Transporter gene expression. Medical search. Frequent questions

Eight soybean MATE transporters clustered together with the previously reported MATE proteins related to aluminum (Al) detoxification and iron translocation were further analyzed. (biomedcentral.com)
Here, we report the use of a targeted liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method for concurrent quantification of multiple cytochrome P450 (P450), UDP-glucuronosyltransferase (UGT), and transporter proteins in cultured primary human hepatocytes. (aspetjournals.org)
Introduction/Background Membrane transporter proteins (for example ABC, SLC and ATPases) take part in oncogenesis and the formation of chemoresistance, however the interpretation of their importance in ovarian cancer prognosis is still limited. (bmj.com)
Genes encoding disrupted complementary interactors tend to be risk genes, and an interaction network built from these proteins is enriched for ASD proteins. (springer.com)
Dopamine transporters (DAT) are dopamine reuptake proteins on the presynaptic terminals of dopaminergic neurones. (bmj.com)
The ATP-binding cassette (ABC) of active transporters comprises a group of proteins that which facilitate efflux of anticancer drugs from cancer cells. (lu.se)
There, I visited Dr. Mark Hahn's lab and performed functional analyses of the Atlantic salmon AHR genes and their expressed proteins in order to find out more about their role in the mediation of toxicity from dioxin exposure. (lu.se)

We examined expression levels of organic anion-transporting polypeptide (OATP)1B1, OATP1B3, OATP1B7, and organic anion transporter (OAT)1 as solute carrier transporters and multidrug resistance-associated protein (MRP)1 and MRP2 as ATP-binding cassette transporters, using real-time polymerase chain reaction and accumulation of 3 H-MTX in cancer cells after 10-Gy irradiation, assuming stereotactic body radiotherapy. (frontiersin.org)
Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene. (wikipedia.org)
The effects of culture format (i.e., sandwich culture versus conventional culture) and of dexamethasone (DEX) media concentrations on mRNA, protein, and activity levels were determined for three donors, and protein expression was compared with that in liver. (aspetjournals.org)
The sandwich culture format and 0.1 μM DEX in media retained the protein expression in the hepatocytes closest to the levels found in liver. (aspetjournals.org)
However, higher in vitro expression was observed for drug transporters, especially for multidrug resistance protein 1 and breast cancer resistance protein. (aspetjournals.org)
Protein transporters move essential metabolites across membranes in all living organisms. (bvsalud.org)
Gene transcripts encoding the ADP / ATP translocase and the mitochondrial phosphate carrier protein were the most abundant mRNAs detected in each Peronospora species. (bvsalud.org)
This study investigated the effect of levels of Watermelon rind meal supplementation as protein source on growth performance and nutrient absorption mRNA expression in Pigs for five-week trial. (ijaar.org)
Here, we show that among 45 transcription factors up-regulated in mycorrhizal roots of the legume Lotus japonicus, expression of a unique GRAS protein particularly increases in arbuscule-containing cells under low phosphate conditions and displays a phylogenetic pattern characteristic of symbiotic genes. (uni-koeln.de)
We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)
Finally, we integrate protein interactions and cell-type-specific co-expression networks together with published association data to implicate novel genes in ASD risk in a cell-type-specific manner. (springer.com)
Consistent with other studies, genes identified by disrupted protein interactions are expressed early in development and in excitatory and inhibitory neuronal lineages. (springer.com)
Disrupted protein interactions identify gene sets involved in risk for ASD. (springer.com)
Using the newly released and larger ASC dataset, we confirm these observations and take them in several new directions: (1) By defining a set of genes encoding these disrupted protein interactors in ASD subjects and another for their siblings, we evaluate their expression patterns in developing brain from fetal to early postnatal development and within general cell types of brain tissue. (springer.com)
One of those molecules, phosphatidylcholine transfer protein (PCTP), suppresses the activity of the other, PPARdelta, a gene regulator critical in burning fat and energy metabolism, under conditions of overnutrition. (anl.gov)
Over the last few decades, it has been studied that the mechanisms of cisplatin-induced kidney damage are complex and involved numerous cellular and molecular processes including inflammation, apoptosis, accumulation of cisplatin in renal tubular cells via renal drug transporters, Ctr1 and OCT2, and involvement of mitogen-activated protein kinases (MAPK) pathways [ 3 ] [ 4 ]. (thieme-connect.com)
In this project, a combination of transporter activity studies, protein localization, and highly accurate determination of the metal distribution in veins will test this hypothesis. (umass.edu)
Western blots measured M2 and M3 protein expression. (lu.se)
Protein and gene expression of M3 was decreased 3 and 7 days post-BPNI, whereas M2 was unchanged. (lu.se)
The ABCC6 gene product is a transmembrane transporter protein that probably plays roles in cellular detoxification. (msdmanuals.com)
The ATP7A gene provides instructions for making a protein that is important for regulating copper levels in the body. (medlineplus.gov)
Many of these mutations delete part of the gene and likely result in a shortened ATP7A protein. (medlineplus.gov)
We focused on the gene amplification and protein expression of ABCC3 (also known as MRP3) in breast cancer cell lines and clinical tumor samples. (lu.se)
ABCC3 (MRP3) protein overexpression was more common in tumors with gene amplification (P = 0.069). (lu.se)
LM aerosols also specifically decreased the mRNA expression of the olfactory marker protein (Omp) and tyrosine hydroxylase (Th) in the olfactory bulb. (cdc.gov)

