Transplantation of human fetal tissue. Medical search. Frequent questions

Transplantation of human organs and tissues1 saves many lives and restores essential functions in circumstances when no medical alternative of comparable effectiveness exists. (who.int)
The transplantation of solid organs, such as kidney, liver, heart or lung, is increasingly a regular component of health care in all countries, and is no longer a feature of health care in high-income countries alone. (who.int)
Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
The persistent and widening gap between patients' need for organs and the number available for transplantation has become a major concern to many Member States. (who.int)
Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, preventing and reversing damage to organs, and restoring balance to compromised immune systems. (nih.gov)
Contrary to popular belief, stem cells are present in the human body throughout life and are found in many adult organs. (jcpa.org)
do not donate blood, organs, tissues, or cells for transplantation after you receive betibeglogene autotemcel injection. (medlineplus.gov)
Of particular concern is organ donation , with legal , medical, and social issues surrounding the procurement of organs, without compensation, for transplantation. (britannica.com)
ESCs are derived from the inner cell mass of blastocysts, whereas ASCs are present in adult tissues and can be found in organs such as bone marrow, adipose tissue, and brain. (mornd.com)
Following the release, last May, of a powerful LifeTalk video featuring "Kelly," a fetal tissue procurer for the Maryland-based Anatomic Gifts Foundation, Life Dynamics has released documentation obtained from fetal tissue wholesalers, that is, companies which place their employees in abortion facilities to harvest tissue, limbs, organs, etc. (blessedquietness.com)
The ICM continues to differentiate into three germ layers-ectoderm, mesoderm and endoderm, each of which follows a specific developmental destiny that takes them along an ever-specifying path at which end the daughter cells will make up the different organs of the human body. (thefutureofthings.com)
Experimentation on, or using the organs or tissues from, a human or other mammalian conceptus in the postembryonic period, after the major structures have been outlined. (bvsalud.org)

Since rodent models cannot recapitulate many of the human disease features, human induced pluripotent stem cells derived from Parkinson's patients have been used to generate brain organoids, greatly contributing to our understanding of the disease pathophysiology. (nature.com)
Between 1988 and 1994, roughly 140 Parkinson's disease patients received fetal tissue (up to six fetuses per patient), with varying results. (lozierinstitute.org)
[12] The results of these two large studies led to a moratorium on fetal tissue transplants for Parkinson's. (lozierinstitute.org)
Methods: This article examines different emotional, cognitive and discursive strategies used by neurobiologists in a foetal cell transplantation trial in Parkinson's disease research, using cells harvested from aborted embryos. (lu.se)
Lundin, S & Widner, H 2000, ' Attitudes to xenotransplantation: interviews with patients suffering from Parkinson's disease focusing on the conception of risk ', Transplantation Proceedings , vol. 32, nr. 5, s. 1175-6. (lu.se)
They can thus develop into brain, muscle, blood, skin, and other tissues and can, in theory, help with many health conditions involving organ dysfunction or failure, as well as cancer, injury, and may even address degenerative and otherwise incurable diseases such as Parkinson's and Alzheimer's disease. (nhsjs.com)
Led by Prof. Malin Parmar, the team differentiated dopaminergic neurons from human embryonic stem cells in culture, then transplanted them into the brains of rats that were modeled to exhibit the symptoms of Parkinson's. (medgadget.com)

Now, researchers in Sweden show that these biosynthetic corneas made with human collagen may allow patients who need corneal transplants but do not have donors to regain normal sight. (aaas.org)
The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
In Europe, hundreds of thousands of tissue transplants are performed each year, and in 1999 an estimated 750 000 people in the United States of America received human tissue, twice as many as in 1990. (who.int)
Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
Composite transplants (composite vascular allografts) involve multiple tissues, usually including skin and soft tissues and sometimes musculoskeletal structures. (msdmanuals.com)
However, the success of fetal tissue transplants has been meager at best, and ethically-derived alternatives exist and are coming to dominate the field. (lozierinstitute.org)
The first recorded fetal tissue transplants were in 1921 in the UK, in a failed attempt to treat Addison's disease, [1] and in 1928 in Italy, in a failed attempt to treat cancer. (lozierinstitute.org)
That attempt also failed, as did subsequent similar fetal tissue transplants in 1959. (lozierinstitute.org)
Between 1970 and 1991 approximately 1,500 people received fetal pancreatic tissue transplants in attempts to treat diabetes, mostly in the former Soviet Union and the People's Republic of China. (lozierinstitute.org)
[8] Subsequent reports showed that severe problems developed from fetal tissue transplants. (lozierinstitute.org)
A second large, controlled study published in 2003 showed similar results (funded by NIH), with over half of the patients developing potentially disabling tremors caused by the fetal brain tissue transplants. (lozierinstitute.org)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
Catecholamine and norepinephrine assays showed that the transplants were more active in the presence of the human hormone and possibly functional seven weeks post-transplantation. (askanacademic.com)
By the end of the twentieth century, many other transplants using different processes had been reported but there were challenges like the lack of appropriate donor tissue and use of immune-suppressive drugs to prevent rejection of the transplant. (livestemcells.asia)
Eight patients with bare light perception (LP) vision due to retinitis pigmentosa (RP) and one patient with bare LP vision due to advanced neovascular age-related macular degeneration (AMD) received subretinal transplants of human fetal retinal microaggregate suspensions without postoperative systemic immunosuppression. (johnshopkins.edu)

