Transport of glucose glucose transport proteins facilitative. Medical search. Frequent questions

Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11) also known as glucose transporter type 10/11 (GLUT-10/11) is a protein that in humans is encoded by the SLC2A11 gene. (wikipedia.org)
The GLUT members belong to a family of glucose transporter proteins that facilitate glucose transport across the cell membrane. (preprints.org)
The recently cloned SLC2A10 gene encodes a 541 amino acid putative facilitative glucose transporter (GLUT10) of the GLUT family class III with between 30 and 34% amino acid homology with the known GLUT proteins ( 1 , 2 ). (diabetesjournals.org)
Failures in the absorptive process of monosaccharides during the early postnatal phase at intestinal level, through SGLT-1 and GLUT-2 glucose transporters could lead to animal death. (edu.pe)
The objective of this study was to determine the hexose transporters SGLT-1 and GLUT-2 distribution in the gut and its relation with blood glucose levels in baby alpacas. (edu.pe)
Blood glucose level was determined by enzymatic test and the presence of transporters by immunohistochemistry, using rabbit policlonal antibody anti SGLT-1 and anti GLUT-2. (edu.pe)
Since the mid-1960s, it has been known that there are energy-dependent, sodium-coupled glucose transporter (SGLT) and energy-independent, facilitative glucose transporter (GLUT) pathways for glucose uptake in the lung [ 1 ], and that glucose can permeate the alveolar epithelial barrier [ 2 ]. (ersjournals.com)
The results obtained showed that high and low glucose concentrations regulate the availability of facilitative glucose transporter (GLUT) isoforms and the glucose transport capacity of human chondrocytes. (biomedcentral.com)
High glucose concentrations decrease the transport capacity and GLUT-1 protein content without affecting its mRNA levels, but this ability to adjust glucose transport capacity as a function of its availability is compromised in aged/OA chondrocytes leading to its intracellular accumulation[ 3 ]. (biomedcentral.com)
This form of glucose transport is predominantly mediated by members of the GLUT transporter family. (medscape.com)
ii) The glucose carriers expressed in the basolateral domain are GULT-1 and GLUT-2 that do not require energy, sodium, or any other ion. (medscape.com)

Drosophila transmembrane protein 214 (dTMEM214) regulates midgut glucose uptake and systemic glucose homeostasis. (ouhsc.edu)
The laforin-malin complex negatively regulates glycogen synthesis by modulating cellular glucose uptake via glucose transporters. (ouhsc.edu)
We found that in intact isolated mouse skeletal muscle, siRNA-mediated knockdown of Rab28 decreases basal glucose uptake. (bath.ac.uk)
Consistent with this paradoxical phenotype, basal glucose uptake was higher in AS160-knockout primary adipocytes and normal in isolated soleus muscle, but their insulin-stimulated glucose uptake and overall GLUT4 levels were markedly decreased. (dundee.ac.uk)
In contrast, insulin-stimulated glucose uptake and GLUT4 levels were normal in EDL muscle. (dundee.ac.uk)
Glucose transport inhibitors blocked both [3H]-2-deoxy-glucose (2dG) uptake and phagocytosis of P. aeruginosa. (aai.org)
Glucose removal is determined by cellular glucose uptake and metabolism ( fig. 1 ) [ 4 , 12 - 14 ]. (ersjournals.com)

They facilitate passive diffusion of GLUCOSE across the CELL MEMBRANE. (ouhsc.edu)
Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. (genetex.com)

A family of monosaccharide transport proteins characterized by 12 membrane spanning helices. (ouhsc.edu)

In humans, a truncation mutation (R363X) in one allele of AS160 decreased the expression of the protein and caused severe postprandial hyperinsulinaemia during puberty. (dundee.ac.uk)

Drosophila Solute Carrier 5A5 Regulates Systemic Glucose Homeostasis by Mediating Glucose Absorption in the Midgut. (ouhsc.edu)
Members of this family play a significant role in maintaining glucose homeostasis. (nih.gov)
Understanding of mechanisms underlying lung glucose homeostasis could identify new therapeutic targets for control of ASL glucose and prevention and treatment of lung infection. (ersjournals.com)
Elucidating how high glucose modulates joint tissue homeostasis will identify novel targets for development of innovative strategies both to identify diagnostic and prognostic biomarkers of OA and to effectively modify disease progression. (biomedcentral.com)
The kidneys play an important role in glucose homeostasis. (medscape.com)
It helps to maintain glucose homeostasis by at least two mechanisms. (medscape.com)