Recently, we isolated a new complementary DNA (cDNA) encoding human liver-specific organic anion transporter (LST-1), representing the multispecificity of human liver. (nih.gov)
The overall homology with human LST-1 was 60.2%, which is the highest among all known organic anion transporters. (nih.gov)
rlst-1 also belongs to the same new gene family as human LST-1, located between the organic anion transporter family and the prostaglandin transporter. (nih.gov)

mainly involved in uptake, and ABC transporters (ABCs), mainly involved in efflux (e.g. (biorxiv.org)
1]MIBG uptake by UVW glioma cells transfected with the NAT gene whose expression is driven by the human telomerase RNA (hTR) promoter (70% the uptake achieved by the strong viral promoter). (gla.ac.uk)
Transport of these nutrients is competitive and a surplus of a given nutrient may saturate the transporter and prevent the uptake of other nutrients. (wikipedia.org)
Since the mid-1960s, it has been known that there are energy-dependent, sodium-coupled glucose transporter (SGLT) and energy-independent, facilitative glucose transporter (GLUT) pathways for glucose uptake in the lung [ 1 ], and that glucose can permeate the alveolar epithelial barrier [ 2 ]. (ersjournals.com)
In this study, they show that PCTPs can repress the activity of a nuclear receptor called PPARdelta, a gene regulator critical in burning fat, maintaining energy balance, and regulating fatty acid uptake. (anl.gov)
Her work on this subject began with the identification of Yellow Stripe1 (YS1), which encodes the iron-phytosiderophore transporter that is responsible for primary iron uptake in grass species. (umass.edu)
[ 10 , 11 ] In an animal model of Hartnup disorder, mice lacking SLC6A19 (B 0 AT1) transporter general neutral aminoaciduria were observed, as well as the decreased body weight, demonstrating the essential role of epithelial amino acid uptake in optimal growth and bodyweight regulation. (medscape.com)
Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)

Multidrug and toxic compound extrusion (MATE) family is an important group of the multidrug efflux transporters that extrude organic compounds, transporting a broad range of substrates such as organic acids, plant hormones and secondary metabolites. (biomedcentral.com)
Multidrug and toxic compound extrusion (MATE) family is the most recent categorized multidrug efflux transporter family, which is a secondary transporter family that couples the translocation of substrates with an electrochemical gradient of cations (such as H + or Na + ions) across the membrane [ 1 , 2 ]. (biomedcentral.com)
We hope to determine which multidrug-resistance genes are important in clinical drug resistance, and then design approaches to circumventing or overcoming these forms of drug resistance. (sciencewatch.com)
We set about to develop models of multidrug-resistant cancers in cultured cells and use sophisticated molecular techniques to isolate the genes whose expression conferred resistance to the drugs. (sciencewatch.com)
Our first discovery, with my colleagues Igor Roninson and Ira Pastan, was that multidrug-resistant cancers overexpressed a gene that encoded an ATP-dependent transporter, termed P-glycoprotein, MDR1 or ABCB1. (sciencewatch.com)
Although this gene is frequently expressed in drug-resistant cancers, inhibiting it had only minor effects on drug resistance in cancer patients, undoubtedly because there are many other multidrug resistance genes. (sciencewatch.com)
So now we are enumerating all of these genes (at last count, there were at least 400) and trying to determine which play a role in clinical multidrug resistance. (sciencewatch.com)