The focus was on the effects of fetal bovine serum (FBS) replacement with pooled human serum (HS). (biomedcentral.com)
and fetal bovine serum (FBS) were obtained from Gibco (USA). (bioskinrevive.com)
Fetal bovine serum is the supplement most widely used for cell culture, but it has disadvantages and it is not safe for cell therapy due to the risks of pathogen transmission and immune reaction. (biomedcentral.com)
hASCs were expanded in Dulbecco's modified Eagle's medium supplemented with pooled allogeneic human serum or fetal bovine serum to enable a side-by-side comparison. (biomedcentral.com)
however, C-MYC protein expression was enhanced in pooled allogeneic human serum cultures compared to fetal bovine serum cultures. (biomedcentral.com)

The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
A century later, in 1979, experiments in rats showed that rat foetal dopamine neurons were able to reduce experimentally-induced Parkinsonism in rats. (askanacademic.com)
One group demonstrated that cells dissected from fetal human forebrain or adult white matter and selected using immunosorting methods could be transplanted into myelin-deficient animals and provide significant myelination of host neurons [5-8]. (scientificarchives.com)
Researchers from Lund University in Sweden have published an article in Cell Stem Cell describing the generation of functional dopaminergic neurons from human embryonic stem cells. (medgadget.com)
Prof. Parmar and colleagues showed that following transplantation, the embryonic stem cell-derived dopaminergic neurons exhibited the functional characteristics of native dopaminergic neurons, including dopamine production as well as long distance extension and connection with target regions in the brain. (medgadget.com)
Unlike fetal stem cells, which have been previously used to create dopaminergic neurons, embryonic stem cells (from existing stem cell lines) offer an abundant, readily accessible supply of cells. (medgadget.com)

The principles and practices of the diverse aspects of immune therapy for cancer, HSC transplantation and regenerative medicine have many commonalities. (nih.gov)
There are other, less controversial alternatives to embryonic stem cells, such as adult, fetal, cord blood, and induced pluripotent stem cells, but they have other biological restrictions that make them less promising for use in regenerative medicine at this time. (nhsjs.com)

PERTINENT ISSUES: The morality of organ transplantation. (christianliferesources.com)
Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
Disappearance of exocrine elements, with only ducts and fibrous tissue remaining, resulted in a pure endocrine organ. (diabetesjournals.org)
Although clearly an experimental procedure, xenotransplantation between closely related species, such as baboons and humans, offers an alternative to allotransplantation as a source of human organ replacement. (cdc.gov)
By providing temporary heart, kidney, or liver support as a bridge-to-transplantation, these biological devices may allow patients to recover end-organ function and await allograft transplantation in a more stable clinical state, thus improving their chances of survival. (cdc.gov)
Bridging strategies cannot alleviate the human organ donor shortage. (cdc.gov)
However, if one views bridging strategies as a first feasibility test, then cross-species transplantation does offer the possibility of eventual long-term organ replacement. (cdc.gov)
Success in this more ambitious goal would help alleviate the human organ donor shortage. (cdc.gov)
Nonhuman primate organ donors have been favored by those wishing to minimize the genetic disparity between donors and human recipients. (cdc.gov)
The ideal treatment option for terminally ill patients is organ transplantation. (frontiersin.org)
In this regard, emerging technologies of chimeric human organ production via blastocyst complementation (BC) holds great promise. (frontiersin.org)
To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
Organ transplantation is the ultimate treatment option for patients suffering from refractory diseases. (frontiersin.org)
Depending on the patient's medical condition, a refractory disease patient also requires an on-time selective option, such as less invasive cellular therapy options or curative organ transplantation that can function immediately after transplantation. (frontiersin.org)
In this review, we summarize the history of interspecies chimerism in various animal models to find hints for BC application and describe the challenges and prospects of utilizing BC for human organ generation. (frontiersin.org)
There is a theoretical concern that transmission could occur through organ or tissue transplantation, and although Zika virus RNA has been detected in breast milk, transmission through breastfeeding has not been documented ( 5 ). (cdc.gov)
In countries with established transplant programs, organ transplantation is highly regulated. (britannica.com)
This immune reaction leads to rejection, the greatest problem in successful tissue and organ grafting. (britannica.com)
The organ decellularization paradigm has opened a breach where multidisciplinary teams of biologists, clinicians, and engineers can explore new ways to engineer complex tissues. (regenerativemedicine.net)
ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)

Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
Similarly, corneal transplantation can successfully relieve corneal blindness in many cases. (who.int)
The purpose of this study is to examine the therapeutic efficacy of human umbilical cord mesenchymal stem/stromal cells (UMSCs) in treating congenital and acquired corneal opacity associated with the loss of collagen V. (molvis.org)
Experimental mice, i.e., wild-type, Col5a1 f/f and Kera-Cre/Col5a1 f/f ( Col5a1 ∆st/∆st , collagen V null in the corneal stroma) mice in a C57BL/6J genetic background, were subjected to a lamellar keratectomy, and treated with or without UMSC (10 4 cells/cornea) transplantation via an intrastromal injection or a fibrin plug. (molvis.org)
UMSC transplantation was successful in recovering some corneal transparency in injured corneas of wild-type, Col5a1 f/f and Col5a1 ∆st/∆st mice. (molvis.org)
Corneal Transplantation Corneal transplantations are done for several reasons: To reconstruct the cornea (eg, replacing a perforated cornea) To relieve intractable pain (eg, severe foreign body sensation due to recurrent. (msdmanuals.com)

