Transplantation transplants clone cells. Medical search. Frequent questions

The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
1] Therapeutic cloning, on the other hand, creates human embryos merely as a source of embryonic stem cells. (reasons.org)
Some in the biomedical community hope to develop techniques to generate replacement tissues from these embryonic stem cells. (reasons.org)
Even though they can't be seen without a microscope, embryonic stem cells are in full view of the public's eye. (reasons.org)
In 1995, they produced a pair of lambs called Megan and Morag from embryonic cells. (shawprize.org)
They performed nuclear transfer experiments in which nuclei from embryonic, foetal and adult cells of the sheep were transplanted into fertilized eggs derived from ewes. (shawprize.org)
Recently, research has increased in the area of transplanting embryonic cells across species and growing kidneys and endocrine pancreas cells in situ. (medscape.com)
When People Say: "Embryonic stem cell research is. (christianliferesources.com)
The generation of the embryonic CNS is a lineage-based process in which neural progenitors, called neuroblasts (NBs), give rise to largely invariant lineages of neural/glial cells. (biologists.com)
Cell lineage analysis techniques have been used to analyse most of the embryonic NB lineages at the histological level. (biologists.com)
SSCs can be isolated from the testis and cultured in vitro for longterm periods in the presence of feeder cells (often mouse embryonic fibroblasts). (molcells.org)
When primary SSCs are derived from the testis and proliferated in vitro , mouse embryonic fibroblasts (MEFs) are the most commonly used feeder cells that play a role of such microniche by allowing secure attachment and proliferation of SSCs. (molcells.org)
In fact to get a embryonic stem cell a human embryo has to be disassembled. (ipl.org)
but one of the most arguable topics of all time is the use of embryonic stem cells. (ipl.org)
In recent years, several competing viewpoints have emerged about embryonic stem cell research. (ipl.org)
All of this debate raises an important question, Should embryonic stem cell research be conducted for treatment of present and future diseases? (ipl.org)
People who believe that an embryo should not be destroyed tend to say that embryonic stem cell research should not be conducted. (ipl.org)
On the other hand, people who believe that embryonic stem cell research creates means of curing diseases reply that the research should be conducted. (ipl.org)
Embryonic stem cell research "uses special cells found in three-to-five day old human embryos to seek cures for a host of chronic disease" (PRC). (ipl.org)
Embryonic stem cell transplants have been an ethical, social, and legal controversy since the first successful transplant of human stem cells in 1998. (ipl.org)
Every human being begins as a single-cell zygote, grows through the embryonic stage, then the fetal stage, is born and develops through infancy, through childhood, and through adulthood, until death. (actionlife.org)
Gurdon's research built on the work of Thomas King and Robert Briggs in the United States, who in 1952 published findings that indicated that scientists could take a nucleus from an early embryonic cell and successfully transfer it into an unfertilized and enucleated egg cell. (asu.edu)
The cells giving rise to the foetus, are called pluripotent embryonic stem cells, since they can form every cell type in the body. (biomedcentral.com)
These cells are commonly termed embryonic germ (EG) cells because they are derived from primordial germ cells found at the genital ridges in developing fetuses. (biomedcentral.com)
A recent study indicates that even adult humans might harbor cells resembling pluripotent embryonic stem cells. (biomedcentral.com)
Embryonic stem cells are derived from early embryos and have the ability to differentiate into any cell type. (spiked-online.com)
In his original report, Thompson demonstrated that human embryonic stem cells could be coaxed into developing gut-like structures, bone, cartilage and muscle (1). (spiked-online.com)
Blastocytes obtained through nuclear transfers would be used to generate the embryonic stem cells that could be differentiated to specific tissues or organs for transfer to the nuclear donor. (spiked-online.com)
The exact process of differentiation is not yet understood and although embryonic stem cells can, in principle, provide for all human tissue, scientists are some way from controlling the process. (spiked-online.com)
Mouse embryonic stem cells are known to be tumorigenic - that is, they can grow uncontrollably and become cancerous. (spiked-online.com)
Totipotency refers to the ability of a cell to differentiate into any embryonic cell, giving biologists a potentially new way to create new plants. (hytiva.com)
Here we report the first successful case of chromosome transplantation by replacement of an endogenous X chromosome carrying a mutation in the Hprt genewith a normal one in mouse embryonic stem cells (ESCs), correcting the genetic defect. (oncotarget.com)
These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)

But generally, stem cells are harvested from autologous tissues - tissues from your own body. (forhims.co.uk)
Adult hair follicle bulge-derived stem cells (HFBSCs) has a capacity of neuronal differentiation, it is easy to harvest and relatively immune-privileged, which makes them potential candidates for autologous stem cell-based therapies. (copgfp.com)
Solid tumors, autoimmune diseases, graft versus host disease (GvHD), genetic diseases and neurodegenerative diseases are investigated using many types of autologous and allogeneic cells with rapidly evolving cell engineering and editing approaches. (bdbiosciences.com)
G-CSF can be used to increase the numbers of circulating haemopoietic precursor cells which are then harvested by leucapheresis and used either as a supplement to or a substitute for aspirated bone marrow cells in autologous haemopoietic cell transplants. (allindianpatents.com)
These data demonstrate that T cells become tolerant to autologous and allogeneic HLA antigens expressed in the thymus via two different mechanisms: hematopoietic cells present in the thymus induce tolerance to "self"-antigens by clonal deletion, whereas thymic epithelial cells induce tolerance by clonal energy and possibly deletion of high affinity clones. (rupress.org)
The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)

