Transporter nucleobase transport proteins. Medical search. Frequent questions

Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" by people in this website by year, and whether "Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" by people in Profiles. (umassmed.edu)
2015) High yield purification and characterization of Equilibrative Nucleoside Transporter 7 (ENT7) from Arabidopsis thaliana. (ualberta.ca)
Basic membrane lipoprotein, component of General nucleoside uptake porter, NupABC/BmpA (transports all common nucleosides as well as 5-fluorocytidine, inosine, deoxyuridine and xanthosine) (Martinussen et al. (lbl.gov)
Adenosine is an endogenous purine nucleoside, composed of nucleobase adenine and β-D-ribose moieties. (turkupetcentre.net)
Adenosine cannot freely pass across the cell and vesicular membranes, but it needs to be transported by nucleoside transporters, which are present in most cells, including erythrocytes . (turkupetcentre.net)
Dipyridamole elevates extracellular adenosine concentrations by inhibiting equilibrative nucleoside transporters (ENTs). (turkupetcentre.net)
Concentrative nucleoside transporters (CNTs) are Na + -dependent transporters, found in most tissue types. (turkupetcentre.net)

The Nucleobase cation symporter-2 (NCS2) family, also called the Nucleobase ascorbate transporter (NAT) family, consists of over 1000 sequenced proteins derived from gram-negative and gram-positive bacteria, archaea, fungi, plants and animals. (wikipedia.org)
Of the five known families of transporters that act on nucleobases, NCS2/NAT is the only one that is most widespread. (wikipedia.org)
Clustering of NCS2/NAT family members on the phylogenetic tree is complex, with bacterial proteins and eukaryotic proteins each falling into at least three distinct clusters. (wikipedia.org)
Proteins of the NCS2 family are 414-650 amino acyl residues in length and probably possess 14 TMSs. (wikipedia.org)
The generalized transport reactions catalyzed by proteins of the NAT/NCS2 family are: Nucleobase (out) H+ (out) → Nucleobase (in) H+ (in). (wikipedia.org)
Several proteins make up the NCS2/NAT family. (wikipedia.org)
A few types of proteins that make up the NCS2/NAT family include: Xanthine permeases, including PbuX (XanP) of Bacillus subtilis (TC# 2.A.40.3.1), involved in cellular xanthine transport. (wikipedia.org)
The nucleobase/ascorbate transporter (NAT) proteins, also known as nucleobase/cation symporter 2 (NCS2) proteins, are responsible for the uptake of nucleobases in all kingdoms of life and for the transport of vitamin C in mammals. (rhea-db.org)
functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)

However, two closely related rat/human members of the family, SVCT1 and SVCT2, localized to different tissues of the body, co-transport L-ascorbate (vitamin C) and Na+ with a high degree of specificity and high affinity for the vitamin. (wikipedia.org)
We recently showed that a urate transporter SLC2A12 is also a physiologically important exporter of ascorbate (the main form of vitamin C in the body) that would cooperate with an ascorbate importer, sodium-dependent vitamin C transporter 2 (SVCT2). (bvsalud.org)
the nucleobase-ascorbate transporter (nat) family includes members in nearly all domains of life. (liverpool.ac.uk)

hSVCT2 mediates the uptake of ascorbic acid (AA) and is the predominantly expressed vitamin C transporter isoform in neuronal systems. (bvsalud.org)
Further, we mutated a classical Nedd4 protein interacting motif ("PPXY") within the hSVCT2 polypeptide and observed markedly decreased AA uptake due to the intracellular localization of the mutated hSVCT2. (bvsalud.org)
Also, we determined the role of the proteasomal degradation pathway in hSVCT2 functional expression in SH-SY5Y cells and the results indicated that the proteasomal inhibitor (MG132) significantly up-regulated the AA uptake and hSVCT2 protein expression level. (bvsalud.org)
functionally characterized nat transporters from bacteria, fungi, plants and mammals are ion-coupled symporters specific for the uptake of purines, pyrimidines and related analogues. (liverpool.ac.uk)
Secondary active transporters of the SLC11/NRAMP family catalyse the uptake of iron and manganese into cells. (nature.com)

In the compound, V is a vitamin that is a substrate for receptor-mediated transmembrane transport in vivo, or a vitamin receptor binding derivative or analog thereof, L is a divalent linker, R is a side chain of an amino acid, M is a cation of a radionuclide, n is 1 or 0, K is 1 or 0, and the compound can be in a pharmaceutically acceptable carrier therefor. (patsnap.com)

Proteins are made of amino acids arranged in a linear chain joined by peptide bonds. (wikipedia.org)
B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases. (patsnap.com)

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. (univ-amu.fr)

All four adenosine receptor subtypes (A 1 , A 2A , A 2B , and A 3 ) are G protein-coupled receptors (GPCRs), either increasing or decreasing intracellular cAMP levels by affecting adenylate cyclase activity. (turkupetcentre.net)

The most important open questions concern the structure of the transporter in an outward-facing conformation and whether, similar to their eukaryotic counterparts, transport in the prokaryotic transporters would be coupled to H + . To resolve these questions we have investigated the structural and functional properties of the SLC11 transporter from the bacterium Eremococcus coleocola (EcoDMT). (nature.com)

or anabolic - the building up (synthesis) of compounds (such as proteins, carbohydrates, lipids, and nucleic acids). (wikipedia.org)

Multispanning membrane protein, translocator of proteins. (ntu.edu.sg)
We confirmed that SspA is a peroxisomal membrane protein that co-localizes significantly with PTS1-tagged mRFP, UOX or HexA, the latter considered a protein of Woronin bodies (WB), organelles originating from peroxisomes that dynamically plug septal pores in ascomycetes. (uoa.gr)