Innovative therapies, such as progenitor and mesenchymal stem cell transplantation, targeting the specific altered pathway rather than the symptoms, are in the process of development. (smw.ch)
Although engraftment of irradiated C.B-17 scid/scid (SCID) mice with human progenitor cells occurred after infusion with human pediatric bone marrow cells, significant engraftment of the mouse bone marrow with human cells was dependent upon continuous treatment with exogenous human cytokines. (elsevierpure.com)
The differentiation mechanisms involving metabolomics products could have an impact on advancing recruitment of stem/progenitor cells during tissue homeostasis. (elsevierpure.com)
Here, we describe a 3D culture system that supports the expansion of adult human pancreatic tissue and the generation of a cell subpopulation with progenitor characteristics. (prinsesmaximacentrum.nl)
We conclude that adult human pancreatic tissue has potential for expansion into 3D structures harboring progenitor cells with endocrine differentiation potential. (prinsesmaximacentrum.nl)

HLA-G differs from the other MHC class I genes by its low polymorphism and alternative splicing that generates seven HLA-G proteins, whose tissue-distribution is restricted to normal fetal and adult tissues that display a tolerogeneic function toward both innate and acquired immune cells. (biovendor.com)
The use of hASCs for therapeutic applications has grown substantially in the last years, because the use of stem cells from adult tissues circumvent some ethical issues associated with the application of embryonic stem cells, and because of their accessibility via isolation from lipoaspirates, a disposable byproduct of cosmetic surgery. (biomedcentral.com)

A fundamental question in the study of MSCs is that the bona fide identity of human MSCs in vivo is not well defined. (bjmu.edu.cn)
In vivo transplantation demonstrated that LIFR+PDGFRB+CD45-CD31-CD235a- MSCs could form bone tissues and reconstitute the hematopoietic microenvironment (HME) effectively in vivo. (bjmu.edu.cn)
UMSC transplantation with a fibrin plug improves the healing of injured corneas and regeneration of transparent corneas, as determined with in vivo HRT II confocal microscopy. (molvis.org)
In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)
Investigation of human hematopoietic maturation has been hampered by the lack of in vivo models. (elsevierpure.com)
Since engraftment occurs in the absence of exogenous cytokine treatment, the BM- SCID-hu mouse model described should provide a useful in vivo system for studying factors important in the maturation of human myeloid and lymphoid cells in the bone marrow and the behavior of the mature human cells after dissemination into the peripheral lymphoid tissue. (elsevierpure.com)
In the context of β cell replacement therapy for diabetes, de Koning and colleagues describe a 3D culture platform that supports ex vivo expansion of human pancreatic tissue as organoids. (prinsesmaximacentrum.nl)
Prior to their clinical application, hASCs must be expanded ex vivo to obtain the required number of cells for transplantation. (biomedcentral.com)
Moreover, the hASCs presented normal karyotype undergoing senescence, and did not form in vivo tumors, eliminating the possibility that spontaneous immortalization of hASCs had occurred with pooled allogeneic human serum. (biomedcentral.com)
Per their article published in Science , Tissue-engineered lungs for in vivo implantation, and reported by Science Daily , the Yale team took adult rat lungs and first removed their existing cellular components, preserving the extracellular matrix and hierarchical branching structures of the airways and vascular system to use later as scaffolds for the growth of new lung cells. (regenerativemedicine.net)
Brain organoids mimic more closely the in vivo tissue composition and architecture and are more physiologically relevant than monolayer cultures. (ehu.eus)
Intestinal organoids are three-dimensional (3D) in vitro tissue cultures that model the in vivo intestine. (stemcell.com)

Researchers participating in a AAAS Annual Meeting news briefing discuss how the use of brain tissue from living donors has prompted a paradigm shift in the study and understanding of the human brain. (aaas.org)
One patient who received transplant of fetal brain tissue (from a total of 3 fetuses) died subsequently, and at autopsy was found to have various non-brain tissues ( e.g, skin-like tissue, hair, cartilage, and other tissue nodules) growing in his brain. (lozierinstitute.org)
NSCs were successfully isolated from human fetal brain tissue, leading to the development of new strategies for neural repair. (mornd.com)
The first attempts of brain tissue. (askanacademic.com)
The first attempts of brain tissue xenotransplants were attempted by Gilman Thompson in 1890, between cats and dogs. (askanacademic.com)
In 2002, thirty patients with advanced Parkinson disease received human foetal brain tissue. (askanacademic.com)

This work not only expands our understanding of human bone marrow MSCs, but also provides great hints for further expansion of primary MSCs in vitro, which would be great help for MSCs-based bone regeneration. (bjmu.edu.cn)
Cell transplantation studies were performed in mice with drug-induced acute liver failure to elicit benefits in hepatic support and tissue regeneration. (elsevierpure.com)
The Massachusetts researchers described their findings in the Nature Medicine article, Regeneration and orthotopic transplantation of a bioartificial lung. (regenerativemedicine.net)

In stem cells exposed to signals from fetal cells, mechanistic gene networks of upstream regulators decreased pluripotency, while simultaneously inducing mesenchymal and epithelial properties. (elsevierpure.com)

