• It inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. (nih.gov)
  • Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene. (wikipedia.org)
  • Organic Anion Transport Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • This graph shows the total number of publications written about "Organic Anion Transport Protein 1" by people in this website by year, and whether "Organic Anion Transport Protein 1" was a major or minor topic of these publications. (ucdenver.edu)
  • Below are the most recent publications written about "Organic Anion Transport Protein 1" by people in Profiles. (ucdenver.edu)
  • TEA transport was temperature dependent and saturable with Vmax and K(m) values of 2.89 +/- 0.448 nmol/mg protein/30 min and 229 +/- 78.4 microM, respectively. (drugbank.com)
  • The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue protein with 12 putative transmembrane domains. (aspetjournals.org)
  • Previous studies have suggested the involvement of organic anion and oligopeptide transporters in membrane transport of β-lactams. (aspetjournals.org)
  • Probenecid has also been reported to inhibit the renal transport of many other compounds including aminohippuric acid (PAH), aminosalicylic acid (PAS), indomethacin, sodium iodomethamate and related iodinated organic acids, 17-ketosteroids, pantothenic acid, phenolsulfonphthalein (PSP), sulfonamides, and sulfonylureas. (nih.gov)
  • A body fluid model coordinated various flows in a human body with scheduled daily activities and could be used as a drug container to describe formulation-dependent disposition of 5-aminosalicylic acid and enterohepatic circulation of a virtual drug. (bvsalud.org)
  • Finally, the adaptive kidney model accurately predicted CLr of para-amino-hippuric acid and memantine, two secreted compounds, in CKD, suggesting successful integration of active secretion into the model, along with passive reabsorption. (bvsalud.org)
  • We tested the interaction of an array of organic cations and other compounds with hOCT1 by determining Ki values in inhibiting 14C-tetraethylammonium (TEA) transport in the transfected cells. (drugbank.com)
  • Pombrio JM, Giangreco A, Li L, Wempe MF, Anders MW, Sweet DH, Pritchard JB, Ballatori N. Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1. (ucdenver.edu)
  • first, organic anions are transported from the peritubular plasma by basolateral organic anion transporter(s) and subsequently effluxed into the tubular lumen by luminal transporter(s). (aspetjournals.org)
  • The transport properties of rOAT1 are nearly identical to those of the classic PAH transporter. (aspetjournals.org)
  • Probenecid is the generic name for 4-[(dipropyl-amino)sulfonyl] benzoic acid. (nih.gov)
  • The chemical name for probenecid is 4-[(dipropylamino) sulfony1] benzoic acid. (nih.gov)
  • Probenecid is uricosuric and renal tubular transport blocking agent.Probenecid is the generic name for 4-[(dipropyl-amino)sulfonyl] benzoic acid. (drugcentral.org)
  • hPepT2, and to a lesser extent hPepT1, may play an important role in apical transport of amoxicillin and cefaclor in the renal tubule. (aspetjournals.org)
  • The process of secreting organic anions through the proximal tubule cells is achieved via unidirectional transcellular transport involving the uptake of organic anions into the cells from the blood across the basolateral membrane, followed by extrusion across the brush-border membrane into the proximal tubule fluid. (aspetjournals.org)
  • inhibit the PAH uptake by binding to some site necessary for normal PAH transport without affecting the cellular viability. (kyobobook.co.kr)
  • Amoxicillin and cefaclor inhibited hOAT1-mediated [ 3 H] para -aminohippuric acid uptake ( K i = 11.0 and 1.15 mM, respectively). (aspetjournals.org)
  • However, our uptake study revealed that neither drug was transported by hOAT1. (aspetjournals.org)
  • Direct uptake studies demonstrated that amoxicillin and cefaclor were transported by hPepT1 and hPepT2. (aspetjournals.org)
  • Measurable changes in proximal tubule function, such as decreased clearance of para-aminohippuric acid also occur over a period of years and precede overt kidney failure. (testcatalog.org)