Even though each cadaveric organ donor can often supply multiple organs for transplantation, many patients still die before a suitable organ becomes available. (scialert.net)
However, there are a number of factors limiting the procurement of organs and accordingly, therapeutic cloning that perhaps can yield still better results needs to be considered as an alternative. (scialert.net)
1999). Majority of the organs for transplantation are donated from patients in whom brain-stem death has been diagnosed and who are then ventilated to maintain adequate oxygenation and circulation-the so called non-heart-beating donors (NHBDs) (D Allessandro et al . (scialert.net)
One such approach, called "xenotransplantation" (the transplantation of living cells, tissues, and organs from one species to another species), turns to pigs as a source of organs for human transplants. (reasons.org)
The researchers then used these cells as the source of genetic material to clone pigs with organs that lacked the sugar groups responsible for HAR. (reasons.org)
In fact, the research team oversaw the birth of four normal, healthy piglets with organs suitable for human transplants. (reasons.org)
During the development of vertebrates, including humans, the fertilized egg develops into the embryo, and the cells in the embryo then proceed to differentiate to form somatic cells of different tissues and organs. (shawprize.org)
The fertilized egg is considered totipotent, as it can develop into a whole organism, while the cells in the embryo are pluripotent because they are capable of differentiating into somatic cells that make up all the organs. (shawprize.org)
Xenotransplantation involves the transplantation of nonhuman tissues or organs into human recipients. (medscape.com)
The concept was pioneered a century ago, when transplanting human organs was considered ethically controversial. (medscape.com)
In light of the lack of supply of human organs for transplantation, several alternatives have been investigated and debated. (medscape.com)
Additionally, organs from animal sources could be transplanted into patients currently excluded from the human organ transplantation list. (medscape.com)
Finally, most patients perceive xenotransplantation as an acceptable bridge to transplantation of human organs in life-threatening situations. (medscape.com)
So say the company T-shirts printed up by biotechnology startup eGenesis, which today raised $38 million to fund a new effort to edit the DNA of pigs so they can serve as the source of transplant organs. (technologyreview.com)
Before any person receives a CRISPR-ized pig organ there will be years of negotiations with regulators, close work with transplant surgeons, and costly experiments putting pig organs in monkeys. (technologyreview.com)
About 116,000 people in the United States currently need organ transplants, but fewer than 35,000 organs become available every year. (leaps.org)
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. (mhh.de)
Cell therapy can be used to reverse disease and restore damaged organs. (personalizemymedicine.com)

What deserves greater attention, however, is therapeutic cloning, a (potential) cloning application considered far more important to the biomedical and scientific communities and one far more ethically challenging. (reasons.org)
Crudely put, therapeutic cloning looks to generate human embryos solely for the body parts they can provide. (reasons.org)
Since then, the work of Wilmut and Campbell has been duplicated in many other animal species and has provided approaches to produce useful therapeutic products with cloned animals and to improve agricultural practices. (shawprize.org)
Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
Can these cells be used as a therapeutic for EBV+ lymphomas? (stanford.edu)
A renewable, tissue culture source of human cells capable of differentiating into a wide variety of cell types would have broad applications in basic research and therapeutic techniques. (spiked-online.com)
One of the most promising techniques is what is known as therapeutic cloning. (spiked-online.com)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)
Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)

Think of organ transplants. (blogs.com)

The motivation for using animal sources for organ or tissue transplantation is driven by supply and demand. (medscape.com)
as well as diagnostic techniques, drug development and tissue transplantation. (who.int)

1995). Though this speaks volumes about the improvement in the level of health-care being provided, it also points to the important fact that the number of potential donors may be decreasing, which in turn is seriously limiting the transplantation programs. (scialert.net)
So they tested their idea by harvesting dermal papillae from seven human donors and cloned them in tissue culture - without adding any additional growth factors. (medicalnewstoday.com)
And when they tested the DNA of the new hair follicles that had been generated in each transplant, the team found it was human and a genetic match to that of the donors. (medicalnewstoday.com)
Differential effects of Belatacept on virus-specific memory versus de novo allo-specific T cell responses of kidney transplant recipients and healthy donors. (mhh.de)
To study the role of thymic education on the development of the human T cell repertoire, SCID-hu mice were constructed with fetal liver and fetal thymus obtained from the same or two different donors. (rupress.org)
Thymocytes of SCID-hu mice transplanted with liver and thymus of two different donors (FLDA/FTDB animals) were nonresponsive to Epstein-Barr virus-transformed B cell lines (B-LCL) established from both the FLDA and FTDB, but proliferated vigorously when stimulated with third-party allogeneic B-LCL. (rupress.org)

[3] Today, patients take insulin shots and pharmaceuticals to control their diabetes, and adult stem cell transplants have shown success at ameliorating the condition. (lozierinstitute.org)

The extraction of G-CSF lymphocytes from the blood and expanding in vitro against a tumour antigen before reinjecting the cells with appropriate stimulatory cytokines. (wikipedia.org)
The current approaches for DC-based vaccination are mainly based on antigen loading on in vitro-generated DCs from monocytes or CD34+ cells, activating them with different TLR ligands, cytokine combinations, and injecting them back to the patients. (wikipedia.org)
a) The cells should exhibits plastic adherence (b) The cell should possess specific set of cell surface markers, i.e. cluster of differentiation (CD) 73, D90, CD105 and lack expression of CD14, CD34, CD45 and human leucocyte antigen-DR (HLA-DR). (c) The cells should have the ability to differentiate in vitro into adipocyte, chondrocyte and osteoblast. (stemcellsgroup.com)
Although several in vitro SSC culture systems without feeder cells have been previously described, our Matrigel-based feeder-free culture system is time- and cost- effective, and preserves self-renewability of SSCs. (molcells.org)
Established SSCs are useful stem cell lines that allow not only to study basic reproductive biology but also to develop an in vitro model for applications in assisted reproductive medicine. (molcells.org)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
In this paper, we review the current literature on both in vitro and in vivo studies on the role of the immune system in fracture repair, the use of MSCs in the enhancement of fracture healing, and interactions between MSCs and immune cells. (hindawi.com)
In Vitro Effects of Streptococcus oralis Biofilm on Peri-Implant Soft Tissue Cells. (mhh.de)
Chromosome transplanted clones maintained in vitro and in vivo features of stemness and contributed to chimera formation. (oncotarget.com)

