Transplants bone marrow mesenchymal stem cells. Medical search. Frequent questions

Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
In the body, perhaps the equivalent peacemakers are mesenchymal stem cells (MSCs). (siliconrepublic.com)
The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
MSCs could be derived from a series of tissues including but not limited to umbilical cord, placenta, adipose tissue, bone marrow, gingiva, and dental pulp [5-12]. (researchsquare.com)
Over the past few years, MSCs researches have achieved some inspiring results and some of which moved up to clinic period from preclinical phases, resulting in the marketing approval of a few cell-based therapy products (CTPs) by different national regulatory authorities [18]. (researchsquare.com)
We established a Good Manufacturing Practice (GMP) grade cell facility to produce clinic-grade human umbilical cord derived MSCs (HUCMSCs) for treating premature ovarian failure (POF) and recurrent uterine adhesion [18, 20]. (researchsquare.com)
MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. (hindawi.com)
Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. (hindawi.com)
The purpose of this review is to bridge the gap in our understanding between the basic science knowledge on MSCs and BMA and the clinical and technical aspects of marrow stimulation-based cartilage repair by examining available data on the role and mechanisms of MSCs and BMA in osteochondral repair. (hindawi.com)
Mesenchymal stem cells (MSCs) play a key role in articular cartilage repair. (hindawi.com)
MSCs have multilineage differentiation potential, allowing them to differentiate, for example, into chondrocytes and osteoblasts, the key cells from the two tissues that constitute the osteochondral unit. (hindawi.com)
They were first isolated from the bone marrow, and the potency of MSCs is currently being employed in the techniques of marrow stimulation for symptomatic small chondral defects. (hindawi.com)
In the orthopaedic field, additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation has been recently studied, since the bone marrow itself is both a source of MSCs, providing a cell population capable of chondrogenesis and of various growth factors stimulating cartilage repair [ 7 - 10 ]. (hindawi.com)
Moreover, the bone marrow clot provides a three-dimensional (3D) environment which supports the chondrogenesis of MSCs. (hindawi.com)
In contrast to the cost- and labor-intensive cultivation and propagation of cells such as MSCs or articular chondrocytes, the clinical use of "minimally processed" autologous BMA that can be prepared in the operation room as a single-step procedure appears straightforward. (hindawi.com)
thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. (biomedcentral.com)
MSCs are multipotent stem cells with the ability to self-renew and differentiate in multiple directions [ 3 ]. (biomedcentral.com)
By performing local transplants, other non-periodontal-derived MSCs such as dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) also aid in the regeneration of periodontal tissue [ 12 ]. (biomedcentral.com)
However, when employing MSC transplantation to treat tissue defects, the research found that: less than one percent of MSCs could home and colonize in the tissue defect area, continuously promoting tissue regeneration, and the paracrine mechanism of MSCs plays a more important role than the replacement of damaged cells by differentiation [ 13 ]. (biomedcentral.com)
The current study aimed to investigate the effect of mesenchymal stem cells (MSCs) transplantation as a new strategy for treatment of diabetes in Streptozotacin (STZ) induced diabetic male albino rats. (alliedacademies.org)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
Fibronectin (FN) is commonly used in the development of serum-free media for the expansion of mesenchymal stem cells (MSCs). (biomedcentral.com)
This study was aimed to observe if thrombin could stimulate FN secretion by human bone marrow MSCs and investigate the potential underlying mechanisms. (biomedcentral.com)
PCR analysis showed that human bone marrow MSCs expressed two subtypes of PARs, PAR-1 and PAR-2. (biomedcentral.com)