We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
Little is known about the functions and gene expression levels of membrane transporters produced by downy mildew causing pathogens during infection of their hosts. (bvsalud.org)

Gene expression of putative Peronospora transporters was measured using RNA sequencing data at two time points following inoculation onto leaves of their hosts. (bvsalud.org)

Regulation of K+ absorption in plant root cells by external K+: interplay of different K+ transporters. (jpmb-gabit.ir)
The objective of this study is to discover ABC genes in Rasbora sarawakensis, a species endemic to Borneo and to understand the respective genes regulation. (unimas.my)
The aim of this study was to isolate a rat counterpart of human LST-1 and examine the expression regulation of its messenger RNA (mRNA) to clarify the molecular basis of cholestasis. (nih.gov)
The expression of rlst-1 may be under feedback regulation of cholestasis by biliary obstruction and/or sepsis. (nih.gov)
Gene expression analysis suggested that the differences derived from repression of PPARdelta gene regulation activity. (anl.gov)
The present study was conducted to determine whether corneal cells differentially express genes for T4 regulation, keratan sulfate proteoglycan (KSPG) synthesis, crystallins, and endothelial cell ion transporters during transparency development and whether these expressions are altered when E9 embryos are treated with T4. (unboundmedicine.com)
Prior work on the regulation and localization of Arabidopsis iron transporters, OPT3, YSL1 and YSL3 has indicated that they have opposite but indispensible roles in controlling shoot-to-root signaling of iron status. (umass.edu)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)

We conclude that targeted absolute LC-MS/MS quantification of drug-metabolizing enzymes and transporters can broaden the scope and significantly increase the impact of in vitro drug metabolism studies, such as induction, as an important supplement or future alternative to mRNA and activity data. (aspetjournals.org)
In both the bile duct ligation model and the cecum ligation and puncture model, mRNA expression levels of rlst-1 were down-regulated. (nih.gov)
We have determined that: 1) expression of all calcium and phosphorus transporters in small intestine (jejunum and ileum) were affected by age, 2) only mRNA expression of calcium transporter Calbidin D28k in jejunum, and calcium sensing receptor in ileum were effected by delay in feed access, and 3) only phosphorus transporter type III was affected by age, delay in feed access and their interaction. (usda.gov)
mRNA expressions were determined by real-time PCR using cDNA synthesized from whole-cell RNA, cells expressing T4 receptor mRNAs assessed by in situ hybridization, and KS disaccharide sulfation measured by electrospray ionization tandem mass spectrometry (ESI-MS/MS). (unboundmedicine.com)
Also, cisplatin increased ERK1/2 phosphorylation and NF-κB expression, which subsequently increased mRNA expression of TNF-α, IL-6, KIM-1, NGAL, and Bax/Bcl-2 ratio as well as decreased mRNA expression of IL-10 in kidney tissues. (thieme-connect.com)
Specifically, increased ABCC3 mRNA and gene copy numbers were most prominent in HER2 amplified and/or HER2-enriched classified tumors. (lu.se)

