• AnxA1 2-26 ) on heterologous skin scaffolds transplantation in BALB/c mice, focusing on inflammation and angiogenesis. (frontiersin.org)
  • In contrast, robust heterologous vaccination with a peptide derived from the BCR-ABL fusion (BAp), a key driver mutation, generated a small population of mice that survived long-term. (jimmunol.org)
  • Checkpoint blockade strongly synergized with heterologous vaccination to enhance overall survival in mice with leukemia. (jimmunol.org)
  • On days 3, 6 or 12 after transplantation the mice were killed and the grafts either prepared for immunohistochemistry or real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR). (diva-portal.org)
  • These findings demonstrate that the transplantation of heterologous T-MSC-SCs induced neuromuscular regeneration in mice and suggest they could be useful for the therapeutic treatment of patients with CMT1A disease. (mdpi.com)
  • After transplantation into β-glucuronidase (GUSB)-deficient NOD/SCID/mucopolysaccharidosis type VII mice, we characterized the distribution of lineage-depleted human umbilical cord blood-derived cells purified by selection using high aldehyde dehydrogenase (ALDH) activity with CD133 coexpression. (elsevier.com)
  • The influence of apoE gene dosage on serum lipid concentrations was determined by transplantation of homozygous apoE-deficient (apoE −/− ), heterozygous apoE-deficient (apoE +/− ), and wild-type (apoE +/+ ) bone marrow in homozygous apoE-deficient mice. (ahajournals.org)
  • Transplantation of skin tissue expressing this epitope onto naïve arthritis susceptible mice induced transient tolerance to the grafted epitope and arthritis protection. (lu.se)
  • A similar observation was also made in the autologous CIA model where transgenic mice expressing the heterologous CII protein in cartilage (MMC mice) were used. (lu.se)
  • Sera obtained from mice following infection with high and low doses of cultured B. burgdorferi sensu stricto, transplantation of infected tissue (host-adapted spirochetes), or tick-borne inoculation all showed protective activity in passive immunization assays. (asm.org)
  • Infection and disease were similar in mice infected with cultured spirochetes or by transplantation. (asm.org)
  • In contrast, actively immune mice infected with different Borrelia species ( B. burgdorferi sensu lato, B. burgdorferi sensu stricto cN40, Borrelia afzelii PKo, and Borrelia garinii PBi) and then treated with an antibiotic were resistant to challenge with cultured homologous but not heterologous spirochetes. (asm.org)
  • Similar results were achieved for actively immune mice challenged by transplantation and by passive immunization with sera from mice infected with each of the Borrelia species and then challenged with cultured spirochetes. (asm.org)
  • Arthritis and carditis in mice that had immunizing infections with B. afzelii and B. garinii and then challenged by transplantation with B. burgdorferi sensu stricto were equivalent in prevalence and severity to those in nonimmune recipient mice. (asm.org)
  • As determined with immunoblots against cultured B. burgdorferi lysate antigen, the antibody response in mice infected following inoculation with low doses of spirochetes is similar to that in mice infected with tick-borne spirochetes as well as that in mice infected with host-adapted spirochetes introduced by transplantation of infected tissue ( 9 , 15 , 27 , 38 , 43 ). (asm.org)
  • We have tested hepatocytes from multiple donors and sources and have not seen any adverse reactions in the more than 40 animals we have tested so far….We conclude that cadaveric hHeps from heterologous sources produce sustained levels of circulating FIX that can almost completely abolish the clotting defect in our hemophilic mice for up to a year after transplantation (if not longer). (genengnews.com)
  • Successful organ transplantation requires treatment approaches that provide effective control of the undesired T cell-dependent rejection response while permitting the maintenance of protective immunity against pathogens. (jimmunol.org)
  • Much like the field of autoimmunity, recent attention in the field of transplantation has focused on the effects of pathogens and protective immunity in the transplant setting. (jimmunol.org)
  • Importantly, cyclophosphamide spares non-alloreactive T-cells, preserving immunity and leading to a low incidence of nonrelapse mortality after HLA-haploidentical transplantation. (springer.com)
  • It has been widely thought that the increased immunity afforded by heterologous prime-boost vaccination is mainly due to the minimization of immune responses to the carrier vectors, which allows a progressive build up of immunity against defined epitopes and the subsequent induction of broader immune responses against pathogens. (biomedcentral.com)
  • Ethics, access and safety in tissue and organ transplantation : issues of global concern, Madrid, Spain, 6-9 October 2003 : report. (who.int)
  • The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease. (freepatentsonline.com)
  • 1. A method of treating a patient in need of cell or tissue transplantation comprising administering to or transplanting into said patient at least one cell or tissue obtained from a cloned ungulate animal or embryo. (freepatentsonline.com)
  • Fetuses and animals derived from a single clonal line offer a safe and genetically modifiable source of transplantation tissue. (freepatentsonline.com)
  • My main area of research is studying the immunobiological processes that result in tissue damage, which has applications in transplantation immunobiology and cancer immunotherapy. (ncl.ac.uk)
