• Furthermore, principles learned from the study of whole organ transplantation may find application in the emerging field of regenerative medicine, in which the use of immune suppression is likely to be contraindicated. (ox.ac.uk)
  • Develop insights into immunosurveillance and how cancer and organ transplantation overcome immune responses. (sfu.ca)
  • Immune suppression after organ transplantation is associated with a markedly increased risk of nonmelanoma skin cancer and a few virus-associated cancers. (nih.gov)
  • Transplantation Laboratory has been organising Principles of organ transplantation course every other year from 2005 onwards for medical students, nurses, and registrars. (helsinki.fi)
  • Find here the program of the Principles of organ transplantation 2016 course in Finnish. (helsinki.fi)
  • Renkonen R, Lemström K, Mäkisalo H. Organ and tissue transplantation, In the textbook of Immunology: microbiology, immunology, and infectious diseases (In Finnish: Elin- ja kudossiirrot, Immunologia: mikrobiologia, immunologia ja infektiosairaudet). (helsinki.fi)
  • His postdoctoral training was performed on minor H antigens in organ- and stem-cell transplantation in the laboratory of Prof. Dr. Els Goulmy, Leiden, The Netherlands. (umcutrecht.nl)
  • Induction of immunologic tolerance has been achieved and studied in numerous laboratory animal models, but it remains an elusive goal in clinical organ transplantation and in the management of autoimmune disease in humans. (medscape.com)
  • Transplantation is the most effective treatment for end-stage organ failure, but organ survival is limited by immune rejection and the side effects of immunosuppressive regimens. (lu.se)
  • Organ and tissue transplantation in the European union : management of difficulties and health risks linked to donors / edited by Yvon Englert. (who.int)
  • Legislative responses to organ transplantation / edited by World Health Organization. (who.int)
  • A secondary advantage is that islet cell transplantation appears to help maintain normoglycemia in patients who require total pancreatectomy for pain due to chronic pancreatitis. (merckmanuals.com)
  • Journal of Allergy and Clinical Immunology. (lu.se)
  • Relapse and graft- versus -host disease (GvHD) are the main impediments to the clinical success of allogeneic hematopoietic cell transplantation (HCT) in curing malignant blood disorders. (haematologica.org)
  • We tested this novel hypothesis in over 6,000 HCT from 8/8 HLA-matched UD reported to the European Group for Blood and Marrow Transplantation (EBMT), to demonstrate that HLA-DPB1 non-TPHE mismatches were associated with worse relapse-free survival and overall survival than TPHE mismatches, present in 21.7% of single HLA-DPB1 disparate pairs. (haematologica.org)
  • With the use of tissue typing and anti-rejection drugs, transplantation of organs and the control of the anti-transplant immune response have made huge strides in the past 50 years. (openstax.org)
  • Tissue transplantation is more complicated than blood transfusions because of two characteristics of MHC molecules. (openstax.org)
  • They determine tissue type for transplantation and cause allograft rejections. (bvsalud.org)
  • Betjes Michiel G.H., Peereboom Emma T.M., Otten Henny G., Spierings Eric 30 Aug 2022, In: Frontiers in Immunology. (umcutrecht.nl)
  • Niemann Matthias, Matern Benedict M, Spierings Eric 29 Jul 2022, In: Frontiers in Immunology. (umcutrecht.nl)
  • Frontiers in Immunology. (lu.se)
  • [ 3 ] Seemingly impossible without genetic identity, the field of transplantation was left silent for another 20 years. (medscape.com)
  • Long-term transplant acceptance in the absence of immunosuppressive therapy remains the ultimate goal in the field of transplantation and many studies are exploring potential therapies. (lu.se)
  • It takes advantage of combining data from all transplant programmes in one unique system to perform comprehensive nationwide reporting and to promote translational and clinical post-transplant outcome research in the framework of Swiss transplantation medicine. (bmj.com)
  • Before transplantation, patients showed altered immune cell composition, and regulatory cells were better than standard therapy at restoring normal composition," explains Prof. Sawitzki. (charite.de)
  • Because SIRs for most types of cancer were not increased before transplantation, immune suppression may be responsible for the increased risk. (nih.gov)
  • The Center of Research in Transplantation and Translational Immunology (CR2TI) gathers researchers and clinicians who develop projects aiming to improve knowledge, diagnosis and treatments in transplantation and immune-mediated inflammatory diseases. (ersnet.org)
  • Advantages of living donation for the recipient include shorter waiting times and shorter cold ischemic times for explanted organs, largely because transplantation can be scheduled to optimize the patient's condition. (msdmanuals.com)
  • For trainees who are on our services, it's important to show them the impact that we can have on our patients by offering them transplantation, getting them through successful transplantation, and seeing how the patient's quality of life can significantly improve. (medscape.com)
  • These criteria plus the absence of extrahepatic and major vessel involvement satisfy the Milan criteria, used to assess suitability of liver transplantation for patients who have cirrhosis and hepatocellular carcinoma. (msdmanuals.com)
  • Promising preliminary results are also emanating from an ongoing open randomized clinical study conducted in collaboration with Prof Katarina LeBlanc, KI, Stockholm, in which the efficacy of islet transplantation with or without the support of autologous MSC is investigated. (uu.se)
  • The patients will receive autologous MSC, although substantially expanded in vitro prior to transplantation, thereby avoiding potential risk of HLA immunization, transfer of viral infections and other diseases. (uu.se)
  • This is followed by a detailed review of the current progress in the field of regulatory T-cell therapy in transplantation and the translation of this therapy to the clinical setting. (lu.se)
  • The new cell therapy was able to reduce the need for immunosuppression in approximately 40 percent of patients, thereby minimizing the risk of side effects," says the study's first author, Prof. Dr. Birgit Sawitzki of the Institute for Medical Immunology on Campus Virchow-Klinikum. (charite.de)
  • His current scientific interest focusses on the role of indirect recognition of mismatched HLA in transplantation and on post-transplant immunomonitoring via Next Generation Sequencing of T- and B-cell receptors and immunoglobulins. (umcutrecht.nl)
  • One of the first clinically relevant observations pertaining to transplantation was made by Dr. Earl Padgett in the 1920s, when skin grafts were noted to survive longer when skin from close relatives was used. (medscape.com)
  • Dr. Spierings received his PhD degree as immunologist at the Leiden University Medical Center, The Netherlands and was subsequently recognized as SMBWO Immunologist by the Dutch Society for Immunology. (umcutrecht.nl)