University personnel ("personnel") may not perform research on a human fetus which meets the definition of a living human conceptus under Minnesota law (shows the presence of evidence of life, such as movement, heart or respiratory activity, or the presence of electroencephalographic or electrocardiographic activity), except to protect the life or health of the fetus. (umn.edu)
ABP also may accept donations of human fetal tissue obtained from a stillborn infant, or an embryo or fetus that died of natural causes in utero as authorized under applicable state laws. (umn.edu)
Similarly, when the fertilized egg divides from two cells into four cells, each of these four cells has the potential to individually form a human fetus. (jcpa.org)
Note that fetal tissue has been taken in a number of cases from fetuses at developmental ages where fetal surgery is now used to correct problems and save lives, and at stages where science now demonstrates that the unborn fetus can feel pain. (lozierinstitute.org)
The resulting virus strain was named from the series: "RA 27/3" indicates "rubella abortus, twenty-seventh fetus, third tissue extract. (avoicefortruth.com)
Tumour the fetus via the maternal circulation utero, but when the reactive metab multiplicity rises to a maximum in must have crossed the placenta, and olites formed in maternal tissues are offspring exposed at approximate consequently are generally referred too unstable to circulate in the mater ly 21 days of gestation, a few days to as transplacental carcinogens. (who.int)

[2] The first fetal tissue transplant in the U.S. was in 1939, using fetal pancreatic tissue in an attempt to treat diabetes. (lozierinstitute.org)
Interestingly, gene expression profiling revealed that ALDH hi cells are closer to human fetal pancreatic tissue compared with adult pancreatic tissue. (prinsesmaximacentrum.nl)

Immunotherapy has become an important part of hematopoietic stem cell (HSC) transplantation and cancer therapy. (nih.gov)
Moreover, hematopoietic stem cell transplantation (HSCT) continued to be a successful treatment modality for various blood disorders. (mornd.com)

There are many types of stem cells, but most of the controversy surrounds embryonic stem cells, as they are derived from human embryos. (nhsjs.com)
In rodents, and even in some preliminary trials in humans, human embryonic stem cells have been shown to bridge gaps in spinal cord injuries , allowing restoration of motor functions. (thefutureofthings.com)
In particular, the advent of human embryonic stem cells followed by reprograming technologies for generation of induced pluripotent stem cells have instigated studies into modeling human brain development and disease by providing a means to simulate a human tissue otherwise completely or largely inaccessible to researchers. (ehu.eus)

Such cells are derived from human embryos, and are undifferentiated, unlike other specialized cells in the human body. (nhsjs.com)
Proponents of stem cell research claim that the blastocyst is not human yet, and the embryos used for stem cell harvest are typically leftover from in vitro fertilization procedures with minimal chance that a human could ever develop from them. (nhsjs.com)
Adversaries of stem cell research argue that embryos are human and destroying one is equal to murdering a child. (nhsjs.com)
Proponents, on the other hand, believe that embryos have not yet been guaranteed their human rights because they are only blastocysts, and the benefits of such research outweigh the concerns. (nhsjs.com)
The emergence of iPSCs eliminated the ethical concerns associated with ESCs, as it avoids the destruction of human embryos. (mornd.com)
The laboratory, which is supported by the National Institutes of Health, can supply tissue from normal or abnormal embryos and fetuses of desired gestational ages between 40 days and term. (blessedquietness.com)

Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
ASCs possess a more limited differentiation potential compared to ESCs, primarily giving rise to cells specific to their tissue of origin. (mornd.com)
The high proliferation and differentiation capacity of fetal MSCs and the role of fetal pancreatic-derived MSCs (FPMSCs) in islet generation make them good candidates for diabetes treatment. (biomedcentral.com)
These studies showed signals emanating from fetal liver cells induced hepatic differentiation in stem cells. (elsevierpure.com)
Bandi, S , Tchaikovskaya, T & Gupta, S 2019, ' Hepatic differentiation of human pluripotent stem cells by developmental stage-related metabolomics products ', Differentiation , vol. 105, pp. 54-70. (elsevierpure.com)
The hASCs expanded in medium with pooled allogeneic human serum did not show remarkable differences in morphology, viability, differentiation capacity or immunophenotype. (biomedcentral.com)

Researchers may accept and/or use human fetal tissue for transplantation into a relative of the donor or other individual designated by the donor (i.e., donor-designated recipient) only if the tissue is obtained from a spontaneous abortion or stillbirth. (umn.edu)
Laboratory-made "biosynthetic" corneas can spur damaged tissue and broken nerves to regenerate, restoring vision in human eyes just as well as donor corneas, according to a two-year study of 10 patients reported in Science Translational Medicine. (aaas.org)
Patients are more likely to die waiting for a human donor heart than in the first 2 years after transplantation. (cdc.gov)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
In the early 90's, Washington University Medical Center reported the success of the first transplant of the pancreatic islet tissue from a donor in a person ailing from Type 1 diabetes. (livestemcells.asia)