Transport urate and fructose. (nih.gov)
Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. (biomedcentral.com)
Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of mTOR. (biomedcentral.com)
These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis, but the details of these interactions remain unclear. (biomedcentral.com)

In this report, we exploit a "selective starvation" strategy by inhibiting Plasmodium falciparum hexose transporter 1 (PfHT1), the sole hexose transporter in P. falciparum, over human glucose transporter 1 (hGLUT1), providing an alternative approach to fight against multidrug-resistant malaria parasites. (princeton.edu)

The Rab-GTPase-activating proteins (GAPs) TBC1D1 and TBC1D4 play important roles in the insulin-stimulated translocation of the glucose transporter GLUT4 from intracellular vesicles to the plasma membrane in muscle cells and adipocytes. (bath.ac.uk)
AS160 (Akt substrate of 160 kDa) is a Rab GTPase-activating protein implicated in insulin control of GLUT4 (glucose transporter 4) trafficking. (dundee.ac.uk)
The insulin-responsive aminopeptidase (IRAP/VP165/gp160) was identified originally in GLUT4-containing vesicles and shown to translocate in response to insulin, much like the glucose transporter 4 (GLUT4). (johnshopkins.edu)
Both of these effects occur without corresponding changes in the subcellular distribution of the GLUT4 glucose transporter isoform. (psu.edu)
In this report, we have utilized the impermeant, exofacial bis-mannose glucose transporter- specific photolabel, 2-N-4- (1-azi-2,2,2-trifluoroethyl)benzoyl-1, 3-bis (D-mannos-4-yloxy) -2-propylamine (ATB-BMPA), to examine the cell surface accessibility of GLUT4 glucose transporters under these conditions. (psu.edu)
Photolabeling the corresponding plasma membranes revealed that these alterations in the ability of the photolabel to bind to GLUT4 are transient as the levels of both photolabel incorporation and plasma membrane glucose transport activity were consistent with the observed GLUT4 concentration. (psu.edu)
These data suggest that insulin-stimulated GLUT4 glucose transporters can exist in two distinct states within the adipocyte plasma membrane, one functional and accessible to extracellular substrate and one non-functional and unable to bind extracellular substrate. (psu.edu)
Insulin-stimulated glycolytic rates and lactate efflux rates were increased by 33% in hyperthyroid rat hearts, mediated by an increased insulin-stimulated translocation of the glucose transporter GLUT4 to the sarcolemma. (ox.ac.uk)

The key enzymes of gluconeogenesis are phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase). (medscape.com)

SLC2A11 belongs to a family of plasma membrane proteins that mediate transport of sugars across the membrane by facilitative diffusion. (wikipedia.org)
In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. (genetex.com)
The three terminal products of carbohydrate digestion are transported through the enterocyte brush border membrane via facilitative transporter proteins such as the sodium-glucose cotransporter 1 (SGLT1), glucose transporter 2 (GLUT2), and glucose transporter S (GLUTS). (your-doctor.net)
Serotonin Plasma Membrane Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
This graph shows the total number of publications written about "Serotonin Plasma Membrane Transport Proteins" by people in this website by year, and whether "Serotonin Plasma Membrane Transport Proteins" was a major or minor topic of these publications. (musc.edu)
Below are the most recent publications written about "Serotonin Plasma Membrane Transport Proteins" by people in Profiles. (musc.edu)
Reabsorption of glucose predominantly occurs on the brush border membrane of the convoluted segment of the proximal tubule. (medscape.com)

This gene encodes a member of the SLC2A facilitative glucose transporter family. (nih.gov)

Heterozygosity for mutations suggest a role of nongenetic factors or other genes involved in renal glucose transport. (medscape.com)

