Treat lymphocyte transfusion. Medical search. Frequent questions

Among all patients with metastatic castration-resistant prostate cancer treated with niraparib and abiraterone acetate plus prednisone in cohort 1 of MAGNITUDE (n = 423), 27% required a blood transfusion, including 11% who required multiple transfusions. (ascopost.com)
Among all patients with metastatic castration-resistant prostate cancer treated with talazoparib plus enzalutamide in TALAPRO-2, 39% required a blood transfusion, including 22% who required multiple transfusions. (jnccn360.org)

For the above complaints, child was shown to a doctor and was investigated and found to have hemoglobin of 3 gm percent for which blood transfusion was given and some medications were given. (pediatriconcall.com)
Blood transfusions and glucocorticoid therapy resulted in stabilization of the hemoglobin level and normalization of the bilirubin levels, which confirmed the appropriateness of this approach. (medscape.com)

The leucocyte count was normal with a differential of 65% neutrophils, 30% lymphocytes and 5%monocytes. (ispub.com)

The presence of inter-current infections, especially diarrhoea and pneumonia, in the presence of lymphocyte B depletion and hypogammaglobulinaemia is known as Good's syndrome and may affect up to 5% of patients with thymoma. (ecancer.org)
BACKGROUND: Recent studies suggest measles-induced immune amnesia could have long-term immunosuppressive effects via preferential depletion of memory CD150+ lymphocytes, and associations with a 2-3 year period of increased mortality and morbidity from infectious diseases other than measles has been shown in children from wealthy and low-income countries. (bvsalud.org)

Jonathan has regular blood tests to monitor his red blood cells, white blood cells and platelets , and he receives transfusions as needed to support chemotherapy. (blood.ca)
He had a blood transfusion just before the holiday to prepare him for another round of chemotherapy, and it gave him a precious boost of energy. (blood.ca)
He was originally diagnosed at 3 years of age with high risk disease with t(16:12), FUS:ERG fusion (which was then classified as intermediate risk) treated with standard AML chemotherapy. (ebmt.org)
The risk of developing TA-GvHD is small, but patients who should take the precaution of using irradiated blood include those with a weakened immune system due to Hodgkin's disease, people who have taken certain chemotherapy drugs, unborn babies, and babies who need exchange transfusions. (biologydictionary.net)
Hospitals had recently found a way to treat the FEL with a combination of chemotherapy to kill off the old bone marrow and then give a bone marrow transplant. (usmfreepress.org)

Leukopaks are enriched leukapheresis products collected from peripheral blood and consist of various blood cells, including lymphocytes, monocytes, and dendritic cells. (marketsandmarkets.com)

Immunotherapy is emerging as a new form to treat cancer by harnessing the activity of cytotoxic CD8 + T lymphocytes (CTLs) that specifically recognize tumor-associated antigens. (lifeboat.com)
T lymphocytes are responsible for cell-mediated immunity , so named because the T cells themselves latch onto the antigens of the invader and then initiate reactions that lead to the destruction of the nonself matter. (britannica.com)
The disease can also affect a person who receives a blood transfusion from a close relative who is homozygous for certain human leukocyte antigens (HLA). (biologydictionary.net)

This child has presented with progressive anemia inspite of blood transfusion suggestive of transfusion dependent anemia. (pediatriconcall.com)
It is very likely that the doctor who treated the child initially would have given iron supplements for the anemia. (pediatriconcall.com)

The efficacy parameters in this study were myeloablation (defined as one or more of the following: absolute neutrophil count [ANC] less than 0.5x109/L, absolute lymphocyte count [ALC] less than 0.1x109/L, thrombocytopenia defined as a platelet count less than 20,000/mm³ or a platelet transfusion requirement) and engraftment (ANC greater than or equal to 0.5x109/L). All patients (61/61) experienced myeloablation. (clustermed.info)