  • Transplantation of tissue typical of one area to a different recipient site. (bioportfolio.com)
  • The tissue may be autologous, heterologous, or homologous. (bioportfolio.com)
  • This study provides evidence for the short-term (7-day) anatomic and functional success of corneal transplantation with a tissue-engineered corneal endothelium reconstructed on a devitalized carrier. (arvojournals.org)
  • ALDH-expressing progenitor cells demonstrated widespread and tissue-specific distribution of variable cellular phenotypes, indicating that these adult progenitor cells should be explored in transplantation models of tissue damage. (elsevier.com)
  • Transplantation of skin tissue expressing this epitope onto naïve. (lu.se)
  • Myoblasts transplantation has also been tried for skeletal muscle tissue engineering [ 6 ] but it failed due to the immunogenic properties of these cells. (biomedcentral.com)
  • Using tissue transplantation, we show that melanophore patterning depends upon the underlying somitic cells, the myotomal derivatives of which - both slow- and fast-twitch muscle fibres - are themselves significantly disorganised in the region of the ectopic collar. (biologists.org)
  • Here, we show that a heterologous immune response - specifically, virally induced alloreactive memory - is a potent barrier to tolerance induction. (jci.org)
  • Ravindra K, Leventhal J, Song D, Ildstad ST (2012) Chimerism and Tolerance in Solid Organ Transplantation. (omicsonline.org)
  • Donor-specific tolerance has been referred to as the "Holy Grail" of organ transplantation. (omicsonline.org)
  • However, since the heterologous CII sequence can be posttranslationally modified (PTM) where lysines can be glycosylated we also investigated the differential effect of these epitopes on tolerance and pathology of T cells. (lu.se)
  • 2002 . Reversal of tolerance induced by transplantation of skin expressing the immunodominant T cell epitope of rat type II collagen entitles development of collagen-induced arthritis but not graft rejection. (lu.se)
  • Our studies aimed to refine the balancing act of immunomodulation following transplantation, in order to promote the tolerance of a foreign organ while simultaneously maintaining protective, pathogen-specific immune responses and limiting off-target side effects. (emory.edu)
  • Transplant international : official journal of the European Society for Organ Transplantation. (ethicshare.org)
  • In recent years, organ transplantation has emerged as standard medical care for many forms of end stage organ failure. (jimmunol.org)
  • The worldwide shortage of organ donors for purposes of transplantation would be overcome if the problems associated with xenografting could be solved. (springer.com)
  • Organ transplantation between widely disparate species. (springer.com)
  • 1995 (Sept) Lecturer in Molecular Biology of Organ Transplantation, Department of Surgery, University of Newcastle Upon Tyne. (ncl.ac.uk)
  • 3. I was awarded special recognition award by Roche Organ Transplantation research Fund for my contribution to research in Transplantation (cash award of 1000 Swiss Francs)-April 2011. (ncl.ac.uk)
  • Transplantation has become standard of care to treat end-organ failure, replacing a failed organ with a functioning one. (omicsonline.org)
  • Conventional HSCT involves the use of aggressive myeloablative conditioning that would not be acceptable in the context of organ transplantation where the recipients have severe physiologic derangement from end stage organ failure. (omicsonline.org)
  • Transplantation is a widely accepted treatment for many end-stage organ diseases. (emory.edu)
  • End-organ disease has emerged as a principal cause of morbidity and mortality in HIV infection, but organ transplantation historically was not made available to HIV-infected individuals. (ucsf.edu)
  • Pig-to-non-human primate heart transplantation: the final step toward clinical xenotransplantation? (helsinki.fi)
  • With an estimated 3.9 million North Americans chronically infected, complications from Hepatitis C infection is now the leading reason for liver transplantation in the United States. (google.com)
  • Liver or combined liver/kidney transplantation has been used to treat those with the most severe clinical manifestations. (deepdyve.com)
  • Phase I/II Trial of Liver Derived Mesenchymal Stem Cells in Pediatric Liver Based Metabolic Disorders: A Prospective, Open Label, Multicenter, Partially Randomized, Safety Study of One Cycle of Heterologous Human Adult Liver-Derived Progenitor Cells (HepaStem®) in Urea Cycle Disorders and Crigler-Najjar Syndrome patients. (nih.gov)
  • FIX is produced in the liver, so liver transplantation is an alternative long-term therapeutic option. (genengnews.com)
  • Depending on the initial number of transplanted cells, anywhere from 10%- 90% of the mouse liver can be humanized by this transplantation and selection approach," the team writes. (genengnews.com)
  • Homologous and heterologous immune sera may inactivate leukemic cells in vitro . (aacrjournals.org)
  • Resistance to homologous transplantation of leukemic cells may be overcome by inoculation of large doses of cells into very young animals. (aacrjournals.org)
  • Typically, protein grafting involves the transplantation of protein side chains from a functional motif onto structurally homologous regions of scaffold proteins. (iavi.org)
