• The results are very promising: there are far fewer tumors and the cells that survive are the correct type of nerve cells. (regenerativemedicine.net)
  • When you develop, for example, nerve cells for transplantation, you always get a small contamination of immature stem cells. (regenerativemedicine.net)
  • We are pleased that we have succeeded in developing a functioning nano-electrode, getting it into place, and capturing signals from nerve cells, says Prof. Jens Schouenborg. (regenerativemedicine.net)
  • At Lund University in Sweden, researchers have, for the first time, succeeded in implanting an ultrathin nanowire-based electrode and capturing signals from the nerve cells in the brain of a laboratory animal. (regenerativemedicine.net)
  • The researchers want to try and reduce the size of the base to which the nanowires are attached, improve the connection between the electrode and the electronics that receive the signals from the nerve cells, and experiment with the surface structure of the electrodes to see what produces the best signals without damaging the brain cells. (regenerativemedicine.net)
  • In the future, we hope to be able to make electrodes with nanostructured surfaces that are adapted to the various parts of the nerve cells parts that are no bigger than a few billionths of a meter. (regenerativemedicine.net)
  • ISCO's parthenogenic stem cell technology enables synthesis of corneal tissue that is immune matched for millions of people. (intlstemcell.com)
  • We have developed a technique that enables us to eliminate immature stem cells and thus create safer stem cell transplantations. (regenerativemedicine.net)
  • The structures are grown to clear hollow spheres with a size of 8-10 mm in diameter and contain tissues and cells similar to those found in normal human corneal tissue. (intlstemcell.com)
  • If transplanted into humans they could replace damaged tissue in the nervous system and support other cells that work to heal a brain injury. (regenerativemedicine.net)
  • The research group has already worked for several years to develop electrodes that are thin and flexible enough not to disturb the brain tissue, and with material that does not irritate the cells nearby. (regenerativemedicine.net)
  • OCEANSIDE, CA - February 16, 2010 - International Stem Cell Corporation ( ISCO .OB), www.intlstemcell.com , announced today that multiple international meetings taking place between ISCO's executive management and researchers and clinicians from commercial entities in both Asia and Europe revealed significant clinical-commercial opportunities for the company's stem cell-derived human cornea technology in those regions. (intlstemcell.com)
  • The researchers have transplanted the stem cells into mice with Parkinson s disease. (regenerativemedicine.net)
  • Researchers at Lund University have come up with a new technique to prevent tumors developing in connection with stem cell transplantations. (regenerativemedicine.net)
  • The researchers from T bingen led by Professor Stefan, in collaboration with Professor Schulze of the German Institute of Human Nutrition (DIfE), a partner of the DZD, and their colleagues from Hamburg and Italy, have developed an improved FLI. (regenerativemedicine.net)
  • This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. (intlstemcell.com)
  • ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. (intlstemcell.com)
  • In addition, non-pharmaceutical interventions limiting human mobility likely reduced SARS-CoV-2 spread over successive pandemic waves and should be encouraged for reducing transmission of future VOCs. (bvsalud.org)
  • This is important because iPS cells don't come with the ethical problems that embryonic cells do. (dailyreckoning.com)
  • On the surface, the press release is about the beginning of ISCO's "Second Pre-Clinical Phase of Testing Retinal Pigment Epithelium (RPE) Derived From Human Parthenogenetic Stem Cells for Treatment of Retinal Diseases. (dailyreckoning.com)
  • Neural stem cells derived from human parthenogenetic stem cells engraft and promote recovery in a nonhuman primate model of Parkinson's disease. (bioengineer.org)
  • ISCO Company Blog: International Stem Cell's Scientists in Collaboration with World Leading Stem Cell Experts Extend Understanding of Human Parthenogenetic Stem Cells. (intlstemcell.com)
  • however, parthenogenetic stem cells have the additional benefit of superior immune-matching capabilities. (intlstemcell.com)
  • Hans Keirstead, Ph.D., Professor of Anatomy and Neurobiology and Neurological Surgery at the University of California, Irvine and the senior author of the paper, said: "This work is the first wide-ranging comparison between these two important pluripotent stem cell types and demonstrates that human parthenogenetic stem cells are capable of differentiation along retinal lineages. (intlstemcell.com)
  • International Stem Cell Corporation is a California-based biotechnology company focused on the therapeutic applications of human parthenogenetic stem cells and the development and commercialization of cell-based research and cosmetic products. (intlstemcell.com)
