AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowBone Marrow CellsTransplantation, HomologousGraft vs Host DiseaseBone and BonesTissue DonorsWhole-Body IrradiationLeukemiaTransplantation, AutologousAnemia, AplasticKidney TransplantationGraft SurvivalCytomegalovirus InfectionsImmunosuppressive AgentsHematopoietic Stem Cell TransplantationGraft RejectionHematopoietic Stem CellsHistocompatibility TestingTransplantation ConditioningBone RemodelingImmunocompromised HostBone Marrow DiseasesHematologic NeoplasmsImmunosuppressionHistocompatibilityTransplantsBone Marrow ExaminationOpportunistic InfectionsCyclosporineTime FactorsBone Marrow PurgingBone Marrow NeoplasmsTreatment OutcomeLeukemia, Myeloid, AcuteTransplantation ChimeraLeukemia, Myelogenous, Chronic, BCR-ABL PositiveRetrospective StudiesHematopoiesisPrecursor Cell Lymphoblastic Leukemia-LymphomaMice, Inbred C57BLMycosesRecurrenceCytomegalovirusBone DensityRadiation ChimeraBusulfanFatal OutcomeTransplantation, IsogeneicAcute DiseaseTransplantationHLA AntigensHeart TransplantationGanciclovirBone ResorptionHematologic DiseasesSurvival AnalysisPneumonia, ViralColony-Forming Units AssayNuclear FamilyCyclophosphamideLymphocyte DepletionAspergillosisPostoperative ComplicationsCombined Modality TherapyT-LymphocytesGraft vs Host ReactionMyelodysplastic SyndromesBlood Group IncompatibilityLeukemia, MyeloidCell DifferentiationAntilymphocyte SerumHepatic Veno-Occlusive DiseaseLung TransplantationCystitisPolymerase Chain ReactionLiving DonorsMucormycosisFollow-Up StudiesBone NeoplasmsSurvival RateBK VirusLymphoma, Non-HodgkinLymphocyte TransfusionFlow CytometryCells, CulturedInfectionLeukocyte CountHerpesvirus 6, HumanBone DevelopmentChimeraBone DiseasesAntigens, CD34SpleenMice, Inbred BALB CMultiple MyelomaDisease-Free SurvivalRemission InductionAntiviral AgentsRisk Factors
DonorTransplantationProcedureFound through national bone marrowNewly transplantedAllogeneic stem cellGraft-versus-Child's bone marrowSevere aplastic anemiaAplasticDonor'sUmbilicalPatient's stem cellsPeripheral blood stem-cellSurvivorsPediatricType of transplantUnhealthyDiseasesSpecialistsDoses of chemotherapy and radiationCord blood transplantCancerDonorsOrgan transplantsAutologous transplantDonnall ThomasReplacesChemotherapyCancersGeneral anesthesiaHaploidenticalKidneyDestroyed and healthy boneOutcomesTypes of bonePerformed in adultsCentersCellsRecipient'sSuccessful boneRejectionPerson'sPost-transplant1950sCorneaCentreSurvivalAdultsBonesDependsHematopoietic2020LeukemiaAppointment
Donor35
  • Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
  • Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
  • National Marrow Donor Program. (mayoclinic.org)
  • Our center is a National Cancer Institute-designated Comprehensive Cancer Center that is fully accredited by the National Marrow Donor Program. (hopkinsmedicine.org)
  • Researchers also plan to study the safety of providing fecal transplants with material from a healthy donor. (mskcc.org)
  • Allogeneic" means the blood or marrow stem cells come from a donor. (mskcc.org)
  • The procedure involves the transplantation of cells taken either from a patient's own blood or bone marrow (autologous transplantation) or from a matched donor (allogeneic transplantation) which effectively "replaces" damaged cells with healthy cells. (science20.com)
  • A match was found through the National Bone Marrow Donor Program. (dukehealth.org)
  • He met his donor at a reunion of Duke adult marrow transplant survivors in September. (dukehealth.org)
  • None of his relatives were good candidates, so doctors turned to the Be The Match , a registry run by the National Marrow Donor Program to find donors for patients with conditions such as leukemia and lymphoma . (dukehealth.org)
  • Dr. Arunkumar Modi, Director of the Bone Marrow Transplant and Cellular Therapy program at Arkansas Children's explains how these treatments work in the body, what a patient and donor can expect during the transplant process, and talks about building a Bone Marrow Transplant and Cellular Therapy program at Arkansas Children's. (buzzsprout.com)
  • The Organ Health BMT test detects any drop in acceptance of donor bone marrow by revealing if there is a reduction in the proportion of blood cells produced by the transplant. (edu.au)
  • The test also analyses DNA markers (a gene or fragment of DNA) in recipients and donors which are unique to the donor and absent in the recipient, or vice versa, and uses these to monitor transplant function. (edu.au)
  • If your child's brother or sister will be the bone marrow donor, it's important that his or her questions are answered as well. (bmtinfonet.org)
  • This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
  • The process is also less painful for the donor since a needle is not being placed into bone. (differencebetween.net)
