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  • mononuclear cells
  • Bone marrow mononuclear cells (BMMC) transplantation is a promising therapy for treating ischemic disease, however the effect in non-ischemic dilated cardiomyopathy is unknown.This study describes a technique of BMMC transplantation utilizing mini-thoracotomy and results up to one year after the procedure. (clinicaltrials.gov)
  • Based on extensive preclinical investigations, the technology of using freshly isolated bone marrow mononuclear cells mixed with proteins seems safe and most effective for a one-step correction of cartilage defect and restoration of the osteochondral complex, because the same mixture can generate cartilage in the vasculature-free knee joint, and bone in the environment of bone defects. (clinicaltrials.gov)
  • Other tests are performed depending on the suspected disorder: Quantification of the different types of mononuclear cells in the blood (i.e. lymphocytes and monocytes): different groups of T lymphocytes (dependent on their cell surface markers, e.g. (wikipedia.org)
  • hematological malignancies
  • NewYork-Presbyterian offers bone marrow and stem cell transplantation for people with hematological malignancies (e.g., leukemia, lymphoma, multiple myeloma, myelodysplastic syndromes (MDS)) for myeloproliferative disorders such as myelofibrosis, for AL-amyloidosis, and for non-malignant blood disorders such as severe aplastic anemia and sickle cell anemia (SCA). (nyp.org)
  • lymphoma
  • In this Cancer.net video, Sonali M. Smith, MD , director of the lymphoma program , provides an introduction to bone marrow/stem cell transplantation. (uchospitals.edu)
  • Chronic lymphocytic leukemia (CLL) and prolymphocytic leukemia, in complete or partial remission, Mantle cell lymphoma, relapsed Hodgkin's and non-Hodgkin's lymphoma. (knowcancer.com)
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • MSCs
  • In animal experiments, intra-bone marrow-BMT (IBM-BMT) has been shown to efficiently recruit not only donor-derived hematopoietic stem cells (HSCs) but also mesenchymal stem cells (MSCs) [ 5 , 10 , 11 ]. (omicsonline.org)
  • OBJECTIVE- Mesenchymal stem cells (MSCs) have been reported to secrete various cytokines that exhibit angiogenic and neurosupportive effects. (diabetesjournals.org)
  • RESEARCH DESIGN AND METHODS- MSCs were isolated from bone marrow of adult rats and transplanted into hind limb skeletal muscles of rats with an 8-week duration of streptozotocin (STZ)-induced diabetes or age-matched normal rats by unilateral intramuscular injection. (diabetesjournals.org)
  • CONCLUSIONS- These results suggest that MSC transplantation could have therapeutic effects on DPN through paracrine actions of growth factors secreted by MSCs. (diabetesjournals.org)
  • Experimental studies have shown that transplantation of mesenchymal stem cells (MSCs) improves cardiac function in heart failure. (ahajournals.org)
  • Bone marrow cells were cultured in medium containing 15% auto serum for 3 weeks to expand adherent fibroblastic cells (MSCs), of which surface antigen expression was mesenchymal type. (ahajournals.org)
  • Adult mesenchymal stem cells (MSCs) are being used by researchers in the fields of regenerative medicine and tissue engineering, to artificially reconstruct human tissue which has been previously damaged. (wikipedia.org)
  • MSCs can be easily extracted through well-established procedures such as bone marrow aspiration. (wikipedia.org)
  • ESCs possess many of the same therapeutic properties as MSCs, including the ability to self-regenerate and differentiate into a number of cell lineages. (wikipedia.org)
  • MSCs have been used to treat a variety of disorders including cardiovascular diseases, spinal cord injury, bone and cartilage repair, and autoimmune diseases. (wikipedia.org)
  • The exact therapeutic mechanisms of MSCs in the treatment of MS are still very much up to debate among stem cell researchers. (wikipedia.org)
  • By suppressing the unregulated proliferation of T and B cells, MSCs can potentially minimize and control on-going damage to the CNS. (wikipedia.org)
  • MSCs can also produce an immunomodulating effect by stimulating the maturation of antigen presenting cells. (wikipedia.org)
  • spinal cord i
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • neutropenia
  • Myelokathexis is a congenital disorder of the white blood cells that causes severe, chronic leukopenia (a reduction of circulating white blood cells) and neutropenia (a reduction of neutrophil granulocytes). (wikipedia.org)
  • precursors
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • acute
  • However, the higher T cell content of PBSC may also lead to increased incidence and severity of acute and chronic graft-versus-host disease (GVHD). (knowcancer.com)
  • blood
  • Our transplantation experts are closely integrated with our world-class teams of blood cancer experts and transplantation immunologists. (nyp.org)
  • For some types of blood diseases, transplantation is the standard of care. (uchospitals.edu)
  • The donated tissue repopulated the marrow and restored production of the blood cells. (uchospitals.edu)
  • HLA typing uses a blood test to analyze human lymphocyte antigens (HLA) found on the surface of white blood cells. (mountsinai.org)
  • However, when using this AM, the BMCs are contaminated with peripheral blood with the result that there are more than 20% of T cells in the BMCs, which in turn leads to the induction of GvHD. (omicsonline.org)
  • Four weeks after transplantation, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) productions in transplanted sites, current perception threshold, nerve conduction velocity (NCV), sciatic nerve blood flow (SNBF), capillary number-to-muscle fiber ratio in soleus muscles, and sural nerve morphometry were evaluated. (diabetesjournals.org)
  • Approximately 20 ml bone marrow was harvested from iliac crests and 400 - 600 ml peripheral blood was collected to prepare serum for culture. (ahajournals.org)
