• Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
  • Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
  • In the last two decades allogeneic hematopoietic cell transplantation (HCT) has been used with increasing frequencies in hematologic malignancies with curative intent. (haematologica.org)
  • NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies. (sagepub.com)
  • Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. (sagepub.com)
  • We have focused on studying T cells in the setting of allogeneic hematopoietic cell transplantation (allo-HCT). (umaryland.edu)
  • Researchers undertook the clinical trial because relapse remains a leading cause of death after allogeneic hematopoietic cell transplantation for patients with high-risk leukemias. (fredhutch.org)
  • The efficacy of allogeneic hematopoietic cell transplantation (HCT) in hematologic malignancies can in large part be attributed to a graft-versus-tumor (GVT) effect, by which the donor immune system achieves immunologic control of the tumor. (mhmedical.com)
  • Welcome to the Blood and Marrow Transplantation & Cellular Therapy Division. (stanford.edu)
  • 10 Data from the European Society for Blood and Marrow Transplantation (EBMT) megafile database indicates that the graft-versus-tumour effect achieved with allo-SCT is weaker and PFS rates lower in MM than in other types of haematological cancers. (medicalupdateonline.com)
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • It is closely linked with graft-versus-host disease (GvHD), as the underlying principle of alloimmunity is the same. (wikipedia.org)
  • CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect. (wikipedia.org)
  • Whereas graft-versus-host-disease (GvHD) has a negative impact on the host, GvL is beneficial for patients with hematopeietic malignancies. (wikipedia.org)
  • After HSC transplantation both GvL and GvHD develop. (wikipedia.org)
  • The interconnection of those two effects can be seen by comparison of leukemia relapse after HSC transplantation with development of GvHD. (wikipedia.org)
  • When transplanting T-cell depleted stem cell transplant, GvHD can be partially prevented, but in the same time the GvL effect is also reduced, because T-cells play an important role in both of those effects. (wikipedia.org)
  • The possibilities of GvL effect in the treatment of hematopoietic malignancies are limited by GvHD. (wikipedia.org)
  • There are some strategies to suppress the GvHD after transplantation or to enhance GvL but none of them provide an ideal solution to this problem. (wikipedia.org)
  • When transplanting HSC during AML, T-cells are usually selectively depleted to prevent GvHD while NK cells help with the GvL effect which prevent leukemia relapse. (wikipedia.org)
  • When using non-depleted T-cell transplant, cyclophosphamide is used after transplantation to prevent GvHD or transplant rejection. (wikipedia.org)
  • Other strategies currently clinically used for suppressing GvHD and enhancing GvL are for example optimization of transplant condition or donor lymphocyte infusion (DLI) after transplantation. (wikipedia.org)
  • G-CSF can help to enhance GvL effect and suppress GvHD by reducing levels of LPS and TNF-α. (wikipedia.org)
  • Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). (nature.com)
  • Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
  • GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
  • Adoptive Allogeneic T-cell therapy (ATCT) might be curative for MM, however current ATCT protocols often lead to graft versus host disease (GvHD). (biomedcentral.com)
  • Transplanting only tumor reactive donor T cells that mediate a graft-versus-myeloma (GvM) but not GvHD may overcome this problem. (biomedcentral.com)
  • These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
  • Since GvT responses involve T-cell recognition of tumor-specific peptides presented by MHC molecules [ 14 ], it may be possible to identify and select donor T cells that provide beneficial GvT responses but minimal GvHD risk. (biomedcentral.com)
  • These data highlight the possibility that tumor-specific ATCT may lead to long-term disease-free survival without GvHD in patients with MM. (biomedcentral.com)
  • However, graft-versus-host disease (GVHD) remains a major obstacle for more successful application of allo-HCT. (umaryland.edu)
  • Therefore, our research aims at developing novel strategies that can prevent GVHD while balancing a reconstituted immune system capable of maintaining tumor immunosurveillance and infection immunity. (umaryland.edu)
  • GVHD is a major complication of stem cell transplantation. (fredhutch.org)
  • An obstacle to survival is that the beneficial graft-vs.-tumor effect of a transplant can be offset by concurrent GVHD. (fredhutch.org)
  • Since more than 20 years, I have been interested in the field of the T-cell response either after hematopoietic stem cell allo-transplantation or in the anti-tumor effect to modulate Graft versus Host disease (GvHD) or to initiate anti-tumoral effects (Graft. (innovativetherapiesdays.com)
  • Differentiation of naïve donor T cells into effector cells subsequently occurs, resulting in immunologic attack on host tissues and the potential development of graft-versus-host disease (GVHD) ( 2 ). (mhmedical.com)