  • The procedure in which bone marrow is extracted from a donor does require the use of either a local or a general anesthetic. (differencebetween.net)
  • The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
  • In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
  • The newly transplanted donor cells attack the transplant recipient's body. (globaldata.com)
  • Bone marrow or stem cells that have been removed from a donor are carefully frozen and stored while the patient receives high-dose chemotherapy and sometimes whole-body radiation treatment. (lymphoma.ca)
  • This means that they receive stem cells (either their own stem cells that were stored prior to myeloablative therapy or stem cells from a donor) to replenish their bone marrow which had previously been destroyed by the high-dose therapy. (lymphoma.ca)
  • Stem cells or bone marrow derived from a donor (allogeneic transplant) are usually collected immediately before use and not stored for any length of time. (lymphoma.ca)
  • The harvested stem cells or bone marrow (obtained from either the patient's own healthy cells or from a donor) are then transplanted intravenously into the bloodstream of the patient. (lymphoma.ca)
  • Allogeneic stem-cell transplants refer to a procedure in which a patient receives stem cells from a donor who is genetically similar to the patient, as defined by the National Cancer Institute. (cmlalliance.com)
  • The idea here is to transplant both kidney & hematopoeitic stem cells from the same donor, which will hopefully induce a state of immune tolerance that allows a sparing (and ideally a complete cessation) of immunosuppressive drugs without inducing rejection. (renalfellow.org)
  • As described in this recent review by Megan Sykes , nonmyeloablative regimens are given-with the goal of not being so toxic as to result in marrow failure but sufficiently strong enough to overcome the potential reactivity of T-cells reactive to the HLA-mismatched donor stem cells. (renalfellow.org)
  • Apparently the key is to generate a state of mixed chimerism (some bone marrow cells from the recipient, some from the donor) to prevent rejection and avoid complications such as graft-versus-host disease. (renalfellow.org)
  • I am the living donor who along with my Son, the recipient, participated in 1996 kidney, bone marrow experiment. (renalfellow.org)
  • If the cancer patient is recommended a transplant, then four common donor sources are identified. (yoursdailynews.com)
  • Approximately 190 cord blood patients meant for transplantation were compared with 123 patients recommended for matched donor transplant. (yoursdailynews.com)
  • Moreover, they also experienced fewer complications when compared to those receiving matched sibling donor transplants. (yoursdailynews.com)
  • We, at Artemis, are doing cord blood, unrelated donor and Haplo-identical (taking father or mother as donor) transplant, so that all the patients who need transplant can have a donor. (artemishospitals.com)
  • Allogeneic Transplant - uses cells from a family member, unrelated donor or umbilical cord blood unit. (artemishospitals.com)
  • We are trying to create a state where instead of completely replacing bone marrow with that of their donors, we are creating a mixture of donor and patient cells because we now know that as low as 20% donor cells is enough to reverse sickle cell disease. (medlineplus.gov)
Transplantation17
Procedure11
  • A bone marrow transplant is a procedure to replace damaged or diseased bone marrow with healthy bone marrow stem cells. (medlineplus.gov)
  • Thanks to improved transplant survival rates, we have now been able to focus our efforts on examining how the procedure affects key aspects of recipients' overall quality of life, including sexual health," said lead study author F. Lennie Wong, PhD, of City of Hope in Duarte, California. (science20.com)
  • When talking about the transplant procedure, be sure to use words your child can understand. (bmtinfonet.org)
  • Further benefits are that the platelets and neutrophil cells (one of the white blood cells) are more easily able to recover if this method is used compared with the bone marrow procedure. (differencebetween.net)
  • The procedure can also be used to replace bone marrow which has been somewhat depleted because of some types of cancer treatments. (differencebetween.net)
  • The procedure is also a more painful one than simply removing stem cells from the blood since the needle has to go into bone. (differencebetween.net)
  • Her transplant was funded in part by a grant from the Atomic Energy Commission (which was funding research in the 1950s and '60s on body irradiation), although Lowry's particular procedure didn't require radiation. (aaas.org)
  • Her procedure became the first successful bone marrow transplant, she says. (aaas.org)
