AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowBone Marrow CellsTransplantation, HomologousGraft vs Host DiseaseHistocompatibilityHematopoietic Stem Cell TransplantationBone and BonesTissue DonorsFetal BloodHistocompatibility TestingLeukemiaGraft SurvivalTransplantation ConditioningHematologic NeoplasmsWhole-Body IrradiationTransplantation ChimeraImmunosuppressive AgentsTransplantation, AutologousAnemia, AplasticHLA AntigensHematopoietic Stem CellsKidney TransplantationGraft RejectionCytomegalovirus InfectionsSevere Combined ImmunodeficiencyLymphocyte DepletionTreatment OutcomeSpinal CordLeukemia, Myeloid, AcuteRecurrenceTime FactorsTransplantsImmunocompromised HostBone RemodelingHaploidyImmunosuppressionBone Marrow DiseasesT-LymphocytesAntigens, CD34Precursor Cell Lymphoblastic Leukemia-LymphomaCyclosporineBone Marrow ExaminationOpportunistic InfectionsRetrospective StudiesBone Marrow PurgingHematopoiesisBone Marrow NeoplasmsLymphocyte TransfusionHaplotypesAcute DiseasePeripheral Blood Stem Cell TransplantationLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAntilymphocyte SerumMice, Inbred C57BLLiving DonorsMycosesCytomegalovirusGraft vs Leukemia EffectBone DensityColony-Forming Units AssayCord Blood Stem Cell TransplantationCyclophosphamideSpinal Cord InjuriesFatal OutcomeRadiation ChimeraFetal TherapiesBusulfanHematologic DiseasesTransplantation, IsogeneicCell DifferentiationStem Cell TransplantationUnrelated DonorsTransplantationSurvival AnalysisHeart TransplantationGanciclovirBone ResorptionSiblingsDisease-Free SurvivalPneumonia, ViralNuclear FamilySurvival RateCells, CulturedFollow-Up StudiesRemission InductionPostoperative ComplicationsFlow CytometryAspergillosisCombined Modality TherapyMyelodysplastic SyndromesGraft vs Host ReactionLeukemia, MyeloidPolymerase Chain ReactionBlood Group IncompatibilityGranulocyte Colony-Stimulating FactorKiller Cells, NaturalHepatic Veno-Occlusive DiseaseLung TransplantationCystitis
DonorDonorsThalassemiaCentersUmbilical cord blood tranGraft-versus-Human leukocyCancersHematologyChemotherapyLeukemiaTypes of transplantsType of transplantChildren's HospitalProcedureTransplantation programPediatricHaploDisordersLeukemiasHSCTPatient's bone marrowHematopoietic cell transplantationNMDPDiseasesCIBMTRRecipientsAllogenic boneComplicationsHealthy bone marrowOutcomesSickle cell diPatients with aplastic anemiaCalled a stem cell trans2023Stem cell transplantCancerMalignantRejectionMultiple myelomaCurativeSevere aplastic anemiaSurvival
Donor57
  • Allogeneic transplant This approach uses stem cells from a related donor, unrelated matched donor or half-matched related (haploidentical) donor. (ucsd.edu)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • 16. Is it time to expand the use of cord blood donor transplantation in relapsed ALL? (nih.gov)
  • The treatment options discussed included allogeneic hematopoietic stem cell transplantation (HSCT) from a matched family donor (MFD), a mismatched haploidentical donor, and unrelated bone marrow donor. (medscape.com)
  • Allogeneic transplants require a matching donor with respect to the tissue or HLA matching. (bloodcancercure.com)
  • There are different types of allogeneic transplants available based on the donor cells source. (bloodcancercure.com)
  • Using the reduced intensity conditioning (RIC) transplant technique, this study evaluated survivorship of recipients who received a bone marrow transplant from a related and partially matched donor. (nih.gov)
  • A first degree relative, if available, is likely to be the best candidate as a bone marrow donor if the human leukocyte antigen (HLA) markers are a sufficient match. (nih.gov)
  • In the BMT CTN 0603 study, HLA-haploidentical (Haplo-marrow) bone marrow was transplanted into recipients from a related donor. (nih.gov)
  • The most common treatment for SCID is bone marrow transplantation, which has been very successful using either a matched related or unrelated donor, or a half-matched donor, who would be either parent. (wikipedia.org)
  • Haploidentical bone marrow transplants require the donor marrow to be depleted of all mature T cells to avoid the occurrence of graft-versus-host disease (GVHD). (wikipedia.org)