Until the late 1960s, lymphocytes and antibodies were thought to act separately and have different functions. (wikipedia.org)
While working on immunotherapy for cancer, Fakhri found that neither lymphocytes nor antibodies were effective against cancer cells. (wikipedia.org)
Inspired by what he had observed in his work with coagulation factors, Dr. Fakhri decided to investigate the cooperation between antibodies and lymphocytes to see if there might be parallels with the way different coagulation factors operated. (wikipedia.org)
He found that when lymphocytes were mixed with cancerous cells in the presence of antibodies the lymphocytes encircled the cancer cells and destroyed them. (wikipedia.org)
Antibodies, the sentinels of the immune system, are Y-shaped proteins made by a class of white blood cells called B lymphocytes. (newscientist.com)
Cross Blood Transfusion Service, they claim to have discovered natural antibodies with a different set of tweezers on each arm. (newscientist.com)
Now, Aalberse and his colleagues believe they have established why, after studying IgG4 antibodies from patients who had been treated for combined allergy to grass pollen and house dust mites. (newscientist.com)

It's a cancer that develops in the lymphatic system and causes infection-fighting white blood cells called lymphocytes to multiply in an abnormal way. (blood.ca)

Coupled with well-established in vitro culture and expansion protocols for T lymphocytes, CAR enabled the antigen-directed cytotoxicity of T cells to be harnessed, expanding the scope of cell therapy. (scienceboard.net)

Lymphocytes in donor unit 'engraft' leading to rash, diarrhoea, liver impairment, and bone marrow failure. (brainkart.com)
In collaboration with investigators in Taiwan, we implanted one type of autologous OMSCs (periodontal ligament progenitors, PDLPs) to treat an orofacial infectious bone defect disease periodontitis. (ca.gov)
Activated T-lymphocytes impaired OMSCs via the Fas/Fas ligand pathway, as occur in long bone MSCs. (ca.gov)
Furthermore, we found that OMSCs are distinct from long bone MSCs with respect to regulating T-lymphocyte survival and proliferation. (ca.gov)
Irradiated blood is used to prevent transfusion-associated graft-versus host disease (TA-GvHD) in people who received bone marrow transplants or transfusions of blood components. (biologydictionary.net)
Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
[4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)

As other scientists began to explore this phenomenon these lymphocytes came to be called "K cells" or "Killer cells" and were found to play a major role in immune response. (wikipedia.org)
Sometimes transfusions of platelets or red blood cells are needed by patients. (differencebetween.net)
Acute lymphoblastic leukemia (ALL) is a type of leukemia that develops rapidly and affects the progenitor cells of either B lymphocytes or T lymphocytes. (differencebetween.net)
Patients may require blood transfusions to replace lost red blood cells and platelets. (differencebetween.net)
Supportive care included transfusion of packed red blood cells, platelets, cryoprecipitate, and fresh frozen plasma. (cdc.gov)
The key cells of the immune system are the white blood cells known as lymphocytes. (britannica.com)
T lymphocytes ( T cells ) and B lymphocytes ( B cells ). (britannica.com)
Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
Diagnosis is by detecting lymphopenia, absence or a very low number of T cells, and impaired lymphocyte proliferative responses to mitogens. (msdmanuals.com)
This episode paralleled with a massive CD8 T- lymphocyte expansion (CD3-663, CD4 106, CD8-568 cells/microliter) following granulocyte infusions, which peaked at day +10 post HSCT. (ebmt.org)
Between 4 and 30 days after transfusion, the resulting cascading immune response causes fever, rash, diarrhea, hepatitis, and reduced levels of red blood cells, white blood cells, and platelets (pancytopenia). (biologydictionary.net)
When irradiating just red blood cells, they should be treated within 14 days of their expiration date and stored for a maximum of 28 days or until their expiration, whichever comes first. (biologydictionary.net)
One approach is to remove the immune cells from the patient's blood and treat them in a lab to get them to react to tumor cells, the immune cells are then given back to the patients as blood transfusion, where it is hoped they will cause the body's immune cell system to attack the cancer (American Cancer Society, 2014). (mesotheliomahelp.org)
The benefits of an allogeneic "off-the-shelf" cell therapy approach are clear: batch-producing cells derived from an unrelated donor or universal cell source that can be used to treat many patients. (scienceboard.net)
This therapeutic technique involves the use of individual T-cells - T-lymphocytes - radical and powerful cellular structures "defending" organisms. (elclinics.com)
Next, a drug containing these cells is administered to people - the procedure has similarity with blood transfusion. (elclinics.com)
Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
The cells defending the body against infection - lymphocytes, a type of white blood cell - produce a protein stimulating the production of cells to clean up after a virus. (usmfreepress.org)
CLL is considered the most common form of leukemia in adults and is a type of cancer that starts in white blood cells, known as lymphocytes. (lu.se)