  • PBSCTs are now more commonly performed than bone marrow transplants, as the procedure is easier and the body is able to regenerate new stem cells faster. (lymphoma.ca)
  • Harvesting is the procedure by which the bone marrow or stem cells are obtained in preparation for the transplant. (lymphoma.ca)
  • Procedure for a Corneal Transplant? (artemishospitals.com)
Found through national bone marrow2
Newly transplanted1
Allogeneic stem cell2
  • The expanded analysis now includes 8,767 stool samples from 1,362 people who have had allogeneic stem cell or bone marrow transplants at four centers around the world. (mskcc.org)
  • The researchers from the study also found that patients who received autologous stem-cell transplants were aged 65 and older and identified as Black, compared with patients who received allogeneic stem-cell transplants. (cmlalliance.com)
Graft-versus-2
  • They also report for the first time that having a lower diversity of microbiota before transplant resulted in a higher incidence of graft-versus-host disease. (mskcc.org)
  • One of the most serious complications of blood stem cell or bone marrow transplants (BMTs) , which are used to treat many types of blood cancer, is graft-versus-host disease (GVHD). (mskcc.org)
Child's bone marrow2
Severe aplastic anemia1
  • Stem cell transplant is a recommended treatment option for diseases such as Acute Myeloid Leukemia which doesn't have the expected outcome of the administrated treatments Acute lymphoblastic leukemia, myelodysplastic syndrome, bone marrow failure (severe aplastic anemia), immune deficiency, Hodgkin's Lymphoma, Neuroblastoma. (saglik.gov.tr)
Aplastic3
  • Although bone marrow transplant is not a standard treatment, it is used in the treatment of leukemia, aplastic anemia, lymphoma, immune deficiency disorders, and some tumor cancers. (health-tourism.com)
  • In 1960, Nancy Lowry was six years old and suffering from aplastic anemia-a blood disorder in which bone marrow fails to create enough new blood cells-that she contracted from taking seizure medication. (aaas.org)
  • Bone Marrow Transplant is the only cure for Thalassaemia, Aplastic Anaemia, Leukaemia (Blood Cancer), Lymphoma and Immunodeficiencies. (artemishospitals.com)
Donor's3
Umbilical5
Patient's stem cells2
  • Autologous stem-cell transplants are when the patient's stem cells are collected and stored before treatment and are returned to the patient after treatment, according to the National Cancer Institute. (cmlalliance.com)
  • Receiving stem cells through this type of transplant replaces the patient's stem cells that may have been harmed by chemotherapy or radiation treatments with healthy stem cells. (cmlalliance.com)
Peripheral blood stem-cell1
Survivors4
  • Data have been limited to this point, prompting us to take a closer look at this issue in a larger, more diverse group of autologous and allogeneic transplant survivors over an extended period. (science20.com)
  • Investigators' analysis of questionnaire results (led by Dr. Wong) confirmed previous studies in demonstrating a definitive impact of SCT on survivors' post-transplant sexual activity. (science20.com)
  • In addition to further crystallizing transplantation's impact on survivors' sexual health, study data specifically associated diminished sexual function and satisfaction with transplant-related total body radiation in men and chronic GVHD with diminished sexual function in men and both sexual function and satisfaction in women. (science20.com)
  • More than 350 Duke bone marrow transplant survivors attended. (dukehealth.org)
Pediatric3
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • For the Pediatric Blood and Bone Marrow Transplant & Cellular Therapies Program, please call 310-825-6708 . (uclahealth.org)
  • The pediatric bone marrow transplant team at UCLA Health provides compassionate care to help give your child the best possible recovery from bone marrow transplant (BMT). (uclahealth.org)
Type of transplant2
  • This time period shows change depending on the type of transplant, individual and disease. (saglik.gov.tr)
  • Your transplant doctor will talk to you about the type of transplant and cell source that is most likely to work best for you based on your disease and other health factors. (artemishospitals.com)
Unhealthy3
Diseases5
Specialists2
Doses of chemotherapy and radiation2
  • Reduced intensity treatment, also called a mini transplant -- Lower doses of chemotherapy and radiation are given before a transplant. (medlineplus.gov)
  • People get lower doses of chemotherapy and radiation prior to a transplant. (iytmed.com)
Cord blood transplant3
  • Studies conducted have revealed the benefits derived from cord blood transplant when compared to bone marrow in non-cancerous and cancerous disorders. (yoursdailynews.com)
  • Researchers conclude that the study supports cord blood transplant efficacy. (yoursdailynews.com)