We further evaluated the impact of ghrelin on dopamine-related gene expression and dopamine turnover in brain areas key in impulsive behavior control. (nature.com)
The effects on dopamine (DA) release and dopamine transporter (DAT) gene expression were assayed in hypothalamic HypoE22 cells. (researchgate.net)
In the same experimental system, IL-10 and BDNF gene expressions increased, and in HypoE22 cells, the extract decreased the extracellular dopamine level and increased the DAT gene expression due to the direct interaction of parthenolide with the DAT. (researchgate.net)
123 I]β-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) is a cocaine derivative radioligand which binds to dopamine transporters with substantial striatal specificity at 24 hours postinjection. (bmj.com)
Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
In contrast, HM aerosols induced the expression of Th and dopamine D5 receptor (Drd5) mRNAs, elicited neuroinflammation and blood-brain barrier-related changes in the olfactory bulb, but did not alter the expression of Omp. (cdc.gov)

In this research, nine gene partial transcripts were isolated via RT-PCR and cloning approaches. (unimas.my)
pSELECT-zeo contains a multiple cloning site (MCS) downstream of the composite promoter for convenient cloning of a gene of interest. (invivogen.com)
Cloning and expression of the mouse SLC6A19 gene demonstrated that this transporter has all the properties of the amino acid transport system B 0 AT1. (medscape.com)

A mutation in the Arabidopsis KT2/KUP2 potassium transporter gene affects shoots cell expansion. (jpmb-gabit.ir)
AtKuP1: a dual-aﬃnity K+ transporter from Arabidopsis. (jpmb-gabit.ir)

One pair stood out: lipid transporter PCTP and nuclear receptor PPARdelta. (anl.gov)
The underlying genetic abnormality in harlequin ichthyosis is a mutation in the lipid-transporter gene ABCA12 on chromosome 2. (medscape.com)

Predicted to enable magnesium ion transmembrane transporter activity and palmitoyltransferase activity. (nih.gov)

Mutations in the SLC6A19 gene, which encodes the SLC6A19 (B 0 AT1) neutral amino acid transporter, causes a failure of the transport of neutral (ie, monoaminomonocarboxylic) amino acids in the small intestine and the renal tubules. (medscape.com)
The glucose transporters expressed in the renal proximal tubule ensure that less than 0.5 g/day (range 0.03-0.3 g/d) is excreted in the urine of healthy adults. (medscape.com)
The UMOD story got a lot more interesting when Trudu et al published an intriguing set of experiments establishing a link between uromodulin, hypertension, and kidney disease via activation of the renal sodium co-transporter NKCC2. (medscape.com)

Glucose is removed from ASL in proximal airways via facilitative glucose transporters, down a concentration gradient generated by intracellular glucose metabolism. (ersjournals.com)
In the distal lung, glucose transport via sodium-coupled glucose transporters predominates. (ersjournals.com)

Perland and Fredriksson, 2017 ) or the pharmaceutical drug substrates of these transporters, and one clue to this may be to understand their differential tissue distribution. (biorxiv.org)
The article "Differential expression of the glucose transporter gene glcH in response to glucose and light in marine picocyanobacterial" by Moreno-Cabezuelo et al. (peerj.com)
Differential gene expression analysis of these eight GmMATE genes in response to Al stress helps us identify GmMATE75 as the candidate gene for Al tolerance in soybean, whose relative transcript abundance increased at 6, 12 and 24 h after Al treatment, with more fold changes in Al-tolerant than Al-sensitive cultivar, which is consistent with previously reported Al-tolerance related MATE genes. (biomedcentral.com)
RNA sequencing is a powerful method to study differential gene expression because it can detect a whole gene expression across particular tissues 1 . (nature.com)

These 117 GmMATE genes were unevenly localized on soybean chromosomes 1 to 20, with both tandem and segmental duplication events detected, and most genes showed tissue-specific expression patterns. (biomedcentral.com)
The cis -elements and expression patterns of eight soybean MATE genes related to Al detoxification/iron translocation were analyzed, and GmMATE75 was identified as a candidate gene for Al tolerance in soybean. (biomedcentral.com)
In conclusion, nucleotide profiles of these genes are comparable to the phylogenetic analysis and expression patterns across family. (unimas.my)
Different gene expression patterns, shown by tools such as quantitative PCR, microarrays, and high-throughput RNA sequencing, reveal how organisms respond to different environments. (nature.com)
For genes encoding the disrupted interactions, we evaluate their expression patterns across developing brains and within specific cell types, using both bulk and inferred cell-type-specific brain transcriptomes. (springer.com)
Therefore, the aim of the present study was to characterize expression patterns of small intestine calcium and phosphorus transporter genes during the first two weeks post-hatch in chickens. (usda.gov)
Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC). (wjgnet.com)
The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC patients. (wjgnet.com)