Prior to the invention of CAR, cell therapies were largely limited to allogeneic hematological transfusion and transplantation. (scienceboard.net)

GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
Unless the T-lymphocytes are destroyed, they will graft themselves in the recipient's tissues. (biologydictionary.net)

Transfusion of autologous tumor-specific CTLs 1-4 and blockade of T cell inhibitory receptors 5-7 have demonstrated to elicit durable clinical benefit in a significant proportion of patients with melanoma, leukemia, lymphoma and other cancers, who failed to respond to conventional treatments. (lifeboat.com)
We examined the clinical outcome of three autologous PDLP-treated patients in an effort to provide primary knowledge on the effectiveness of this treatment approach and preliminary clinical evidence for randomized controlled trial in the future. (ca.gov)

The principal immunological abnormalities described for this syndrome include hypogammaglobulinaemia, B-cell lymphopaenia, CD4/CD8 ratio inversion, low T CD4 lymphocyte counts, and alteration of the mitogenic T cell response [ 4 ]. (ecancer.org)
Individuals developing M. avium-complex infections had lower baseline CD4 cell counts, hematocrits, lymphocyte counts, and total white blood cell counts than those who did not develop M. avium-complex infection. (johnshopkins.edu)
Current HAART use was independently associated with low risk of in-hospital mortality (OR 0.33), while central nervous system symptoms (OR 4.12), sepsis (OR 6.98) and low total lymphocyte counts (OR 3.60) were associated with increased risk. (who.int)
4.12), sepsis (OR 6.98) and low total lymphocyte counts (OR 3.60) were associated with increased risk. (who.int)

During 1989-1990, he worked for the Department of Dermatology at Westminster Hospital as a clinical assistant, where he successfully treated several patients with psoriasis using electrotherapy. (wikipedia.org)
We have successfully established BRONJ minipig and mouse models treated with oncologic doses of zolendronate (Zometa)/Dexamethasone (Dex) developed BRONJ-like pathological lesions with similar clinical, radiographic, and histological features as described in the human disease. (ca.gov)
Achieving hematologic complete response is an important treatment goal, and today's approval based on this clinical endpoint will provide doctors and the larger medical community with a new option to treat newly diagnosed patients. (biospace.com)

Tremelimumab is an antibody that blocks Cytotoxic T lymphocyte antigen4. (mesotheliomahelp.org)

Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD3-UNLB followed by Goat F(ab') 2 Anti-Mouse IgG(H+L), Human ads-AF488 (SB Cat. (southernbiotech.com)

Infections can be treated with antimicrobial medications. (differencebetween.net)
Infections: Monitor for fever and other signs of infection or reactivation of infections and treat promptly. (nih.gov)

A scanning electron micrograph of a human T lymphocyte (or T cell) from the immune system of a healthy person. (britannica.com)
If the person's own immune system is incapable of mounting an immune response to them, the T-lymphocytes get the upper hand and attack the recipient's body as if it were a foreign invader. (biologydictionary.net)
Tremelimumab blocks the lymphocyte CTLA4 from slowing the immune system which enhances the immune response against mesothelioma (MSKCC, 2014). (mesotheliomahelp.org)

During that period he also worked at the Institute of Ophthalmology, where he also successfully treated a number of exophthalmos cases using the electrotherapy methods he had developed in Baghdad. (wikipedia.org)
Four children before her were successfully treated this way. (usmfreepress.org)

Most people are diagnosed as having CLL based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes . (wikipedia.org)

Children with this condition were typically given blood transfusions, but with little improvement. (wikipedia.org)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)

