Transplant recipients heart lung transplantation. Medical search. Frequent questions

Two donors were unrelated, but six were siblings of the recipients. (genomeweb.com)
recipients who are seronegative for Herpes Simplex Virus (HSV) receiving an organ from HSV seropositive donors [2D]. (bts.org.uk)
Human donor lungs not suitable for transplantation from type A donors were put in the EVLP circuit. (eurekalert.org)
The current virus pandemic can cause severe disease in transplant patients and could be transmitted from donors,' explains assistant professor Dr. Deepali Kumar, an expert in transplant-related infectious diseases from the University of Alberta, Canada. (infectioncontroltoday.com)
The International Society for Heart and Lung Transplantation has already developed guidelines for heart and lung transplant recipients in the pandemic setting, raising concerns about transmission from donors to recipients. (infectioncontroltoday.com)
Transplant patients and donors should receive at least one dose of H1N1 vaccine. (infectioncontroltoday.com)
Treatment with a new class of drugs, called senolytics, in donors improved the physical fitness of the recipients, a new study has shown. (medicaldaily.com)
Donors must be under 65 years old, have never smoked, and not have a lung disorder. (msdmanuals.com)
Furthermore, there are no legal requirements in place for recipients and deceased donors, only for living donors. (who.int)
Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)

Journal of Heart and Lung Transplantation. (monash.edu)
Journal of Heart and Lung Transplantation , 20 (4), 486-489. (elsevierpure.com)

In 2009, the FDA notified healthcare professionals that a clinical trial conducted by Wyeth showed an increased mortality in stable liver transplant patients after switching from a calcineurin inhibitor-based immunosuppressive regimen to sirolimus. (wikipedia.org)
Because of the high incidence of morbidity and mortality associated with invasive fungal infections, antifungal prophylaxis is often used in solid organ transplant recipients. (hindawi.com)
Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction. (ucsf.edu)
Background: Primary graft failure (PGF) remains the most common cause of short-term mortality after heart transplantation. (lu.se)
The main objective was to develop and validate a risk model for prediction of short-term mortality due to PGF after heart transplantation using the ISHLT Heart Transplant Registry. (lu.se)

Many lung transplant physicians advocate surveillance bronchoscopy with transbronchial lung biopsy and bronchoalveolar lavage (TBB/BAL) to monitor lung recipients despite limited evidence this strategy improves outcomes. (nih.gov)
Today, a main focus of the transplant community is the long-term outcomes of lung and heart allograft recipients. (terasaki.org)
Outcomes after heart and lung transplants have improved, and many recipients survive long enough to develop secondary renal failure, yet remain healthy enough to undergo kidney transplantation. (johnshopkins.edu)
We used national data reported to United Network for Organ Sharing (UNOS) to evaluate outcomes of 568 kidney after heart (KAH) and 210 kidney after lung (KAL) transplants performed between 1995 and 2008. (johnshopkins.edu)
Outcomes were compared with primary kidney recipients using matched controls (MC) to account for donor, recipient and graft characteristics. (johnshopkins.edu)

Outbreaks of health care-associated mucormycosis have been identified, most commonly in persons with marked immunosuppression, such as bone marrow and solid organ transplant recipients ( 1 , 2 ). (cdc.gov)
He will help to develop guidelines for immunosuppression and rejection management in heart transplant recipients. (pitt.edu)
Mentioned above issues are exacerbated during the current Covid-19 pandemic, creating novel challenges in Covid-19 prevention, immunization, and adjusting or modifying the existing immunosuppression regimens in the multi-organ transplant recipients. (frontiersin.org)
Thus, the mycophenolate mofetil dose or mycophenolic acid plasma concentration are not a primary factor related to organ rejection, but chronic lung allograft dysfunction may be influenced by other components of immunosuppression or other factors. (smw.ch)
Scheffert JL, Raza K. Immunosuppression in lung transplantation. (smw.ch)
Immunosuppression by a kidney or heart transplant. (who.int)
Because increased diagnostic accuracy can eliminate confusion between transplant rejection and organ injury, treatment can be more precise and the administration of unnecessary immunosuppression drugs can be prevented, he said. (medscape.com)