The glucose transporter GLUT1 catalyses facilitative diffusion of glucose into erythrocytes and is responsible for glucose supply to the brain and other organs. (princeton.edu)
Structural comparison of the uniporter GLUT1 with its bacterial homologue XylE, a proton-coupled xylose symporter, allows examination of the transport mechanisms of both passive facilitators and active transporters. (princeton.edu)
The facilitative glucose transporter GLUT1 mRNA transcript was detected by PCR in preparations from purified macrophages. (aai.org)
GLUT1 protein was detected with anti-GLUT1-peptide polyclonal Abs. (aai.org)
We conclude that glucose exerts its effect on the macrophage, not on the bacterium, in the glucose-dependent nonopsonic phagocytosis of P. aeruginosa and that glucose transport via GLUT1 by the macrophages is required to trigger ingestion. (aai.org)
Hydrodynamic analysis and electron microscopy of GLUT1/lipid/detergent micelles and freeze fracture electron microscopy of GLUT1 proteoliposomes support the hypothesis that the glucose transporter is a multimeric (probably tetrameric) complex of GLUT1 proteins. (umassmed.edu)
GLUT1 does not appear to exchange rapidly between protein/lipid/detergent micelles but is able to self-associate in the plane of the lipid bilayer. (umassmed.edu)
Quantitatively deglycosylated GLUT1 displays aberrant electrophoretic mobility, but each protein band contains full-length GLUT1 and the less mobile species, when treated with additional detergent and reductant, converts to the more mobile species. (umassmed.edu)

Examination of primary human breast fibroblasts in vitro confirmed that CA IX mRNA and protein can be induced by hypoxia. (ox.ac.uk)

P. aeruginosa ingestion by macrophages occurs only in the presence of D-glucose or D-mannose, sugars present in low concentrations in the endobronchial space. (aai.org)
Here, we consider a newly identified role for pulmonary glucose transport in maintaining low airway surface liquid (ASL) glucose concentrations and propose that this contributes to lung defence against infection. (ersjournals.com)
These processes vary between species but universally maintain ASL glucose at 3-20-fold lower concentrations than plasma. (ersjournals.com)
ASL glucose concentrations are increased in respiratory disease and by hyperglycaemia. (ersjournals.com)
This is in contrast to conditions in the gut and kidney, where luminal glucose concentrations regularly exceed plasma glucose concentrations [ 6 , 7 ]. (ersjournals.com)
ASL glucose concentrations are the net result of diffusion of glucose from blood and interstitial fluid across the respiratory epithelium into the ASL, and removal of glucose from ASL by epithelial glucose transport processes. (ersjournals.com)
Current model of the mechanisms controlling glucose concentrations in the surface liquid lining the airway and distal lung epithelium. (ersjournals.com)
Renal glucosuria is the excretion of glucose in the urine in detectable amounts at normal blood glucose concentrations in the absence of any signs of generalized proximal renal tubular dysfunction due to a reduction in the renal tubular reabsorption of glucose. (medscape.com)
Renal glucosuria is the excretion of glucose in the urine in detectable amounts at normal blood glucose concentrations in the absence of any signs of generalized proximal renal tubular dysfunction. (medscape.com)

Consequently the affinity of the transporters for glucose along the tubule increases to allow for complete reabsorption of glucose from the urine. (medscape.com)

The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas. (diabetesjournals.org)

Despite having lower blood glucose levels under both fasted and random-fed conditions, the AS160-knockout mice exhibited insulin resistance in both muscle and liver in a euglycaemic clamp study. (dundee.ac.uk)

The glucose transporters expressed in the renal proximal tubule ensure that less than 0.5 g/day (range 0.03-0.3 g/d) is excreted in the urine of healthy adults. (medscape.com)

Glucose is removed from ASL in proximal airways via facilitative glucose transporters, down a concentration gradient generated by intracellular glucose metabolism. (ersjournals.com)
Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart. (ox.ac.uk)

Glucose diffusion is determined by epithelial permeability to glucose, the transepithelial glucose gradient and surface area. (ersjournals.com)

Glucose transporters (GLUTs) and sodium-glucose co-transporters (SGLTs) are overexpressed in multiple malignancies, and are correlated with treatment resistance, clinical factors, and poor overall survival (OS). (nih.gov)
The arrangement of multiple GLUTs across all somatic tissues signifies the important role of glucose across all organisms. (preprints.org)

Our understanding of the role of glucose transport in the lung and the mechanisms that regulate glucose movement across the human lung epithelium lags far behind that of the gut and kidney. (ersjournals.com)
Rosa SC, Rufino AT, Judas FM, Tenreiro CM, Lopes MC, Mendes AF: Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes. (biomedcentral.com)

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. (genetex.com)

Insulin-stimulated glucose transport activity in rat adipocytes is inhibited by isoproterenol and enhanced by adenosine. (psu.edu)