  • David Vetter, the original "bubble boy", had one of the first transplantations also, but eventually died because of an unscreened virus, Epstein-Barr (tests were not available at the time), in his newly transplanted bone marrow from his sister, an unmatched bone marrow donor. (wikipedia.org)
  • Allogeneic means that the transplanted cells are coming from a donor - this may be a sibling, relative, or someone unrelated to the patient (these cells can even come from umbilical cord blood). (oncolink.org)
  • About 70% of patients will not have a family member match and will need to enlist the help of the National Marrow Donor Program . (oncolink.org)
  • In cord blood transplants, a well-matched donor seems to be less important. (oncolink.org)
  • Blood is taken out, run through the pheresis machine to remove the stem cells, and the rest of the blood is returned to the donor. (oncolink.org)
  • Patients who cannot use their stem cells for a transplant due to certain conditions must have an allogeneic bone marrow transplant (donor stem cells). (bonemarrowtransplantations.com)
  • Doctors can explore foreign donor registers and cord blood registries for an unrelated donor who gives a match if a patient does not have a relative who is a match. (bonemarrowtransplantations.com)
  • Making transplant available to children who do not have a fully matched donor. (seattlechildrens.org)
  • The transplant has a better chance of success if there is a close match between the cells of the donor and the child getting the transplant. (seattlechildrens.org)
  • Stem cells for transplants may come from your child or a healthy donor. (seattlechildrens.org)
  • From 2003 to 20 22 , the total number of HSCT cases was 9,757 , including 4,664 cases of haploidentical (haplo) transplantation, 1,180 cases of unrelated donor (URD) transplantation. (ludaopei.com)
  • We have the best outcomes in haploidentical and matched unrelated donor HSCT in the world. (ludaopei.com)
  • Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
  • Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
  • During leukapheresis, blood is removed from the donor through an IV line. (medlineplus.gov)
  • The red blood cells are returned to the donor. (medlineplus.gov)
  • He has an experience of over 21 years and has performed more than 400 blood marrow transplants including 50 unrelated donor/cord transplants and 50 Haplo identical Bone marrow transplants. (unimediks.com)
  • 7 National Marrow Donor Program, Minneapolis, MN. (nih.gov)
  • The stem cells in autologous transplants come from the same person who will get the transplant, so the patient is their own donor. (cancer.org)
  • The stem cells in allogeneic transplants are from a person other than the patient, either a matched related or unrelated donor. (cancer.org)
  • The donor cells will live in the recipient's bone marrow and make blood and immune system cells. (primaryimmune.org)
  • As a result of lack of blood cells in the interim period before the donor stem cells start working). (livertransplantsurgery.org)
  • It occurs when the new bone marrow from the donor, called graft, does not recognize the person who receives it, called the host. (livertransplantsurgery.org)
  • This complication is seen with Allogeneic transplants, in which the transplant comes from either a related or unrelated donor. (livertransplantsurgery.org)
  • An allogeneic stem cell transplant kurapwa kwakasimba uko kwaunogamuchira kuisirwa donor (mumwe munhu) stem cell. (lymphoma.org.au)
  • Mu lymphoma, allogeneic (donor) transplants ishoma zvikuru pane autologous. (lymphoma.org.au)
  • iyi ndiyo nzira yekukohwa stem maseru, nekuti allogenic transplant inobva kune donor, timu yekurapa inoda kutsvaga mechi yekusiira. (lymphoma.org.au)
  • An allogeneic stem cell transplant ay isang masinsinang paggamot kung saan makakatanggap ka ng transplant ng mga stem cell ng donor (ng ibang tao). (lymphoma.org.au)
  • Sa lymphoma, ang mga allogeneic (donor) transplant ay mas bihira kaysa sa autologous ( sarili) mga transplant. (lymphoma.org.au)
  • Ang lymphoma ay maaaring lumalaban sa mga donor stem cell, o ang katawan ng tatanggap (tinatawag na host) ay maaaring lumaban sa mga donor cell (tinatawag na graft) na nagreresulta sa graft kumpara sa host disease (isang komplikasyon ng allogeneic transplant). (lymphoma.org.au)