Mesenchymal stem cells (MSCs) are adult multipotent cells that were initially isolated from bone marrow[ 1 ] and characterized by the fibroblast-like appearance in culture and the capacities to form bone, adipose and cartilage. (biomedcentral.com)
However, the quantity of MSCs is very low in bone marrow (about 0.001 to 0.01% of the mononuclear cells) and in vitro expansion is the prerequisite for their clinical application. (biomedcentral.com)
Background Mesenchymal stem cells (MSCs) have a great potential for the treatment of acute lung injury. (uni-koeln.de)
The clinical use of human bone marrow-derived mesenchymal stem cells (BM-MSCs) has been expanded but failure of the transplanted stem cells in the heart still remains a problem. (medicaldesignbriefs.com)
The research team mixed genetically engineered stem cells (genetically engineered hepatocyte growth factor-expressing MSCs, HGF-eMSCs) developed by SL Bigen Co., Ltd. to make bioink in the form of a patch and introduced a new therapy by transplanting it to a damaged heart. (medicaldesignbriefs.com)
The joint research team first genetically engineered the existing BM-MSCs to produce hepatocyte growth factor consistently to improve the therapeutic potential of stem cells. (medicaldesignbriefs.com)
The engineered stem cells (HGF-eMSCs) were then mixed with BM-MSCs to make the bioink. (medicaldesignbriefs.com)
Implanted cells in a patch survived longer in vivo and had more myocardiocytes survive than the experimental group of BM-MSCs transplanted. (medicaldesignbriefs.com)
The use of physiomimetic decellularized extracellular matrix-derived hydrogels is attracting interest since they can modulate the therapeutic capacity of numerous cell types, including mesenchymal stromal cells (MSCs). (ibecbarcelona.eu)
Remarkably, extracellular vesicles (EVs) derived from MSCs display similar functions as their parental cells, mitigating tissue damage in lung diseases. (ibecbarcelona.eu)
The number of ECM-vesicles released from acellular L-HG was 10-fold greater than EVs from conventional MSCs cell culture revealing that L-HG is an important source of bioactive vesicles. (ibecbarcelona.eu)
The inclusion criteria are original articles, rat burns experimental models, stem cells therapy using MSCs for experimental groups, non-functional solution, excipient or no treatment for control group, and healing rate of the burn wounds as the main outcome. (com.pk)
12 Bang and colleagues reported the safety and feasibility of intravenous infusion of autologous mesenchymal stem cells (MSCs) with no reported adverse effects in five patients treated with intravenous MSCs. (bmj.com)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
2 (2007) observed that cell adhesion and proliferation, as well as the osteogenic differentiation of mouse mesenchymal stem cells (MSCs) to Ti discs were significantly similar to those on the plastic surface of the culture, indicating Ti as an excellent material for repairing hard tissue in the field of bone tissue engineering. (bvsalud.org)
Therefore, the present study aimed to evaluate the adhesion capacity of mouse bone marrow MSCs to smooth and plasmanitrided Ti surfaces in the cathodic cage configuration. (bvsalud.org)
Mesenchymal stem cells ( MSCs) are known to be multipotent stromal cells that can differentiate into a variety of cell types which include osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (stemcellsgroup.com)
Thus, these properties of MSCs make these cells potentially ideal candidates for tissue technology. (stemcellsgroup.com)
In addition, it has been discovered that MSCs, when transplanted systemically, have the ability to transport to sites of physical harm or damage in animals, suggesting that MSCs have migratory capacity. (stemcellsgroup.com)
Arnold Caplan (1991), coined the term "mesenchymal stem cell and stated that the cells as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies. (stemcellsgroup.com)
Mesenchymal stem/stromal cells (MSCs) can be isolated from neonatal tissues, most of which are discarded after birth, including placental tissues, fetal membranes, umbilical cord, and amniotic fluid. (stemcellsgroup.com)
Thus, neonatal tissues are easily available and they have biological advantages in comparison to adult sources that make them a useful source for stem cells including MSCs. (stemcellsgroup.com)