  • While allogeneic transplantation can be life saving for patients with hematologic malignancies, or inherited disorders such as several forms of immuno-deficiency, the transplant-related side effects and complications remain the biggest hurdles. (stanford.edu)
  • This phenomenon could be offset by a dual-CAR system incorporating both an activating CAR against the cognate tumor antigen and an NK self-recognizing inhibitory CAR that transferred a 'don't kill me' signal to NK cells upon engagement with their TROG + siblings. (nature.com)
  • This system prevented trogocytic antigen-mediated fratricide, while sparing activating CAR signaling against the tumor antigen, and resulted in enhanced CAR-NK cell activity. (nature.com)
  • CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. (nature.com)
  • SEATTLE - Feb. 27, 2013 - In a significant advance for harnessing the immune system to treat leukemias, researchers at Fred Hutchinson Cancer Research Center for the first time have successfully infused large numbers of donor T-cells specific for a key anti-leukemic antigen to prolong survival in high-risk and relapsed leukemia patients after stem cell transplantation. (fredhutch.org)
  • Reporting results of a pilot clinical trial in the Feb. 27 issue of the journal Science Translational Medicine , researchers describe the use of T-cells that were taken from a donor, programmed in the lab to recognize the Wilm's Tumor Antigen 1 (WT1) and kill leukemia cells, grown in large numbers, and then infused into patients to promote anti-leukemic activity. (fredhutch.org)
  • Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
  • 8 The pivotal trial testing ATG in the setting of unrelated donors and intensive conditioning suggested a significant reduction in the incidence of chronic graft- versus -host disease without an increase in the risk of relapse. (haematologica.org)
  • While the graft-versus-tumor effect provided by the donor graft can be very powerful in controlling the disease, disease relapse is still the primary reason that patients do not do well after an allogeneic transplantation. (stanford.edu)
  • Use of donor-derived CAR T cell for relapse prophylaxis, minimal residual disease clearance or salvage from relapse is therefore highly effective, and risk of graft versus host disease flare is very low. (arizona.edu)
  • Unfortunately, such strategies are not always successful, and may adversely affect immune reconstitution leading to infection or a reduced GVT effect that may result in cancer relapse or secondary malignancy. (umaryland.edu)
  • Some blood cancer patients, especially those with chronic myeloid leukemia (CML), who have a relapse after stem cell transplantation or for whom transplantation isn't successful, may benefit from an immune cell treatment called donor lymphocyte infusion. (tlls.org)
  • All four survived after T-cell therapy without relapse for more than 30 months without suffering graft-vs.-host-disease and required no additional anti-leukemic treatment, according to the study. (fredhutch.org)
  • The increased understanding of immune tolerance and allogeneic antileukemic immune reactivity has led several investigators to develop optimized conditioning protocols and new strategies to manipulate the effector cells either within the graft or in vivo . (haematologica.org)
  • Analysis of immunologic recovery showed fast reappearance of potentially immunocompetent natural killer (NK) and T cells, which might have acted as effector cells responsible for the graft-versus-tumor (GVT) effect. (lu.se)
  • γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
  • While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
  • The stem cell transplantation procedure (also called a bone marrow or cord blood transplant ) is typically preceded by chemotherapy and radiation therapy to eliminate as much of the cancer as possible. (autm.net)
  • Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
  • Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. (sagepub.com)
  • Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
  • We used an MHC-matched/miHA-disparate B10.D2 → Balb/c bone marrow transplantation (BMT) murine model and MOPC315.BM MM cells to develop an ATCT protocol consisting of total body irradiation, autologous-BMT and infusion of selective, myeloma-reactive lymphocytes of T cell receptor (TCR) Vβ 2, 3 and 8.3 families (MM-auto BMT ATCT). (biomedcentral.com)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • Donor lymphocyte infusion has been helpful in treating relapsed CML after allogeneic bone marrow transplantation. (tlls.org)
  • A beneficial variant of GVH is the graft-versus-leukaemia (GVL) effect that is sometimes witnessed after bone marrow transplantation in leukaemia patients. (wur.nl)
  • Currently, a small number of SAPs that can elicit a GVL effect are known and these are used to select the right bone marrow donor for a leukaemia patient. (wur.nl)
  • Cleveland BioLabs Announces Publication of Studies on Effect of Entolimod(TM) (CBLB502) on Graft-Versus-Tumor Activity in Models of Allogeneic Bone Marrow Transplantation . (mohanfoundation.org)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