  • ito ang proseso ng pag-aani ng mga stem cell, dahil ang isang allogenic transplant ay mula sa isang donor, ang pangkat ng medikal ay kailangang makahanap ng katugma para sa transplant. (lymphoma.org.au)
  • This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
  • We also perform umbilical cord blood transplants, in which blood rich in stem cells is taken directly from a donor umbilical cord immediately after a baby's birth. (bmtinfonet.org)
  • Haploidentical transplants are a type of blood and marrow transplant that uses healthy blood cells from a half-matched donor. (bmtinfonet.org)
  • Through the use of haploidentical transplants, we have expanded and diversified our pool of donors to include more people from underrepresented ethnic and minority groups, so that every patient can find a potential donor. (bmtinfonet.org)
  • We are also a full member of the National Marrow Donor Program , which gives us access to donors from across the country and around the world, increasing your chances of finding a matching donor. (bmtinfonet.org)
  • It is categorized into two significant subtypes: autologous, where a patient donates the marrow stem cells to themselves, and allogeneic, which is a complex process of bone marrow transplantation where a patient receives the stem cell graft from a healthy donor. (zenonco.io)
  • 2012). The allogenic bone marrow transplantation involves the process of stem cell transplantation where a stem cell donor is matched with their related siblings or any other family member who is closely related (haploidentical). (zenonco.io)
  • Additional Patient Inclusion Criteria for Patients Assigned to Haploidentical BM Arm: Patients must be HLA typed at high resolution using DNA based typing at the following HLA-loci: HLA-A, -B, -C and DRB1 and have available a related haploidentical BM donor with 2, 3, or 4 HLA-mismatches. (stanfordhealthcare.org)
  • In patients with a median age of 66 years who had received a donor transplant, the overall survival (OS) at 3 years was almost double compared with patients who did not receive a transplant - 47.9% vs 26.6% for the "no donor" group. (medscape.com)
  • This study seeks to determine if administration of the drug belumosudil (KD025) will be safe and improve transplant tolerance in subjects undergoing combined Human Leukocyte Antigen (HLA) single haplotype-matched related or 0-3 antigen (at A, B, C, DR) HLA mismatched unrelated living donor kidney and hematopoietic stem cell transplantation. (researcherprofiles.org)
  • This study is for kidney transplant recipients who receive a kidney from a sibling donor. (researcherprofiles.org)
  • Regular treatment for patients with aplastic anemia who have a matched sibling (brother or sister), or family donor is a bone marrow transplant. (researcherprofiles.org)
  • Collection of Peripheral Blood Progenitor Cells in One Day is Associated with Decreased Donor Toxicity compared to Two Days in Unrelated Donors. (stembook.org)
  • Optimal donor for African Americans with hematologic malignancy: HLA-haploidentical relative or umbilical cord blood transplant. (stembook.org)
Donors10
  • In this multicenter study, 106 patients with ADA-deficient SCID received 119 transplants from matched sibling donors (MSDs), matched family donors (MFDs), matched unrelated donors (MUDs), and haploidentical donors. (medscape.com)
  • Survival was 86% in MSDs, 81% in MFDs, and 66% in MUDs, compared with 43% in haploidentical donors. (medscape.com)
  • They keep the HLA typing records from donors around the world and have access to millions of potential donors and numerous cord blood units. (oncolink.org)
  • This includes using stem cells from donors whose cell types are not a close match, such as half-matched or haploidentical donors. (seattlechildrens.org)
  • Donors who are not related to you, yet still match, may be found through national bone marrow registries. (medlineplus.gov)
  • Bone marrow transplants from healthy donors are used successfully to treat certain blood cancers for which the course of the disease is so severe that the destruction of the patient's own immune system through high-dose chemotherapy and radiation seems an effective compromise. (nih.gov)
  • In a recent study, they demonstrated that they could transplant bone marrow cells from HLA-matched sibling donors without needing to completely destroy the patient's immune system. (nih.gov)