Bioactive agents, including cytokines and growth factors such as stromal cell-derived factor-1, platelet-derived growth factor, VEGF, and others, were shown to promote cell recruitment and have a helpful effect on the repair of articular cartilage injuries ( 8 , 10 , 11 ). (spandidos-publications.com)
Systematic review and meta-analysis of randomized controlled trials of mesenchymal stromal cells to treat coronavirus disease 2019: is it too late? (mathec.com)
Human bone marrow derived mesenchymal stromal cells (hMSC) is an excellent source, as these cells can be genetically modified to express proteins/drugs and also have an exceptional migratory or homing ability towards tumors, injury or inflammation. (brainsciencefoundation.org)
This project will study the use genetically modified human mesenchymal stromal cells as a local therapeutic drug delivery vehicle for the targeted delivery and secretion of chemotherapeutic/biologic agents for treatment of brain tumors. (brainsciencefoundation.org)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
One type of stem cell is involved in producing blood cells and the other is involved in producing stromal cells, which are responsible for the supporting stroma. (medscape.com)

The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
Among all, cell transplantation therapy is considered the most favourable treatment strategy for femoral head necrosis. (ijpsonline.com)
In conclusion: treatment with MSC.s transplantation as a cell-therapy could restore pancreatic β-cell function and improved liver and kidney functions in diabetes as a new strategy for diabetes treatment. (alliedacademies.org)
Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Should It Be Considered? (mdpi.com)
Autologous stem cell transplantation in refractory Crohn's disease - low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. (wizaxe-prod.com)
European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP). (wizaxe-prod.com)
Autologous Haematopoietic Stem Cell Transplantation for Crohn's Disease: A Retrospective Survey of Long-term Outcomes from the European Society for Blood and Marrow Transplantation. (wizaxe-prod.com)
Immune Reconstitution After Autologous Hematopoietic Stem Cell Transplantation in Crohn's Disease: Current Status and Future Directions. (wizaxe-prod.com)
A Review on Behalf of the EBMT Autoimmune Diseases Working Party and the Autologous Stem Cell Transplantation In Refractory CD-Low Intensity Therapy Evaluation Study Investigators. (wizaxe-prod.com)
Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial. (wizaxe-prod.com)
Hematopoietic stem cell transplantation in a severe refractory Crohn's disease patient with intestinal stoma: a case report. (wizaxe-prod.com)
Resetting of the Mucosal T Cell Repertoire after Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease. (wizaxe-prod.com)
Improving safety of autologous haematopoietic stem cell transplantation in patients with Crohn's disease. (wizaxe-prod.com)
Stem Cell Transplantation for Refractory Crohn Disease. (wizaxe-prod.com)
Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial. (wizaxe-prod.com)
Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
Background: This study proposed to examine the possibility of homing of bone marrow derived-mesenchymal stem cells after allograft transplantation in irradiated and healthy bone marrows. (ac.ir)
PCR results for the healthy and irradiated rats in all time gaps after transplantation were negative indicating that male mesenchymal stem cells were failed to home in bone marrow of transplanted female rats. (ac.ir)
Systemic transplantation of stem cells from human exfoliated deciduous teeth (SHED) is used to treat systemic lupus erythematosus (SLE)-like disorders in MRL/lpr mice. (elsevierpure.com)

ELAC's strength approximates that of tendon/ligament, and emerging results indicate that ELAC supports the differentiation of mesenchymal stem cells to tenocytic lineage. (uhhospitals.org)

However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. (nature.com)
The patient's stem cells are stored in a clinical-grade cryogenic biorepository for future withdrawal, expansion, and use in disease prevention, longevity treatments, and regenerative medical treatments. (wikipedia.org)
Hundreds of clinical trials are currently underway studying the effects of stem cell therapy. (wikipedia.org)
Implications of findings from both translational and clinical studies using BMA concentrate-enhanced marrow stimulation are discussed. (hindawi.com)
His research interests include imaging informatics, artificial intelligence and machine learning, telemedicine, cell-based therapies and clinical trial design. (stanford.edu)
However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)
Regeneration of large bone defects is a common clinical problem. (dovepress.com)
Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
Recently, stem cell- and gene-based therapy has been applied in BTE and achieved some good clinical results. (dovepress.com)
Mesenchymal stem cells for chronic wound healing: current status of preclinical and clinical studies. (trdizin.gov.tr)
Although microfractures, arthroscopic debridement, and cell-based or cell-free approaches have been introduced for osteochondral reconstruction, the clinical application and repair effects remain barely satisfactory owing to donor morbidity, possible contamination and potential problems in cell transportation ( 4 , 5 ). (spandidos-publications.com)
Human stem cells are used in the clinical therapies of a dead heart, which happens when a blood vessel is clogged or whole or a part of heart muscle is damaged. (medicaldesignbriefs.com)
Several recent clinical trials have reported safety and some improvement in outcomes following cell therapy administration in ischaemic stroke, which are reviewed. (bmj.com)
9 Clinical trials of cell therapy completed in the 2000s mostly treating small cohorts of patients with chronic stroke demonstrated adequate safety and a suggestion of efficacy with the use of cell therapy. (bmj.com)
13 These early clinical trials mostly focused on chronic subcortical strokes, but more recent trials are now investigating cell therapy for treatment of both cortical and subcortical infarcts. (bmj.com)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)
hMSC is an ideal candidate and compatible for clinical use as these cells can be harvested by bone marrow aspiration from individual patients without difficulty, processed ex vivo very efficiently, and later transplanted back into the same patients during surgery thereby reducing immunological consequences. (brainsciencefoundation.org)
The first source of Mesenchymal stem cells was in the bone marrow and considered to be the gold standard for clinical research, although various other sources have being discovered which include: Adipose tissue, Dental pulp, Mobilised Peripheral blood, Amniotic fluid, Joint synovium, synovial fluid, Endosteum, Periosteum, Menstrual blood and birth-derived tissues. (stemcellsgroup.com)
Dimethyl sulfoxide (DMSO) is a cryopreservative used in cell research, but it is potentially toxic, which would make it impossible to use cryopreserved ADMSCs in clinical practice. (bvsalud.org)

