• thiamine/thiamine pyrophosphate ABC transporter ATPase. (ntu.edu.sg)
  • 10TM putative phosphate transporter, cytosolic domain [Interproscan]. (ntu.edu.sg)
  • and a magnesium binding site: Walker B. Besides these two regions, three other conserved motifs are present in the ABC cassette: the switch region which contains a histidine loop, postulated to polarize the attaching water molecule for hydrolysis, the signature conserved motif (LSGGQ) specific to the ABC transporter, and the Q-motif (between Walker A and the signature), which interacts with the γ phosphate through a water bond. (expasy.org)
  • Phosphate uptake transporter. (expasy.org)
  • They may be needed respectively for the formation of pyridoxal phosphate (PLP) and thiamine pyrophosphate (TPP) which will be the important cofactors for most enzymes involved with amino acidity rate of metabolism (Eliot and Kirsch 2004 Lonsdale 2006 General the result can be consistent with decreased price of mass-specific rate of metabolism in longer-lived mammals. (healthanddietblog.info)
  • Well-known syndromes caused by thiamine deficiency include Wernicke-Korsakoff syndrome and beriberi , diseases also common with chronic alcoholism. (wikidoc.org)
  • The damage caused by thiamine deficiency occurs throughout the body, but it tends to be most pronounced parts of the body that have the highest energy requirements, including the brain and heart. (unitedbrainassociation.org)
  • Orchestration of Thiamin Biosynthesis and Central Metabolism by Combined Action of the Thiamin Pyrophosphate Riboswitch and the Circadian Clock in Arabidopsis. (mpg.de)
  • A core set of 46 proteins, encompassing 2.2% of the total pan-plasmid (2,095 CDS), conserved among all LPP-1 plasmid sequences, includes those required for thiamine and pigment biosynthesis. (uni-bielefeld.de)
  • Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. (easyomics.org)
  • Thiamine pyrophosphate (TPP or ThPP), or thiamine diphosphate (ThDP), or cocarboxylase is a thiamine (vitamin B1) derivative which is produced by the enzyme thiamine diphosphokinase. (wikipedia.org)
  • TPP works as a coenzyme in many enzymatic reactions, such as: Pyruvate dehydrogenase complex Pyruvate decarboxylase in ethanol fermentation Alpha-ketoglutarate dehydrogenase complex Branched-chain amino acid dehydrogenase complex 2-hydroxyphytanoyl-CoA lyase Transketolase Chemically, TPP consists of a pyrimidine ring which is connected to a thiazole ring, which is in turn connected to a pyrophosphate (diphosphate) functional group. (wikipedia.org)
  • Hydrophobic amino acid uptake transporter. (expasy.org)
  • L-Lysine is imported into liver through low affinity cationic amino acid transporter 2 (cationic amino acid transporter 2/SLC7A2). (smpdb.ca)
  • Carbohydrate uptake transporter. (expasy.org)
  • Cobalt uptake transporter (cbiO). (expasy.org)
  • Ferric iron uptake transporter. (expasy.org)
  • Manganese/Zinc/Iron chelate uptake transporter. (expasy.org)
  • Molybdate uptake transporter. (expasy.org)
  • Nitrate/Nitrite/Cyanate uptake transporter. (expasy.org)
  • Peptide/Opine/Nickel uptake transporter. (expasy.org)
  • Phosphonate uptake transporter. (expasy.org)
  • Polyamine/Opine/Phosphonate uptake transporter. (expasy.org)
  • Quaternary amine uptake transporter. (expasy.org)
  • Sulfate uptake transporter. (expasy.org)
  • Thiamin uptake transporter (thiamin/thiamin pyrophosphate) (thiQ/yabJ). (expasy.org)
  • Therefore, it was demonstrated that p53 causes transactivation of thiamine transporter 1 (THTR-1) gene manifestation leading to an increase in thiamine uptake. (nibbp2p.org)
  • Moreover, relating to current evidence, PT-PP could efficiently block TPK while OT-PP could compete with TPP coenzyme function and inhibit TPP-dependent enzymes leading to an impairment in thiamine homeostasis7, 9C12. (nibbp2p.org)
  • Thiamine pyrophosphate (TPP), also known as thiamine diphosphate (ThDP), is a coenzyme for several enzymes that catalyze the dehydrogenation ( decarboxylation and subsequent conjugation to Coenzyme A ) of alpha-keto acids. (wikidoc.org)
  • It was first discovered as an essential nutrient (vitamin) in humans through its link with the peripheral nervous system disease beriberi, which results from a deficiency of thiamine in the diet. (wikipedia.org)
  • A deficiency of thiamine (vitamin B-1) is responsible for the symptom complex manifested in WKS, and any condition resulting in a poor nutritional state places patients at risk. (medscape.com)
  • Thiamine or thiamin , also known as vitamin B 1 and aneurine hydrochloride , is one of the B vitamins . (wikidoc.org)
  • In particular, vitamin B1 (thiamine) is utilized as an essential cofactor for metabolic enzymes that intersect at critical junctions within the glycolytic network. (northwestern.edu)
  • Wernicke-Korsakoff syndrome (WKS) is a brain disorder caused by an abnormally low level of thiamine, a nutrient also known as vitamin B1. (unitedbrainassociation.org)
  • Wernicke-Korsakoff syndrome (WKS) is a brain-related disorder triggered by a below-average level of thiamine (also known as vitamin B1) in the brain. (unitedbrainassociation.org)
  • Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP . (guidetopharmacology.org)
  • Swelling, gliosis and variations in oxidative rate of metabolism often accociated with reductions in thiamine linked processes result in DNA damage and neuronal cells death, which are thought to be the basis for many neurodegenerative diseases2, 3. (nibbp2p.org)
  • While growing body of evidence suggests a critical function of p53 in thiamine homeostasis, the part of p53 inside a coordination of cellular events induced by changes in thiamine rate of metabolism are not completely elucidated. (nibbp2p.org)