SLC6A19 is a sodium-dependent and chloride-independent neutral amino acid transporter, expressed predominately in the kidneys and intestine. (medscape.com)
These transporters require energy and are sodium dependent. (medscape.com)

Gene expression of glial glutamate transporter EAAT2 and the predominantly neuronal glutamate transporter EAAT3 were examined by in situ hybridization. (cshl.edu)
Using inferred gene co-expression for three neuronal cell types-excitatory, inhibitory, and neural progenitor-we implicate several hundred genes in risk (FDR \(\le \hspace{0.17em}\) 0.05), ~ 60% novel, with characteristics of genuine ASD genes. (springer.com)
Across cell types, these genes affect neuronal morphogenesis and neuronal communication, while neural progenitor cells show strong enrichment for development of the limbic system. (springer.com)
Bladder sections were stained with Masson's trichrome for SM content and immunofluorescence staining for nerve terminals expressing vesicular acetylcholine transporter (VAChT), tyrosine hydroxylase (TH), and neuronal nitric oxide synthase (nNOS). (lu.se)

We found that levels of expression of calcium transporter genes differed between resistant and susceptible lettuce varieties. (harper-adams.ac.uk)

The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-binding cassette (ABC) transporters. (frontiersin.org)
This study investigated relationships between accumulation of methotrexate and gene expression levels of solute carrier and ATP-binding cassette transporters in cancer cells after a single and high-dose X-ray irradiation. (frontiersin.org)
The ATP-Binding Cassette transporters (ABC transporters) function in various physiological activity, allowing vertebrate to thrive even in polluted environment. (unimas.my)
Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)

The levels of metabolizing enzymes and transporters expressed in hepatocytes are decisive factors for hepatobiliary disposition of most drugs. (aspetjournals.org)
Induction via nuclear receptor activation can significantly alter those levels, with the coregulation of multiple enzymes and transporters occurring to different extents. (aspetjournals.org)
Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)

A total of 117 MATE transporters were identified in soybean and their potential functions were proposed by phylogenetic analysis with known plant MATE transporters. (biomedcentral.com)

Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma. (wjgnet.com)
UMOD risk variants identified in the above-mentioned GWAS are located in the promoter region of the gene, leading to a theory that they altered UMOD expression. (medscape.com)

The Gini index (coefficient) characterises inequalities of distributions, and is used in a novel way to describe the distribution of the expression of each transporter among the different tissues and cell lines. (biorxiv.org)
In many cases, transporters exhibit extremely high Gini coefficients, even when their supposed substrates might be expected to be available to all tissues, indicating a much higher degree of specialisation than is usually assumed. (biorxiv.org)
Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)
By contrast, the Gini coefficients for ABC transporters tend to be larger in cell lines than in tissues, implying that some kind of a selection process has taken place. (biorxiv.org)
PCBP1 is both reasonably highly expressed and has a low Gini coefficient in both tissues and cell lines, and is an excellent novel housekeeping gene. (biorxiv.org)
Expression profiles in six tissues (i.e., brain, eye, gill, intestine, muscle, and skin) revealed divergence that shed light on tissue-specific gene functional specialization, with highlight on B4, B8, and E1 which are expressed in all six organs. (unimas.my)
Methodology Gene expression profiling was performed on 39 ABC and 12 SLC transporters and 3 ATPases in epithelial ovarian cancer (EOC) tissues and the results were assessed with respect to prognosis and clinical presentation of EOC patients. (bmj.com)
In a cohort of tissues with primary EOC (n = 57) and control tissues (n = 14) we assessed relative expression of genes and compared it with the clinical and survival information. (bmj.com)
Results 6 ABC genes and the SLC22A18 gene were considerably over-expressed in the cancer tissues in comparison with control tissues and the expression of 12 ABC genes, 5 SLC genes, ATP7A, ATP11B was reduced. (bmj.com)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)