Objective: To evaluate the allogeneic mesenchymal stem cells' efficacy in treating burn wounds in rats. (com.pk)
Placenta is an ideal starting material for the large-scale manufacture of multiple cell doses of allogeneic MSC. (stemcellsgroup.com)

The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. (scielo.br)

Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
To avoid immune recipient's rejection of the transplanted bioengineered lung, autologous bone marrow/adipose tissue-derived mesenchymal stem cells, lung progenitor cells or induced pluripotent stem cells are used for biofabricating the bioengineered lung. (ibecbarcelona.eu)
Making a distinction with the human mesenchymal stem cells into cells can transfer along the paths that bear a resemblance to neuronal progenitor cells. (neurospineandpain.com)

This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
The main objective of this communication is to study the treatment of femoral head necrosis with cell replacement therapy and also its effects by focusing on the disease stages. (ijpsonline.com)
However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)
Preclinical studies suggest that cell therapy may be safe and effective in improving functional outcomes. (bmj.com)
Cell therapy may provide a promising new treatment for stroke reducing stroke-related disability. (bmj.com)
Further investigation is needed to determine specific effects of cell therapy and to optimise cell delivery methods, cell dosing, type of cells used, timing of delivery, infarct size and location of infarct that are likely to benefit from cell therapy. (bmj.com)
Cell therapy is one approach to enhancing recovery after stroke. (bmj.com)
These positive results have allowed the doctors, researchers and scientists to accept the potentialities of stem cell therapy for stroke treatment. (neurospineandpain.com)
Since germ therapy is too late for everyone alive, we have to correct the genotype of a significant number of our somatic cells or replace them by new ones. (senescence.info)
Stem Cell Therapy is proving to be the best treatment option for patients with Parkinson's Disease due to its success in providing relief without any surgery or side effects of drugs. (plexusnc.com)
Under the guided supervision of Dr Na'eem Sadiq, we provide the most advanced Stem Cell Therapy for treating Parkinson's Disease. (plexusnc.com)
Two major concerns in cancer therapy are the short half-life, availability or excessive toxicity of the drugs, and the extreme invasiveness of the malignant tumor cells to infiltrate into the surrounding tissue and recur locally near the neurosurgical resection site. (brainsciencefoundation.org)
The results at the conclusion of this project will provide us all the information necessary for a pilot phase I feasibility and safety study for treating brain tumor patients with mesenchymal stem cells that have been engineered to express cytosine deaminase (MSC-CD) followed by 5-FC therapy. (brainsciencefoundation.org)

For the bone marrow aspiration, an EZIO-10 drill with 28mm bone marrow needle was used. (caringmedical.com)
Bone marrow aspiration was conducted from the patients' bilateral anterior iliac crest under general anesthesia in an operating theater. (biomedcentral.com)
Bone marrow aspiration was conducted from the patients' bilateral anterior iliac crest under general anesthesia in an operating theater at Vinmec Times City International Hospital. (biomedcentral.com)
There are two main types - bone marrow aspiration and bone marrow biopsy. (medlineplus.gov)