Chronic lymphocytic leukemia (CLL) is a form of leukemia where the B lymphocytes are affected. (differencebetween.net)

The structure of the T-lymphocyte is modified artificially by introducing a virus created in the laboratory. (elclinics.com)

The number of T-lymphocytes that have undergone modification is increased by artificially catalyzing the process of cell division. (elclinics.com)

Fever and rigors occur within few hours of starting or completing the transfusion. (brainkart.com)
[10] Immune defects occur early in the course of CLL and these increase the risk of developing serious infection, which should be treated appropriately with antibiotics. (wikipedia.org)

What cancerogenic pathologies are treated with CAR-T therapies? (elclinics.com)

All treated patients showed no adverse effects during the entire course of follow up. (ca.gov)

In total, Rachel has had 298 blood transfusions - the most of anyone else living in Maine. (usmfreepress.org)

On January 11th 2014, the patient showed symptoms of an influenza-like illness (ILI) (fever, cough, sore throat, dizziness, headache and myalgia) and self-treated with Analginum (Fig. 1 ). (biomedcentral.com)

The minimum radiation dose to kill the T-lymphocytes of 25 Gy10. (biologydictionary.net)

In advanced HIV infection treated with zidovudine, M. avium-complex infection is significantly associated with the risk of death. (johnshopkins.edu)

During his PhD research, Fakhri carried out a series of experiments to determine an effective method to treat cancer with immunotherapy. (wikipedia.org)

When Jonathan started getting his blood transfusions and I found out we had the same blood type, I told him he could have my blood any time. (blood.ca)
Recently, an infant developed severe immune deficiency and an opportunistic infection several months after receiving a transfusion of platelets derived from the blood of a man subsequently found to have AIDS (12). (cdc.gov)

0.250 x 10 9 /L initially treated with zidovudine between April 1987 and April 1988. (johnshopkins.edu)

WBC transfusion for the treatment of neutropenia and granulocyte deficiencies increases the risk of causing an immune response against transfused WBCs. (marketsandmarkets.com)

This phase I trial studies the side effects and the best dose of wild-type reovirus (viral therapy) when given with sargramostim in treating younger patients with high grade brain tumors that have come back or that have not responded to standard therapy. (mayo.edu)

If not treated promptly, HLH can progress rapidly to multiorgan failure and death ( 3 ). (cdc.gov)

HLH is a rare disease, characterized by impaired function of natural killer and cytotoxic T-lymphocytes that results in an unchecked inflammatory response. (cdc.gov)

And blood transfusions have continued to play a role. (blood.ca)
What is the role of lymphocytes in the fight against cancer? (elclinics.com)

0.100 x 10 9 /L, baseline AIDS diagnosis, and transfusion independently predicted an increased risk of death. (johnshopkins.edu)

There was no prior history of blood transfusion. (ispub.com)
Since the dark stools have started later and the child has been on some medicines following the blood transfusion, one would have to go more in detail about the medicine history. (pediatriconcall.com)
There was no history of previous drug or food allergies or blood transfusions. (biomedcentral.com)

From 1992, he worked at the Hale Clinic in London, a private clinic promoting alternative medicine, using electrotherapy to treat patients. (wikipedia.org)

Anatomy1

Diseases1

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes1

Anthropology, Education, Sociology and Social Phenomena1

Humanities2

Information Science1

Named Groups1

Health Care4

Required a blood transfusion2

Hemoglobin2

Neutrophils1

Depletion2

Chemotherapy5

Monocytes1

Antigens3

Anemia2

Platelet count1

Antibodies7

Abnormal1

Cytotoxicity1

Bone7

Cells20

Allogeneic1

Graft2

Autologous2

Counts4

Clinical3

Antibody1

Peripheral1

Infections2

Immune system3

Successfully2

Count1

Typically2

Leukemia1

Laboratory1

Cell1

Occur2

Therapies1

Adverse1

Total1

Cough1

Radiation1

Significantly1

Immunotherapy1

Found2

Initially1

Treatment1

Therapy1

Rapidly1

Results1

Role2

Risk1

History3

Medicine1