  • When this happens, a bone marrow transplant or cord blood transplant could be the best treatment option. (artemishospitals.com)
Cancer13
  • High-dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose chemotherapy with autologous bone marrow transplant (HDC/ABMT or just ABMT), was an ineffective treatment regimen for metastatic breast cancer, and later high-risk breast cancer, that was considered promising during the 1980s and 1990s. (wikipedia.org)
  • http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
  • Our multidisciplinary program collaborates with Johns Hopkins Sidney Kimmel Comprehensive Cancer Center and Children's Center to potentially cure children with a variety of cancers and other disorders of the blood, immune system and bone marrow. (hopkinsmedicine.org)
  • We perform bone marrow transplants at the Sidney Kimmel Cancer Center's Weinberg Building in Baltimore, MD. (hopkinsmedicine.org)
  • Bone marrow transplant (BMT) can strengthen the body to fight cancer by replacing the blood building cells in the body that are destroyed by chemotherapy and radiation treatments, which are used to kill the cancer cells, with healthy stem cells found in bone marrow. (emoryhealthcare.org)
  • Here at Winship Cancer Institute Bone Marrow Transplant Center we believe patient information is a vital part of the transplant process. (emoryhealthcare.org)
  • It can also be used to help patients whose own bone marrow has been destroyed because of cancer treatments. (differencebetween.net)
  • Eastern India's first dedicated comprehensive Bone Marrow Transplant Unit was launched by Dr. Preetha Reddy, Managing Director, Apollo Hospitals Group at Apollo Gleneagles Cancer Hospital, the only super specialty Cancer hospital in the region. (apollohospitals.com)
  • The Bone Marrow Transplant Unit at Apollo Gleneagles Cancer Hospital is the only dedicated comprehensive BMT in the region. (apollohospitals.com)
  • This process kills all or most normal stem and bone marrow, while destroying cancer cells. (lymphoma.ca)
  • Less than 40% had visits related to BMT and about 30% have actually gone to the transplant center, or the place where their cancer was treated, to get care in the past few years. (cmlalliance.com)
  • The results showed that cancer patients who have undergone cord blood transplants were reported to show quick improvement. (yoursdailynews.com)
  • They also suggested that cancer patients provided with higher dosage of pre-transplant radiotherapy or chemotherapy should be recommended with cord blood as the preferred stem cell transplant source. (yoursdailynews.com)
Donors2
  • These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
  • I wanted to develop a way to have half-match donors contribute bone marrow and for the outcomes to be successful. (medlineplus.gov)
Organ transplants1
Autologous transplant2
  • Stem cells or bone marrow harvested from the patient (autologous transplant) are generally preserved and stored in a freezer until ready for use. (lymphoma.ca)
  • Autologous Transplant - It uses your own cells which are collected from the blood stream and stored for your transplant. (artemishospitals.com)
Donnall Thomas1
  • 3 The idea for high-dose chemotherapy (HDC) with autologous bone marrow transplant (ABMT) originated in the 1950s as a leukemia treatment, when E. Donnall Thomas had shown that bone marrow could be harvested from a person and transplanted into the same or another person. (wikipedia.org)
Replaces1
Chemotherapy5
  • With an overall idea that more is better, this process involved taking cells from the person's bone marrow to store in a lab, then to give such high doses of chemotherapy drugs that the remaining bone marrow was destroyed, and then to inject the cells taken earlier back into the body as replacement. (wikipedia.org)
  • The treatment of high-dose chemotherapy with autologous bone marrow transplant had serious, lasting, and sometimes deadly side effects for the patient, including cardiac toxicity, sepsis, pulmonary failure, and nephrotoxicity, among others. (wikipedia.org)
  • A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
  • High-dose chemotherapy, with or without myeloablative radiation therapy, is then administered to the patient to destroy the cancerous cells, as well as the healthy cells in the bone marrow. (lymphoma.ca)
  • Since the 1990s, to do a bone marrow transplant, a patient had to have a sibling with a complete tissue match and take a medication that suppresses their immune system (Cyclophosphamide), as well as high dose chemotherapy. (medlineplus.gov)
Cancers2
General anesthesia2
  • Bone marrow harvest -- This minor surgery is done under general anesthesia . (medlineplus.gov)
  • In a bone marrow transplant, the stem cells are withdrawn from the bone marrow under general anesthesia by inserting a needle into a bone in the pelvic region, called the iliac crest. (lymphoma.ca)
Haploidentical1
Kidney4