  • This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • Family members,unrelated donors or banked umbilical cordblood units with similar tissue type can be used for HCT. (stanfordhealthcare.org)
  • At least low resolution DNA based human leukocyte antigen (HLA) typing at HLA-A, -B, and -DRB1 for potential haploidentical sibling donors is required. (stanfordhealthcare.org)
Thalassemia3
  • Several diseases like bone marrow disorders, leukemias, lymphomas, aplastic anemia sickle cell anemia, multiple myelomas, thalassemia, pediatric tumors etc can be treated by bone marrow transplant (BMT). (bloodcancercure.com)
  • A stem cell transplant is a procedure needed to treat some types of cancers like leukemias, multiple myeloma, lymphomas, and various haematological disorders like aplastic anaemia, thalassemia etc. (aakashhealthcare.com)
  • Some involve leukaemias, bone marrow failures, hemoglobinopathies (thalassemia, sickle cell disease), immunodeficiencies, and other HSC transplant-based treatments for solid tumors and other genetic disorders such as lysosomal storage disease along with autoimmunity. (zenonco.io)
Centers7
  • This Notice of Funding Opportunity (NOFO) issued by the National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer Institute (NCI) invites applications to participate as Core Clinical Centers and Consortia (CCCs) in the Blood and Marrow Transplant Clinical Trials Network (BMT CTN). (nih.gov)
  • Core Clinical Centers and Consortia are expected to support and conduct multi-site trials to compare novel treatment approaches and management strategies for children and adults undergoing hematopoietic stem cell transplantation (HCT) for non-malignant and malignant blood diseases, either alone or in combination with novel adoptive cell-based therapies. (nih.gov)
  • EBMT registry is a voluntary working group of more than 500 transplant centers, participants of which are required once a year to report all consecutive stem cell transplantations and follow-up. (nature.com)
  • However, there are only a few centers in Bangladesh that conduct bone marrow transplants due to the interdisciplinary high-level assistance needed. (bonemarrowtransplantations.com)
  • New advances let us transplant patients who were not eligible in the past or who would be considered too high risk at other centers. (seattlechildrens.org)
  • He said that academic centers will continue to offer transplants, and suggested that community oncologists encourage referral to transplant centers early in a patient's disease course in order to maximize search time and provide patients all potential options for therapy. (medscape.com)
  • Impact of Public Reporting of Center-Specific Survival Analysis Scores on Patient Volumes at Hematopoietic Cell Transplant Centers. (dana-farber.org)
Umbilical cord blood tran6
Graft-versus-6
  • Effective control of the graft-versus-host disease (GVHD) and immune reconstitution are crucial in improving the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) as well as the quality of life of the transplant survivors. (apbmt.org)
  • These transplants are prone to certain complications like graft-versus-host disease and other complications like graft failure, complete rejection etc. (bloodcancercure.com)
  • For recipients who find a suitable match, high doses of chemotherapy are administered preemptively in an attempt to reduce the likelihood of transplant rejection or graft-versus-host disease (GVHD). (nih.gov)
  • Chronic Graft-Versus-Host Disease, Non-Relapse Mortality and Disease Relapse in Older versus Younger Adults Undergoing Matched Allogeneic Peripheral Blood Hematopoietic Cell Transplantation: A CIBMTR Analysis. (stembook.org)
  • We have also worked to characterize the chronic pulmonary conditions associated with allogeneic transplant in the pediatric setting and, in conjunction with our colleagues in dental medicine, described the oral manifestations of graft-versus-host disease (GVHD). (dana-farber.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
Human leukocy1
  • In PNP deficiency, human leukocyte antigen (HLA)-matched bone marrow transplantations have been successful in patients who have received pretransplantation conditioning. (medscape.com)