Toronto (February 16, 2022) - A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN's Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation. (eurekalert.org)
Transplant Proc 1992;24:2022-2023. (medigraphic.com)

A prospective multicenter cohort of LTRs was identified in the four lung transplant centers. (nature.com)
therefore, some transplant centers prefer not to use it immediately after the transplant operation, but instead administer it only after a period of weeks or months. (wikipedia.org)
Transplant centers having the capability of performing and managing multi-organ transplant surgeries are increasingly faced with the task of discerning how to address this scenario and balance the patient's needs with the availability of donor organs. (frontiersin.org)
Whilst addressing the topic of multi-organ transplants to provide insight on the current incidence and prevalence of multi-organ chronic disease and how transplant centers are addressing the needs of these very sick patients. (frontiersin.org)
Halloran and his colleagues assessed endomyocardial biopsy samples from 462 patients who had undergone heart transplantation at one of eight centers. (medscape.com)

4 These diseases are not only the major causes of death but are also associated with chronic lung allograft dysfunction (CLAD). (nature.com)
Pulmonary hypertension is often the common link between lung dysfunction and the heart in cor pulmonale. (medscape.com)
INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. (smw.ch)
We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite mycophenolic acid affect the development of chronic lung allograft dysfunction. (smw.ch)
An event-time-analytical Cox proportional-hazards regression model with time-varying-covariates (18,431 measurements for MPA, mycophenolate mofetil dosage, lymphocytes) was used to predict chronic lung allograft dysfunction, with adjustment for sociodemographic factors and lung function at baseline. (smw.ch)
RESULTS: 37 patients did not develop chronic lung allograft dysfunction (age 41.3 ± 15.6 years, baseline FEV1 95.5 ± 19.1% predicted) and 34 patients developed chronic lung allograft dysfunction (age 50.9 ± 13.3 years, baseline FEV1 102.2 ± 25.4% predicted). (smw.ch)
0.001), but only the traditional risk factor age predicted chronic lung allograft dysfunction. (smw.ch)
Continuously measured mycophenolic acid did not predict chronic lung allograft dysfunction (hazard ratio 0.98, 95% confidence interval 0.90-1.06, p = 0.64 over a period of 382.97 patient-years). (smw.ch)
CONCLUSION: Mycophenolate mofetil dosage and mycophenolic acid were not associated with chronic lung allograft dysfunction development. (smw.ch)
Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT. (smw.ch)

Iwijn De Vlaminck, an assistant professor of biomedical engineering at Cornell and senior author of the study, said that previous work had identified that donor-derived cell-free DNA is a "good marker of transplant rejection" because increased levels of donor cfDNA indicates more damage to the graft and thus, rejection. (genomeweb.com)
CT12 Chapter 5: Factors Affecting Graft Survival Within 1-year Post-Transplantation in Heart and Lung Transplant: An Analysis of the OPTN/UNOS Registry. (terasaki.org)
Factors Affecting Graft Survival Within 1-year Post-Transplantation in Heart and Lung Transplant: An Analysis of the OPTN/UNOS Registry. (terasaki.org)
However, even early post-transplant survival (within the first post-transplant year) needs improvement, as early graft failure still accounts for many allograft losses. (terasaki.org)

New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. (ucsf.edu)
METHODS: In this retrospective cohort study we recruited 71 patients with a lung transplant between 2010 and 2014 which survived the first year after transplantation up to 1 July 2021. (smw.ch)

Severe allograft rejection (AR) and pulmonary infection (PI) are the most common complications within 1 year after the transplant. (nature.com)
His mother, Tracey Ferguson, has said he has been suffering complications from atrial fibrillation and deteriorating heart failure and has been treated at hospitals around Boston. (bostonglobe.com)
Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
however, severe post-transplant complications reflecting the syndromic nature of their disease appear to occur at higher rates. (ersjournals.com)
Complications of lung transplantation include rejection of the transplanted lung and infection. (medlineplus.gov)