Over time, they form a fibrocartilaginous repair tissue in the defect and close the connection with the subchondral bone. (hindawi.com)
A focus is on the steps of mobilization of cells from the subchondral bone and repair tissue formation, including adherence of the bone marrow clot to the subchondral bone. (hindawi.com)
In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. (biomedcentral.com)
One great advantage of MSC is that these cells may be directly obtained from individual patients, thereby eliminating the complications associated with immune rejection of allogenic tissue and infectious diseases. (biomedcentral.com)
Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
2 , 3 Bone tissue engineering (BTE) attempts to solve the referred problems mentioned. (dovepress.com)
For this purpose, mesenchymal stem cells were isolated from canine adipose tissue and bee venom samples were collected from Apis mellifera anatoliaca in Muğla province of Türkiye. (trdizin.gov.tr)
The application of L‑PRF and F‑PRF for osteochondral defects in rabbits contributed to massive host remodeling and reconstruction of osteochondral tissues, thus offering a prospective bioactive scaffold for the simultaneous reconstruction of articular cartilage and subchondral bone tissue. (spandidos-publications.com)
Tissue engineering and function reconstruction through host remodeling and autologous cell recruitment effectively was shown to overcome the aforementioned limitations and represent a fundamental shift from cell-based approaches ( 6-8 ). (spandidos-publications.com)
Platelet-rich fibrin (PRF), commonly known as a second-generation PC, was shown to have a high capacity to improve wound healing and tissue repair owing to the gradual release of growth factors during its slow degradation along with its intrinsic fibrin scaffolding, which offers a unique three-dimensional (3-D) microstructure for promoting proliferation and differentiation of recruited cells ( 12 , 13 ). (spandidos-publications.com)
In individuals with this condition, pancreatic acinar cells do not develop in utero and are replaced by fatty tissue. (medscape.com)
mechanical properties of bone tissue. (uhhospitals.org)
Implant materials performance, wear and degradation of UHMW polyethylene, implant retrieval analysis and implant design, mechanical performance of normal and diseased bone tissue. (uhhospitals.org)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
Accordingly, the association of Ti implants with bone tissue culture may contribute to bone tissue regeneration 7 . (bvsalud.org)
Bone marrow is the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones. (medscape.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
Bone marrow can be 1 of 2 types, red or yellow, depending on whether it consists of mainly hematopoietic (and therefore, red-colored) tissue or fatty (and therefore a yellow-colored) tissue. (medscape.com)
Given this, the ALINE MANICA2 cryopreservation of adipose tissue-derived mesenchymal stem cells (ADMSCs) could be a JULIANA CRISTINA SCHMIDT2 way to collect them in one surgical procedure and after performing fractional fat grafting. (bvsalud.org)

SDS is the second most common cause of inherited pancreatic insufficiency after cystic fibrosis and the third most common inherited bone marrow failure syndrome after Fanconi anemia and Diamond-Blackfan anemia. (medscape.com)
Shwachman-Diamond syndrome is considered one of the inherited bone marrow failure syndromes. (medscape.com)

However, for cell therapies MSC have to be expanded and/or manipulated to obtain a sufficient amount of cells that can be subsequently used for treatment. (biomedcentral.com)
Bertolo A, Steffen F, Malonzo-Marty C, Stoyanov J. Canine Mesenchymal Stem Cell Potential and the Importance of Dog Breed: Implication for Cell-Based Therapies. (paraplegie.ch)
Stem cell-based therapies provide a promising approach for treatment of tumors in humans. (brainsciencefoundation.org)

Furthermore, making use of the patient's own bone marrow cells for stroke stem cell treatment, averts all immune related problems, which makes stroke stem cell treatment extremely effective & safe. (neurospineandpain.com)

Various cells release lipid-enclosed particles known as extracellular vesicles (EVs), which are rich in bioactive substances. (biomedcentral.com)
It is a complex and dynamic process to form a continuous construct via the cells' adhesion, proliferation, differentiation, and extracellular matrix (ECM) deposition on a scaffold. (dovepress.com)
Considering the limited amount of cells that could be transferred, they used heart-derived extracellular matrix bioink to make a cardiac patch. (medicaldesignbriefs.com)
Exosome, a type of nanoparticles also known as small extracellular vesicles are gaining attention as novel therapeutics for various diseases because of their ability to deliver genetic or bioactive molecules to recipient cells. (molcells.org)
More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
This formation helps deposition and adhesion of the extracellular matrix on the bone-implant interface. (bvsalud.org)