Whether donor leukocytes persist within kidney transplants or play any role in rejection is unknown, however, in part because of limited techniques for distinguishing recipient and donor cells. (biorxiv.org)
To address this question, we performed paired whole exome sequencing of donor and recipient DNA and single cell RNA sequencing (scRNA-seq) of 5 human kidney transplant biopsy cores. (biorxiv.org)
By analyzing expressed SNVs in the scRNA-seq dataset we could define recipient vs. donor cell origin for all 81,139 cells. (biorxiv.org)
The leukocyte donor to recipient ratio varied with rejection status for macrophages and with time post-transplant for lymphocytes. (biorxiv.org)
Recipient origin T cells expressed cytotoxic and pro-inflammatory genes consistent with an effector cell phenotype whereas donor origin T cells are likely quiescent expressing oxidative phosphorylation genes relative to recipient T cells. (biorxiv.org)
Finally, both donor and recipient T cell clones were present within the rejecting kidney, suggesting lymphoid aggregation. (biorxiv.org)
Our results indicate that donor origin macrophages and T cells have distinct transcriptional profiles compared to their recipient counterparts and donor macrophages can persist for years post transplantation. (biorxiv.org)
They developed the buttonhole technique for anastomosis of donor and recipient vessels in kidney transplantation to prevent thrombus formation. (medscape.com)
We detected WU polyomavirus (WUPyV) in a bronchoalveolar lavage sample from lungs transplanted into a recipient with Job syndrome by using immunoassays specific for the WUPyV viral protein 1. (cdc.gov)
We report WUPyV cell tropism in lungs transplanted into a recipient with Job syndrome. (cdc.gov)
By comparison, tumor-initiating buy Myrislignan cells are regular buy Myrislignan in syngeneic mouse versions of Capital t and N lymphoma and comprise higher than 10% of the growth mass.9,10 In these experiments, one primary E-N-RASCinduced T lymphoma was assessed for tumor-initiating potential by transplantation into syngeneic recipient pets. (researchhunt.com)
As a dual transplant recipient, I've experienced firsthand that transplantation is not a singular event, or a cure, but a lifelong journey. (newsbiztrends.com)
Dr. Sharma is well published and has been a recipient of research funding for investigator-initiated studies and clinical trials his clinical research interest is focused on novel diagnostics and therapeutics for antibody-mediated rejection and kidney transplant. (newsbiztrends.com)
Here, the stem cell line is created using the genetic properties of the prospective recipient via somatic cell nuclear transfer. (spiked-online.com)
Using new approaches of synthetic biology, it is now possible to clone a bacterial genome into yeast, to modify it and to transplant it back to a recipient cell. (emynet.eu)

General Assembly the following year,3 and the World Medical Association's Resolution on Cloning, endorsed in 1997, have confronted the issue but lack binding legal force. (who.int)

This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)

T-ALLs were transplanted into sublethally IR AB-strain recipients also. (researchhunt.com)
I believe, Thermo Fisher including the patient voice today demonstrates their care and commitment to our amazing community because when the trials and triumphs of transplant recipients are understood I believe it leads to better innovation to improve our quality of life. (newsbiztrends.com)
His surgical philosophy is centered on delivering best possible care and achieving best possible outcomes for transplant recipients and their families. (newsbiztrends.com)
His translational research interest is focused on bk virus-specific cell-mediated immune response and immune surveillance and kidney transplant recipients. (newsbiztrends.com)
in 1956 and Till and McCulloch in 1961, demonstrating that lethally irradiated mice could be rescued with cells from freshly isolated bone marrow [ 10 ] and that BM cells formed spleen clonies (CFU-S) following transplantation to irradiated recipients [ 30 ], respectively. (biomedcentral.com)

As of 2016, the main set up treatment utilizing immature microorganisms is hematopoietic foundational microorganism transplantation (HSCT). (hilarispublisher.com)
Right now, hematopoietic stem cell transplantation (HSCT) is the foremost dependable healing treatment with amazing comes about for patients with HLAmatched family or disconnected givers. (alliedacademies.org)
Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). (lidsen.com)

Some prohibit only cloning for reproductive purposes and allow the creation of cloned human embryos for research, whereas others prohibit the creation of cloned embryos for any purpose. (who.int)
Stem cells from the human body exist in both adults and embryos. (forhims.co.uk)
Tragically, however, in order to harvest stem cells from human embryos, the embryos must be destroyed. (reasons.org)
This means that hundreds of human embryos would die to achieve a single live human clone birth. (reasons.org)
In the ongoing debate about cloning human embryos for research, and about destroying them in order to harvest their stem cells, it is important to keep some basic facts in mind. (actionlife.org)

I was diagnosed with polycystic kidney disease at 10 years old which led to me needing a kidney transplant at 19 and a liver transplant at 35. (newsbiztrends.com)
This August, I am so excited to be celebrating my 20-year kidney transplant anniversary, and my 4-year liver transplant anniversary! (newsbiztrends.com)
I am currently conducting surgeries to gain insight into chronic rejection after liver transplants in rat liver transplant models, as well as high-dimensional mass cytometry (CyTOF) analysis using the samples of vascularized composite tissue transplant to discern cell populations and subsets involved in the rejection. (stanford.edu)
The selective use of anticoagulation, vascular stents, transjugular intrahepatic portosystemic stent-shunt and liver transplant has resulted in a significant increase in survival. (medscape.com)

