Transplantation of autologous bone marrow mesenchymal stem. Medical search. Frequent questions

The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)
Mesenchymal stem cells (MSCs) have immunomodulatory properties. (nature.com)
Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and biomedical interest. (biomedcentral.com)
Pain management, osteochondral, nerve, or blood vessel support by MSCs derived from both autologous and allogeneic sources have been examined. (biomedcentral.com)
MSCs can be isolated from a range of tissues, but the most commonly cited sources are bone marrow (BM), adipose tissue, muscle, bone, and perinatal tissues (e.g. (biomedcentral.com)
Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
The use of physiomimetic decellularized extracellular matrix-derived hydrogels is attracting interest since they can modulate the therapeutic capacity of numerous cell types, including mesenchymal stromal cells (MSCs). (ibecbarcelona.eu)
Adipose tissue derived mesenchymal stem cells (AT-MSCs) are relatively easy in isolation procedure compared to bone marrow-derived. (ui.ac.id)
This experimental study used cryopreserved adipose tissue derived MSCs stored in Stem Cell Medical Technology Integrated Service Unit Cipto Mangunkusumo Hospital. (ui.ac.id)
Self-restoration is only produced when the defect reaches the subchondral bone and bone marrow mesenchymal stem cells (MSCs) invade the defect. (upv.es)
Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
These correlations were not observed in group B. Conclusion: Injection of MSCs with marrow stimulation treatment was encouraging in patients older than 50 years compared with patients treated with marrow stimulation treatment alone, especially when the lesion size was larger than 109 mm(2) or a subchondral cyst existed. (researchgate.net)
Mesenchymal stem cells (MSCs) are promising candidates for cell-based therapies. (biomedcentral.com)
However, bone marrow-derived MSCs and adipose tissue-derived MSCs have not yet been directly compared with each other under human platelet lysate conditions. (biomedcentral.com)
The bone marrow- and adipose tissue-derived MSCs were cultured under human platelet lysate conditions and their biological characteristics evaluated for cell therapy (morphology, immunophenotype, colony-forming unit-fibroblast efficiency, proliferation capacity, potential for mesodermal differentiation, secreted proteins, and immunomodulatory effects). (biomedcentral.com)
Under human platelet lysate-supplemented culture conditions, bone marrow- and adipose tissue-derived MSCs exhibited similar fibroblast-like morphology and expression patterns of surface markers. (biomedcentral.com)
Adipose tissue-derived MSCs had greater proliferative potential than bone marrow-derived MSCs, while no significantly difference in colony efficiency were observed between the two types of cells. (biomedcentral.com)
However, bone marrow-derived MSCs possessed higher capacity toward osteogenic and chondrogenic differentiation compared with adipose tissue-derived MSCs, while similar adipogenic differentiation potential wase observed between the two types of cells. (biomedcentral.com)
There were some differences between bone marrow- and adipose tissue-derived MSCs for several secreted proteins, such as cytokine (interferon-γ), growth factors (basic fibroblast growth factor, hepatocyte growth factor, and insulin-like growth factor-1), and chemokine (stem cell-derived factor-1). (biomedcentral.com)
Adipose tissue-derived MSCs had more potent immunomodulatory effects than bone marrow-derived MSCs. (biomedcentral.com)
Over the past decade, MSCs which are isolated from the umbilical cord, umbilical cord blood, bone marrow (BM), adipose tissue (AT) and many other adult tissues have been explored as potential therapeutic strategies for a number of diseases [ 2 ], but AT and BM are the most widely used sources of MSC, especially in autologous cell-based therapies due to ease of harvest and potential autologous application [ 3 ]. (biomedcentral.com)
The efficacy and safety profile of mesenchymal stem cells (MSCs) augmentation in chondral procedures are controversial. (springer.com)
Mesenchymal stromal cells (MSCs) have shown benefit in other inflammatory diseases. (unav.edu)
Objectives: To evaluate the safety and feasibility of endobronchial administration of bone marrow autologous MSCs (BM-MSC) in patients with mild-to-moderate IPF. (unav.edu)
Methods: A phase I multicentre clinical trial (ClinicalTrials.gov NCT01919827) with a single endobronchial administration of autologous adult BM-MSCs in patients diagnosed with mild-to-moderate IPF. (unav.edu)
Due to their immunomodulatory properties, mesenchymal stem cells (MSCs) have come into focus as a potential therapeutic concept. (biomedcentral.com)
Magnetically isolated naive and non-naive CD4 + T-cells were stimulated under Th17-polarizing proinflammatory cytokine conditions in presence and absence of bone marrow derived mesenchymal stromal cells (MSCs). (biomedcentral.com)
Mesenchymal stem cells (MSCs) are multipotent adult stem (or stromal) cells with the capacity of self-renewal and differentiation potential towards several mesodermal linages such as osteogenic, chondrogenic and adipogenic differentiation (more citations) [ 1 ]. (biomedcentral.com)
Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
MSCs can be isolated from different locations, such as bone marrow, umbilical cord, placenta, adipose and dental tissues. (bvsalud.org)

Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or grafting stem cells to regenerate diseased tissues. (wikipedia.org)
Although such attempts produced no positive benefit, further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation as has become common practice in treatment for patients that have compromised bone marrow after disease, infection, radiation or chemotherapy. (wikipedia.org)
In general, for patients presenting damaged or destroyed bone marrow, for example after chemotherapy and/or radiation for acute myeloid leukemia (AML), bone marrow derived cells can be infused into the patients blood stream. (wikipedia.org)
Here the injected cells are able to home into the affected bone marrow, integrate, proliferate and recover or re-establish its biological function e.g. the haematopoiesis. (wikipedia.org)
However, there are two main principles by which cells facilitate therapeutic action: Stem, progenitor, or mature cell engraftment, differentiation, and long-term replacement of damaged tissue. (wikipedia.org)
After UMSC transplantation (UMSCT), the frequencies of Tregs and CD4 + memory T cells were significantly increased, and the frequencies of T helper (Th) 17 and CD4 + naive T cells were significantly decreased in peripheral blood (PB) of psoriasis patients. (nature.com)
Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
Stem Cells Transl. (sciendo.com)
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Adipose stem cells in reparative goat mastitis mammary gland. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)
Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
Bone marrow-derived mononuclear cells with their angiogenic and osteogenic properties appear to have the potential to halt the disease process when injected intralesionally following core decompression. (nih.gov)
Forty patients (60 hips) with stage I, II or III (ARCO system) osteonecrosis of femoral head were treated by either core decompression and isolated mononuclear cells (group A) or core decompression and unprocessed bone marrow injection (group B). The patients were followed up clinically and radiologically for a minimum of 2 years. (nih.gov)
Implantation of autologous bone marrow stem cells in avascular necrosis of femoral head is a safe and effective procedure and has better outcome than bone marrow for early stage of avascular necrosis of femoral head. (nih.gov)
Clinical Outcomes of Repeated Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Chronic Haemorrhagic Stroke. (openneurologyjournal.com)
O n November 17 th , BrainStorm Cell Therapeutics Inc. announced the results of their Phase 3 clinical trial testing the efficacy of their stem cell treatment, NurOwn (MSC-NTF cells), in Amyotrophic lateral sclerosis (ALS) patients. (geneonline.com)
NurOwn technology uses a subtype of the patients' bone marrow stem cells known as mesenchymal stem cells (MSC). (geneonline.com)
Following these results, the focus is now firmly on the use of stem cells for the treatment of ALS, particularly for companies that recently announced a push for Phase 3 clinical trials. (geneonline.com)
Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
To avoid immune recipient's rejection of the transplanted bioengineered lung, autologous bone marrow/adipose tissue-derived mesenchymal stem cells, lung progenitor cells or induced pluripotent stem cells are used for biofabricating the bioengineered lung. (ibecbarcelona.eu)
These physical stimuli to the organ are translated into the stem cell local microenvironment - e.g. shear stress and cyclic stretch - so that cells sense the physiological conditions in normally functioning mature lungs. (ibecbarcelona.eu)
Can mesenchymal stem cells ameliorate testicular damage? (jsurgmed.com)
Many recent studies have demonstrated the therapeutic effects of mesenchymal stem cells (MSC) in different disease models. (jsurgmed.com)
Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives. (jsurgmed.com)
Stem cell viability was measured, and then the cells were cultured to assess their PDT. (ui.ac.id)
Mesenchymal stem cells: clinical applications and biological characterization. (ui.ac.id)
Isolation and cultivation of mesenchymal stem cells from iliac crest bone marrow for further cartilage defect management. (ui.ac.id)
Safety of mesenchymal stem cells for clinical application. (ui.ac.id)
Stem Cells Int. 2012;2012:652034. (ui.ac.id)
Side-by-side comparison of the biological characteristics of human umbilical cord and adipose tissue-derived mesenchymal stem cells. (ui.ac.id)
Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites. (ui.ac.id)
Prospect of adipose tissue derived mesenchymal stem cells in regenerative medicine. (ui.ac.id)
Mesenchymal stem cells: immunology and therapeutic benefits. (ui.ac.id)
Stem Cells in Clinic and Research. (ui.ac.id)
2011. http://www.intechopen.com/books/stem-cells-in-clinic-and-research/mesenchymal-stem-cells-immunology-and-therapeutic-benefits . (ui.ac.id)
Functional recovery of spinal cord injury following application of intralesional bone marrow mononuclear cells embedded in polymer scaffold? (ui.ac.id)
Transplantation of autologous chondrocytes has been proposed to regenerate articular cartilage but this therapy fails mainly to the absence of a material support (scaffold) for the adequate stimulation of cells. (upv.es)
Stem Cell therapy means the transplant or use of stem cells or other cells to treat or prevent a disease or condition. (allstemcells.com)