Image: A new method for heart transplantation in Institute for Clinical and Experimental Medicine (IKEM), using a pioneering method of organ retrieval that keeps the heart pumping outside the patient's body for several hours. (physio-pedia.com)
His outpatient clinical time is split between three clinics (1) the lung transplantation clinic, where he sees patients with advanced lung disease before and after transplantation, (2) the pulmonary hypertension clinic, where he sees patients with pulmonary hypertension and pulmonary emboli, and (3) the general pulmonary clinic, where he supervises the excellent care provided by fellows in the UCSF Pulmonary and Critical Care Fellowship Program. (ucsf.edu)
Surgeons and other healthcare professionals specializing in solid organ transplants have been issued with expert advice to guide them through the complex clinical issues posed by the global H1N1 influenza pandemic. (infectioncontroltoday.com)
This pandemic has important clinical implications for all stages of the solid organ transplant process. (infectioncontroltoday.com)
Clinical features of lung transplantation-related pathology can range from an absence of symptoms to signs and symptoms of respiratory distress and/or infection and are not detailed in this article. (medscape.com)
The Registry of the International Society for Heart and Lung Transplantation (ISHLT) monitors and reports statistics on clinical lung transplantation. (medscape.com)
Techniques of successful clinical double-lung transplantation. (medigraphic.com)
Clinical Transplantation. (helsinki.fi)
Our findings that renal grafts function well and provide survival benefit in KAH and KAL recipients, but are limited in longevity by the general life expectancy of these recipients, might help inform clinical decision-making and allocation in this population. (johnshopkins.edu)
We invite the research and review papers on the basic, preclinical, and clinical studies in the multi-organ transplantation field. (frontiersin.org)
BACKGROUND: The performance of the American College of Cardiology/American Heart Association pooled cohort equation (PCE) for atherosclerotic cardiovascular disease (ASCVD) in real-world clinical practice has not been evaluated extensively. (bvsalud.org)
Whether this model with improved discrimination can assist in clinical decisions at the time of transplant should be tested. (lu.se)

5 United Nations General Assembly - Resolution A/RES/71/322 on Strengthening and promoting effective measures and international cooperation on organ donation and transplantation to prevent and combat trafficking in persons for the purpose of organ removal and trafficking in human organs, September 2017. (who.int)

We report a case of Mycobacterium marinum infection in a lung transplant recipient who presented with nodules on the hand and forearm following exposure to fish-tank water of a superficial hand burn. (elsevierpure.com)

Eur Heart J. 2018;39(7):586-95. (smw.ch)
Molecular diagnosis is more objective and reproducible than histology, and provides new understanding of an organ's reduced function in response to injury, he explained here at International Society for Heart and Lung Transplantation 2018 Scientific Sessions. (medscape.com)

Greer M, Werlein C, Jonigk D. Surveillance for acute cellular rejection after lung transplantation. (smw.ch)

This disparity is also present for other organs, she adds, where a patient who is type O or B in need of a kidney transplant will be on the waitlist for an average of 4 to 5 years, compared to 2 to3 years for types A or AB. (eurekalert.org)
Median time to kidney transplant was 100.3 months after heart, and 90.2 months after lung transplant. (johnshopkins.edu)
For molecular diagnosis, the researchers used a molecular diagnostic system developed for kidney transplant biopsies ( Nat Rev Nephrol . (medscape.com)