  • One of the interesting ongoing protocols at the Massachusetts General Hospital Kidney Transplant Program is the combined kidney/bone marrow transplant protocol. (renalfellow.org)
  • The protocol would be most useful in younger patients who want their kidney transplants to last for as long as possible-with a goal of minimizing the use of calcineurin inhibitor therapy, which we know can lead to progressive allograft toxicity over the long-term. (renalfellow.org)
  • In the following 2008 NEJM article , five patients with ESRD underwent a combined kidney/bone marrow transplant. (renalfellow.org)
  • Shouldn't these patients be LESS prone to rejection given that matched nature of the kidney & stem cells transplanted as well as the additional myeloablative therapy that is given beforehand? (renalfellow.org)
Destroyed and healthy bone1
Outcomes2
  • Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
  • To maximise outcomes, we must know how well the transplant is working and if something goes wrong, a swift medical response is vital to ensure patient survival. (edu.au)
Types of bone1
Performed in adults1
Centers1
Cells30
Recipient's1
  • In the past few years, researchers from Memorial Sloan Kettering and other institutions have found that a transplant recipient's microbiota plays an important role in their survival after a BMT. (mskcc.org)
Successful bone1
Rejection4
  • This test is saving lives by identifying transplant rejection and recurrence of disease earlier than other approaches. (edu.au)
  • Bone Marrow Transplant Rejection is a complication that can occur after a stem cell or bone marrow transplant. (globaldata.com)
  • The Bone Marrow Transplant Rejection - drugs in development research report provides a comprehensive overview on the therapeutics under development for Bone Marrow Transplant Rejection, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (globaldata.com)
  • Additionally, the report provides an overview of key players involved in therapeutic development for Bone Marrow Transplant Rejection and features dormant and discontinued projects. (globaldata.com)
Person's1
  • Now, for the first time, investigators have found an association between the health of the microbiota before a transplant and a person's survival afterward. (mskcc.org)
Post-transplant5
  • Participants completed two questionnaires that together evaluated specific areas of sexual function (sexual cognition/fantasy, sexual arousal, sexual behavior/experience, orgasm, and drive/relationship) as well as sexual satisfaction at a median time of 17 days pre-transplant and at six, 12, 24, and 36 months post-transplant. (science20.com)
  • During the three-year post-transplant analysis period, the percentage of men who self-reported being "sexually active" (defined as having sex with a partner at least once in the preceding month) declined 7 percentage points, with 61 percent of men reporting sexual activity pre-transplant and 54 percent reporting activity post-transplant. (science20.com)
  • The opposite - a 15 percentage point increase in sexually active individuals - was observed in women, with 37 percent reporting sexual activity pre-transplant and 52 percent reporting activity post-transplant. (science20.com)
  • Men surveyed who had developed the dangerous post-transplant complication reported a 21 percent decrease in sexual cognition/fantasy and a 24 percent decrease in the quality of orgasm since their transplant. (science20.com)
  • Lack of complications combined with improved overall recovery rate resulted in fewer expenses that are crucial in post-transplant care. (yoursdailynews.com)
1950s1
  • A few years ago, Lowry began researching old newspaper and journal articles surrounding the first transplants in the 1950s and '60s, and was struck by how amazing the transplants had seemed. (aaas.org)
Cornea2
  • A cornea transplant is required in these cases to restore functional vision. (artemishospitals.com)
  • In these cases corneal transplants are performed in order to protect the integrity of the eye, relieve pain and remove the diseased cornea. (artemishospitals.com)
Centre1
  • Once it's decided that a corneal transplant is required, the patient's name is listed at a registered centre. (artemishospitals.com)
Survival1
  • For the first time, researchers have found that having a healthy balance of microorganisms in the body before a bone marrow transplant is associated with higher survival rates after the transplant. (mskcc.org)
Adults1
Bones4
Depends2
  • The amount of marrow removed depends on the weight of the person who is receiving it. (medlineplus.gov)
  • The quantity of marrow eliminated depends on the weight of the individual who is getting it. (iytmed.com)
Hematopoietic1
20201
  • Available at http://www.transplant- observatory.org/download/2016-activity-data-report/ Accessed 11 March 2020. (who.int)
Leukemia2
Appointment1