Research is underway to develop various sources for stem cells, and to apply stem cell treatments for neurodegenerative diseases and conditions, diabetes, heart disease, and other conditions. (allstemcells.com)
5. Adipose Tissue-derived Stem Cells Treatment for Crohn's Fistula. (allstemcells.com)
How can we get adult stem cells? (allstemcells.com)
While bone-marrow transplantation might mitigate hematopoietic syndrome, currently there are no approved medical countermeasures to alleviate radiation-induced gastrointestinal syndrome (RIGS), resulting from direct cytocidal effects on intestinal stem cells (ISC) and crypt stromal cells. (elsevierpure.com)
We examined whether bone marrow-derived adherent stromal cell transplantation (BMSCT) could restitute irradiated intestinal stem cells niche and mitigate radiation-induced gastrointestinal syndrome. (elsevierpure.com)
Methodology/Principal Findings: Autologous bone marrow was cultured in mesenchymal basal medium and adherent cells were harvested for transplantation to C57Bl6 mice, 24 and 72 hours after lethal whole body irradiation (10.4 Gy) or abdominal irradiation (16-20 Gy) in a single fraction. (elsevierpure.com)
Conclusion/Significance: Mitigation of lethal intestinal injury, following high doses of irradiation, can be achieved by intravenous transplantation of marrow-derived stromal cells, including mesenchymal, endothelial and macrophage cell population. (elsevierpure.com)
In a recent STEM CELLS Translational Medicine article, researchers from the laboratory of Robert Bowers (Emory University, Atlanta, Georgia, USA) compared symptomatic knee osteoarthritis patients treated with intra‐articular autologous bone marrow aspirate concentrate (BMAC) and microfragmented adipose tissue (MFAT) injections with regards to their ability to provide significant pain and functional improvements [5]. (stemcellsportal.com)
For all the future showdowns of MSC-based treatments for osteoarthritis, stay tuned to the Stem Cells Portal ! (stemcellsportal.com)
STEM CELLS Translational Medicine 2019;8:1149-1156. (stemcellsportal.com)
The Stem Cells Portal provides coverage of the latest research, clinical applications, policies, and developments in the stem cell and regenerative medicine fields. (stemcellsportal.com)
The stem cells are isolated from the patient's own blood and cultured. (tci-thaijo.org)
We have isolated a cardiomyogenic cell line (CMG cell) from murine bone marrow mesenchymal stem cells. (elsevierpure.com)
These findings indicated that cell transplantation therapy for the patients with heart failure might possibly be achieved using the regenerated cardiomyocytes from autologous bone marrow cells in the near future. (elsevierpure.com)
Fukuda, K 2002, ' Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes ', Comptes Rendus - Biologies , vol. 325, no. 10, pp. 1027-1038. (elsevierpure.com)
Since progenitor cells multiply and are signaled to form tissue such as cartilage, tendon and bone when necessary, they allow your body to create the tissue it needs to heal itself. (futuremedicalgroup.com)
For over 30 years, bone marrow derived progenitor cells have been used to treat a variety of conditions because they have remarkable healing and regenerative properties. (futuremedicalgroup.com)
The marrow is then placed into a centrifuge to extract the progenitor cells and growth factors that are then used for treatment. (futuremedicalgroup.com)
Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. (futuremedicalgroup.com)
Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial. (futuremedicalgroup.com)
Osteogenic stem cells and the stromal system of bone and marrow. (ijoro.org)
Stromal stem cells: marrow-derived osteogenic precursors. (ijoro.org)
Reichert P, Rutowski R, Gosk J. Treatment of delayed union of long bones by percutaneous injection of Autologous stem cells. (ijoro.org)
Kitoh H, Kitakoji T, Tsuchiya H, Mitsuyama H, Nakamura H, Katoh M, Ishiguro N. Transplantation of marrow-derived mesenchymal stem cells and platelet rich plasma during osteogenesis - a preliminary result of these cases. (ijoro.org)
PEG-MGF has been shown to enhance the proliferation and migration of bone marrow-derived mesenchymal stem cells, which are a source of autologous stem cells for transplantation to the heart. (peptide-powder.com)
Studies have shown that mesenchymal stem cells have a positive effect on the improvement of liver diseases. (dergipark.org.tr)
The aim of this study was to investigate the potential protective effects of fetal kidney-induced mesenchymal stem cells on Doxorubicin-induced hepatotoxicity in rats. (dergipark.org.tr)
Intraperitoneal mesenchymal stem cells were treated with BrdU prior to transplantation so that they could be followed up after invivo transplantation. (dergipark.org.tr)
As a result, it has been revealed that mesenchymal stem cells administered intraperitoneally to rats with Doxorubicin-induced hepatotoxicity, prevent degeneration and necrosis in hepatocytes, and TNF-α, COX-2, and Caspase-3 levels were significantly decreased immunohistochemically, proving increased liver regeneration. (dergipark.org.tr)
2013). Short-term evaluation of autologous transplantation of bone marrow-derived mesenchymal stem cells in patients with cirrhosis: Egyptian study. (dergipark.org.tr)