Cancers10
  • 1] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma, and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
  • Three significant kinds of blood cancers are as leukemia, lymphoma, and multiple myeloma. (bloodcancercure.com)
  • Individuals with aggressive forms of the blood cancers leukemia and lymphoma typically receive targeted therapy, chemotherapy, and radiation as part of their treatment options. (nih.gov)
  • Bangladesh's highly qualified, multidisciplinary staff is committed to using bone marrow, peripheral blood, cord blood, and cellular therapy therapeutically to treat cancers, non-cancerous conditions, and conditions involving the blood. (bonemarrowtransplantations.com)
  • Blood and bone marrow transplants have been used successfully since 1968 to treat diseases such as leukaemia, lymphoma, aplastic anaemia, immunodeficiency disorders and some solid tumour cancers. (ludaopei.com)
  • These include blood cancers, bone marrow failure (such as aplastic anaemia), some immunodeficiency diseases and so on. (ludaopei.com)
  • For many cancers, the donor's white blood cells may attack any remaining cancer cells, which are seen as foreign, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)
  • All solid cancers and Hematological cancers (Blood cancers- Leukemias, Lymphomas & Myeloma) management. (medanta.org)
  • A bit of this nay be needed to get rid of difficult blood cancers. (livertransplantsurgery.org)
  • Search clinical trials for adult and pediatric cancers and blood disorders offered through Dana-Farber and our clinical partners. (dana-farber.org)
Hematology1
  • The finding comes from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Study 1102 (NCT02016781) presented at the American Society of Hematology (ASH) 2020 virtual meeting. (medscape.com)
Chemotherapy14
  • Receive standard-of-care therapies, as well as the most promising investigational chemotherapy agents, immunotherapies, and novel stem cell transplant methods. (ucsd.edu)
  • Reduced-intensity allogeneic transplant It involves a lower dose of chemotherapy or radiation to safely treat older and more fragile patients. (ucsd.edu)
  • Every type of bone marrow transplant (BMT) is available in India and the hospitals are fully equipped with all necessary equipment like a proper radiation and oncology unit for total body radiation, and chemotherapy drugs and equipments. (bloodcancercure.com)
  • Specifically, recipients were given lower doses of chemotherapy prior to receiving the transplant and also received a smaller quantity of transplanted bone marrow than is typically administered. (nih.gov)
  • Stem cells from the patient are taken out of the patient's bone marrow and then put back into the body following chemotherapy and/or radiation to treat specific disorders. (bonemarrowtransplantations.com)
  • Reduced intensity treatment, also called a mini transplant -- Lower doses of chemotherapy and radiation are given before a transplant. (medlineplus.gov)
  • After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
  • A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
  • A bone marrow transplant replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation. (medlineplus.gov)
  • Stem cell transplants are used to put blood stem cells back into the body after the bone marrow has been destroyed by disease, chemotherapy (chemo), or radiation. (cancer.org)
  • The main risk at this stage is that of bacterial infections, often coming from the stomach to the blood through the damage caused by high-dose chemotherapy. (livertransplantsurgery.org)
  • Minsan kailangan ng mga tao na magkaroon ng 'salvage' chemotherapy upang subukan at mabawasan ang lymphoma bago mag-transplant. (lymphoma.org.au)
  • Clinical Outcomes in Patients With FLT3-ITD-Mutated Relapsed/Refractory Acute Myeloid Leukemia Undergoing Hematopoietic Stem Cell Transplant After Quizartinib or Salvage Chemotherapy in the QuANTUM-R Trial. (stembook.org)
  • Older patients with AML are candidates for and benefit from the entire spectrum of AML therapy, including intense chemotherapy, allogeneic stem cell transplant, and clinical trial participation after thorough patient assessment. (ochsnerjournal.org)
Leukemia14
Types of transplants1
Type of transplant4
Children's Hospital2