Secondary active transport occurs in the intestine and the kidney tubules (predominantly proximal tubule) and is mediated by members of the SGLT transporter family. (medscape.com)
i) The apical transporters are SGLT-1 (type 1) and SGLT-2. (medscape.com)

Gray triangles = other expression annotations only (e.g. absence of expression or data from mutants). (jax.org)

This form of glucose transport is predominantly mediated by members of the GLUT transporter family. (medscape.com)

Particularly, the expression levels of ABCA9, ABCA10, ABCC9 and SLC16A14 were considerably related to PFS in both pilot and verification groups. (bmj.com)
Conclusion The genes ABCA2, ABCA9, ABCA10, ABCC9, ABCG2 and SLC16A14 represent new potential markers of epithelial ovarian cancer progression and collectively with the discovered association between the expression of ABCA12, ABCC3, ABCC6, ABCD3, ABCG1, SLC22A5 and HGSC they should be investigated more extensively in future studies. (bmj.com)

The mammalian MATE transporters can excrete the metabolic waste and xenobiotic organic cations in the kidney and liver [ 12 , 13 ]. (biomedcentral.com)

The scientists first created a whole-body PCTP knockout male mouse (meaning one in which genes have been activated or deactivated), assessing its fat metabolism under different dietary conditions, including normal and high-fat diet. (anl.gov)
In particular, extracellular-regulated kinase (ERK) 1/2, one of the MAPK pathway is considered as an important mediator of signal transduction processes, namely cell survival, cell division, gene expression, and cell metabolism that plays role in injury, death, and inflammation of kidney tubular cells due to cisplatin administration [ 5 ]. (thieme-connect.com)

In particular, with some exceptions such as olfactory receptors and genes involved in keratin production, transporter genes are significantly more heterogeneously expressed than are most non-transporter genes. (biorxiv.org)
Immunohistocytochemical examination of the skin reveals characteristic abnormalities in the structure of lamellar granules and in the expression of epidermal keratin. (medscape.com)

45% WMR-M supplementation may be recommended in diets of piglets due to its improved growth performance and up regulated nutrient related transporters in the epithelial cells of Pigs. (ijaar.org)

Developmental expression of ascidian neurotransmitter synthesis genes. (taconic.com)
In summary, we have shown, for the first-time, developmental changes in expression of calcium and phosphorus transporter genes in broiler chickens. (usda.gov)
In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate i n utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. (biomedcentral.com)
Multivariable linear regression analysis was used to examine their relationship with arsenic exposure and with key developmental genes, after stratification by fetal sex. (biomedcentral.com)

Inventory and functional characterization of the HAK potassium transporters of rice. (jpmb-gabit.ir)
Molecular characterization of the mouse vesicular acetylcholine transporter gene. (taconic.com)

In silico analysis of 804 breast cancers with matched gene expression and copy number microarray data revealed significant differences ABCC3 across the molecular subtypes. (lu.se)

In contrast to some previously described early genes, most of the novel genes are not induced in cortex by apomorphine, indicating specificity of induction. (jneurosci.org)

The requirement for 2 transport-impairing mutations for disease expression confirmed a recessive mode of inheritance. (medscape.com)
Several mutations in the ATP7A gene are responsible for a condition called occipital horn syndrome or X-linked cutis laxa, which is considered a mild form of Menkes syndrome (described below). (medlineplus.gov)
Researchers have identified more than 150 mutations in the ATP7A gene that cause Menkes syndrome. (medlineplus.gov)
Other mutations insert additional DNA building blocks (nucleotides) into the gene or change single nucleotides. (medlineplus.gov)
Mutations in the sodium-glucose cotransporter 2 gene are responsible for the majority of cases. (medscape.com)