Researchers say they can grow large amounts of the transplantable tissue using cells from a small number of donors. (aaas.org)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
Recently, the team published a research paper titled 'Characteristics of Dental Stem Cells in Human Fetal Bone Marrow by Single Cell Transcriptive and Functional Analysis' in the 'Signal Transmission and Targeted Therapy (STTT)', we reported the expression landscape of human fetal BM nucleated cells (BMNCs) based on the single-cell transcriptomic analysis. (bjmu.edu.cn)
Another critical question about the MSC-based bone tissue engineering is the necessity to expand the cells prior to use. (bjmu.edu.cn)
[5] Conditions such as anemias and immunodeficiencies, for which fetal tissue attempts largely failed, are now treated routinely with adult stem cells, including umbilical cord blood stem cells, [6] even while the patient is still in the womb. (lozierinstitute.org)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
The transformation process contains different phases, and in the interview material we observed that the foetal material or cells were considered objects, subjects or rejected as abject by the researchers handling them, depending on what phase of process or practice they referred to or had experience of. (lu.se)
Conclusions: The marginal and ambiguous status of the embryo that emerges in the accounts turns the scientists handling foetal cells into liminal characters in modern medicine. (lu.se)
Furthermore, despite cytokine treatment, only minimal peripheral engraftment of these mice with human cells was observed. (elsevierpure.com)
In the present study, after infusion of irradiated SCID mice with pre-cultured human fetal bone marrow cells (BM-SCID-hu mice), their bone marrow became significantly engrafted with human precursor cells and their peripheral lymphoid compartment became populated with human B cells and monocytes independently of the administration of extraneous human cytokines. (elsevierpure.com)
When the stem cells divide, the new cell may remain a stem cell to divide again or may differentiate to become any of the 200 types of specialized cells in the human body. (nhsjs.com)
These cells have the capacity to distinguish "self" substances from such "nonself" substances as microorganisms and foreign tissue cells. (britannica.com)
Endogenous cell signals regulate tissue homeostasis and are significant for directing the fate of stem cells. (elsevierpure.com)
To determine mechanisms in these stage-specific lineage interactions, we modeled potential effects of soluble signals derived from immortalized human fetal liver parenchymal cells on stem cells, including embryonic and induced pluripotent stem cells. (elsevierpure.com)
In addition to their ability to supply cells at the turnover rate of their respective tissues, they can be stimulated to repair injured tissue caused by liver damage, skin abrasions and blood loss. (thefutureofthings.com)
The ability of our body to regenerate some of its tissues is largely owed to the reserves of adult stem cells. (thefutureofthings.com)
Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. (prinsesmaximacentrum.nl)
Engrafted organoids differentiated toward insulin-positive (INS + ) cells, and circulating human C-peptide was detected upon glucose challenge 1 month after transplantation. (prinsesmaximacentrum.nl)
Transplantation of glial cells or glial progenitors into the diseased or injured CNS can provide therapeutic benefits. (scientificarchives.com)
Here we report a method that enables the efficient generation and expansion of glial precursors from tissue-restricted neural stem cells (NSC). (scientificarchives.com)
Upon transplantation into different animal models of demyelination a substantial proportion of these cells become oligodendrocytes with the capacity to myelinate host axons. (scientificarchives.com)
These results demonstrate that tissue-restricted human neural stem cells can serve as an efficient source for myelinating oligodendrocytes with therapeutic potential. (scientificarchives.com)
This unmet medical need is a primary driver for the development of therapies based on transplantation of neural stem cells that have the potential to replace cells of the central nervous system (CNS) lost to disease or injury [1]. (scientificarchives.com)
The potential therapeutic value of oligodendrocytes has been demonstrated in animal studies by transplantation of oligodendrocyte precursor cells purified directly from neural tissue. (scientificarchives.com)
Human trials using stem cells for remyelination have begun. (scientificarchives.com)
Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. (biomedcentral.com)
and (2) through the paracrine release of trophic factors to induce tissue repair by endogenous cells [ 6 ]. (biomedcentral.com)
Theoretically, stem cells can be used to treat Type 1 diabetes by inducing them to be b-cells in the lab, and then introducing them to the body where they would repair the damaged tissue and help maintain enough b-cell mass. (livestemcells.asia)
Trang chủ Công trình KHCN Sách/Chương sách Expanded Adipose Tissue-Derived Stem Cells for Articular Cartilage Injury Treatment: A Safety. (vinastemcelllab.com)
They then cultured a combination of lung-specific cells on the extracellular matrix, using a novel bioreactor designed to mimic some aspects of the fetal lung environment. (regenerativemedicine.net)
Under the fetal-like conditions of the bioreactor, the cells repopulated the decellularized matrix with functional lung cells. (regenerativemedicine.net)
They soaked these in a bioreactor along with several types of human lung cells, creating pressures to simulate the pressure inside a body to make the lung workable and flexible. (regenerativemedicine.net)
The cells took up residence and grew into different tissue sub-types seen in a lung, Ott's team reported. (regenerativemedicine.net)
Gupta AK, Jadhav SH, Tripathy NK, Nityanand S. Fetal kidney stem cells ameliorate cisplatin induced acute renal failure and promote renal angiogenesis. (wjgnet.com)
Since the introduction of the mouse small intestinal organoid model in 2009, 1 there has been an avalanche of developments in this field, including development of culture conditions for human organoids derived from primary colonic tissue, 2 as well as from human pluripotent stem cells (hPSCs). (stemcell.com)
which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)

Between 1960 and 1990, numerous attempts were made to transplant fetal liver and thymus for various conditions. (lozierinstitute.org)