Secondary active transport occurs in the intestine and the kidney tubules (predominantly proximal tubule) and is mediated by members of the SGLT transporter family. (medscape.com)

Laiguillon M-C, Courties A, Houard X, Auclair M, Sautet A, Capeau J, et al: Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis. (biomedcentral.com)

A leucine-sensitive amino acid transport system with high affinity for basic amino acids( AMINO ACIDS, BASIC). (musc.edu)

Glucose enters the cell along with sodium, and sodium exits the cell at the basolateral side of the cell, which is sodium-independent and a facilitative transport requiring no energy. (medscape.com)

Glucose enters at the luminal side of the proximal tubular cells by an active carrier-mediated transport process that requires energy provided by the sodium gradient between the intra- and extracellular compartments generated by sodium-potassium ATPase. (medscape.com)

These effects are only observed in the intact adipocyte and are not retained in isolated plasma membranes isolated from these cells when analyzed for the ability to transport glucose or bind photolabel. (psu.edu)
0.01 mM and plasma glucose 0.19 mM [ 3 ]. (ersjournals.com)
As plasma glucose concentration increases, there is concordant increase in the filtered load of glucose. (medscape.com)

As the rate of glucose entering the nephron rises above 260-350mg/1.73m 2 /min (14.5-19.5mmol/1.73m 2 /min), the excess glucose exceeds the reabsorptive capacity of proximal tubule and is excreted in the urine (i.e. glucosuria). (medscape.com)

FRG is a rare disorder due mainly to mutations in the sodium-glucose cotransporter 2 gene ( SGLT2 ) that are responsible for the majority of cases. (medscape.com)
Although the pattern of inheritance that best fits FRG is one of co-dominance, increased glucose excretion was not observed in all individuals with similar or identical mutations. (medscape.com)
Mutations in the sodium-glucose cotransporter 2 gene are responsible for the majority of cases. (medscape.com)

Facilitative transport occurs in essentially all cell types and is driven by the concentration gradient across cellular membranes. (medscape.com)

For over 50 years, glucose has been recognised to cross the lung epithelial barrier and be transported by lung epithelial cells. (ersjournals.com)
In primary cultures of human bronchial epithelial cells (HBECs) with 16.6±0.4 mM glucose in the basolateral medium, ASL glucose was 2.2±0.5 mM [ 11 ]. (ersjournals.com)
In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. (biomedcentral.com)

In immortalised human airway cells (line H441) with 10 mM glucose in the basolateral medium, apical ASL glucose was 0.24±0.07 mM [ 10 ]. (ersjournals.com)

However, much subsequent research in this area was focused on the role of pulmonary SGLT transport as a modifier of lung liquid volume [ 3 , 4 ], and the effects of starvation and diabetes on glucose transport [ 1 , 5 ]. (ersjournals.com)

10 (8):e0135262 c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction. (genetex.com)

Defects in glucose transport have been linked to metabolic disorders, insulin resistance and diabetes. (preprints.org)

The secretin-glucagon family of hormones includes glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), growth hormone-releasing hormone (GHRH), and pituitary adenylyl cyclase-activating peptide (PACAP). (your-doctor.net)

Glycosaminoglycans are polymers of forms of glucose (glucosamine, glucuronic acid, iduronic acid) suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus. (biomedcentral.com)

McNulty AL, Stabler TV, Vail TP, McDaniel GE, Kraus VB: Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. (biomedcentral.com)

Whether and how glucose directly affects joint tissues and cells is just beginning to be unraveled. (biomedcentral.com)
Indirect effects of high glucose can result from enhanced formation of advanced glycation end products (AGEs) which accumulate in OA cartilage in an age-dependent manner and play a pro-inflammatory and pro-catabolic role mediated by activation of their specific receptor, RAGE, on chondrocytes and synovial cells. (biomedcentral.com)

Organelles from endosperm of etiolated seedlings were isolated and subjected to liquid chromatography-tandem mass spectrometry (LC-MS/MS). Computer-assisted deconvolution algorithms were applied to reliably assign the identified proteins to their correct subcellular localization and to determine the abundance of the different organelles in the heterogeneous protein samples. (bvsalud.org)

Elevated ASL glucose in intensive care patients was associated with increased Staphylococcus aureus infection. (ersjournals.com)

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