To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
With a variety of assays we could show that MSC represent a cell population which can be expanded for therapeutic applications. (biomedcentral.com)
In recent years mesenchymal stem cells (MSC) have generated a great deal of interest as a potential source for cell-based therapeutic strategies. (biomedcentral.com)
In this mini-review, we will discuss the manufacturing challenges of therapeutic exosomes, including cell line development, upstream cell culture, and downstream purification process. (molcells.org)
This therapeutic strategy employs genetic modification of hMSC and exploits the tumor tropic behavior, for tracking to sites of tumor cell invasion and allows on-site generation of drug to control tumor growth. (brainsciencefoundation.org)

It comprises of two types of stem cells, that are hematopoietic and mesenchymal stem cells. (powershow.com)
In animal models, delivery of several different types of stem cells reduce infarct size and improve functional outcomes. (bmj.com)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)

Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
The expression of osteogenesis-related gene was increased, which demonstrated that released BMP-2 could effectively induce the cell sheet osteogenic differentiation in vitro. (dovepress.com)
Bertolo A, Gemperli A, Gruber M, Gantenbein B, Baur M, Pötzel T, Stoyanov J. In vitro cell motility as a potential mesenchymal stem cell marker for multipotency. (paraplegie.ch)
Kondziolka and colleagues used N-Tera 2 cells derived from a lung metastasis of a human testicular germ cell tumour that when treated with retinoic acid generate postmitotic neurons that maintain a fetal neuronal phenotype indefinitely in vitro (LBS neurons). (bmj.com)
HADSCs were induced to confirm that they can express the characteristics of endothelial cells (ECs) in vitro. (molvis.org)
Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
a) The cells should exhibits plastic adherence (b) The cell should possess specific set of cell surface markers, i.e. cluster of differentiation (CD) 73, D90, CD105 and lack expression of CD14, CD34, CD45 and human leucocyte antigen-DR (HLA-DR). (c) The cells should have the ability to differentiate in vitro into adipocyte, chondrocyte and osteoblast. (stemcellsgroup.com)
Subsequently, recipient bone marrow mesenchymal stem cells (BMMSCs) isolated from SHED-EV-administered MRL/lpr mice were examined for the in vitro and in vivo activity of hematopoietic niche formation and immunoregulation. (elsevierpure.com)

This study aimed to identify the density of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of patients with three neurologic conditions. (biomedcentral.com)
Bone marrow mononuclear cells (BMMNCs) consist of hemopoietic stem cells and mesenchymal stem cells together with progenitors of endothelial cells or somatic cells [ 1 , 2 ]. (biomedcentral.com)
In this study, we aimed to identify the concentrations of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of these patients and their correlation with treatment outcomes. (biomedcentral.com)

As with other bone marrow failure syndromes, a predilection for developing severe cytopenias, myelodysplastic syndrome (MDS), and leukemia is observed with SDS. (medscape.com)

To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
Bone marrow supersedes the liver as the major hematopoietic organ at 32-36 weeks' gestation. (medscape.com)

MSC derived from placenta have long-term proliferation and immunomodulatory capacity, superior to bone marrow-derived MSC. (stemcellsgroup.com)

We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)
The objective of this study is to determine the effects of bee venom on the proliferation capacity of mesenchymal stem cells and wound healing. (trdizin.gov.tr)
According to the results of our study's cell proliferation assay and wound healing test, bee venom had no proliferative effect on mesenchymal stem cells within the defined dose range. (trdizin.gov.tr)
We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
The term "adhesion" to the biomaterial refers to the most important phase, since the quality of it will influence morphology and the capacity of cell proliferation and differentiation 3 . (bvsalud.org)
Similarly, they are characterized by an extensive capacity for self-renewal, proliferation, potential to differentiate into multiple lineages and their immune-modulatory role on various cells. (stemcellsgroup.com)

To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)

This form of regenerative medicine uses autologous mesenchymal stem cells from the patient's bone marrow to repair the damaged cells within their body. (plexusnc.com)

Human MSC are easy to isolate from small aspirate of bone marrow via their adherence ability. (biomedcentral.com)