As a report in The Stream indicates: "Under the NIH Revitalization Act of 1993 , the U.S. Department of Health and Human Services (HHS) should be performing audits on Planned Parenthood, since Planned Parenthood is involved in research on aborted fetuses and HHS is supporting its work with funding. (lifenews.com)
OHRP is in charge of overseeing any research done on human fetuses. (lifenews.com)

Stem cell research has emerged as a ground-breaking field with the potential to revolutionize medicine and improve human health. (mornd.com)

University researchers ("researchers") may conduct research on the transplantation of human fetal tissue or cell lines derived from human fetal tissue ("human fetal tissue") for therapeutic purposes only in accordance with applicable federal and state laws and regulations and University policies and procedures. (umn.edu)
Ultimately, the only documents turned over were the redacted emails and several letters from HHS to Congress stating that the National Institute of Health (another part of HHS) had no required reports to give Congress about research on transplanting human fetal tissue for therapeutic purposes because NIH hadn't been involved with any such work. (lifenews.com)

Until now, no other vascular graft engineered from human tissue has tolerated simple storage. (aaas.org)
Although a definite positive effect on visual function could not be demonstrated, the apparent high tolerance for graft tissue is promising for future efforts in the field of neural retinal transplantation. (johnshopkins.edu)

With this technique, cryopreserved ovarian tissue could possibly be used to make oocytes that can directly undergo in vitro fertilization. (wikipedia.org)
Sites which bind oxytocin and vasopressin with high affinity were detected in the brain and upper spinal cord of 12 human subjects, using in vitro light microscopic autoradiography. (shengsci.com)
Here we highlight the journey towards recapitulating human brain development and disease in a dish, progressing from two‐dimensional in vitro systems to the third dimension provided by brain organoids. (ehu.eus)

However, heart, kidney, and liver xenografts have been able to support human life for an extended period. (cdc.gov)
tell your doctor if you have or have ever had seizures, hepatitis B or C (a virus that infects the liver and may cause severe liver damage), human immunodeficiency virus (HIV), or kidney or liver disease. (medlineplus.gov)
The extent of metabolic and synthetic functions in stem cell-derived hepatocytes was sufficient for providing hepatic support along with promotion of tissue repair to rescue mice in acute liver failure. (elsevierpure.com)

For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
Streptozotocin-induced diabetes in rats was completely reversed by transplantation of syngeneic fetal pancreases placed beneath the kidney capsule. (diabetesjournals.org)

and single cell RNA-seq technology helped us to gain a global recognition of the heterogeneous populations in the murine bone marrow (BM), however, the cell census of human fetal BM remains underestimated owing to material limitations. (bjmu.edu.cn)
The mature egg cell, observes Roger Gosden, a reproductive biologist at the University of Leeds in England, is the rarest cell in the human body. (discovermagazine.com)
As demonstrated in the analysis, it is the human origin of the cell that makes it abjective and activates pollution discourse, when the researchers talk of their practice. (lu.se)
ES are pluripotent, as they can transform into almost any human cell type. (nhsjs.com)
A scanning electron micrograph of a human T lymphocyte (or T cell) from the immune system of a healthy person. (britannica.com)
Researchers focused on improving transplantation techniques and understanding stem cell niche interactions to enhance engraftment and minimize complications. (mornd.com)
In our recent study, we examined the impact of the three-dimensional co-culture of FPMSCs on human embryonic stem cell-derived pancreatic progenitors' development. (biomedcentral.com)
Gene expression profiling and comparison of regulatory networks in immature and mature hepatocytes revealed stem cell-derived hepatocytes represented early fetal-like stage. (elsevierpure.com)
In this study, GFP-expressing hWMSCs were transplanted into burn rat models by cell spray transplantation after the creation of damage. (bioskinrevive.com)
This complete characterization of hASCs cultivated in pooled allogeneic human serum, a suitable xeno-free approach, shows that pooled allogeneic human serum provides a high proliferation rate, which can be attributed for the first time to C-MYC protein expression, and showed cell stability for safe clinical applications in compliance with good manufacturing practice. (biomedcentral.com)
Stem cell technologies have opened up new avenues in the study of human biology and disease. (ehu.eus)
Over the past year, the basic facts of COVID-19 vaccines and fetal cell lines have become familiar to most of us. (avoicefortruth.com)
The creation of a successful human fetal cell line is not a neat science: it may require dozens of abortions. (avoicefortruth.com)

Researchers must apply for approval from the FTR for the use of human fetal tissue and apply for approval from the IRB to conduct human fetal tissue transplantation research. (umn.edu)
Researchers must either: 1) obtain the human fetal tissue through ABP or 2) obtain approval from ABP for the source of human fetal tissue supplied by a research sponsor, collaborator or other source. (umn.edu)
Results: The findings indicate that the labour performed by the researchers in the trial work involves transforming the foetal material practically, as well as culturally, from trash to treasure. (lu.se)
Focusing on how practical as well as emotional and cultural strategies and rationalizations of the researchers emerge in interview accounts, this study adds insights on the rationale of practically procuring, transforming and utilizing the foetal material to the already existing studies focused on the donations. (lu.se)
In the world of fetal tissue research, researchers and abortionists work together to obtain viable tissue. (avoicefortruth.com)