2018). Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase‐ and indoleamine 2,3‐dioxygenase‐dependent manner. (dergipark.org.tr)
2014). Histological improvement following administration of autologous bone marrow-derived mesenchymal stem cells for alcoholic cirrhosis: a pilot study. (dergipark.org.tr)
Therapeutic Effects of Mesenchymal Stem Cells for Patients with Chronic Liver Diseases: Systematic Review and Meta-analysis. (dergipark.org.tr)
2008). Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. (dergipark.org.tr)
2018). Directed Differentiation of Adult Liver Derived Mesenchymal Like Stem Cells into Functional Hepatocytes. (dergipark.org.tr)
Background: Stem cells are undifferentiated cells that can turn into any number of differentiated and specific cell types. (ac.ir)
One of the main concerns in the field of stem cell therapy research is the safety of these cells. (ac.ir)
This article assessed the safety of using mesenchymal fibroblasts, keratinocytes, melanocytes and skeletal myoblasts in clinical trials.Methods: A systematic search of reliable electronic databases was performed in order to find all articles related to safety of the mentioned cells. (ac.ir)
However, according to serious complications reported for skeletal myoblast cells transplantation, giving ethical approval for using this cell type in human research requires strict commitment to precise methods (such as inclusion criteria, patient follow-up methods, and prophylactic treatments). (ac.ir)
It comprises of two types of stem cells, that are hematopoietic and mesenchymal stem cells. (powershow.com)
Bone marrow is mainly responsible for the haematopoiesis, (formation of blood cells), production of lymphocytes, and the storage of fats. (powershow.com)
A two-year follow-up study of co-transplantation with neural stem/precursor cells and mesenchymal stromal cells in ischemic stroke patients. (cellsurgicalnetwork.com)
Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. (cellsurgicalnetwork.com)
Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. (cellsurgicalnetwork.com)
Enhancing trophic support of mesenchymal stem cells by ex vivo treatment with trophic factors. (cellsurgicalnetwork.com)
Stem cells in human neurodegenerative disorders-time for clinical translation? (cellsurgicalnetwork.com)
The potential of mesenchymal stem cells for neural repair. (cellsurgicalnetwork.com)
On the contrary, reconnection of transected stumps by using biocompatible sealants may significantly facilitate the process, as well as taking the advantage of employing the adhesive as scaffold to engraft stem cells, as well as neurotrophic substances, to the injury site. (hindawi.com)
The aim of this study is to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. (unav.edu)
What are Stem Cells? (hindustanmetro.com)
A stem cell's primary function is to provide your body with specific cells and replace damaged, dead, and old ones. (hindustanmetro.com)
Millions of stem cells are needed. (hindustanmetro.com)
In order to inject stem cells into the body, stem cells are produced and expanded in a sterile environment. (hindustanmetro.com)
In advance medicine, stem cells are a promising area because they can regenerate and repair damaged tissue. (hindustanmetro.com)
As a result of their potential to regenerate damaged cells and tissues, stem cells are already used in some current therapies, such as bone marrow transplantation and anti-aging. (hindustanmetro.com)
We specialise in autologous stem cells and Regenerative medicine using hypoxic technology. (hindustanmetro.com)
We provide more than 4 cell products, including Stromal Vascular Fraction (SVF), fibroblasts, Multipotent Mesenchymal Stromal Cells (MMSC) and many more. (hindustanmetro.com)
Our focus lies on making stem cell therapy a preferred natural cure using your own body cells for treating complex disorder and chronic disabilities. (hindustanmetro.com)
We specialise in providing autologous stem cell therapeutic products using own body cells at minimal cost. (hindustanmetro.com)
Culminating to a potency that is "10 - 100 times" more than the regenerative capabilities of normal human stem cells isolated from any current standard operating procedure. (hindustanmetro.com)
With our patient-centric approach, our focus is on speeding up the therapy procedure for the patient and to provide them the best improvement in the least amount of time and superior quantity of stem cells. (hindustanmetro.com)
Apoptosis tolerance is high in our Stem cells Products. (hindustanmetro.com)
Introduction Functions of somatic stem cells are strictly governed by an appropriate balance between self-renewal and differentiation. (conferencedequebec.org)
This balance is in turn regulated by interactions between MK2-IN-1 hydrochloride stem cells and their microenvironment-the so-called niche. (conferencedequebec.org)
In the case of hematopoietic stem and progenitor cells, the dormancy of the most primitive HSPC is maintained by the bone marrow niche by means of several key molecular interactions between receptor-ligand pairs1C3. (conferencedequebec.org)
For example, it has been suggested that homophilic, N-cadherin-mediated adhesion between HSPC and mesenchymal stem cells (MSC) supports long-term maintenance of the primitive HSPC pool4C6. (conferencedequebec.org)
In recent years, peripheral HSPC have largely replaced bone marrow-derived cells for autologous transplants, and they have become the major source of stem cells also for allogeneic transplantations16C21. (conferencedequebec.org)