These proteins are highly conserved across all kingdoms of life and thus likely share a common transport mechanism. (nature.com)

Many functionally characterized members are specific for nucleobases including both purines and pyrimidines, but others are purine-specific. (wikipedia.org)
To investigate whether PMP22 channels have a role in peroxisomal uric acid transport and catabolism, we functionally analyzed the closest homologue in Aspergillus nidulans, named SspA. (uoa.gr)

The plant and animal proteins cluster loosely together, but the fungal proteins branch from one of the three bacterial clusters forming a tighter grouping. (wikipedia.org)
In an in silico search for correlated gene loss with fungal peroxisomal uric acid oxidase (UOX), we identified PMP22-like proteins, some of which function as promiscuous channels in organellar membranes. (uoa.gr)

Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
Transporters are essential transmembrane proteins that mediate the selective translocation of solutes, ions or drugs across biological membranes. (uoa.gr)

while in other cases (such as Aprataxin) it appears to bind both non-covalently through a zinc finger motif, and covalently through a separate region of the protein [3]. (sdsc.edu)

PTS not only transports specific sugars but also in the absence of its substrates, stimulates, through adenylate cyclase (Cya), the production of c AMP which in turn activates the transcription of many c AMP-CRP dependent catabolic genes, including those involved in glycerol utilization [ 1 ]. (biomedcentral.com)

Here we report the crystal structure of a representative NAT protein, the Escherichia coli uracil/H(+) symporter UraA, in complex with uracil at a resolution of 2.8 Å. (rhea-db.org)

A distinctive characteristic of transporters is their cotranslational translocation and folding in a membrane bilayer, this being the endoplasmic reticulum (ER) in eukaryotes or the cell membrane in prokaryotes. (uoa.gr)
This review discusses how paradigmatic work on transporters of a model mould, Aspergillus nidulans, has contributed to novel findings related to transporter functioning in eukaryotes. (uoa.gr)
This domain is also found on its own in a family of proteins from bacteria, archaebacteria and eukaryotes. (sdsc.edu)

here, we investigated the nucleo-cytoplasmic shuttling mechanism that transports xyr1 across the nuclear pore complex. (liverpool.ac.uk)
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. (systemsbiology.net)
and proteins that play a direct role in the transport of karyopherin complexes through the nuclear pore complex. (nih.gov)

The function of PM transporters is finely regulated at the cellular level, in response to physiological or stress signals that promote, via α-arrestin-assisted ubiquitination, their endocytosis and vacuolar/lysosomal degradation, and in some cases recycling to the PM. Importantly, transporter oligomerization and specific interactions with membrane lipids are emerging as important players in transporter expression, function and turnover. (uoa.gr)

For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. (lbl.gov)

Our research centers around studying membrane proteins involved in disease, using X-ray crystallography and other biophysical techniques, to reveal structural, functional and mechanistic details of membrane proteins that could one day aid in the development of new drugs and vaccines targeted towards membrane proteins. (ualberta.ca)

the filamentous fungus aspergillus oryzae is a well-known expression host used to express homologous and heterologous proteins in a number of industrial applications. (liverpool.ac.uk)
Highly homologous prokaryotic SLC11 family members transport Mn 2+ into the cytoplasm 11 . (nature.com)

1 L/d of drinking water was associated with concurrent changes in carbohydrate, protein, lipid, and micronutrient metabolism, a metabolomic pattern of carbohydrate oxidation via the tricarboxylic acid (TCA) cycle, instead of glycolysis to lactate, and a reduction of chronic disease risk factors in Week 6. (ppexmed.com)

The accumulation of ER-retained transporters, in most cases, elicits endoplasmic reticulum-associated degradation, but also ubiquitination-dependent, chaperone-mediated, selective autophagy. (uoa.gr)

By determining the structure of EcoDMT in an outward-facing conformation, we provide a framework that defines the conformational changes underlying transport by the alternate access mechanism 19 . (nature.com)

Proteins involved in the process of transporting molecules in and out the cell nucleus. (nih.gov)

Nothing is currently known about the role of ubiquitin E3 ligase, neural precursor cell-expressed developmentally down-regulated gene 4 (Nedd4-1) and the proteasomal degradation pathway in regulating human vitamin C transporter-2 (hSVCT2) in neuronal cells. (bvsalud.org)
Vitamin C (VC) is a key antioxidant of the Central Nervous System (CNS) and SLC23A2 (SVCT2) is the only transporter that actively transports VC into the brain. (bvsalud.org)

Many proteins are enzymes that catalyze the chemical reactions in metabolism. (wikipedia.org)

We have optimized our transport assays to show that EcoDMT transports Mn 2+ with a K M in the low μM range and that metal ion transport is coupled to the cotransport of protons. (nature.com)

Endothelial cells have a very active transport system for adenosine, and also high rate of metabolism, converting adenosine to inosine, hypoxanthine, xanthine, uric acid, and other compounds. (turkupetcentre.net)

GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. (lbl.gov)

Chemicals and Drugs18

Phenomena and Processes4

Information Science1

Nucleoside9

NCS29

Ascorbate3

Uptake5

Transmembrane transport1

Amino2

Localization1

Intracellular1

Eukaryotic1

Nucleic1

Membrane protein2

Kingdoms of life1

Functionally2

Fungal2

Membranes2

Motif1

Sugars1

Symporter1

Eukaryotes3

Pore3

Lipids1

Bacteria1

Mechanistic1

Homologous2

Carbohydrate1

Endoplasmic1

Conformation1

Molecules1

Vitamin2

Enzymes1

Assays1

Metabolism1

Genome1