My research focuses on the molecular mechanisms and biomarkers of rejection after allograft transplantation. (stanford.edu)
Meanwhile, I am investigating the role of extracellular vesicles and HLA-A2 in the rejection after organ transplantation. (stanford.edu)
My current research focus is biomarker discovery of graft rejection in solid organ transplant patients and studying natural killer cells in viral infection using omics methods including Mass Cytometry and Next Generation Sequencing. (stanford.edu)
Not only might stem cell technology obviate the need for cadaver donation - it could also resolve the problem of rejection. (spiked-online.com)
The resulting tissue will be an almost exact genetic match to the patient and will therefore not face rejection and transplantation can be made much safer without the need for immune suppression. (spiked-online.com)
Antibody Mediated Rejection in Liver Transplantation Part I - Role of DSA's and Treatment Options. (tts.org)

the field of transplantation. (copgfp.com)
The Medawar Prize, named after Society co-founder Sir Peter Medawar, is recognized as the world's highest dedicated award for the most outstanding contributions in the field of transplantation. (tts.org)
The Transplantation Society bestows Honours and Awards to recognize individuals contributing to the field of transplantation through outstanding achievement (for basic scientists, clinicians and in developing countries), and mentorship and training. (tts.org)

Hematopoietic cells are almost totally absent. (medscape.com)
The microenvironment, consisting of lymphocytes, macrophages, fibroblasts, endothelial elements, and stroma in which hematopoietic cells reside, creates a regulatory niche that determines the local area network. (medscape.com)
The WASP quality has 12 exons and encodes a 502 amino-acid protein (WASP), which is overwhelmingly communicated in nonerythroid hematopoietic cells [ 3 ]. (alliedacademies.org)
Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus. (rupress.org)

[ 5 ] and pig neuronal cells have been transplanted into patients with Parkinson (Parkinson's) disease and Huntington (Huntington's) disease . (medscape.com)
[12] The results of these two large studies led to a moratorium on fetal tissue transplants for Parkinson's. (lozierinstitute.org)
Scientists anticipate that in the future stem cell lines will provide a virtually unending supply of pancreatic cells for diabetic patients, neuronal cells for patients with neural disorders such as Parkinson's or Alzheimer's disease, and a host of heart cells that may treat a variety of cardiac problems. (spiked-online.com)
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)

3] An international research team genetically engineered pig cells that lacked a functional form of the gene that codes for a key enzyme involved in the production of the cell surface sugars that cause HAR. (reasons.org)
They further created a sheep called Polly in which they showed that it was possible to incorporate a human gene into the donor's DNA before cloning, thus indicating that it may be possible to use animals to produce human proteins for the benefit of mankind. (shawprize.org)
He and cofounder Luhan Yang, who is also chief scientific officer, showed in 2015 that using gene editing, a novel and powerful way of modifying DNA inside living cells, they could eliminate viruses that lie latent in the pig's genome. (technologyreview.com)
Our tests focus on the huge quantities of zebrafish that can end up being experimentally evaluated by cell transplantation and create brand-new high-throughput strategies to functionally interrogate gene paths included in cancers self-renewal. (researchhunt.com)
If you cannot or do not want to get into the heavy research, I am about to give you a detailed report on the state of genetic engineering, human-animal cloning and gene splicing. (real-agenda.com)
Alternatively, transgenesis and gene targeting techniques can be used to introduce the patient's genes into the stem cell line. (spiked-online.com)
Elsa Abranches, Head of Cell Therapy Bioprocess Development and Manufacturing of AstraZeneca, gave a brilliant talk about developing cell and gene therapies for commercialization from a pharmaceutical perspective. (personalizemymedicine.com)
Cell and gene therapies are very novel therapies. (personalizemymedicine.com)
Understanding disease mechanisms and developing gene and protein technologies as well as advances in cell cultures and manufacturing have allowed the field of cell therapy to see significant growth in the last 30 years. (personalizemymedicine.com)
The molecular cloning of GCSF gene (Nagata et al. (allindianpatents.com)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)

TTS is seeking your opinion on your preferred location for the 29th International Congress of The Transplantation Society in 2022 to help the Congress Selection Committee decide between the three potential locations: Buenos Aires, Istanbul and Montreal. (tts.org)
Bone marrow transplantation 2022 9 57 (12): 1781-1787. (cdc.gov)

Beyond this scientific interest, the commercial concern in animal cloning focuses on replicating large numbers of genetically identical animals, especially those derived from a progenitor that has been modified genetically. (who.int)
The etiology of bone marrow failure (BMF) includes defective stem/progenitor cells and/or stroma/accessory cells/growth factors, as well as deficient nonspecific nutrients or, as in the case of acquired aplastic anemia, immune-mediated abnormalities. (medscape.com)
Inherited bone marrow failure syndromes (IBMFS) are usually the result of intrinsic stem cell/progenitor defects. (medscape.com)
In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)
No obvious correlations between clinical parameters, including age, karyotype, existence of paroxysmal nocturnal hemoglobinuria clones, pretreatment blood counts, progenitor cell counts, and the response to immunosuppressive therapy (IST), were found. (springermedizin.at)
We also examined the numbers of colony-forming progenitor cells (CFUs) before and after therapy. (springermedizin.at)
It stimulates the survival, proliferation, differentiation and function of neutrophil granulocyte progenitor cells and mature neutrophils. (allindianpatents.com)
Most type II PNH cells (total lack of GPI-linked protein) are due to a frame shift mutation occurring in the early hematopoietic progenitor cells, resulting in same mutation in all blood cell lines. (medscape.com)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)