A 64-year-old male underwent bilateral lung transplantation at an outside hospital in 2011 for idiopathic pulmonary fibrosis with pulmonary hypertension. (hindawi.com)
All four patients underwent solid organ transplantation during the same admission as their mucormycosis diagnosis and were receiving immunosuppressive medications as well as voriconazole for antifungal prophylaxis. (cdc.gov)
The three probable cases were in patients who were primary heart (two cases) and lung transplant (one case) recipients who underwent transplantation 31-93 days before mucormycosis diagnosis. (cdc.gov)
Late last month, Ferguson underwent open-heart surgery, and surgeons inserted a device that will mechanically pump his heart until a donor becomes available, according to ABC News. (bostonglobe.com)
We gathered an international series of telomerase mutation carriers who underwent lung transplant in the USA, Australia and Sweden. (ersjournals.com)

That is typically true in cases of heart or lung transplantation, but not in the case of bone marrow transplants or even kidney transplantation, he said. (genomeweb.com)
Next, they tested the model for individuals who had received bone marrow transplants from relatives. (genomeweb.com)
They analyzed 76 samples from eight bone marrow transplant recipients. (genomeweb.com)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
We identified West Nile Virus RNA in spleen/lymph node homogenate, skin, fat, muscle, tendon, and bone marrow samples obtained postmortem from a donor associated with transmission of West Nile Virus through solid organ transplantation. (cdc.gov)

CPT 33933 describes the standard backbench preparation of a cadaver donor heart/lung allograft before transplantation, including the dissection of the allograft from surrounding soft tissues to prepare the aorta, superior vena cava, inferior vena cava, and trachea for implantation. (codingahead.com)
In the 1980s, when Vunjak-Novakovic began her career, the mainstream approach was to combine cells and biomaterials, and insert them into the body, with the intention of this transplant finding a way to regenerate tissues. (prweb.com)
Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
West Nile Virus transmission through tissue transplantation, for instance, skin, muscle, or connective tissues, has not been identified, and the risk for transmission by this route is not known. (cdc.gov)
none of the donor tissues were transplanted. (cdc.gov)

If the damage is severe in both organs, replacing the heart or lungs alone may not be possible. (physio-pedia.com)
Although advances in tissue typing and cross-match testing have helped to deter severe transplant rejection, rejection may result from direct cellular attack (cellular rejection) or be mediated by antibodies (humoral rejection). (medscape.com)
A randomized trial comparing lung-volume- reduction surgery with medical therapy for severe emphysema. (medigraphic.com)
Given that sicker/riskier patients are now receiving more heart and lung transplants, future studies need to take place to better understand these patients so that they can have the same survival as patients entering transplant with less severe illnesses. (terasaki.org)
Heart Transplantation Heart transplantation is the removal of a healthy heart from a recently deceased person and then its transfer into the body of a person who has a severe heart disorder that can no longer be. (msdmanuals.com)

In the EU, sirolimus, as Rapamune, is indicated for the prophylaxis of organ rejection in adults at low to moderate immunological risk receiving a renal transplant and, as Hyftor, is indicated for the treatment of facial angiofibroma associated with tuberous sclerosis complex. (wikipedia.org)
Here we present a rare case of invasive infection caused by Microascus trigonosporus species complex in a human, which developed during voriconazole prophylaxis in a lung transplant recipient. (hindawi.com)
1.6 Consider Valganciclovir prophylaxis for at least 3 months after starting treatment for acute allograft rejection if either donor or recipient are CMV positive (D+/R-, D+/R+ or D-/R+) [2C]. (bts.org.uk)
If the donor has not completed a course of treatment, the current recommendation is to give the recipient five to 10 days of antiviral therapy, at therapeutic not prophylaxis doses. (infectioncontroltoday.com)