  • Stem cells can mature into blood cells (white blood cells, red blood cells, and platelets), which are often damaged by cancer. (doctors-hospital.net)
  • they enter your blood stream and travel to your bone marrow where they replace damaged stem cells and begin to make healthy blood cells. (doctors-hospital.net)
  • This allows the bone marrow to recover, proliferate and continue producing healthy blood cells. (wikipedia.org)
  • The transplantation may be autologous (an individual's own blood cells saved earlier), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin). (wikipedia.org)
  • Granulocyte colony stimulating factor (GCSF) are naturally occurring glycoproteins that stimulate white blood cell proliferation. (wikipedia.org)
  • He is an expert at hematology, bone marrow transplantation, and blood stem cells transplantation. (wikipedia.org)
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • CLL results in the build up of B cell lymphocytes in the bone marrow, lymph nodes, and blood. (wikipedia.org)
  • These cells do not function well and crowd out healthy blood cells. (wikipedia.org)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • Most people are diagnosed without symptoms as the result of a routine blood test that shows a high white blood cell count. (wikipedia.org)
  • Less commonly, CLL may present with enlarged lymph nodes without a high white blood cell count or no evidence of the disease in the blood. (wikipedia.org)
  • CLL is usually first suspected by a diagnosis of lymphocytosis, an increase in a type of white blood cell, on a complete blood count test. (wikipedia.org)
  • Most often the lymphocyte count is greater than 5000 cells per microliter (µl) of blood, but can be much higher. (wikipedia.org)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • Myelokathexis is amongst the diseases treated with bone marrow transplantation and cord blood stem cells. (wikipedia.org)
  • They reside in the connective tissue of nearly every organ, bone marrow and peripheral blood. (wikipedia.org)
  • Muse cells are shown to home into the damage site and spontaneously differentiate into tissue-compatible cells according to the microenvironment to contribute to tissue regeneration when infused into the blood stream. (wikipedia.org)
  • Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes). (wikipedia.org)
  • Instead, the drugs affect new blood cells that are being made by the bone marrow. (wikipedia.org)
  • Because the bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency of blood cells. (wikipedia.org)
  • This condition can rapidly lead to life-threatening infection, as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as leading to anaemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets. (wikipedia.org)
  • Bernard Babior made key contributions in linking the defect of superoxide production of white blood cells, to the cause of the disease. (wikipedia.org)
  • Evans syndrome is an autoimmune disease in which an individual's antibodies attack their own red blood cells and platelets. (wikipedia.org)
  • Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen and carbon dioxide are destroyed by an autoimmune process. (wikipedia.org)
  • diseases
  • Bone marrow transplantation (BMT) is a powerful strategy for the treatment of leukemia, aplastic anemia, congenital immunodeficiency and autoimmune diseases. (omicsonline.org)
  • Andrew Louis Pecora (born 1957) is an American hematologist and oncologist who has been involved in the research on the use of stem cells and oncolytic viruses to treat diseases, including cancer. (wikipedia.org)
  • Chronic granulomatous disease (CGD) (also known as Bridges-Good syndrome, chronic granulomatous disorder, and Quie syndrome) is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. (wikipedia.org)
  • PBSC
  • These observations led to the hypothesis that transplantation of PBSC would lead to lower mortality compared to transplantation of marrow. (knowcancer.com)
  • In addition, PBSC grafts have a higher T cell content, predicting a possibly more powerful anti-leukemia effect. (knowcancer.com)
  • The objective of the trial is to test the null hypothesis that there is no difference in overall survival after PBSC versus marrow transplants from HLA compatible unrelated donors. (knowcancer.com)
  • PBSC donors are given a course of GCSF prior to PBSC collection, this ensures a better outcome, as stem cell proliferation increases, thus increasing the number of peripheral stem cells in circulation. (wikipedia.org)
  • proliferation
  • This can be explained in part by their intrinsically low telomerase activity, eradicating the risk of tumorigenesis through unbridled cell proliferation. (wikipedia.org)
  • therapeutic
  • To help discover the therapeutic uses of these stem cells they are grown in laboratories or by using medication to stimulate new cell growth within the human body. (wikipedia.org)
  • Once inside the body the vector introduces the therapeutic gene into host cells, and the protein encoded by the newly inserted gene is then produced by the body's own cells. (wikipedia.org)
  • donors
  • Our care teams perform more than 200 stem cell transplants a year and we perform more allogeneic transplants (transplants using bone marrow or stem cells from donors) for older adults than any other center in the tri-state area. (nyp.org)
  • NewYork-Presbyterian participates in the National Marrow Donor Program providing us access to all available donors worldwide and enhancing your chances of finding an appropriate donor. (nyp.org)
  • anemia
  • In some individuals, the disease comes to light only after the cancerous cells overwhelm the bone marrow resulting in anemia producing tiredness or weakness. (wikipedia.org)
  • Infiltration of the bone marrow may cause pallor from anemia. (wikipedia.org)
  • Autoantibodies targeted at different antigenic determinants on red cells and platelets are assumed to cause isolated episodes of hemolytic anemia and thrombocytopenia, respectively. (wikipedia.org)