  • The efficacy of allo-SCT in MM relies on the transplanted immune system having an anti-tumour effect on the host bone marrow, the so-called graft-versus-myeloma (GvM) effect. (medicalupdateonline.com)
  • Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)
  • The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)
  • As of June 30, 2017, nearly 83,925 liver transplant recepients were living with a functioning liver graft. (medscape.com)
  • An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
  • A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease. (nature.com)
  • Oral beclomethasone dipropionate for treatment of human intestinal graft-versus-host disease. (nature.com)
  • Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes. (nature.com)
  • 12 Interestingly, ATG reduced the cumulative incidence of acute graft- versus -host disease while it did not affect the rate of chronic graft- versus -host disease. (haematologica.org)
  • Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
  • Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
  • In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
  • In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
  • [6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
  • Only five out of 72 patients (6.9%) developed graft versus host disease. (arizona.edu)
  • These single amino acid polymorphisms (SAPs) play a key role in graft-versus-host (GVH) effects that often accompany tissue transplantations. (wur.nl)
  • No primary acute graft-versus-host disease (aGVHD) was observed. (lu.se)
  • release of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), is induced by tissue damage from the conditioning regimen, activating the host innate immune system ( Fig. 16-1 ). (mhmedical.com)
  • The aim of this study was to evaluate the outcome and prognostic parameters in terms of patient survival after allo-HSCT and admission to the ICU within the first 30 days after transplantation. (bvsalud.org)
  • Clinical utility of circulating miR-371a-3p for the management of patients with intracranial malignant germ cell tumors. (cdc.gov)
  • Since the first large cohort of patients was cured in the 1970s, much has been learned about the long-term effects of exposure to chemotherapy, radiation, and surgery in childhood. (medscape.com)
  • [ 4 , 5 ] The late effects of exposure to chemotherapy, radiation and surgery make the care of survivors highly complex and mandate structured, coordinated long-term follow-up. (medscape.com)
  • It generally results in fewer short-term side effects than chemotherapy does. (tlls.org)
  • from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)
  • Therefore, we analyzed the influence of graft manipulation on IR in 40 patients with acute leukemia in remission. (uni-wuerzburg.de)
  • Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens. (sagepub.com)
  • Although 131 I-MIBG treatment did not achieve complete remission, the size of the tumor was reduced after treatment. (biomedcentral.com)
  • Histopathology of microbiological remission of the infection, dos- the graft showed organisms consistent with Crypto- age was adjusted on the basis of renal function coccus yeast cells, suggesting fungal pyelonephritis. (cdc.gov)
  • A cogent issue in cancer research is how to account for the effects of tumor microenvironment (TME) on the response to therapy, warranting the need to adopt adequate in vitro and in vivo models. (crick.ac.uk)
  • Novel research is being conducted with the goal of developing a quality in-vitro device capable of modelling tumor metastasis in a simulated microenvironment, with focus specifically on the phenomena of tropism, cancer's predisposition to colonize particular tissue. (openwetware.org)
  • Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
  • The biology of GvT response is still not fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is involved. (wikipedia.org)
  • However, tissue rejection following ESCs derivatives transplantation greatly hinders its application. (benthamscience.com)
  • MetaMouse offers researchers the ability to order mouse models with a predetermined cancer type grafted or cultured in a tissue or organ of interest. (openwetware.org)
  • This technique allowed researchers to "implicate a number of genes in organ-specific metastasis, including IL-11, osteopontin and the connective tissue growth factor (CTGF) in osteolytic metastasis," which generated a method to specifically modulate the factors affecting these genes and increase the efficacy of targeted treatments [3 ]. (openwetware.org)
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
  • This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • The implication of these results would be that myeloma-specific T cell subfamilies might be positively selected from the donor inoculum and infused to myeloma patients post ASCT, to afford separation of allo- from tumor-reactive T cells without the prior need to define specific target antigens. (biomedcentral.com)
  • Manmade antibodies are able to attach to antigens on the cancer cell, using samples of tumors. (tlls.org)
  • Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