Lung transplantation is a potentially curative therapy for patients with end-stage pulmonary disease. (nature.com)
12 These results supported that potential gut microbiome-targeted interventions could influence the survival of patients received solid organ transplantation. (nature.com)
It is particularly advantageous in patients with kidney transplants for hemolytic-uremic syndrome, as this disease is likely to recur in the transplanted kidney if a calcineurin-inhibitor is used. (wikipedia.org)
Serious side effects including hypersensitivity and swelling (edema) have been observed in renal transplant patients. (wikipedia.org)
Looking retrospectively at 382 blood samples taken at various time points from 51 lung transplant patients, the researchers found that the two models were highly correlated. (genomeweb.com)
Analyzing 435 samples from 59 heart transplant patients, they found that the two methods were still highly correlated, although not as close as for the lung transplants. (genomeweb.com)
The three patients with probable health care-associated mucormycosis all received care in the same room (room A) of the 20-bed cardiothoracic intensive care unit (CTICU) in hospital A for 14-58 days between their transplantations and mucormycosis diagnoses. (cdc.gov)
An organ transplant is an established life-saving therapy for these patients. (physio-pedia.com)
Total artificial hearts are now available and have been implanted in a few patients. (physio-pedia.com)
In a statement, the hospital said the COVID-19 vaccination requirement for transplant patients is based on the "best available evidence" related to immunocompromised patients who are at risk for COVID-19 infection following transplantation. (bostonglobe.com)
He is one of the attending physicians on the inpatient lung transplantation service, where he cares for patients with advanced lung disease before and after lung transplantation. (ucsf.edu)
Nicholas Kolaitis' research focuses on ways to improve health-related quality of life for patients with advanced lung disease. (ucsf.edu)
With the current matching system, wait times can be considerably longer for patients who need a transplant depending on their blood type," explains Dr. Marcelo Cypel, Surgical Director of the Ajmera Transplant Centre and the senior author of the study. (eurekalert.org)
Having universal organs means we could eliminate the blood-matching barrier and prioritize patients by medical urgency, saving more lives and wasting less organs," adds Dr. Cypel, who is also a Thoracic Surgeon at UHN's Sprott Department of Surgery, a Professor in the Department of Surgery at U of T and the Canada Research Chair in Lung Transplantation. (eurekalert.org)
Patients who are type O wait on average twice as long to receive a lung transplant compared to patients who are type A, explains Dr. Aizhou Wang, Scientific Associate at Dr. Cypel's lab and first author of the study. (eurekalert.org)
Patients who are type O and need a lung transplant have a 20% higher risk of dying while waiting for a matched organ to become available," says Dr. Wang. (eurekalert.org)
TDM using C2 as an estimate of AUC requires further evaluation before being applied in long-term, stable cardiac transplant patients, as it may lead to inappropriate dose adjustment of CsA in patients receiving concomitant metabolic inhibitors. (uri.edu)
recipients constituted 42% of those patients, while underlying malignancies were found in 26% (Table 1). (who.int)
Does Transplantation Induce Aging In Patients? (medicaldaily.com)
Trends indicate that sicker patients are increasingly being transplanted, thereby limiting improvements in early post-transplant survival. (terasaki.org)
More lung and heart transplant patients are coming to transplant on dialysis. (terasaki.org)
In heart transplant, there is an increase in the number of heart retransplant patients and an increase in patients on extracorporeal membrane oxygenation. (terasaki.org)
For lung transplant, more patients are on a ventilator prior to transplant than in the past 25 years. (terasaki.org)
A total of 50% of the patients died by the ninth post-transplant year. (smw.ch)
While these findings need to be expanded to other cohorts, caution should be exercised when approaching the transplant evaluation and management of this subset of pulmonary fibrosis patients. (ersjournals.com)
The persistent and widening gap between patients' need for organs and the number available for transplantation has become a major concern to many Member States. (who.int)
Even between countries which have similar levels of health resources, patients' access to transplantation also varies. (who.int)
Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)

Since then, operations have been developed to transplant both lungs, a single lung, and even partial lung (lobes). (physio-pedia.com)
Results of single-lung transplantation for bilateral pulmonary fibrosis. (medigraphic.com)
To investigate possible changes following lung transplantation, the structure and in vitro ciliary beat frequency (CBF) of airway epithelium from the cytology brushings of 9 heart-lung (HLT) and 5 single-lung (SLT) transplant recipients were examined. (soton.ac.uk)