  • The acid is a known carcinogen, and its use has been associated with and may cause end-stage renal disease and cancers of the urinary tract that may occur many years after usage has stopped. (unboundmedicine.com)
  • Any of the complex acids that occur as salts in bile, e.g., cholic, glycocholic, and taurocholic acids. (unboundmedicine.com)
  • Corticosteroids inhibit formation of arachidonic acid from phospholipids when cell membranes are damaged. (unboundmedicine.com)
  • The effects of anions on net accumulation of (ρ-aminohippuric acid)(PAH) were studied in rabbit kidney cortical slices. (kyobobook.co.kr)
  • In these cases when alkali is administered, the acid-base balance of the patient should be watched. (nih.gov)
  • Analysis of heterologous expression systems of rOAT1 in oocytes and culture cells revealed that rOAT1 has the ability to transport anionic drugs, such as β-lactam antibiotics, NSAIDs, methotrexate, and antiviral drugs, as well as various endogenous organic anions and exogenous substances. (aspetjournals.org)
  • Predicted to be involved in transmembrane transport. (mcw.edu)
  • Until early 1990s, renal organic anion transport was thought to be carried out by a few carrier proteins that showed wide substrate specificity. (aspetjournals.org)
  • It is a building block of proteins, participates in the citric acid and urea cycles, and is a neurotransmitter. (unboundmedicine.com)
  • As shown in Table 1 , thiazide and loop diuretics, which carry as a common chemical characteristic a sulfamoyl group (sulfonamide diuretics), are weak organic acids. (aspetjournals.org)
  • H 3 BO 3 , a white crystalline acid that in water forms a very weak acid solution poisonous to plants and animals. (unboundmedicine.com)
  • In particular, the organic anion transport pathway has been shown to mediate the elimination of various drugs. (aspetjournals.org)
  • C 10 H 18 N 4 O 6 , a compound intermediate in the synthesis of arginine, formed from citrulline and aspartic acid. (unboundmedicine.com)
  • When expressed in Xenopus laevis oocytes, hOAT3 mediated the transport of estrone sulfate ( K m = 3.1 μM), p -aminohippurate ( K m = 87.2 μM), methotrexate ( K m = 10.9 μM), and cimetidine ( K m = 57.4 μM) in a sodium-independent manner. (aspetjournals.org)
  • OAT1 is a PAH/dicarboxylate exchanger and mediates the high-affinity transport of PAH in a sodium-independent manner. (aspetjournals.org)
  • Liquid organic acids or solutions should be diluted, if necessary, and carefully neutralized with sodium hydrogen carbonate (Cat. (alphachemikaindia.com)
  • Not recommended in persons with known blood dyscrasias or uric acid kidney stones. (nih.gov)
  • Hypersensitivity to probenecid.Children under years of age.Not recommended in persons with known blood dyscrasias or uric acid kidney stones.Therapy with probenecid should not be started until an acute gouty attack has subsided. (drugcentral.org)
  • Because hOAT1 has been suggested to show rather limited capacity for organic anion transport, hOAT3 might play a large role in the human kidney. (aspetjournals.org)
  • An acid reacts with a metal to form a salt, neutralizes bases, and turns litmus paper red. (unboundmedicine.com)
  • Transiently transfected HeLa cells represent a useful tool in studying the interactions and kinetics of organic cations and other xenobiotics with hOCT1 and in understanding the molecular events involved in organic cation transport. (drugbank.com)
  • it is practically insoluble in water and in dilute acids. (nih.gov)
  • ABBR: AHA Any of a class of water-soluble acids derived from fruit or milk, having a hydroxyl moiety in the first position in the molecule. (unboundmedicine.com)
  • We demonstrated that 2,4-D is consistently transported into saliva using both in vitro and in vivo models, making 2,4-D a potential candidate for human non-invasive salivary biomonitoring. (cdc.gov)
  • The objective of this study was to evaluate the potential for non-invasive biomonitoring of 2,4-Dichlorophenoxyacetic acid (2,4-D) in saliva. (cdc.gov)
  • Glacial (highly purified) acetic acid contains at least 99.5% acetic acid by weight. (unboundmedicine.com)
  • 3. See Metals Analysis Specimen Collection and Transport for complete instructions. (testcatalog.org)
  • Probenecid is a uricosuric and renal tubular transport blocking agent. (nih.gov)