G-CSF, the standard and most widely used agent for this purpose over the past 25 years, mobilizes stem cells from the marrow niche by secretion of neutrophil-associated extracellular proteases which subsequently releases HSPC from their niche22,23. (conferencedequebec.org)
For example, plerixafor (AMD3100)25,26 has been proven highly effective for the mobilization of CD34+ cells for autologous transplantations, especially in poor mobilizing patients27C35. (conferencedequebec.org)
In addition to mobilizing HSPC, the interference with the CXCR4-SDF1 axis has also been proposed as a possible strategy to mobilize malignant stem cells from their protective niche, hence making tumor stem cells even more susceptible to irradiation or chemo- therapy. (conferencedequebec.org)
Autologous hematopoietic stem cells for refractory Crohn's disease. (wizaxe-prod.com)
The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. (scielo.br)
On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). (scielo.br)
The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. (scielo.br)
One explanation for deficient repair is when undifferentiated adult stem repair cells are inadequate in number or cannot be stimulated within the damaged tissue site. (journalofprolotherapy.com)
1, 2 Recently, Prolotherapists have begun to utilize the potential of autologous adipose (fat)-derived stem/stromal cells (AD-SC) within non-manipulated fat graft scaffolding, combined with high-density PRP concentrates (HD-PRP) to provide a potent biological therapeutic combination. (journalofprolotherapy.com)
At first, the mesenchymal stem cell was thought to be the primary component of this undifferentiated cell type, however it is now evident that within the adipose extracellular matrix are also adipocytic precursors (known as progenitor cells) adherent to adipocytes, and in close approximation to a variety of additional undifferentiated multipotent and pluripotent cells, including pericytes and endothelial cells, all thought to play important roles in mesenchymal-stromal derived tissue regeneration. (journalofprolotherapy.com)
Therefore we have chosen to use the term "adipose-derived stem/stromal cells" (AD-SC's), rather than simply "mesenchymal stem cells. (journalofprolotherapy.com)
However, as preclinical results provided some rationale for the use of stem cells as support cells for the dying motor neurons, stem cells are being considered as a potential treatment strategy. (csnn.eu)
Based on the preclinical models, translational human trials have been carried out using various types of stem cells, as well as a range of cell delivery methods. (csnn.eu)
Here, we provide a critical review of current clinical trials using either mesenchymal or neural stem cells to treat ALS patients. (csnn.eu)
In order to provide robust assessment of the efficacy of stem cells, it will be essential to standardize administration protocols, identify the most suitable cell type as well as to validate more reliable biomarkers of disease progression in longitudinal clinical studies. (csnn.eu)
Objective: the aim of this study was to conduct a literature review of the types of stem cells of dental origin and their applications in Dentistry. (bvsalud.org)
Results: there are five main sources of stem cells of dental origin: stem cells from dental pulp of permanent teeth and deciduous teeth, apical papilla, periodontal ligament and dental follicle. (bvsalud.org)
These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)
1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)
3 Embrionic stem cells (ESCs) are derived from the inner cell mass of the blastocyst and form all cell types, derived from the three germ layers, and are therefore pluripotent. (bvsalud.org)
Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)
In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
One type of stem cell is involved in producing blood cells and the other is involved in producing stromal cells, which are responsible for the supporting stroma. (medscape.com)
However, the yellow marrow can revert to red if there is increased demand for red blood cells, such as in instances of blood loss. (medscape.com)
As needed, the stem cells differentiate to become a particular kind of cell-a white blood cell, red blood cell, or platelet. (medscape.com)
Normally, only mature cells are released from the marrow into the bloodstream. (medscape.com)
All types of blood cells are derived from 1 common stem cell. (medscape.com)
Stem cells exist throughout the life of an individual. (medscape.com)
The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)
These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)
Bone marrow thus contains blood cells at varying stages of development. (medscape.com)
Illustration of the pelvis to show the site of bone marrow and blood cells derived from bone marrow. (medscape.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)
Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)
As age progresses, more of the red bone marrow turns into yellow bone marrow and the production of new blood cells becomes more difficult. (medscape.com)
The bone marrow stroma contains mesenchymal stem cells. (medscape.com)
The blood vessels constitute a barrier, inhibiting immature blood cells from leaving the bone marrow. (medscape.com)