  • The Blood and Marrow Transplantation Program at the Morgan Stanley Children's Hospital of New York-Presbyterian is an international transplant center, specializing in the treatment of children and young adults. (bethematch.org)
  • In 1998, she became medical director of the Pediatric Transplant Unit at Children's Hospital and, in 2007, was appointed clinical director of the Pediatric Stem Cell Transplant Program. (dana-farber.org)
Procedure11
Transplantation program1
  • The UC San Diego Health and Sharp HealthCare joint blood and marrow transplantation program is the largest BMT program in San Diego and one of the largest in California. (ucsd.edu)
Pediatric2
  • Dr. Satya Prakash Yadav is one the leading consultants in the field of Pediatric- Hemato-oncology & bone marrow transplant. (unimediks.com)
  • In recognition of our high-quality patient care and laboratory practices, we are accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) for autologous and allogeneic transplants and cell therapy for adult patients, and autologous transplants for pediatric patients. (bmtinfonet.org)
Haplo2
  • The BMT CTN 0603, or Haplo-marrow trial, researched the effectiveness of a type of bone marrow transplant called reduced intensity conditioning (RIC) or nonmyeloablative transplant for individuals who were only a partial or haploidentical match with a family member. (nih.gov)
  • A Multi-Center, Phase III, Randomized Trial of RIC and Transplantation of (dUCB) Versus HLA-Haplo Related Bone Marrow for Patients With Hematologic Malignancies. (stanfordhealthcare.org)
Disorders5
  • A blood and bone marrow transplant is a special type of treatment for people with certain types of cancer or other bone marrow disorders. (ludaopei.com)
  • The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
  • In today's era, bone marrow transplantation has become standard care for hematologic malignancies and congenital or acquired disorders of the hematopoietic system. (zenonco.io)
  • Bone marrow transplantation is employed for novel indications in treating autoimmune and inherited metabolic disorders (Daikeler et al. (zenonco.io)
  • It helps increase the bone marrow function that depends upon the treatment of the disease in eliminating the tumor cells with malignancy or generating the functional cells that replace the dysfunctional cells in certain disorders such as immune deficiency syndromes, hemoglobinopathies, and other diseases. (zenonco.io)
Leukemias1
HSCT12
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
  • Chronic GVHD is also a major cause of late non-relapse mortality (NRM) after HSCT and significantly impairs the quality of life of the transplant survivors 1 . (apbmt.org)
  • Under the leadership of Dr Daopei Lu, our HSCT department performs 1/10 of the total transplant cases in China every year. (ludaopei.com)
  • As one of the most active HSCT centre, our HSCT department performs 1/10 of the total transplant cases in China every year. (ludaopei.com)
  • When primary immunodeficiency is likely to cause significant harm or death, an allogeneic hematopoietic stem cell transplant (HSCT), more commonly known as a bone marrow transplant (BMT), may be the best treatment option. (primaryimmune.org)
  • Allogeneic HSCT also fixes any problems with other blood cells. (primaryimmune.org)
  • For instance, if an individual with IPEX has diabetes before transplant, they will still have diabetes after transplant, because the cells in the pancreas that make insulin have been destroyed by this disease, and HSCT cannot replace pancreatic cells. (primaryimmune.org)
  • Hematopoietic stem cells may be collected from the bone marrow, the peripheral blood, or from umbilical cord blood, so HSCT procedures may be called bone marrow transplants (BMT), peripheral blood stem cell transplants, or cord blood transplants depending on the source of the stem cells. (primaryimmune.org)
  • Hematopoietic stem cell transplantation (HSCT) involves the regeneration of haematopoiesis, and the recipient's immune system is found within the bone marrow. (zenonco.io)
  • Approximately 50% of the transplants in case of acute myeloid leukaemia and ALL account for allogeneic HSCT. (zenonco.io)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Patient's bone marrow1