  • It is identified that thiamine antagonists - amprolium (AM), oxythiamine (OT) and pyrithiamine (PT) metabolically interfere with thiamine metabolism and its functions7. (nibbp2p.org)
  • taurine transporter ATP-binding subunit [Ensembl]. (ntu.edu.sg)
  • Pyruvate is decarboxylated by the PDH subunit (E 1 ) in the presence of thiamin pyrophosphate (TPP). (bmj.com)
  • Thiamine can also be seen directly in whole blood following the conversion of thiamine to a fluorescent thiochrome derivative. (wikidoc.org)
  • Afterwards, L-lysine is imported into mitochondria via mitochondrial ornithine transporter 2. (smpdb.ca)
  • Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified. (guidetopharmacology.org)
  • Accumulated thiamine and its active form - thiamine pyrophosphate (TPP) are further implicated in bad feedback mechanisms that suppress intracellular p53 activity5, 6. (nibbp2p.org)
  • Notably, the cells appeared to be mostly vulnerable to PT and OT with the less degree to AM. This observation suggested that cells with neuronal phenotype treated with AM were still Licofelone able to retain a low intracellular concentration of thiamine and undergo death slower than after treatment with OT or PT13, 14. (nibbp2p.org)
  • Intracellular availability of thiamine is facilitated by the activity of thiamine transporters and thiamine pyrophosphokinase-1 (TPK-1). (northwestern.edu)
  • ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). (expasy.org)
  • To support this metabolic phenotype, cancer cells adaptively regulate the expression of glycolytic enzymes and nutrient transporters. (northwestern.edu)
  • ABC transporter ATP-binding protein & cell division. (ntu.edu.sg)
  • ABC transporter ATP-binding protein-unknown substrate. (ntu.edu.sg)
  • The risk seems to be associated with a gene called SLC19A2, which provides instructions for making a protein called thiamine transporter 1. (unitedbrainassociation.org)
  • This protein is essential for transferring thiamine into cells, where it's necessary to help the cells produce energy. (unitedbrainassociation.org)
  • ELAC1 has been in the use and may as define as an RNase Z. In pyrophosphates subfamilies are transcribed from coupling tubules in the function by a two receptor chromatin that appears ultraviolet from protein threatening( reviewed in Popow et al. (evakoch.com)
  • OT and PT, as competitive substrates of thiamine pyrophosphokinase (TPK), can restrict the level of TPP and at the same time become pyrophosphorylated (PP) by TPK. (nibbp2p.org)
  • Thiamine Responsive Megaloblastic Anemia with diabetes mellitus and sensorineural deafness (TRMA) [2] is an autosomal recessive disorder caused by mutations in the gene SLC19A2 , [3] a high affinity thiamine transporter. (wikidoc.org)
  • In the current study, we prompted to identify the effects of thiamine antagonists AM, OT and PT on the level of p53 gene expression, its post-translational modification, DNA-binding activity and its role in the regulation of metabolic and signaling pathways using RA-differentiated SH-SY5Y cells which are a widely-used model of human neurons. (nibbp2p.org)
  • However, some carboxyl heterodimers enabling gene 5-phosphatases belong often established by development so the molecules for releasing thiamin are predominantly clinically as congenital( adored in Rebbapragada and Lykke-Andersen 2009). (erik-mill.de)
  • However, evidences also suggest that p53 may be involved in DNA restoration via preventing the replication of damaged DNA and activation of the manifestation of genes important for the protection of the cell from oxidative damage and molecules that are essential to thiamine homeostasis. (nibbp2p.org)
  • ET strain also has mutations in two transporters putatively involved in cation homeostasis. (researchgate.net)
  • Therefore, the objective of this study was to establish if the cellular determinants regulating thiamine homeostasis differ between breast cancer and normal breast epithelia. (northwestern.edu)
  • The mitochondrial NAD(+) transporter (NDT1) plays important roles in cellular NAD(+) homeostasis in Arabidopsis thaliana. (mpg.de)
  • putative ABC superfamily (atp_bind) transporter. (ntu.edu.sg)
  • Thiamine pyrophosphate is a cofactor that is present in all living systems, in which it catalyzes several biochemical reactions. (wikipedia.org)
  • ABC transporters are involved in the export or import of a wide variety of substrates ranging from small ions to macromolecules. (expasy.org)
  • ABC superfamily ATP binding cassette transporter, ABC. (ntu.edu.sg)
  • ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which uses the hydrolysis of ATP to energize diverse biological systems. (expasy.org)
  • Overall, these findings demonstrate an adaptive response by breast cancer cells to increase cellular availability of thiamine. (northwestern.edu)
  • After a course of treatment with high-dose parenteral thiamine and reversal of the acute effects of Wernicke encephalopathy, if there is no improvement in the Korsakoff amnestic state or other mental status abnormalities for 7 days, then a strategy of secondary harm prevention should be pursued. (medscape.com)
  • 4-pyridoxate (catabolite of supplement B6) in mind and thiamine (supplement B1) in kidney and liver organ also adversely correlated with life-span (Desk S4H). (healthanddietblog.info)
  • All different types of transporters with a functional attribution are listed below (references are only provided for recently characterized proteins). (expasy.org)
  • Thiamine pyrophosphate is synthesized in the cytosol and is required in the cytosol for the activity of transketolase and in the mitochondria for the activity of pyruvate-, oxoglutarate- and branched chain keto acid dehydrogenases. (wikipedia.org)