Autologous osteochondral mosaicplasty and autologous chondrocyte implantation are the oldest modern cartilage repair options. (ivis.org)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
These promising therapies - as PRP therapy just mentioned or hyaluronic acid therapy (improving the viscoelastic properties of the diseased tissue) - involve numerous applications: for example after cartilage operations such as micro-fracturing, mosaicplasty or autologous chondrocyte transplantation. (primomedico.com)

Bone marrow transplants are the most common and well established cell transplantation therapies. (wikipedia.org)
From a research, medical, and business standpoint, mesenchymal stem cell (MSC)-based therapies are fascinating. (biomedcentral.com)
Bone marrow transplant is the most widely used stem cell therapy, but some therapies derived from umbilical cord blood are also in use. (allstemcells.com)
Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology. (ijoro.org)

Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Both in animal models and humans, it has been shown that cell therapy can induce therapeutic angiogenesis, making mesenchymal stromal cell-based therapy one of the most promising therapeutic alternatives. (unav.edu)

Ruengsakulrach P, Visudharom K, Chaothawee L, Belkin M. Safety and Efficacy of Intramyocardial Implantation of Peripheral Blood Stem Cell for Cardiomyopathy. (tci-thaijo.org)

A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions. (stemcellsportal.com)
In an adult, roughly half of the bone marrow is still red. (medscape.com)

Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor. (ui.ac.id)

To the best of our knowledge, this is the first report in which autogenous bone marrow transplantation, noninvasive to the iliac crest, was performed in an incomplete AFF patient. (hindawi.com)
A needle is placed into the iliac crest and approximately 30-60ccs of bone marrow is extracted. (futuremedicalgroup.com)