  • After extracting and isolating precursor CD34+ cells from patients, they use viral transduction to insert a correct copy of the β-globin gene before returning the cells to the patient's bone marrow. (nih.gov)
Hematopoietic cell transplantation4
  • Aetna considers autologous hematopoietic cell transplantation for the treatment of persons with relapsed or primary refractory (see "Note" below) non-Hodgkin's lymphoma (NHL) medically necessary if the person meets the transplanting institution's protocol eligibility criteria. (aetna.com)
  • Aetna considers allogeneic hematopoietic cell transplantation medically necessary for the treatment of persons with relapsed NHL (including persons who have relapsed after autologous hematopoietic cell transplantation) or primary refractory (see "Note" below) NHL (low-grade, intermediate-grade, and high-grade) if the person meets the transplanting institution's protocol eligibility criteria. (aetna.com)
  • Aetna considers non-myeloablative allogeneic hematopoietic cell transplantation medically necessary ("mini-transplant", reduced intensity conditioning transplant) for the treatment of persons with relapsed NHL (including persons who have relapsed after ABMT) or primary refractory (see note below) NHL (low-grade, intermediate-grade, and high-grade) when they are eligible for conventional allografting or a reduced intensity regimen is preferred by the transplant center. (aetna.com)
  • Racial and Socioeconomic Disparities in Long-Term Outcomes in =1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A Center for International Blood and Marrow Transplant Research Analysis. (dana-farber.org)
NMDP3
  • We are a FACT, COG, NMDP-accredited transplant program. (bethematch.org)
  • The Adult Blood and Marrow transplant program at New York Presbyterian is accredited by the NMDP and FACT accredited for autologous and allogeneic transplantation. (bethematch.org)
  • This center has been performing allogeneic transplants since 1997 and has been an NMDP/Be The Match transplant center since May 2002. (bethematch.org)
Diseases9
CIBMTR2
  • EBMT (European Bone Marrow transplant group), - CIBMTR (Center for International Blood and Marrow Transplant Research, - NIH (National Institute of Health). (centrescientifique.mc)
  • A Simple Prognostic System in Myelofibrosis Patients Undergoing Allogeneic Stem Cell Transplant: A CIBMTR/EBMT analysis. (stembook.org)
Recipients5
  • For the BMT CTN 0604 study, double umbilical cord blood (dUCB) was transplanted in unrelated recipients. (nih.gov)
  • Most transplant recipients will eventually become transfusion-independent within weeks to months from transplant. (medscape.com)
  • The purpose of this study is to find out if an investigational treatment will allow kidney transplant recipients to better accept their new kidney and stop immunosuppressive medicines. (researcherprofiles.org)
  • Mixed chimerism may help create a state of 'tolerance' in kidney transplant recipients in which all immunosuppressive medications can be stopped without rejection of the transplanted kidney. (researcherprofiles.org)
  • Impact of SARS-CoV-2 in hematopoietic stem cell transplant and CAR-T cell therapy recipients. (stembook.org)
Allogenic bone1
Complications1
  • With respect to decreasing the acute complications of transplant, we have examined the role of defibrotide, an agent that is effective in treating patients with severe veno-occlusive disease of the liver, and explored how to best address the nutritional needs of our patients. (dana-farber.org)
Healthy bone marrow2
Outcomes2
  • Fludarabine and Melphalan Compared with Reduced Doses of Busulfan and Fludarabine Improves Transplant Outcomes in Older MDS Patients. (stembook.org)
  • We conduct research to improve transplant outcomes provide support and resources for patients, and partner with a global network. (bethematch.org)
Sickle cell di3
  • The Cellular and Molecular Therapeutics Laboratory, led by Dr. John F. Tisdale, is working on multiple strategies both in the laboratory and in the clinic to cure sickle cell disease by repairing or replacing the precursor bone marrow cells that give rise to sickled red blood cells. (nih.gov)
  • Dr. Tisdale and his colleagues recently completed a modified bone marrow transplant strategy for the first time in adult patients with sickle cell disease. (nih.gov)