  • Potential y neoplastic cel s that of the effect increases with increasing tem to respond effectively to foreign arise natural y, or that have been dose or continuing exposure - and is antigens, including surface antigens transformed by carcinogens acting usually transient: immune function on tumour cells. (who.int)
  • The graft contains donor T cells (T lymphocytes) that can be beneficial for the recipient by eliminating residual malignant cells. (wikipedia.org)
  • As the name of this effect indicates, GvL is a reaction against leukemic cells of the host. (wikipedia.org)
  • This blood disorder affects your body's ability to produce red blood cells. (clevelandclinic.org)
  • This disorder affects white blood cells. (clevelandclinic.org)
  • In a successful transplantation, the donor cells seek out the latent cancer cells, eradicate them, and you have the potential for a cure. (autm.net)
  • This desired characteristic of the donor cells is called the graft-versus-tumor (GVT) reaction. (autm.net)
  • What's more, he found that this variation in the NK cell's gene content, as well as the matching between the donor KIR and recipient HLA, affects the strength of the cells' immune response and its cancer-killing ability following transplantation. (autm.net)
  • New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. (frontiersin.org)
  • In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
  • However, direct injection of IL-2 has been shown to be accompanied by severe side effects, such as vascular leak syndrome, activation-induced cell death, and strong induction of regulatory CD4 pos T cells, which did not occur after IL-15 administration ( 15 , 16 ). (frontiersin.org)
  • Indeed, one critical question contemplated at the Workshop was whether tumors derive from organ stem cells that retain self-renewal properties but acquire epigenetic and genetic changes required for tumorigenicity or whether tumor stem cells are proliferative progenitors that acquire self-renewal capacity. (aacrjournals.org)
  • Either mechanism is different from the widely held notion that most cells in a tumor should be competent for tumor formation. (aacrjournals.org)
  • The participants critically discussed the need for a precise definition of cancer stem cells, the requirement for new markers and more rapid and tractable in vitro and in vivo assays, and the need to develop drug screening strategies to selectively target cancer stem cells to generate therapeutics for this subpopulation of cells that could be resistant to classic treatments while possessing potent tumor-forming capacity. (aacrjournals.org)
  • In the cancer stem cell model of tumors, there is a small subset of cancer cells, the cancer stem cells, which constitute a reservoir of self-sustaining cells with the exclusive ability to self-renew and maintain the tumor. (aacrjournals.org)
  • These cancer stem cells have the capacity to both divide and expand the cancer stem cell pool and to differentiate into the heterogeneous nontumorigenic cancer cell types that in most cases appear to constitute the bulk of the cancer cells within the tumor. (aacrjournals.org)
  • If cancer stem cells are relatively refractory to therapies that have been developed to eradicate the rapidly dividing cells within the tumor that constitute the majority of the nonstem cell component of tumors, then they are unlikely to be curative and relapses would be expected. (aacrjournals.org)
  • Fig. 1: CAR19-mediated trogocytosis in NK cells cocultured with CD19 + tumor targets. (nature.com)
  • In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
  • Once in the bloodstream, these cells are classified as circulating tumor cells. (openwetware.org)
  • Under certain conditions, these circulating cells can extravasate from the blood vessel into a new environment and begin forming a secondary tumor. (openwetware.org)
  • More specifically, cancer cells metastasize by degrading local extracellular matrix (ECM) proteins, which allows them to break away from the primary tumor and breach the ECM. (openwetware.org)
  • Perhaps the most pervasive technique is one where cancer cells of a particular phenotype with specific tropic factors can be grafted into host mice to develop a model. (openwetware.org)
  • Effects of immune serum and spleen cells on c3hf/he tumor graft surviv" by J M. Cruse, W W. Germany et al. (jax.org)
  • Effects of immune serum and spleen cells on c3hf/he tumor graft survival in tennessee swiss mice. (jax.org)
  • Much of the curative potential of allografts is attributed to the graft-versus-tumor (GvT) response that aims to destroy residual tumor cells that persist after induction therapy and ASCT [ 5 ]. (biomedcentral.com)
  • The scientific interests of my lab have been directed towards understanding the complexities of T cell biology and how T cells contribute to tumor immunity and transplantation immunity. (umaryland.edu)
  • On the other hand, donor-derived T cells can protect the host from infection, and can also identify and attack host tumor cells, producing the beneficial graft-versus-tumor (GVT) effect. (umaryland.edu)