  • Results from a placebo-controlled trial provide a strategy for improving fecal microbiota transplantation (FMT) for patients with recurrent Clostridium difficile infection. (medicalxpress.com)
  • The study, published online this week in mBio , an open-access journal of the American Society for Microbiology, identified microorganisms that are key for cure with fecal microbiota transplantation. (medicalxpress.com)
  • CIA is induced in susceptible mouse strains after immunization with heterologous type II collagen (CII). (lu.se)
  • Furthermore, the ability to isolate and expand from patients various types of muscle progenitor cells capable of committing to the myogenic lineage provides the opportunity to establish cell lines that can be used for transplantation following ex vivo manipulation and expansion. (frontiersin.org)
  • In this study, we used heterologous MTSs of human, nuclear‐encoded mitochondrial proteins, to target the human MCM protein into the mitochondria. (deepdyve.com)
  • For his doctorate, he had worked on the transplantation of mouse cancers into rats. (encyclopedia.com)
  • Evidence that intrathymic islet transplantation does not prevent diabetes or subsequent islet graft destruction in RT6-depleted, diabetes-resistant BioBreeding/Worcester rats. (umassmed.edu)
  • Emphasis will be placed on describing the potential of using the patient own stem cell as source of transplantation and the challenges that gene editing technologies face in the field of regenerative biology. (frontiersin.org)
  • 4 Heterologous type I collagen (HTIC) has been shown to promote cell and fibroblast proliferation and improve cutaneous extracellular matrix metabolism. (jcadonline.com)
  • Similarly, the effects of an encounter with a given pathogen can vary dramatically dependent on if the infection occurs concurrently with, before, or after transplantation. (jimmunol.org)
  • In the new study, Dr. Sadowsky and colleagues conducted a clinical trial in 27 patients with recurrent C. difficile infection, using fecal microbiota from healthy patients (a heterologous transplant ) and, as a placebo, the patient's own stool microbes (an autologous transplant). (medicalxpress.com)
  • Rapamycin, an anti-fungal macrolide used for decades in transplantation to inhibit graft-specific T cell proliferation, has recently been shown to paradoxically enhance CD8 + T cell responses to pathogen infection. (emory.edu)
  • Data from the early years of the epidemic are limited to case reports and small case series, but in general, mortality was high, particularly in those with unrecognized HIV infection at the time of transplantation, and HIV-infected patients experienced significantly higher 5-year mortality and rates of graft loss relative to HIV-uninfected individuals. (ucsf.edu)
  • Induction of Cross-neutralizing Antibodies by Sequential Immunization with Heterologous Papillomavirus L1VLPs and its Implications for HPV Prophylactic Vaccines. (physiciansweekly.com)
  • The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. (freepatentsonline.com)
  • Heterologous antibodies are encoded by immunoglobulin genes not normally found in the genome of that species of non-human animal. (freepatentsonline.com)
  • In one aspect of the invention, one or more transgenes containing sequences of unrearranged heterologous human immunoglobulin heavy chains are introduced into a non-human animal thereby forming a transgenic animal capable of functionally rearranging transgenic immunoglobulin sequences and producing a repertoire of antibodies of various isotypes encoded by human immunoglobulin genes. (freepatentsonline.com)
  • Such heterologous human antibodies are produced in B-cells which are thereafter immortalized, e.g., by fusing with an immortalizing cell line such as a myeloma or by manipulating such B-cells by other techniques to perpetuate a cell line capable of producing a monoclonal heterologous antibody. (freepatentsonline.com)
  • In 2014, according to the World Marrow Donor Association (WMDA), stem cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone marrow donations, 12,506 peripheral blood stem cell donations, and 3,949 cord blood units). (wikipedia.org)
  • My subsequent work has convincingly shown that this chemokine-GAG interaction is essential for in vivo activity of these cytokines ( American Journal of Transplantation, 2010, 10:47-58, PNAS, 2012 ). (ncl.ac.uk)
  • Transplantation is the preferred method of treatment for end-stage renal disease (ESRD) in children. (clinicaltrials.gov)
  • 18 Month Outcomes of Heterologous Bilateral Hand Transplantation in a Child: A Case Report The Lancet Child & Adolescent Health 1(1): 35-44, 2017. (upenn.edu)
  • left panels) and the corresponding heterologous allo-specific responses (right panels). (jci.org)
  • Successful transplantation requires the establishment of an ongoing state in which there is simultaneous inhibition of the undesired T cell-dependent rejection response and yet retention of the ability to develop effective cell-mediated primary and memory responses to pathogens. (jimmunol.org)
  • While CoB better targets graft-reactive immune responses and offers a reduced toxicity profile compared to current standard of care drugs, several barriers remain that limit the widespread adoption of CoB in transplantation. (emory.edu)
  • These viruses contain a single or plurality of sequences encoding antigens from pathogenic viruses heterologous to the recombinant virus. (federallabs.org)
  • Using this approach, we previously transplanted the human immunodeficiency virus 2F5 and 4E10 epitopes onto heterologous proteins to design novel 'epitope-scaffold' antigens. (iavi.org)