Pasca, one of three stem cell investigators to receive the award, develops new approaches for studying human brain development and examining the mechanisms of neuropsychiatric disorders. (stanford.edu)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
Methods MSC derived from human bone marrow were labeled by DiI and administered intravascularly or endobronchially to the lungs of donor pigs after a period of 3 hours warm and 3 hours cold ischemia. (uni-koeln.de)
Comparative Characterization of Canine and Human Mesenchymal Stem Cells Derived from Bone Marrow. (paraplegie.ch)
Bertolo A, Häfner S, Taddei AR, Baur M, Pötzel T, Steffen F, Stoyanov J. Injectable microcarriers as human mesenchymal stem cell support and their application for cartilage and degenerated intervertebral disc repair. (paraplegie.ch)
Bertolo A, Arcolino F, Capossela S, Taddei AR, Baur M, Potzel T, Stoyanov J. Growth Factors Cross-Linked to Collagen Microcarriers Promote Expansion and Chondrogenic Differentiation of Human Mesenchymal Stem Cells. (paraplegie.ch)
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas, including insulin producing beta cells (4). (diabetesresearch.org)
Promotes osteogenic, adipogenic, and chondrogenic differentiation of human mesenchymal cells (Jaiswal et al. (stemcell.com)
Promotes differentiation of mature hepatocytes from mouse and human embryonic stem (ES) cells (Cai et al. (stemcell.com)

Pasca , assistant professor of psychiatry and behavioral sciences, and Scherrer , assistant professor of anesthesiology, perioperative and pain medicine and of neurosurgery, were named 2017 New York Stem Cell Foundation Robertson Investigators. (stanford.edu)

Osteogenesis in transplants of bone marrow cells. (trdizin.gov.tr)
In the mechanobiology realm, the lab has been breaking ground in understanding the role of VEGF in osteogenesis by studying 3D cultures of ossifying bone marrow explants. (uhhospitals.org)

At 16 weeks after implantation surgery, full‑thickness osteochondral defects with a diameter of 5 mm and a depth of 4 mm were well‑filled with newly regenerated tissues, exhibiting the simultaneous regeneration of avascular articular cartilage and well‑vascularized subchondral bone, as proven through macroscopic and microscopic observations in PRF‑treated groups compared with that in the untreated group. (spandidos-publications.com)
Moreover, to produce acceptable structural and functional repair, all three kinds of tissues involved in osteochondral lesions, including subchondral bone, the osteochondral interface and articular cartilage, need to be reconstructed simultaneously ( 3 ). (spandidos-publications.com)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)
Leukemia starts in blood-forming tissues such as the bone marrow. (medlineplus.gov)
Cells Tissues Organs. (cancercentrum.se)

10 11 Using a similar stereotactic approach implanting cells into the basal ganglia, Savitz and colleagues transplanted LGE cells (fetal porcine striatum-derived cells, Genvec) in five patients. (bmj.com)
Bone marrow first appears in the clavicle near the end of fetal life and becomes active about 3 weeks later. (medscape.com)

The particular nature of hyaline articular cartilage, including the avascular nature and the low number of chondrocytes and stem cells in the surrounding cartilage lesions, results in limited potential to reconstruct osteochondral defects through a self-healing process ( 1 , 2 ). (spandidos-publications.com)

The study's outcomes may be enhanced by investigating the effect of bee venom on mesenchymal stem cells in combination with other substances or by improving the bee venom's purification process. (trdizin.gov.tr)
This study demonstrated safety and feasibility of stereotactic cell implantation, although there was no significant improvement in functional outcomes. (bmj.com)

While the collection and storage of infant cord blood has become commonplace since the 1990s, Forever Labs is notable for being the first company to offer collection and storage of adult stem cells. (wikipedia.org)
We can augment the function of adult stem cells approved by Ministry of Food and Drug Safety and FDA using this newly developed and promising 3D bioprinting technology with the engineered stem cells. (medicaldesignbriefs.com)

BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. (medscimonit.com)
Furthermore, the recipient BMMSCs were secondarily transplanted into MRL/lpr mice. (elsevierpure.com)

As chondrocyte survival is critically influenced by the time between graftharvest and implantation, ultra-fresh transplants may provide better long-term results. (ivis.org)

The additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation is thought to enhance cartilage repair as it may provide both an additional cell population capable of chondrogenesis and a source of growth factors stimulating cartilage repair. (hindawi.com)
Such enhanced techniques of marrow stimulation have been shown to improve articular cartilage repair in both animal models and patients. (hindawi.com)
This type of cartilage repair technique is often fortified by bone marrow acquired autologous mesenchymal stem cell support. (ivis.org)