Ethical questions about face transplantation are even more prominent than those about extremity transplantation because the surgical procedure is extremely demanding and the immunosuppression required puts the recipient at considerable risk of opportunistic infections. (msdmanuals.com)
Transplantation raises important ethical considerations concerning the diagnosis of death of potential donors, and, particularly, how far resuscitation should be continued. (britannica.com)
Why, in a year when millions will receive abortion-derived vaccines, did we not remember the victims of fetal tissue harvesting, mourn them, and call for ethical alternatives? (avoicefortruth.com)

Human fetal tissue transplantation research : report of the Advisory Committee to the Director, National Institutes of Health, December 14, 1988, Bethesda, Maryland. (who.int)
notify ABP when the research is complete to arrange for disposition of any remaining human fetal tissue. (umn.edu)
If the proposed research involves aborted fetal tissue, the application to FTR will include a written explanation of the need for human fetal tissue from induced abortions. (umn.edu)
FTR will assess whether alternatives, including non-aborted human fetal tissue, can be used for the research, and share that assessment with the IRB before the IRB makes its decision. (umn.edu)
Specifically, according to HHS's own documents, 'Section 498A of the Public Health Service Act [42 USC 289g-1] requires the annual submission to Congress of a report describing research involving therapeutic transplantation of human fetal tissue supported or conducted by the NIH. (lifenews.com)
The Stream filed its FOIA request with the Office for Human Research Protections (OHRP) of HHS in July, asking for documents and emails related to Planned Parenthood and the audits. (lifenews.com)
After that, "The NIH did not provide any financial support for human fetal tissue transplantation research. (lifenews.com)
If this is accurate, what about all the harvesting of fetal body parts that Planned Parenthood itself categorizes as research? (lifenews.com)
Human fetal tissue research has gone on for decades. (lozierinstitute.org)
In cold, clinical research terms, here is the end product of the "fetal tissue issue" - an economically important byproduct of the sexual revolution. (blessedquietness.com)
Here, courtesy of the National Institutes of Health, in taxpayer-funded black and white, is the reality of America's culture of death: commercial cannibalism of the young of the human species, a business about to break into the mainstream as a coalition of major medical and health organizations, businesses, and associations press for federal funding of lethal embryo research. (blessedquietness.com)
The tissue is then shipped to universities, pharmaceutical and biologics firms, and government research centers. (blessedquietness.com)
After nearly 150 years of research, brain transplantation remains fictional. (askanacademic.com)
This research aims to evaluate the safety and efficacy of expanded ADSC transplantation in a mouse model. (vinastemcelllab.com)
Why the blackout on fetal tissue research among pro-lifers? (avoicefortruth.com)
A neglected subset of the abortion holocaust, the victims of fetal tissue research make us so very uncomfortable that, in the name of showing a unified face to the world, the pro-life movement focused instead on the big picture, the easily understandable messages: "Abortion Kills Babies" and "Love them both. (avoicefortruth.com)
In their memory, I offer here a tutorial on fetal-tissue research and its connection to the vaccine industry. (avoicefortruth.com)

Examination of the bone marrow of the BM-SCID-hu mice for human cytokine mRNA gene expression demonstrated human leukemia inhibitory factor mRNA and interleukin 7 mRNA in nine of nine BM-SCID-hu mice and macrophage-colony-stimulating factor mRNA in seven of eight BM-SCID-hu mice. (elsevierpure.com)

It has been suggested that tissue-matched MSCs may increase the efficacy of their regenerative effects [ 7 ]. (biomedcentral.com)
It is suggested that MSCs isolated from each tissue may be a more appropriate source for regenerating the same tissue. (biomedcentral.com)

Hazel T, Hefferan M, Schwartz K, Yu N, Johe K, Levy M. Generation of Human Oligodendrocyte Progenitors for Treatment of Demyelinating Diseases and Spinal Cord Injury. (scientificarchives.com)
Expanded neural progenitors derived from regions of human fetal forebrain have been shown to have significant capacity to remyelinate rodent spinal cord upon grafting into areas of focal demyelination [9], and can myelinate host axons in a mouse model Pelizaeus-Merzbacher disease, which is characterized by severe hypomyelination [10]. (scientificarchives.com)

Alternatives to allograft donors, such as baboon or pig xenografts, require serious investigation if clinical transplantation is ever to meet the current demand and continue the explosive growth pattern it has established over the past quarter century. (cdc.gov)
Increasing clinical experience worldwide has shown that rejection and infection can be managed successfully in most patients who receive human cardiac allografts. (cdc.gov)
Although considerable advances have been made in the field of cardiac xenotransplantation since its first clinical application by Hardy in 1964 (1) , it remains uncertain whether xenotransplantation as destination therapy can be successfully applied to humans. (cdc.gov)
Overall, the results of this study demonstrate an important pre-clinical proof of concept, with an estimated time to human trials set for approximately 3 years. (medgadget.com)

However, not all tissues possess the ability to regenerate. (thefutureofthings.com)

A pilot study of human neural retinal transplantation was undertaken to investigate three major issues: whether a safe surgical procedure could be devised for transplantation of neural retinal tissue into the subretinal space, whether the transplant would be accepted in the subretinal space, and whether an improvement in vision could be achieved. (johnshopkins.edu)
Initially, two‐dimensional neural cultures presented an innovative landmark for investigating human neuronal and, more recently, glial biology, as well as for modeling brain neurodevelopmental and neurodegenerative diseases. (ehu.eus)

Consultative and Diagnostic Pathology, Inc., will be asking to obtain tissue specimens from your patient's medical procedure. (blessedquietness.com)