National Institutes of Health (NIH) Frequently Asked Questions (FAQs) Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers about these Adult/NONembryonic Stem Cells Key Points Hematopoietic or blood-forming stem cells are. (physiciansforlife.org)
The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
These could be fat stem cells or mesenchymal stem cells (harvested from bone marrow cells, fat tissue or dental pulp). (forhims.co.uk)
The first source of Mesenchymal stem cells was in the bone marrow and considered to be the gold standard for clinical research, although various other sources have being discovered which include: Adipose tissue, Dental pulp, Mobilised Peripheral blood, Amniotic fluid, Joint synovium, synovial fluid, Endosteum, Periosteum, Menstrual blood and birth-derived tissues. (stemcellsgroup.com)
This typically appears as a bone marrow transplantation, however the phones can likewise be gotten from umbilical line blood. (hilarispublisher.com)
Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses. (immunetolerance.org)
describes a novel colony stimulating factor (CSF) that has the ability to promote the differentiation and proliferation of human bone marrow cells to neutrophils, and a method to produce the same from a novel cell line which has been established from tumor cells in patients with oral cancer, The most published studies have used filgrastim as it was the first form of G-CSF to be approved. (allindianpatents.com)
Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (msdmanuals.com)
Treatment usually involves immunosuppression with equine antithymocyte globulin and cyclosporine, or bone marrow transplantation. (msdmanuals.com)
Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation. (cdc.gov)

They also performed heterotopic experimental transplantation. (medscape.com)
Areas related to clinical and experimental transplantation are also of interest. (lidsen.com)

Immune effector cells such as lymphocytes, macrophages, dendritic cells, natural killer cells, and cytotoxic T lymphocytes work together to defend the body against cancer by targeting abnormal antigens expressed on the surface of tumor cells. (wikipedia.org)
Topical immunotherapy utilizes an immune enhancement cream (imiquimod) which produces interferon, causing the recipient's killer T cells to destroy warts, actinic keratoses, basal cell cancer, vaginal intraepithelial neoplasia, squamous cell cancer, cutaneous lymphoma, and superficial malignant melanoma. (wikipedia.org)
In solid organ transplantation, donor derived immune cells are assumed to decline with time after surgery. (biorxiv.org)
Job syndrome is an immune disorder characterized by eczematoid dermatitis, recurrent skin and pulmonary infections, increased levels of IgE, and impaired T and B cell memory ( 9 ). (cdc.gov)
Similarly, they are characterized by an extensive capacity for self-renewal, proliferation, potential to differentiate into multiple lineages and their immune-modulatory role on various cells. (stemcellsgroup.com)
The precise spatial and temporal impact of immune cells and their cytokines on fracture healing remains obscure. (hindawi.com)
Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
The normal process of fracture repair begins with an immediate inflammatory response as the innate immune system (macrophages, monocytes, neutrophils, and NK cells) responds with a variety of cytokines that recruit and activate several cell types, including osteoprogenitor mesenchymal stem cells (MSCs), to the site of injury [ 1 , 2 ]. (hindawi.com)
MSCs are able to evade the host cell immune system due to their low expression of major histocompatibility complex (MHC) class I molecules and complete lack MHC class II molecules and other costimulatory molecules (CD40, CD40L, CD80, and CD86) required for immune cell stimulation [ 15 - 17 ]. (hindawi.com)
Self-renewal is a feature of cancers and may end up being assessed by cell transplantation into immune-compromised or immune-matched pets. (researchhunt.com)
Cell transplantation trials in which the writers utilized T-ALLs from Pten-deficient rodents have got discovered the c-KitmidCD3+ subpopulation as the leukemia-initiating cell (LIC).6 This cell people engrafts disease into sublethally irradiated (IR) severe mixed immune insufficiency (SCID) rodents better than either the CD3? (researchhunt.com)
The precise mechanism remains unclear, but in the majority of acquired cases, the mechanism involves an immune attack on the hematopoietic stem cell. (msdmanuals.com)

Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
Half a century ago, it was found by John Gurdon that this developmental clock can be reversed, and that differentiated somatic cells in a frog model could regain their pluripotency or totipotency. (shawprize.org)
PNH is caused by somatic mutations in PIGA (which encodes phosphatidylinositol N-acetylglucosaminyltransferase subunit A) in one or more HSC clones. (medscape.com)
Clinical manifestations of PNH occur when a HSC clone carrying somatic PIGA mutations acquires a growth advantage and differentiates, generating mature blood cells that are deficient of GPI-anchored proteins. (medscape.com)
Due to its location on the X chromosome, and due to X inactivation in female somatic cells, only one mutation is required in either males or females to abolish the expression of GPI-linked proteins. (medscape.com)

The drug of choice for prevention of CMV disease in solid-organ transplant patients is valganciclovir. (medscape.com)

Chimpanzee kidneys have been transplanted into patients with renal failure. (medscape.com)

Clonaid's claim to have produced the first human clones propelled the ethical debate about human cloning to the headlines last December. (reasons.org)
The scientific community expects the same for human clones. (reasons.org)

Most natural cloning occurs in those species that produce their descendants asexually, that is, without combining the male and female genetic material. (who.int)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)
Eventually, both sets of genetic changes will be merged into a single pig cell. (technologyreview.com)
The pig cells can be scrutinized for any genetic errors while still in a lab dish. (technologyreview.com)
Similarly, a clone would be a genetic duplicate of another human being, but there is no denying that it would also be a separate individual. (actionlife.org)
Building off experience in hematopoietic stem cell transplant and exploiting advances in genetic engineering, genome editing, immunology, immunotherapy, stem cell biology, understanding disease mechanisms and cell therapy manufacturing, considerable progress has been made with hundreds of clinical trials underway. (bdbiosciences.com)
My question regarding genetic engineering deregulation was then: What would happen if scientists who are provided with unlimited money and resources have no legal liability to realize their experiments cloning humans and literally engineering new species? (real-agenda.com)
Banking of multiple cell lines with varying genetic spectrum that can be matched to patients is one possibility. (spiked-online.com)
We also adapted several genetic tools for the efficient engineering of mycoplasma genomes cloned in yeast, including a CRISPR/Cas9 system. (emynet.eu)
A clone is an organism that is a genetic copy of an existing one. (who.int)
The common denominator in the disease, a biochemical defect, appears to be a genetic mutation leading to the inability to synthesize the glycosyl-phosphatidylinositol (GPI) anchor that binds these proteins to cell membranes. (medscape.com)