Moreover, the BMA clot provides a three-dimensional environment, possibly further supporting chondrogenesis and protecting the subchondral bone from structural alterations. (hindawi.com)
Finally, it is possible that it protects the subchondral bone plate and the subarticular spongiosa from structural alterations of its microarchitecture. (hindawi.com)

Lung biofabrication is based on seeding cells into an acellular organ scaffold and on culturing them in an especial purpose bioreactor. (ibecbarcelona.eu)
These physical stimuli to the organ are translated into the stem cell local microenvironment - e.g. shear stress and cyclic stretch - so that cells sense the physiological conditions in normally functioning mature lungs. (ibecbarcelona.eu)
organ transplants are unlikely to be the solution for aging, and at least not a definitive cure. (senescence.info)

Note: Since this article first appeared in the Journal of Prolotherapy in 2012, new research has continued to support the use of direct Bone Marrow injections in cases of avascular necrosis. (caringmedical.com)
While arthroscopy with or without core decompression is the standard of care for unresolved cases of avascular necrosis of the talus, we present a case of avascular necrosis of the talar dome where symptoms resolved satisfactorily with direct bone marrow injections into structures into and around the ankle. (caringmedical.com)
A Systematic Review and Meta-analysis of Mesenchymal Stem Cell Injections for the Treatment of Perianal Crohn's Disease: Progress Made and Future Directions. (wizaxe-prod.com)

Bone marrow is mainly responsible for the haematopoiesis, (formation of blood cells), production of lymphocytes, and the storage of fats. (powershow.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

The bone marrow transplant is the last alternative generally recommended by the physicians in the cases of fatal bone marrow diseases and bone or skin cancer. (powershow.com)
The growing amount of bone marrow diseases will help in escalating the growth of the bone marrow market. (powershow.com)

Autologous hematopoietic stem cells for refractory Crohn's disease. (wizaxe-prod.com)

Various preventive measures required to treat femoral head necrosis include revascularization, adequate supply of osteogenic cells and establishing enough strength to avoid collapse. (ijpsonline.com)
Although, a list of contributing factors such as sickle cell anaemia, use of steroids, femoral neck fractures are involved in the loss of osteogenic cells via obstructing blood supply especially in the greater trochanteric region[ 1 , 2 ]. (ijpsonline.com)
Mesenchymal stem cells were isolated from femoral bone marrow of male rats. (ac.ir)

At the same time, the first three trials using cells derived from pluripotent cells have begun. (biomedcentral.com)

A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. (hindawi.com)
If bone marrow fills a cartilage defect either as a result of marrow stimulation for chondral defects or the course of the spontaneous repair of osteochondral defects, a bone marrow clot forms within the cartilage defect. (hindawi.com)
Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)

Assays on the cell culture showed that the genetically engineered cells released the BMP-2 for at least 14 days. (dovepress.com)
The name came from the principle that maximized function of mesenchymal stem cells is maintained in vivo as well as through its exposure to the growth factor secreted by the genetically engineered stem cells. (medicaldesignbriefs.com)

The pathogenic mechanisms involve a wide range of cells and soluble factors. (mdpi.com)

Anatomy48

Organisms18

Diseases22

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Phenomena and Processes46

Disciplines and Occupations3

Technology, Industry, Agriculture8

Named Groups1

Health Care2

MSCs54

Stromal6

Transplantation20

Differentiation of mesenchymal stem1

Clinical24

Allogeneic2

Potential of mesenchymal1

Progenitor3

Therapy15

Aspiration4

Tissue20

Inherited bone marrow failure2

Therapies3

Patient's own bone1

Extracellular6

Therapeutic5

Types of stem cells3

Vitro10

Mononuclear cells3

Failure syndromes1

Liver3

Placenta1

Proliferation6

Osteogenic potential1

Regenerative medicine1

Adherence1

Human11

20171

Osteogenesis2

Tissues5

Fetal2

Chondrocytes1

Outcomes2

Adult stem2

BMMSCs3

Implantation1

Cartilage repair3

Subchondral bone2

Organ3

Injections3

Lymphocytes2

Diseases2

Refractory Crohn's Disease1

Femoral3

Pluripotent cells1

Defects3

Genetically2

Mechanisms1