However, the authors hope that these findings will provide the basis for future clinical trials in osteoarthritis patients with randomized and controlled head‐to‐head comparisons of autologous tissue sources, while also factoring in tissue analysis and the exploration of multiple injections and varying MSC doses. (stemcellsportal.com)
Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis. (stemcellsportal.com)
Singh AK, Shetty S, Saraswathy JJ, Sinha A. Percutaneous autologous bone marrow injections for delayed or non-union of bones. (ijoro.org)
A Systematic Review and Meta-analysis of Mesenchymal Stem Cell Injections for the Treatment of Perianal Crohn's Disease: Progress Made and Future Directions. (wizaxe-prod.com)

Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: A meta-analysis. (stemcellsportal.com)

In recent decades, however, stem cell and cell transplantation has gained significant interest by researchers as a potential new therapeutic strategy for a wide range of diseases, in particular for degenerative and immunogenic pathologies. (wikipedia.org)
As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
Why to choose Stemcelline for Stem Cell Therapeutic Products? (hindustanmetro.com)

After more than 50 years of research, airway transplantation remains a major challenge in the fields of thoracic surgery and regenerative medicine. (biomedcentral.com)

This study aims to examine the efficacy and safety of ABM-MSC and ABM-MNC transplantation in T2DM and explores alterations in glucose-insulin homeostasis by metabolic studies. (drcalapai.com)
While this first-of-its-kind comparison underscores the overall efficacy of these MSC-based treatments for knee osteoarthritis and notes a lack of differences between adipose tissue or bone marrow origin, the authors do highlight significant limitations to their study, including the lack of a control group or randomization and a lack of analysis of BMAC/MFAT content prior to injection. (stemcellsportal.com)
To determine the safety and efficacy of intramyocardial autologous blood stem cell injection for cardiomyopathy. (tci-thaijo.org)

Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macacafascicularis. (cellsurgicalnetwork.com)

The first recording of a successful bone marrow transplant, dates back to 1956 by dr. (wikipedia.org)
Bone marrow transplant also referred to as hematopoietic stem cell. (powershow.com)
The bone marrow transplant is the last alternative generally recommended by the physicians in the cases of fatal bone marrow diseases and bone or skin cancer. (powershow.com)
Bone Marrow Transplant. (wizaxe-prod.com)

Annually an estimated 18,000 patients require potentially life-saving bone marrow transplants in the US. (wikipedia.org)
McGaw WH, Harbin M. The role of bone marrow, an experiment study of bone marrow and endosteal transplants and endosteum in bone regeneration. (ijoro.org)

2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)

Immune Reconstitution After Autologous Hematopoietic Stem Cell Transplantation in Crohn's Disease: Current Status and Future Directions. (wizaxe-prod.com)
Hematopoietic stem cell transplantation in a severe refractory Crohn's disease patient with intestinal stoma: a case report. (wizaxe-prod.com)
Resetting of the Mucosal T Cell Repertoire after Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease. (wizaxe-prod.com)

For a long time, bone marrow transplantation was the only clinically applicable method of cell transplantation, however, since the 1990s, cell therapy has been investigated for a wide scale of pathologies and disorders. (wikipedia.org)
1 ] reported that long-term alendronate therapy could cause severely suppressed bone turnover (SSBT), resulting in delayed healing of nonspinal fractures. (hindawi.com)
Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
NEURONATA-R also uses autologous bone marrow mesenchymal stem cell therapy. (geneonline.com)
4. Mesenchymal stem cell therapy for knee osteoarthritis. (allstemcells.com)
For years, stem cell assisted therapy has been accepted as a standard treatment method for the management of some diseases. (ac.ir)
Are you looking for a stem cell therapy in India but confused about where to begin from? (hindustanmetro.com)
Why Should I consider Stem Cell Therapy? (hindustanmetro.com)
Autologous stem cell transplantation in refractory Crohn's disease - low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. (wizaxe-prod.com)
A Review on Behalf of the EBMT Autoimmune Diseases Working Party and the Autologous Stem Cell Transplantation In Refractory CD-Low Intensity Therapy Evaluation Study Investigators. (wizaxe-prod.com)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)

Autologous Haematopoietic Stem Cell Transplantation for Crohn's Disease: A Retrospective Survey of Long-term Outcomes from the European Society for Blood and Marrow Transplantation. (wizaxe-prod.com)
Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial. (wizaxe-prod.com)
Improving safety of autologous haematopoietic stem cell transplantation in patients with Crohn's disease. (wizaxe-prod.com)