  • This Phase I clinical trial will assess the safety and initial evidence for efficacy of an autologous transplant of lentiviral vector modified peripheral blood for adults with severe sickle cell disease. (researcherprofiles.org)
Patients with aplastic anemia1
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
Called a stem cell trans1
20231
Stem cell transplant2
Cancer12
  • Your doctor may recommend a BMT to treat blood cancer or a blood disorder . (ucsd.edu)
  • Some patients may be able to receive their transplant on an outpatient basis at Moores Cancer Center in La Jolla. (ucsd.edu)
  • Blood Cancer Cure is a common type of cancer majorly attacks the blood, bone marrow, or lymphatic system. (bloodcancercure.com)
  • Blood cancer can be very treatable in some cases, because of the revolution in the traditional treatment methods. (bloodcancercure.com)
  • Many patients brought back to their healthy lives and stretched their life-span by strengthening the body cells against the blood cancer cells. (bloodcancercure.com)
  • The first reported case of successful transplant was a Spanish child patient who was interned in Memorial Sloan Kettering Cancer Center in 1982, in New York City. (wikipedia.org)
  • Although this surgery is used to treat a variety of illnesses, blood cancer patients are the ones who typically undergo it. (bonemarrowtransplantations.com)
  • Using T-cell immunotherapy to put patients' cancer into remission so they can receive a transplant. (seattlechildrens.org)
  • In a typical stem cell transplant for cancer, a person first gets very high doses of chemo , sometimes along with radiation therapy , to try to kill all the cancer cells. (cancer.org)
  • Henry Fung, MD, chair of the Department of Bone Marrow Transplant and Cellular Therapies at Fox Chase Cancer Center, Philadelphia, Pennsylvania, agreed. (medscape.com)
  • The cure for blood cancer is in the hands of ordinary people. (bethematch.org)
  • A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of abnormal myeloblasts, which are immature, dysfunctional white blood cells. (nih.gov)
Malignant3
  • NCIt Code NCIt PT Subset PT Subset SY NCIt Definition Subset Definition NCIt Code of First Parent First Parent NCIt Code of Second Parent Second Parent NCIt Code of Subset PT of NICHD Subset Subset Antiquated PT Subset Antiquated SY C5448 Malignant Childhood Central Nervous System Neoplasm Malignant Childhood Central Nervous System Neoplasm Malignant neoplasms which occur in the brain, spinal cord, or meninges of children. (nih.gov)
  • A malignant neoplasm of the brain, spinal cord, or meninges occurring in children. (nih.gov)
  • C5132 Childhood Central Nervous System Neoplasm C132009 C5132 Childhood Central Nervous System Neoplasm Childhood Central Nervous System Neoplasm A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in children. (nih.gov)
Rejection1
  • This study will test whether (1) the investigational treatment will allow patients to stop immunosuppressive medications after their kidney transplant and (2) if the treatment impacts the rate of kidney rejection and the side effects of immunosuppressive medications. (researcherprofiles.org)
Multiple myeloma1
  • The purpose of this study is to evaluate whether elranatamab monotherapy can provide clinical benefit compared to lenalidomide monotherapy (control) in participants with newly diagnosed multiple myeloma after undergoing autologous stem cell transplant. (researcherprofiles.org)
Curative2
  • Transplant is curative for MDS," he emphasized. (medscape.com)
  • Almost all older patients will benefit from therapy, whether intensive curative therapy, such as allogeneic stem cell transplant that should be considered whenever possible, or low-intensity therapy that should be offered with concurrent palliative care at diagnosis to improve patient survival and quality of life. (ochsnerjournal.org)
Severe aplastic anemia1
Survival2
  • The primary outcome for both trials was participant survival from the time of transplant to 180 days measured at 6 and 12 month intervals. (nih.gov)
  • The Intergroupe Francophone du Myelome 3 was the first to demonstrate, in a large randomized trial, the long-term benefits in survival of double ASCT in comparison with single transplants. (haematologica.org)