Whether you've been diagnosed with androgenetic alopecia or another form of hair loss, we're guessing you already know this and are curious if stem cell therapies might be your pathway to new hair follicles . (forhims.co.uk)
Multimodal imaging of stem cell-derived bulge of hair follicles in a mouse model of traumatic brain injury. (copgfp.com)
Where are hair follicles taken from for hair transplantation? (estheticana.com)
If I do not have enough hair follicles for hair transplantation, can I have hair transplantation with someone else's hair follicle? (estheticana.com)
What if the hair follicles in my donor area are not sufficient for hair transplantation? (estheticana.com)
The patient may not be suitable for hair transplantation due to the lack of hair follicles in the donor area and other reasons. (estheticana.com)
For the first time, a team of scientists reports successfully growing human hairs from dermal papilla cells taken from the inside of donor hair follicles. (medicalnewstoday.com)
Current hair transplant treatments relocate hair follicles from one part of the head to another, usually from the back to the front. (medicalnewstoday.com)
This method offers the possibility of inducing large numbers of hair follicles or rejuvenating existing hair follicles, starting with cells grown from just a few hundred donor hairs. (medicalnewstoday.com)
The idea of cloning hair follicles has been around for decades. (medicalnewstoday.com)
Scientists already know that dermal papilla cells, that are found inside the hair follicles, can give rise to new follicles. (medicalnewstoday.com)
However, once the dermal papilla cells are put into conventional, two-dimensional tissue culture, they revert to basic skin cells and lose their ability to produce hair follicles. (medicalnewstoday.com)
The first is the difficulty in getting dermal papilla cells in humans to self-aggregate and form hair follicles and the second is the inability, thus far, of scientists to generate normal hairs and follicles. (bernsteinmedical.com)

[2] The first fetal tissue transplant in the U.S. was in 1939, using fetal pancreatic tissue in an attempt to treat diabetes. (lozierinstitute.org)
Between 1970 and 1991 approximately 1,500 people received fetal pancreatic tissue transplants in attempts to treat diabetes, mostly in the former Soviet Union and the People's Republic of China. (lozierinstitute.org)

Mesenchymal stem cells ( MSCs) are known to be multipotent stromal cells that can differentiate into a variety of cell types which include osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (stemcellsgroup.com)
Mesenchymal stem cells have the ability to expand in many folds in culture while retaining their growth and multilineage potential. (stemcellsgroup.com)
Multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have the capacity to differentiate into a variety of cell types (Figure 1 ), including adipocytes, chondrocytes, and osteocytes [ 9 , 10 ]. (hindawi.com)
In fact, human papillae, when grown in a laboratory culture, can act as "mesenchymal stem cells" and differentiate into a variety of cell types. (bernsteinmedical.com)

The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)
John D. Gearhart is a renowned American developmental geneticist best known for leading the Johns Hopkins University research team that first identified and isolated human pluripotent stem cells from human primordial germ cells, the precursors of fully differentiated germ cells. (asu.edu)
The pluripotent stem cells differentiate further into cells commonly called multipotent stem cells. (biomedcentral.com)
Knockout-Induced Pluripotent Stem Cells for Disease and Therapy Modeling of IL-10-Associated Primary Immunodeficiencies. (mhh.de)

Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
Effect of everolimus-based drug regimens on CMV-specific T-cell functionality after renal transplantation: 12-month ATHENA subcohort-study results. (mhh.de)

The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
T cells are modified ex vivo by transduction with viral vectors containing CAR or other modifications of interest. (bdbiosciences.com)

Below, we'll share some basics about stem cell treatments and their effectiveness, along with the potential risks, costs and controversies associated with trying to treat hair loss this way. (forhims.co.uk)
The good news for stem cell treatments is that the recovery time is often quite quick. (forhims.co.uk)
Most stem cell treatments aren't FDA-approved. (forhims.co.uk)
This means any stem cell hair transplants will be considered cosmetic treatments, investigational therapies or clinical trials - and not covered by your insurance. (forhims.co.uk)
Organ transplantation is currently preferred for many different treatments. (estheticana.com)
If it leads to clinical success, the technique could benefit not only men in early stages of baldness , but also women with hair loss , who are mostly unable to use current transplant treatments because of insufficient donor hair. (medicalnewstoday.com)
While many people say the use of the cell research is a way to advance medical knowledge and expand treatments, there is no guarantee that the treatments will work. (ipl.org)
That life may not even be worth it because it takes multiple tries before the stem cells are even suitable for use in medical treatments. (ipl.org)

The cells then destroy the tumour cells that express the antigen. (wikipedia.org)
Dendritic cells (DC) can be stimulated to activate a cytotoxic response towards an antigen. (wikipedia.org)
Dendritic cells, a type of antigen-presenting cell, are harvested from the person needing the immunotherapy. (wikipedia.org)
These cells are then either pulsed with an antigen or tumour lysate or transfected with a viral vector, causing them to display the antigen. (wikipedia.org)
Upon transfusion into the person, these activated cells present the antigen to the effector lymphocytes (CD4+ helper T cells, cytotoxic CD8+ T cells and B cells). (wikipedia.org)
This initiates a cytotoxic response against tumour cells expressing the antigen (against which the adaptive response has now been primed). (wikipedia.org)
The cells stained positive with PAb416, a monoclonal antibody against the SV40 large T antigen. (cdc.gov)
Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes. (immunetolerance.org)
Engineered chimeric antigen receptor (CAR) T cell therapies (CAR-T) are now commercially available to treat certain leukemias and lymphomas. (bdbiosciences.com)
The technique has also shown preliminarily promising outcomes in B cell acute lymphoblastic leukemia (B-ALL), B cell non-Hodgkin's lymphoma (B-NHL), chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma and multiple myeloma in clinical trials targeting CD19, CD20, CD22, CD30 and B-cell maturation antigen (BCMA), with many more under investigation. (bdbiosciences.com)
In the transplant population, antigen assays or PCR is used (sometimes in conjunction with cytopathology) for diagnosis and treatment determinations. (medscape.com)

Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
Stem cell transplantation may lead to recovery of function through different mechanisms, such as the replacement of cells through differentiation, angiogenesis stimulation and support for micro environment. (copgfp.com)
Adipose-derived MSCs, in particular, pose an attractive option for cell-based therapy due to their relatively decreased morbidity during isolation and potential for expansion and differentiation [ 12 ]. (hindawi.com)
Multipotential differentiation of MSCs into adipogenic, osteogenic, and chondrogenic cell lineages. (hindawi.com)
The established dogma has however been challenged by recent findings suggesting that multipotent stem cells have a broader differentiation potential than previously thought. (biomedcentral.com)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)

Improvement in transplantation procedures, beginning with the advent of immunosuppressive therapies in the early 1980s, has lead to more and more patients benefiting from organ transplantation. (scialert.net)
Investigational cell therapies are addressing a wide range of hematological malignancies. (bdbiosciences.com)
Dr. Claire Higgins and her colleague Dr. Colin Jahoda have published an overview of hair cloning and the challenges scientists face in attempting to develop hair regeneration therapies for androgenetic alopecia or common balding. (bernsteinmedical.com)
The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)

[ 2 ] A baboon liver was transplanted to a patient with hepatic failure. (medscape.com)
Seven patients were transplanted using a matched sibling donor upfront, and one patient was treated with CSA and growth factors only. (springermedizin.at)
Diet-induced compromised microenvironments fatty liver was established to mimic the clinical and patient non-alcoholic steatohepatitis (NASH) and the ability of tumorigenic cells Hepa1-6 evaluated. (copgfp.com)
[5] Conditions such as anemias and immunodeficiencies, for which fetal tissue attempts largely failed, are now treated routinely with adult stem cells, including umbilical cord blood stem cells, [6] even while the patient is still in the womb. (lozierinstitute.org)
One patient who received transplant of fetal brain tissue (from a total of 3 fetuses) died subsequently, and at autopsy was found to have various non-brain tissues ( e.g, skin-like tissue, hair, cartilage, and other tissue nodules) growing in his brain. (lozierinstitute.org)
If there is not enough hair follicle in the donor area of the patient, hair transplantation from another person will not be applied to him. (estheticana.com)
We're going to start by handing you over to Valen Keefer who is our transplant patient advocate at Thermo Fisher Scientific. (newsbiztrends.com)
It means a lot to have this incredible opportunity to represent our transplant community and bring the patient perspective into today's conversation. (newsbiztrends.com)
Allogeneic stem cell transplantation in a patient with the Wiskott-Aldrich syndrome. (alliedacademies.org)
Patient PBMCs are collected by leukapheresis followed by enrichment approaches to isolate T cells while removing other cells such as B cells, monocytes, neutrophils, dendritic cells and contaminating tumor cells. (bdbiosciences.com)
Quality control testing is essential to ensure the CAR-T cell product meets established specifications for manufacturing release and patient infusion. (bdbiosciences.com)
Harvested cells are then administered to the patient. (bdbiosciences.com)
Cell therapy involves transferring new, healthy cells into the body to replace diseased cells and thereby modulate other cells present in patient´s body. (personalizemymedicine.com)
Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)
The advent of iPSCs has opened up the possibility to graft patient-specific cells which most likely would circumvent the need for immunosuppression. (lu.se)
However, patient-derived cells may be more prone to develop disease-associated pathology after grafting. (lu.se)
Instead, for sporadic patient cells alternative strategies need to be evaluated. (lu.se)

Stem cell research - specifically, stem cell hair restoration research - is a growing and complicated field. (forhims.co.uk)
Stem cell hair transplants can happen in several ways. (forhims.co.uk)
The price of stem cell hair transplant varies greatly. (forhims.co.uk)
In this case, stem cell hair transplantation , hair cloning or other treatment methods may be considered. (estheticana.com)

The Hep3B and HepG2 cell subpopulations in terms of EpCAM-low and high EpCAM was evaluated in an orthotopic model of athymic mice. (copgfp.com)
After a few days, they transplanted the papillae clones, which had formed into three-dimensional "spheroids" in the tissue culture, between the dermis and epidermis of human skin that had been grafted onto the backs of mice. (medicalnewstoday.com)

Muhammad Mohiuddin, chief of the transplantation section at the National Heart, Lung, and Blood Institute and the National Institutes of Health, says he's pleased xenotransplantation is attracting new commercial investment. (technologyreview.com)

A number of scientists are trying to create life in the lab, specifically artificial cells. (reasons.org)
The scientists honoured by the 2008 Shaw Prize in Life Science and Medicine used different approaches to reprogramme an adult cell into the totipotent or pluripotent state, and in doing so made important contributions to potential new approaches to improve agriculture practices and to treat human diseases. (shawprize.org)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Having made significant progress in improving this vital communication link between dermal papillae cells, scientists still have to contend with a series of obstacles that stand in the way of a hair cloning therapy for human hair loss. (bernsteinmedical.com)
It might be expected that the richest nation on Earth would encourage its top scientists to pursue this work with vigor rather than limiting funding opportunities, creating legal barriers and fencing off any newly developed cell lines. (spiked-online.com)
1. Cloning is an umbrella term traditionally used by scientists to describe different processes for duplicating biological material. (who.int)

Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
The expression of the epithelial cell adhesion molecule (EpCAM) is correlated with a poor prognosis, and treatment failure early tumor recurrence of hepatocellular carcinoma (HCC) patients. (copgfp.com)
Here, we have systematically investigated the role of EpCAM + cancer cells in tumor initiation in an orthotopic model of HCC. (copgfp.com)
FACS-sorted cells were inoculated into the left lobe of the liver, and the tumor growth was monitored by high frequency ultrasound. (copgfp.com)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
or c-Kit?Compact disc3+ cells and comprises much less than 0.01% of the total tumor. (researchhunt.com)
Used collectively, these rival reviews recommend that there can be still quite a controversy in the field regulating the amounts of T-ALL cells needed to rebuilding growth and focus on the want for further tests to accurately determine the cell types and figures of tumor-initiating cells in human Rabbit Polyclonal to PHACTR4 being and hereditary versions of T-ALL. (researchhunt.com)
The resultant activation of T cells is then exploited for tumor elimination. (bdbiosciences.com)
The fourth generation of CAR-T design attempts to deliver cytokines to modulate the tumor microenvironment either by activating host effector T cells or hampering host suppressors and reinforcing memory T cells. (bdbiosciences.com)
Current screening of potential new drugs is done using cell lines derived from animals or 'abnormal' human tissue such as tumor cells. (spiked-online.com)

CAR-T cells, which incorporate an antibody-derived extracellular receptor and T cell derived intracellular signaling domains, have shown convincing outcomes in certain types of leukemia and lymphoma, including commercial licensure of CD19 CAR-Ts for the treatment of relapsed/ refractory large B cell lymphoma and acute lymphoblastic leukemia. (bdbiosciences.com)
Hospitalization whilst waitlisted for kidney transplantation is associated with a reduced likelihood of transplantation and worse posttransplant outcomes. (tts.org)

Elaboration of an international convention against reproductive cloning of human beings has been under consideration in the United Nations since December 2001 when the subject was included in the agenda of the fifty- sixth session as a supplementary agenda item at the request of France and Germany. (who.int)
Given this fanfare, the debate has tended to focus on reproductive cloning-the use of cloning to generate a human being-and its bizarre societal and familial side effects. (reasons.org)
Though fraught with problems, reproductive cloning at least strives to reproduce a human being and, in principle, preserves the value of human life. (reasons.org)
Practical implementation of reproductive cloning suffers significant problems. (reasons.org)
Those two factors make attempts to clone humans for reproductive purposes ethically troubling. (reasons.org)
2. Over the years, the international community has tried without success to build a consensus on an international convention against the reproductive cloning of human beings. (who.int)
3. Creating awareness among ministries of health in the African Region will provide them with critical and relevant information on the reproductive cloning of human beings and its implications to the health status of the general population. (who.int)
7. The WHO Regional Committee for Africa is invited to review this document for information and guidance concerning reproductive cloning of human beings. (who.int)
3. Media reports on nuclear transfer are usually about one form, reproductive nuclear transfer, also known as reproductive cloning of human beings . (who.int)

Dendritic cells and macrophages of fetal liver donor (FLD) origin were abundantly present in the medullary and cortico-medullary areas. (rupress.org)

A 28-year-old woman with Job syndrome was seen at the NIH Clinical Center 6 months after bilateral lung transplantation. (cdc.gov)
Arnold Caplan (1991), coined the term "mesenchymal stem cell and stated that the cells as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies. (stemcellsgroup.com)
T cell-targeted immunomodulators such as monoclonal antibodies against PD-1 or CTLA4 may be used in combination with CAR-T cells in clinical trials. (bdbiosciences.com)
There are major obstacles to overcome before a stem cell line is liable to reach clinical trials. (spiked-online.com)
The name of the disorder is a descriptive term for the clinical consequence of red blood cell (RBC) breakdown with release of hemoglobin into the urine, which manifests most prominently as dark-colored urine in the morning (see image below). (medscape.com)
A second press release [2] has indicated stem cell source, resulting in widespread excitement that the program is planning to move forward very rapidly, with all of the patients being enrolled in the Correspondence to: Roger A. Barker, John van Geest Centre first quarter of 2016 and interim results being shared for Brain Repair, Department of Clinical Neurosciences, Univer- in October 2016. (lu.se)
Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)

Between 1960 and 1990, numerous attempts were made to transplant fetal liver and thymus for various conditions. (lozierinstitute.org)
These animals were studied between 7 and 12 mo after transplantation, at which times all thymocytes and peripheral T cells were derived from stem cells of the fetal liver graft. (rupress.org)

Anatomy21

Organisms10

Diseases51

Chemicals and Drugs36

Analytical, Diagnostic and Therapeutic Techniques and Equipment100

Psychiatry and Psychology2

Phenomena and Processes25

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena4

Information Science7

Named Groups4

Health Care31

Geographicals1

Embryonic33

Autologous7

Organs18

Therapeutic10

Organ transplants1

Tissue transplantation2

Donors6

Adult Stem Cell Transp1

Vitro9

Recipient15

Endorsed in 19971

Allogeneic hematopoietic cell2

Recipients5

HSCT3

Embryos5

Liver transplant4

Rejection6

Field of transplantation3

Hematopoietic cells4

Parkinson's8

Gene11

20222

Progenitor9

Bone marrow13

Experimental transplantation2

Immune12

Somatic8

Solid organ transplant patients1

Kidneys1

Human clones2

Genetic11

Hair follicles13

Pancreatic2

Mesenchymal stem4

Pluripotent stem4

Renal2

Vivo2

Treatments8

Antigen11

Differentiation6

Therapies4

Patient17

Stem cell hair4

Mice2

Xenotransplantation1

Scientists6

Tumor10

Outcomes2

Reproductive9

Macrophages1

Clinical7

Fetal liver2