  • Bian G, Ding X, Leigh ND, Tang Y, Capitano ML, Qiu J, McCarthy PL, Liu H, Cao X . Granzyme B-mediated damage of CD8+ T cells impairs graft-versus-tumor effect. (umaryland.edu)
  • The patient cells are removed through apheresis and modified in a laboratory so they can be reprogrammed to target tumor cells through a gene modification technique. (tlls.org)
  • When the GVL effect occurs, the donor's immune cells actively destroy residual tumour cells in the patient. (wur.nl)
  • This is the first time patients have received an infusion of WT1 specific T-cells, and thus also the first demonstration that such cells can provide a therapeutic anti-leukemic effect, as has been suggested from earlier vaccine trials that induce less potent responses," said Philip Greenberg, M.D. , corresponding author and head of the Immunology Program at Fred Hutch. (fredhutch.org)
  • This suggests that lymphocytes present in engrafted donor stem cells can cause a concurrent therapeutic graft-vs.-tumor effect. (fredhutch.org)
  • We evaluated the feasibility and efficacy of using high-dose iodine-131-metaiodobenzylguanidine ((131)I-MIBG) followed by reduced-intensity conditioning (RIC) and transplantation of T cell-depleted haploidentical peripheral blood stem cells (designated haplo-SCT) to treat relapsing/refractory neuroblastoma (RRNB). (lu.se)
  • However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
  • First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)
  • These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
  • According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
  • In culture, cells from affected individuals exhibit elevated rates of chromosomal breakage or instability, leading to chromosomal rearrangements. (medscape.com)
  • Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)
  • The advent of iPSCs has opened up the possibility to graft patient-specific cells which most likely would circumvent the need for immunosuppression. (lu.se)
  • However, patient-derived cells may be more prone to develop disease-associated pathology after grafting. (lu.se)
  • Lastly, we evaluated the strategy of knocking out a-syn as a means to protect the cells from transfer of pathology upon grafting. (lu.se)
  • Through the use of a Mouse Mammary Tumor Virus (MMTV), two genes have been identified as primary targets for generating malignant tumors. (openwetware.org)
  • The mandibular defects may be caused by a variety of factors, including trauma, osteomyelitis, osteonecrosis, well as benign or malignant tumors. (bvsalud.org)
  • While the role for the individual cell population of the donor graft is not fully understood after allogeneic transplant, recent works in the field have yielded some interesting observations which may lead to advances in clinical care. (stanford.edu)
  • After clinical and perienced delayed graft function. (cdc.gov)
  • Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
  • Not to be confused with Host-versus-graft disease . (wikipedia.org)
  • [ 3 ] . An increasing number of orthotopic and living-donor liver transplantations are being performed to salvage patients with otherwise incurable end-stage liver disease (ESLD). (medscape.com)
  • Two children are alive and well, with no evidence of disease 40 and 42 months after transplantation. (lu.se)
  • One patient rejected the graft, was rescued with autologous backup, and died of progressive disease 5 months after transplantation. (lu.se)
  • 7 In the recently completed LenaRIC study patients undergoing allo-SCT with reduced-intensity conditioning received lenalidomide for 12 months from day 35 post-transplantation, with DLI for mixed chimerism or persistent disease. (medicalupdateonline.com)
  • The rationale for the provision of nutrition support includes (1) to mitigate the effects of semi-starvation, and (2) to favorably alter the natural history or response to treatment for a disease. (nationalacademies.org)
  • During the current outbreak, CDC has received reports of people with monkeypox who have severe manifestations of disease, including but not limited to · Atypical or persistent rash with coalescing or necrotic lesions, or both, some which have required extensive surgical debridement or amputation of an affected extremity. (cdc.gov)
  • Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease. (lu.se)
  • Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model. (lu.se)
  • Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease. (lu.se)
  • Parkinson's disease (PD) affects approximately 1% of people over the age of 60. (lu.se)
  • Graft-versus-leukemia (GvL) is a specific type of GvT effect. (wikipedia.org)
  • The optimization of graft composition should not only enable a sufficient IR but also improve graft vs. leukemia/tumor effects, overcome infectious complications and, finally, improve patient survival. (uni-wuerzburg.de)
  • Hokkaido Hematology Study Group: Effects of the mean daily doses of imatinib during the first year on survival of patients with chronic myeloid leukemia in Japan: a study of the Hokkaido Hematology Study Group. (hokudai-hematology.jp)
  • [ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
  • Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain. (lu.se)