This type of cartilage repair technique is often fortified by bone marrow acquired autologous mesenchymal stem cell support. (ivis.org)
These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
EN] Articular cartilage is a tissue with low capacity for self-restoration due to its avascularity and low cell population. (upv.es)

It is located on the surface of the subchondral bone covering the diarthrodial joints. (upv.es)

Bone marrow first appears in the clavicle near the end of fetal life and becomes active about 3 weeks later. (medscape.com)

Bone marrow harvested progenitor cell treatment. (futuremedicalgroup.com)
If you are interested in discussing if a Bone Marrow Harvested Progenitor Cell treatment may be right for you, please contact us for additional information. (futuremedicalgroup.com)

The bone marrow market is expected to gain market growth in the forecast period of 2021 to 2028. (powershow.com)

Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
But the stem cell research is responsibly undergoing for treating patients. (allstemcells.com)
Purpose: To compare the clinical outcomes of MSC injection and arthroscopic marrow stimulation treatment with those of arthroscopic marrow stimulation treatment alone for the treatment of OLTs in older patients. (researchgate.net)
Patients were divided into 2 groups: 35 patients (37 ankles) treated with arthroscopic marrow stimulation treatment alone (group A) and 30 patients (31 ankles) who underwent MSC injection along with arthroscopic marrow stimulation treatment (group B). Clinical outcomes were evaluated according to the visual analog scale (VAS) for pain, the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale, and the Roles and Maudsley score. (researchgate.net)
15 patients with delayed and nonunion of long bone fractures were studied between January 2013 to January 2015 and were followed up for a period of 1 year. (ijoro.org)
A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. (cellsurgicalnetwork.com)
Results: 21 bone marrow samples were obtained from 17 patients. (unav.edu)
About 10C15% of patients intended for autologous transplantation have difficulties in mobilizing an adequate amount of HSPC for transplantation24. (conferencedequebec.org)

For extended osteochondral defects new types of osteochondral allograft transplantation are recommended. (ivis.org)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)

The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
With improved understanding of tissue healing and regeneration, stem cell Prolotherapy is gaining significant clinical importance and potential. (journalofprolotherapy.com)

The present report shows a minimally invasive procedure, which could facilitate bone union in incomplete AFF. (hindawi.com)
Percutaneous autologous bone marrow injection is a minimally invasive, safe and cost effective option in the management of delayed and nonunion of long bone fractures and gives good functional results. (ijoro.org)

However, NSI-566 is slightly different as it uses spinal cord neural stem cell transplantation. (geneonline.com)

17.Shenoy RM, Pinto D, Dinesh KVN, Chandra G. Osteoinduction using autologous bone marrow in difficult orthopaedic problems - a clinical study. (ijoro.org)

A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. (futuremedicalgroup.com)
Various modalities of treatment are available for the management of delayed and nonunion of long bone fractures. (ijoro.org)
Romano CL, Romano D, Logoluso N. Low-intensity pulsed ultrasound for the treatment of bone delayed union or nonunion: a review. (ijoro.org)
Treatment of ununited fractures by onlay bone grafts without screws or tie fixation and without breaking down of fibrous union. (ijoro.org)
Bone marrow injection in treatment of long bone nonunion. (ijoro.org)
Mini-invasive treatment for delayed or nonunion: the use of percutaneous autologous bone marrow injection. (ijoro.org)

Anatomy33

Organisms11

Diseases41

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment75

Phenomena and Processes42

Disciplines and Occupations2

Technology, Industry, Agriculture5

Information Science2

Named Groups2

Health Care11

MSCs30

Cells166

Chondrocyte3

Therapies4

Stromal cell2

Implantation1

Adult2

Granulocyte-macrop1

Iliac crest2

Injections4

Safety of mesenchymal1

Therapeutic3

Regenerative medicine1

Efficacy3

Human mesenchymal1

Transplant4

Transplants2

Fibroblasts1

Hematopoietic stem3

Therapy11

Crohn's Disease3

Cartilage3

Subchondral bone1

Fetal1

Progenitor cell2

20211

Patients8

Defects2

Regeneration2

Minimally2

Neural1

Orthopaedic1

Treatment6