One version of the approach he envisions involves giving a woman back some of her ovarian tissue if she has been somehow sterilized. (discovermagazine.com)

Tissue can then be thawed and implanted near the fallopian, either orthotopic (on the natural location) or heterotopic (on the abdominal wall), where it starts to produce new eggs, allowing normal conception to take place. (wikipedia.org)
In 2003, after freeze-thawing, orthotopic autotransplantation of ovarian cortical tissue was done by laparoscopy and five months after reimplantation regular ovulatory cycles were reinitiated. (wikipedia.org)

The main difference observed was a significantly higher proliferative effect on hASCs cultured in pooled allogeneic human serum. (biomedcentral.com)

Lastly, the endocrine system within humans and certainly within species is finely-tuned to meet the needs of each brain, thus any disruption in that balance will most likely have unfavourable effects. (askanacademic.com)

Sterilization methods, when applicable (as with some tissues), can be inadequate. (who.int)
METHODS: Prostate tissues were obtained from radical prostatectomy. (bvsalud.org)

Cryopreservation of ovarian tissue is of interest to women who want fertility preservation beyond the natural limit, or whose reproductive potential is threatened by cancer therapy, for example in hematologic malignancies or breast cancer. (wikipedia.org)
The single most effective therapy for it is transplantation. (cdc.gov)

Whole autologous brain structures such as the adrenal cortex was transplanted in rats, with or without administration of 200 units/100 gram weight of human chorionic gonadotrophic hormone. (askanacademic.com)
When transplanted into rats, the lung tissue worked for about six hours, although imperfectly. (regenerativemedicine.net)

Ovarian tissue cryopreservation is cryopreservation of tissue of the ovary of a female. (wikipedia.org)
A study of 60 procedures concluded that ovarian tissue harvesting appears to be safe. (wikipedia.org)
A study has also concluded that culturing a thawed fetal ovarian tissue for a few days before transplanting can be beneficial to the development of follicles. (wikipedia.org)
Strips of cortical ovarian tissue can also be cryopreserved, but it must be re-implanted into the body to allow the encapsulated immature follicles to complete their maturation. (wikipedia.org)
For autotransplantation of cryopreserved ovarian tissue in cancer survivors, metastases have been repeatedly detected in ovarian tissue obtained from patients with leukemia, as well as in one patient with Ewing sarcoma. (wikipedia.org)
Ovarian tissue autotransplantation may pose a risk of cancer recurrence in patients with colorectal, gastric and endometrial cancer. (wikipedia.org)
However, no metastases have been detected in ovarian tissue from lymphoma and breast cancer patients who have been undergoing ovarian tissue cryopreseration. (wikipedia.org)
The first transplant of cryopreserved ovarian tissue was performed in New York by Kutluk Oktay in 1999, but it did not restore menstrual cycles to the patient. (wikipedia.org)
The first birth following transplantation of ovarian tissue stored at a central cryo bank and transported overnight has been achieved by centers of the Fertiprotekt network in Germany 2011. (wikipedia.org)
This demonstrated that ovarian tissue can be stored centrally in specialized centers. (wikipedia.org)
Roger Gosden is the most outspoken champion of transplanting ovarian tissue and has provided much of the experimental support for it. (discovermagazine.com)
In one set of experiments, begun in 1994, he removed ovaries from ewes, froze strips of the ovarian tissue, then later reimplanted the tissue in the same animals. (discovermagazine.com)
No one knew whether human ovarian tissue could survive the process--after all, that kind of deep freeze normally kills mature eggs. (discovermagazine.com)
Gosden and his colleagues explored this idea by freezing strips of ovarian tissue donated by women undergoing medical treatments. (discovermagazine.com)

The stromal vascular fraction from abdominal adipose tissue was subcultured for ten passages to enrich for and expand the number of ADSCs. (vinastemcelllab.com)

The first hand transplantation was done in 1998. (msdmanuals.com)
Later, a breakthrough occurred in 1998 with the isolation of human ESCs by James Thomson. (mornd.com)

Long-term follow-up of a few of the patients in these large studies showed that even in fetal tissue that grew in patients' brains, the grafted tissue took on signs of the disease and were not effective. (lozierinstitute.org)

If replacement lung tissue is inappropriately fibrous or weak, long-term outcomes will be insufficient. (regenerativemedicine.net)

Anatomy17

Organisms4

Diseases23

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Phenomena and Processes18

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena4

Humanities6

Information Science3

Named Groups3

Health Care18

Organs13

Parkinson's7

Transplants15

Bovine serum5

Neurons6

Regenerative medicine2

Organ20

Corneal6

Progenitor5

Adult tissues2

Vivo12

Brain tissue6

Regeneration3

Mesenchymal1

Fetus6

Pancreatic tissue2

Hematopoietic2

Embryonic stem3

Embryos6

Differentiation6

Donor5

Cells36

Thymus1

Fetuses2

Stem cell res1

Therapeutic purposes2

Graft2

Vitro3

Liver3

Kidney3

Cell13

Researchers5

Ethical3

Research17

Bone1

MSCs2

Progenitors2

Clinical4

Regenerate1

Neural2

Patient's1

Involves1

Orthotopic2

Allogeneic1

Endocrine1

Methods2

Therapy2

Rats2

Ovarian tissue14

Vascular1

19982

Studies showed1

Outcomes1