  • The therapeutic effect of hGMSC was mediated, in part, by the suppression of inflammatory infiltrates and inflammatory cytokines/mediators at the colonic sites. (ca.gov)
  • X-rays or other types of ionizing in much higher dosage, are used to and there is excess risk of B-cel radiation, immunosuppression is maintain the functional and anatom- non-Hodgkin lymphoma (NHL) when most pronounced if the entire body, ical integrity of foreign tissues graft- immunosuppression is accompanied rather than a limited area, is irra- ed onto another individual, such as by continuing immune stimulation diated. (who.int)
  • The severe immune plants is that suppression of the patients in whom it has been used deficiency that is characteristic of immune response can allow occult as an antineoplastic agent ( IARC, AIDS results from a deficiency in tumours or metastatic tumour cel s 2012b ). (who.int)
  • This effect applies in myeloma and lymphoid leukemias, lymphoma, multiple myeloma and possibly breast cancer. (wikipedia.org)
  • Further functional analyses revealed enhanced degranulation and secretion of pro-inflammatory cytokines such as interferon-γ and tumor necrosis factor-α. (frontiersin.org)
  • The results of this study elucidated the anti-inflammatory effect of U. cannabina water extract in vitro and in vivo and showed that the extract elicits the anti-inflammatory effects by regulating the activity of inflammatory cytokines. (referencecitationanalysis.com)
  • Some localized melanomas may result from azathioprine, which acts synergistically with ultraviolet radiation, while T-cell depleting induction therapies may promote late stage tumors. (cdc.gov)
  • Other promising developments to improve outcomes in allo-SCT include conditioning with radiolabelled anti-CD66, as well as salvage therapy with daratumumab 8 or newer imids which suggest that allo-SCT has the potential to enhance the efficacy of other therapies that may have been less effective pre-transplantation. (medicalupdateonline.com)
  • Especially in haploidentical SCT, the optimization of graft composition is controversial. (uni-wuerzburg.de)
  • We examined the cell recovery post haploidentical SCT in patients receiving a CD34(+)-selected or CD3/CD19-depleted graft, considering the applied conditioning regimen. (uni-wuerzburg.de)
  • He contributed to the establishment of graft-engineering techniques to introduce new concepts in haploidentical transplantation, and pioneered the T-cell receptor alpha/beta depletion technology in allogeneic transplantation. (globalleukemiaacademy.com)
  • Solid organ transplant recipients, who are medically immunosuppressed to prevent graft rejection, have increased melanoma risk, but risk factors and outcomes are incompletely documented. (cdc.gov)
  • An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)
  • I joined Roswell Park Cancer Institute as an assistant professor in 2008 and since established an independent laboratory that explores T cell biology using tumor and transplantation models. (umaryland.edu)
  • Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients. (nature.com)
  • However, of the roughly 25,000 patients who receive a stem cell transplant each year worldwide , only about half survive, according to the Worldwide Network for Blood & Marrow Transplantation . (autm.net)
  • Some of these products are approved for other indications but are known to have a neuroprotective effect. (researchandmarkets.com)
  • What's the difference between allogeneic and autologous stem cell transplantations? (clevelandclinic.org)
  • A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. (aacrjournals.org)
  • [ 4 ] Doppler ultrasonography plays an important role in the postoperative management of liver transplantation. (medscape.com)
  • Spectral Doppler ultrasonographic waveform of the right hepatic artery in a 60-year-old man, 8 years after orthotopic liver transplantation. (medscape.com)
  • Lee et al retrospectively enrolled 75 patients who had undergone liver transpalantation and found that although MDCT in the late period should be interpreted with caution in patients with suspected biliary complication, MDCT is a reliable diagnostic technique for the identification of early and late abdominal complications after liver transplantation. (medscape.com)
  • indicates that the article is not about the liver in general, but about the effect of drugs on the liver. (who.int)
  • For example, inhibition of mitochondrial complex I (CI), despite showing promising results as an anticancer approach, triggers TME-mediated survival mechanisms in subcutaneous osteosarcoma xenografts, a response that may vary according to whether the tumors are induced via subcutaneous injection or by intrabone orthotopic transplantation. (crick.ac.uk)
  • Side effects include cytokine release syndrome, tumor lysis syndrome, B-cell aplasia along with CNS toxicity. (arizona.edu)
  • In the authors' institute, massive frozen allografts have been used as a means of reconstruction after segmental resection for bone tumors since 1984. (lww.com)
  • This study to investigate the in vitro and in vivo anti-inflammatory effect of U. cannabina, the underlying mechanisms, and its phytochemical profile. (referencecitationanalysis.com)