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  • genes
  • Evidence on the associations of emerging cardiovascular disease risk factors/markers with genes may help identify intermediate pathways of disease susceptibility in the general population. (beds.ac.uk)
  • The evidence on the associations of four novel risk factors/markers with these genes may help identify intermediate pathways of CVD susceptibility in the general population. (beds.ac.uk)
  • We found that the transcription of the mecA and mecB genes encoding CBS and CGL was upregulated by excess of homocysteine as well as by shortage of cysteine. (springer.com)
  • A bioinformatics approach to understanding the transcriptional regulation of the genes involved in amino acid metabolism under abiotic stress is also presented. (springer.com)
  • Folate
  • Findings from experimental studies have indicated that thyroid hormones affect folate metabolism. (medscape.com)
  • Aiming to investigate the role of low maternal B-vitamin status and hyperhomocysteinemia in complicated pregnancies in Syria, maternal B-vitamin (folate, vitamin B12, vitamin B6) and related metabolic markers, including homocysteine, cystathionine, and methylmalonic acid were measured in a group of Syrian normotensive pregnant women and those whose pregnancy was complicated with preeclampsia. (spotidoc.com)
  • Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap. (abnova.com)
  • several pathways
  • Although several pathways affected by mHtt have been extensively studied, exact mechanisms whereby mHtt disrupts cellular function in HD have been unclear. (pnas.org)
  • endogenous
  • Many diseases including cardiovascular diseases, neurological diseases, shock, sepsis, metabolic disorders, and cancers have been linked to abnormal endogenous H 2 S functions and metabolism [ 4 ]. (hindawi.com)
  • metabolite
  • Elevation was maintained on normalization for age or to a control heme pathway metabolite (uroporphyrin) in the same samples. (avn.org.au)
  • Huntington's
  • We have harnessed this pathway to mitigate toxicity associated with cysteine deprivation in Huntington's disease (HD). (pnas.org)
  • Huntington's disease (HD), a neurodegenerative disorder, is associated with disrupted cysteine metabolism caused by depletion of CSE leading to abnormal redox balance and stress response. (pnas.org)
  • Aberrant amino acid metabolism has been reported in Huntington's disease (HD), but its molecular origins are unknown. (pnas.org)
  • Disturbances in amino acid metabolism, which have been observed in Huntington's disease (HD), may account for the profound inanition of HD patients. (pnas.org)
  • gene expression
  • Each antitumor agent elicited concerted changes in gene expression of multiple pathway components across the cell lines. (biomedcentral.com)
  • Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. (abnova.com)
  • In this work, we confirm the control of cystathionine γ-lyase gene expression by the CYS3 transcriptional activator through the loss of cys-16 + expression in a Δ cys-3 mutant and through the in vitro binding of CYS3 to the cys-16 + promoter at four sites. (biomedcentral.com)
  • antioxidant
  • Increased levels of oxidative stress markers have been linked to disease progression in HD, in which the antioxidant defense pathways are compromised ( 12 , 13 ). (pnas.org)
  • oxidative stress
  • Depletion of CSE occurs due to the sequestration of SP1, the basal transcription factor for CSE leading to lowered cysteine levels and elevated oxidative stress ( 9 ⇓ - 11 ). (pnas.org)
  • Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. (abnova.com)
  • hepatic
  • This pathway is dependent on adequate intake of vitamin B-6 and the hepatic conversion of vitamin B-6 into its active form, pyridoxal-5'-phosphate (P5P). (medscape.com)
  • Hepatic S -adenosylmethionine (SAMe) metabolism. (nih.gov)
  • cellular
  • Cysteine is a semiessential amino acid with multifaceted cellular functions ( 14 , 15 ). (pnas.org)
  • H 2 S is involved in an array of cellular signals regulating cardiac, neurological, and respiratory functions, as well as cellular metabolism and survival [ 5 , 7 ]. (hindawi.com)
  • mitochondrial
  • Anderson MD, Che P, Song JP, Nikolau BJ, Wurtele ES (1998) 3-Methylcrotonyl coenzyme A carboxylase is a component of the mitochondrial leucine catabolic pathway in plants. (springer.com)