  • ISCO Company Blog: International Stem Cell Corporation Parthenogenetic Stem Cell Line Shown to Carry the Most Common Immune Genes Matched to the U.S. Population. (intlstemcell.com)
  • OCEANSIDE, Calif. - March 2, 2010 - International Stem Cell Corporation (OTCBB: ISCO), www.interna t ionalstemcell.com , announced today that human parthenogenetic stem cell lines ("hpSC"), created by scientists from its Research and Therapeutic Development Group, have demonstrated ability to maintain the essential properties of immortal stem cells throughout extended laboratory cultivation. (intlstemcell.com)
  • To date, ISCO has created 10 human parthenogenetic stem cell lines. (intlstemcell.com)
  • The differentiated derivatives of human parthenogenetic stem cells, obtained by ISCO scientists, promise to overcome the problem of immune-matching in tissue-replacement therapy. (intlstemcell.com)
  • This achievement is another step toward the creation by ISCO of its proprietary " UniStem Cell Bank"™, confirming the importance of human parthenogenetic stem cells in possible therapeutic application and their ability to meet clinical transplant standards. (intlstemcell.com)
  • hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. (intlstemcell.com)
  • Embryonic SCs - These cells are taken from embryos and are therefore ethically objectionable to many people. (dailyreckoning.com)
  • Scientists also knew that induced pluripotent stem (iPS) cells made from adult cells (not embryos) would have the same ability. (dailyreckoning.com)
  • This study used hpNSCs because the cells demonstrate characteristics of human embryonic stem cells, but are not sourced from viable embryos, which may be destroyed in the process. (bioengineer.org)
  • Western blot analysis and metabolic assays revealed that the diapause embryos produced by Ar-Crk-knocked-down Artemia had similar characteristics of diapause markers, arrested cell cycle, and suppressed metabolism with those diapause embryos produced by natural oviparous Artemia. (bvsalud.org)
  • Ruslan Semechkin, Ph.D., Vice President of ISCO and co-author on this paper, said: "We are excited about being involved in Dr. Loring's work, which compares molecular characteristics of hundreds of different human pluripotent cell lines. (intlstemcell.com)
  • ISCO ) about its parthenogenic stem cells. (dailyreckoning.com)
  • In other words, ISCO has evidence that its nonembryonic parthenogenic RPE cells halt the advance of age-related macular degeneration. (dailyreckoning.com)
  • ISCO has established collaborations with other leading stem cell researchers to exploit the unique qualities of hpSCs. (intlstemcell.com)
  • In addition to the collaboration with Keirstead, ISCO scientists co-authored a publication with Jeanne Loring, Ph.D., the Director of the Center for Regenerative Medicine at The Scripps Research Institute in La Jolla, entitled "Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture" published in Cell Stem Cell in January, 2011. (intlstemcell.com)
  • ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. (intlstemcell.com)
  • ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology and cell-based skin care products through its subsidiary Lifeline Skin Care. (intlstemcell.com)
  • International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. (intlstemcell.com)
  • Scientists have long known that embryonic stem cells have the ability to repair damaged tissues in animals. (dailyreckoning.com)
  • After 30 years of research to cure HIV infection and AIDS, this opens a whole new avenue in understanding how scientists could track and find infected cells, then wake up and kill the virus hiding deep inside. (regenerativemedicine.net)
  • A membrane designed to support the cultivation and differentiation of human nasal epithelial stem cells was inserted into a small chamber on the device and fresh or contaminated air was fed through a tiny channel. (regenerativemedicine.net)
  • Five weeks after seeding the membrane with human nasal epithelial stem cells the researchers could observe the formation of beating cilia. (regenerativemedicine.net)
  • This is a significant differentiator from embryonic stem cells and a major reason why hpSC have the potential to become the first population-specific pluripotent stem cells available for use in the treatment of human diseases for d ifferent genders and racial groups across the world. (intlstemcell.com)
  • The researchers also reported that the intracerebral injection and transplantation of hpNSCs was "safe and well-tolerated" for the two transplantation test animal groups with moderate to severe PD symptoms. (bioengineer.org)
  • Experiments using stem cells have offered benefits in pre-clinical studies, but have also provided "a wide variety of patient outcomes," said the researchers. (bioengineer.org)
  • This was the first comprehensive study showing functional recovery after transplantation of human parthenogenetic neural stem cells in a non-human primate with moderate to severe PD symptoms," concluded the researchers. (bioengineer.org)
  • At even higher formaldehyde concentrations of 3.0 milligrams per cubic meter, however, the researchers observed an unexpected decrease in cilia beating frequency, possibly due to irreversible cell damage caused by the formaldehyde. (regenerativemedicine.net)