Identification of novel potential interaction partners of UDP-galactose (SLC35A2), UDP-N-acetylglucosamine (SLC35A3) and an orphan (SLC35A4) nucleotide sugar transporters. (invivogen.com)

A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)
these gene expression changes may be responsible for the alterations in striatal physiology. (jneurosci.org)

Irradiation of cancer cells thus alters gene expression levels of both solute carrier transporters (OATP1B1/1B3/1B7) and ABC transporters (MRP1/2) and decreases accumulation of 3 H-MTX in cancer cells over time due to elevated expression of MRP1/2. (frontiersin.org)

The locus at chromosome 1q21 was identified by linkage mapping in 1998, but the gene has only recently been discovered due to difficulty with sequencing this highly repetitive region and was previously missed using next-generation sequencing. (medscape.com)

Human placental Na+-dependent multivitamin transporter. (wikipedia.org)

Expressions of most genes involved in KS synthesis increased from E9 to E16, and then decreased from E16 to E20. (unboundmedicine.com)
Thyroxine modifies expressions of KSPG synthesis and carbonic anhydrase genes. (unboundmedicine.com)

Introgression of Bacterial Blight Resistance Genes in the Rice Cultivar Ciherang: Response against Xanthomonas oryzae pv. (mdpi.com)

In control, gene expression levels of OAT1 in all cells was below the limit of measurement. (frontiersin.org)
Given that the basic genome of a differentiated organism is constant between cells (and we here ignore epigenomics), what mainly discriminates one cell type from another is its expression profile. (biorxiv.org)
A working hypothesis that explains current observations is that OPT3 and YSL1/YSL3 together modulate phloem companion cell Fe status, and that low concentrations of Fe in the companion cells results in the production of a phloem mobile signal that initiates iron deficiency regulated gene expression in roots. (umass.edu)

Plus, there are many other genes whose expression can confer drug resistance. (sciencewatch.com)

Transporters expressed during grape berry (Vitis vinifera L.) development are associated with an increase in berry size and berry potassium accumulation. (jpmb-gabit.ir)
Rohan A. Patil, Martin E. Kolewe, Jennifer Normanly, Elsbeth L. Walker, Susan C. Roberts (2012) Contribution of taxane biosynthetic pathway gene expression to observed variability in paclitaxel accumulation in Taxus suspension cultures. (umass.edu)

0.05) increased excitatory amino acid transporter 3 (EAAT 3) by 5, 12 and 15 times in 15%, 30% and 45% groups. (ijaar.org)

Seven stress-responsive cis -elements such as ABRE, ARE, HSE, LTR, MBS, as well as a cis -element of ART1 (Al resistance transcription factor 1), GGNVS, were identified in the upstream region of these eight GmMATE genes. (biomedcentral.com)
In fact, ABCB1 belongs to a family of 48 human ATP-dependent transporters, of which approximately 50% can confer resistance to one or another drug. (sciencewatch.com)

Gene expression was assessed by qPCR for muscarinic receptor types 2 (M2) and 3 (M3), collagen type 1α1 and 3α1, and SM actin. (lu.se)

Anatomy19

Organisms16

Diseases3

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes83

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science6

Named Groups1

Health Care3

Proteins7

Protein25

Organic anion3

Uptake8

Multidrug7

Membrane2

Putative1

Regulation12

MRNA6

Dopamine6

Cloning3

Arabidopsis2

Lipid transporter2

Transmembrane transporter1

Renal3

Glucose transporters2

Differential4

Patterns9

Sodium-dependent2

Neuronal4

Calcium transporter1

Cassette4

Enzymes3

Phylogenetic analysis1

Promoter2

Tissues9

Phenotypes1

SGLT2

Mutants1

GLUT1

ABCC92

Mammalian1

Metabolism2

Keratin2

Epithelial1

Developmental4

Characterization2

ABCC31

Specificity1

Mutations5

Nucleotide1

Striatal2

Cancer cells1

Chromosome1

Placental1

Synthesis2

Bacterial1

Cells3

DRUG-RESISTANCE1

Accumulation2

Excitatory1

Resistance2

Receptor1