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  • 2016
  • In 2006 Eaves retired as required by provincial law at that time, becoming Professor Emeritus of Hematology and spending more time on several companies he founded to further the fields of cellular therapy and regenerative medicine - STEMCELL Technologies, STEMSOFT Software Inc. and Malachite Management Inc. These companies continue to grow under his leadership and by 2016, STEMCELL had over 900 employees making Canada's largest biotechnology company. (wikipedia.org)
  • In 2016, STEMCELL was awarded overall Exporter of the Year, as well as won in the Advancing Technology & Innovation category, while Dr. Eaves won in the Leadership category at the BC Export Awards. (wikipedia.org)
  • severe
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • These T cells cause continuous destruction of hematopoietic stem cells (HSCs), progenitors, and mature blood cells, leading to severe and if left untreated fatal marrow hypoplasia and pancytopenia. (springer.com)
  • Peinemann F, Grouven U, Kröger N, Pittler M, Zschorlich B, Lange S. Unrelated donor stem cell transplantation in acquired severe aplastic anemia: a systematic review. (springer.com)
  • This condition can rapidly lead to life-threatening infection, as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as leading to anaemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets. (wikipedia.org)
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • However, the severe immunosuppression that bone marrow transplantation requires causes a significant risk of serious infections in patients with large scale blisters and skin erosions. (wikipedia.org)
  • An ultrasound examination shows accumulation of chalky material (calcification) in the adrenal gland in about half of infants with LAL-D. Complications of LAL-D progress over time, eventually leading to life-threatening problems such as extremely low levels of circulating red blood cells (severe anemia), liver dysfunction or failure, and physical wasting (cachexia). (wikipedia.org)
  • Severe sickle cell crises, in some cases resulting in death, have been associated with the use of filgrastim in patients with sickle cell disorders. (wikipedia.org)
  • Heart transplantation is performed on patients with end-stage heart failure or severe coronary artery disease. (wikipedia.org)
  • leukemia
  • Bagby GC, Meyers G. Myelodysplasia and acute leukemia as late complications of marrow failure: future prospects for leukemia prevention. (springer.com)
  • The chance of recovery (prognosis) depends on how the leukemia cells look under a microscope. (powershow.com)
  • V-25 Leukemic cells in acute lymphoblastic leukemia characterized by round or convoluted nuclei, high nuclear/cytoplasmic ratio and absence of cytoplasmic graulnes. (powershow.com)
  • Although graft or bone marrow rejection can have detrimental effects, there are immunotherapy benefits when cytotoxic T lymphocytes are specific for a self antigen and can target antigens expressed selectively on leukemic cells in order to destroy these tumor cells referred to as graft-versus- leukemia effect (GVL). (wikipedia.org)
  • Multiple mutations on GATA2 gene have been recently implicated as the cause of primary immunodeficiency in patients with MonoMAC Syndrome, and cases of dendritic cell, monocyte, B NK lymphoid deficiency and leukemia. (wikipedia.org)
  • Allen C. Eaves (born 1941) was the founding Director of the Terry Fox Laboratory for Hematology/Oncology Research, which over a 25 year period (1981-2006) he grew into an internationally recognized[citation needed] centre for the study of leukemia and stem cell research. (wikipedia.org)
  • Eaves' personal research has focused on leukemia where he pioneered "culture purging" as a novel approach to doing autologous bone marrow transplantation for chronic myelogenous leukemia. (wikipedia.org)
  • regenerative medicine
  • Stem cell research plays an important role in orthopedic regenerative medicine today. (hindawi.com)
  • There, great hope was set on regenerative medicine to develop alternative therapies for cartilage damage, arthritis, large bone defects, or atrophic tendon ruptures during the last decade. (hindawi.com)
  • In this review, we focus on application of stem cells in regenerative medicine for orthopedic indications. (hindawi.com)
  • We present current approaches in stem cell-based therapy in orthopedics and review recent successes in basic science and clinical application of regenerative medicine approaches within the field. (hindawi.com)
  • Stem cells are of particular interest in regenerative medicine. (hindawi.com)
  • clinical
  • While early clinical results are already published for bone and cartilage repair, the data about tendon repair is limited to animal studies. (hindawi.com)
  • This paper aims to provide a better understanding of current basic research and clinical data concerning stem cell research in bone, tendon, and cartilage repair. (hindawi.com)
  • In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. (wikipedia.org)
  • The safety and efficacy of Caphosol has been demonstrated in a double-blind prospective, randomized clinical trial in patients undergoing bone marrow transplantation. (wikipedia.org)
  • Her current efforts are directed toward the translation of stem cell laboratory research to clinical transplantation studies and protocols. (rochester.edu)
  • chronic
  • In immunocompromised patients, B19 infection may persist for months, leading to chronic anemia with B19 viremia due to chronic marrow suppression. (wikipedia.org)
  • survival
  • Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice. (springer.com)
  • immunity
  • Heterologous immunity provides a potent barrier to transplantation tolerance. (springer.com)
  • The low number of T cells (T cell lymphopenia) and other lymphocytes appears to be responsible for the susceptibility to infections, and the poor humoral immunity is responsible for low response to vaccines. (wikipedia.org)
  • Vast
  • Mammalian hematopoiesis is a unique developmental process in which stem cells continue to generate vast numbers of diverse cell types throughout adult life. (rochester.edu)
  • gene
  • The unique capacity of Notch to function both as a cell-surface receptor and transcriptional regulator provides a mechanism by which cell-cell interactions can directly influence gene expression in neighboring cells. (rochester.edu)
  • The male bone marrow cells were found to be presenting a peptide in the MHC groove encoded by a gene on Y chromosome. (wikipedia.org)
  • The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells. (wikipedia.org)
  • Once inside the body the vector introduces the therapeutic gene into host cells, and the protein encoded by the newly inserted gene is then produced by the body's own cells. (wikipedia.org)
  • liver
  • Liver biopsy findings will generally show a bright yellow-orange color, enlarged, lipid-laden hepatocytes and Kupffer cells, microvesicular and macrovesicular steatosis, fibrosis, and cirrhosis.The only definitive tests are genetic, which may be conducted in any number of ways. (wikipedia.org)
  • Liver transplantation is the replacement of a diseased liver with a healthy liver allograft. (wikipedia.org)
  • tissue
  • This may be due to different application techniques varying from simple mesenchymal stem cell injection up to complex tissue engineering. (hindawi.com)
  • therapeutic
  • The use of human ESCs as a resource for cell therapeutic approaches is currently an intensively researched field [ 11 - 13 ]. (hindawi.com)