  • Before arriving at a potential treatment for humans, the researchers are planning to evaluate the effectiveness of new drugs to awaken similar virus reservoirs in monkeys and determine where the virus is hidden. (regenerativemedicine.net)
  • Cell-based therapies are offering promise as an alternative. (bioengineer.org)
  • The study showed evidence of safety in using these cells, which is an improvement upon previous stem cell therapies that have shown some lineages may result in tumor formation. (bioengineer.org)
  • Dr. And rey Semechkin, ISCO's СЕО, says: "The a bility of a stem cell line to maintain stable properties during long-term cultivation is one of the necessary properties that stem cells must have in order to be used in cell-based therapies. (intlstemcell.com)
  • The laboratory of Dr. Daniel Kaufmann has developed a highly accurate technique for detecting the rare cells that hide the virus and prevent current therapies from curing HIV infection. (regenerativemedicine.net)
  • Their previous studies with hpNSCs, said the authors, had shown that the cells could also be "chemically directed" to differentiate into multipotent neural stem cells and were able to be frozen for future use. (bioengineer.org)
  • The use of neural stem cells derived from human parthenogenic cells may be a new avenue for treating a variety of conditions," said Dr. Paul Sanberg, distinguished university professor at the University of South Florida in Tampa Florida and co-editor-in-chief of Cell Transplantation. (bioengineer.org)
  • After more than one hundred passages over more than two years of continuous in vitro cultivation, the line phSC-Hhom-4 has maintained pluripotent stem cell properties and continues to be used in experiments to create therapeutic derivatives targeted for treatment of liver, cornea, retina and neurodegenerative diseases. (intlstemcell.com)
  • His team has developed an innovative technique for detecting these reservoirs -- a way of taking a "photo" of each individual cell hiding the virus -- a significant breakthrough, as this approach is 1,000 times more accurate than current technologies. (regenerativemedicine.net)
  • While our studies were conducted in the laboratory, a clinical trial would involve using such drugs to wake up the virus while the patient continues taking ART to ensure that the reactivated virus cannot infect other cells," explained Dr. Kaufmann. (regenerativemedicine.net)
  • Uterine transplantation: review in human research. (ijpsat.org)
  • They solve the immune problem through the creation of ISCO's HLA typed cell bank. (dailyreckoning.com)
  • This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. (intlstemcell.com)
  • We were able to identify and quantify the cells containing hidden virus and then test drugs to wake up HIV," said Kaufmann, who is a researcher and infectious disease specialist at the University of Montreal Hospital Centre (CHUM). (regenerativemedicine.net)
  • To develop new, targeted treatments to eliminate these residual infected cells, we need to find exactly where in the CD4 T lymphocyte population the virus hides. (regenerativemedicine.net)
  • One of these lines, named phSC-Hhom-4, has the most common set of HLA genes found in various U.S. population groups and may be useful to treat millions of people world-wide from a single cell line. (intlstemcell.com)
  • The discovery of a novel, advanced technique to identify the rare cells where human immunodeficiency virus hides in patients taking antiretroviral therapy is an important step forward in the search for a HIV/AIDS cure. (regenerativemedicine.net)
  • The results of this and other studies support the clinical translation of hpNSCs and the approval of the world's first pluripotent stem cell-based therapy for treating Parkinson's disease. (bioengineer.org)
  • The Co-Editors-in-Chief for CELL TRANSPLANTATION are at the Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, USA and the Center for Neuropsychiatry, China Medical University Hospital, TaiChung, Taiwan. (bioengineer.org)
  • Cell cycle and metabolism were highly suppressed in this state of quiescence. (bvsalud.org)
  • Firstly, the HIV must be woken up from its dormant state in the cells. (regenerativemedicine.net)
  • Engineered male and female biomimetic reproductive tissues are being created as self-supporting in vitro units or as incorporated multi-organ in vitro constructions to help germ cell and embryo function, and to show characteristic endocrine phenotypic patterns, for example, the 28-days human ovulatory cycle. (ijpsat.org)
  • These cells prevent blindness just as RPE cells from cadavers and embryonic sources do. (dailyreckoning.com)
  • Kupffer cells (KCs) are a dominant population of macrophages that reside in the liver, playing a crucial role in innate immunity. (bvsalud.org)
  • The ingenol derivative activates a population called central memory cells. (regenerativemedicine.net)
  • They have efficacy and they solve the immune problem because they are the donor's own cells. (dailyreckoning.com)