been recently hospitalized, and/or has an occurrence of diarrhea within 48 hours or more after hospitalization. (medscape.com)
The results of parasitological specifications and diagnosis should be available quality RDT's within less than two hours of the patient presenting. (who.int)

It is also important to distinguish between "lapse", which is the sporadic use of the substance, and "relapse", which refers to the usage prior to the start of the intervention (5-6) . (bvsalud.org)

C difficile infection (CDI) occurs primarily in hospitalized patients. (medscape.com)
This condition is associated with a deficient cell-mediated immunity that enables the parasite to disseminate in the subcutaneous tissues and has been reported in patients with human immunodeficiency virus (HIV) infection . (medscape.com)
Approximately 5-10% of hospitalised patients acquire an infection in hospital. (hrb.ie)

For those patients achieving a PR or better, we will assess whether the combination of pomalidomide/dexamethasone/ixazomib increases the duration of response (DOR) compared to pomalidomide/dexamethasone. (clinicaltrialsgps.com)
For patients on the pomalidomide/dexamethasone arm who opt to cross-over to the pomalidomide/dexamethasone/ixazomib arm, assessment of response rate (ORR, CBR, DCR), DOR, TNT, PFS and OS will be evaluated from date of cross-over. (clinicaltrialsgps.com)
Azer-cel achieved an 83% overall response rate and a 61% complete response rate with 55% durable response greater than or equal to six months in the difficult-to-treat auto CAR T relapse setting. (smallcaps.com.au)
1 Additionally, the daratumumab combination regimen resulted in an ORR of 82 percent vs. 62 percent (p=0.2028), with very good partial response (VGPR) or better achieved in 64 percent vs. 35 percent of patients, and CR or better achieved in 34 percent vs. 9 percent of patients. (jnj.com)
However, response is variable and almost all patients relapse with a cure remaining elusive. (edu.au)
Lack of response to the ini- niasis patients in eastern Sudan. (who.int)

Each subsequent relapse can be more difficult to treat. (healthline.com)

Clinicians and public health practitioners need to be familiar with current epidemiology and features of TBRF to adequately diagnose and treat patients and recognize that any TBRF case might indicate an ongoing source of potential exposure that needs to be investigated and eliminated. (cdc.gov)

The cutaneous form tends to heal spontaneously leaving scars which, depending on the species of Leishmania responsible, may evolve into diffuse cutaneous leishmaniasis, recidivans leishmaniasis, or mucocutaneous leishmaniasis, with disastrous aesthetic consequences for the patient. (who.int)

Organisms2

Diseases5

Chemicals and Drugs3

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science1

Health Care1

Geographicals1

Tumor6

Reduces the risk of relapse2

Refractory disease1

Myeloma23

Median11

Rituximab9

Acute10

Clinical15

Survival9

Significantly3

Therapies4

Treatment42

Lenalidomide1

Chemotherapy2

Outcomes1

Sodium stibogluconate2

Remission6

Progression1

Recurrence2

Tumors4

Hematopoietic Stem Cell Trans1

Postmenopausal2

Morbidity1

Treatments4

Risk8

Cancer6

Participants2

Remissions2

Disease7

Lymphoproliferative2

Fever3

Investigational1

Subsequently1

Years7

Lymphoma5

Toxicity1

Abstinence3

Depressive2

Allogeneic2

Study10

Experience4

Predict2

Severe3

Incurable1

Newly1

Multiple3

Malaria3

Diagnosis2

Refers1

Infection3

Response6

Subsequent1

Diagnose1

Diffuse1