A 2019 cohort study of nearly 10,000 lung transplant recipients in the US demonstrated significantly improved long-term survival using sirolimus + tacrolimus instead of mycophenolate mofetil + tacrolimus for immunosuppressive therapy starting at one year after transplant. (wikipedia.org)

This report compares rates of infection (INF), acute rejection (AR), bronchiolitis obliterans syndrome (BOS) and survival in lung allograft recipients managed with surveillance TBB/BAL (SB) versus those with clinically indicated TBB/BAL (CIB). (nih.gov)

1 Nevertheless, the overall survival after a lung transplant is still inferior compared to other solid-organ transplantation modalities. (nature.com)
Erasmus ME, van der Bij W. Death after lung transplantation: improving long term survival despite perilous early postoperative years. (smw.ch)
Survival in adult lung transplantation: where are we in 2020? (smw.ch)
Lung transplantation is the only intervention that prolongs survival in idiopathic pulmonary fibrosis (IPF). (ersjournals.com)
Idiopathic pulmonary fibrosis (IPF) is progressive and fatal, and lung transplantation is the only therapy that has been shown to prolong survival [ 1 ], [ 2 ]. (ersjournals.com)
For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)

The paper, published online by the American Journal of Transplantation , also urges them to stay alert to the significant concerns that swine flu could combine with seasonal flu, and possibly even bird flu (H5N1), to develop into a strain with unpredictable virulence. (infectioncontroltoday.com)
American Journal of Transplantation , 9 (3), 578-585. (johnshopkins.edu)

This Research Topic focuses on advancing the science of combined solid-organ transplants, including combined abdominal transplants, combined thoracic transplants, and the combination of transplanting thoracic and abdominal organs. (frontiersin.org)

In the first year after the transplant, the majority of cases are thoracic. (secondwindstl.org)
In contrast to the early cases of PTLD after lung transplantation, those that manifest after the first year are usually extra-thoracic, often presenting in the abdomen or pelvis with abdominal pain, gastrointestinal bleeding, or non-healing ulcers. (secondwindstl.org)

Right-sided ventricular disease caused by a primary abnormality of the left side of the heart or congenital heart disease is not considered cor pulmonale, but cor pulmonale can develop secondary to a wide variety of cardiopulmonary disease processes. (medscape.com)

A1 on bronchial biopsy for lung transplant rejections in accordance with International Society of Heart and Lung Transplantation 2004 and 2007 grading guidelines. (cdc.gov)
The group described the method this month in PLOS Computational Biology and plans to work with the National Institutes of Health's Genome Research Alliance for Transplantation consortium to test their approach alongside other methods, including the gold standard of invasive biopsy. (genomeweb.com)
In fact, a similar study looking at the molecular diagnosis of lung biopsy - conducted by a team led by Halloran's son, Kieran Halloran, MD, also from the University of Alberta - will be presented at the meeting later this week. (medscape.com)

I am a practicing pulmonologist and intensivist and I maintain a basic science laboratory investigating acute lung injury. (ucsf.edu)
The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models. (ucsf.edu)
Urinary thromboxane B2 as an indicator of acute rejection in lung allotransplantation. (medigraphic.com)
Urinary thromboxane B2 excretion during acute rejection in cyclosporine treated experimental lung allotransplantation. (medigraphic.com)
The immunological response of the multi-organ recipient, receiving multiple organs from the same donor, differs (the acute and chronic rejection are usually milder) than that in single organ transplantation. (frontiersin.org)

Available at http://www.transplant- observatory.org/download/2016-activity-data-report/ Accessed 11 March 2020. (who.int)

The most common underlying conditions requiring heart-lung transplants are congenital cardiac diseases with Eisenmenger syndrome and certain pulmonary hypertension disorders [1] . (physio-pedia.com)
Over the last few decades, lung transplantation has become an accepted modality of treatment for many end-stage lung diseases. (medscape.com)
Obesity-related diseases including heart disease, stroke, type 2 diabetes, and cancer are a leading cause of preventable death. (cshlpress.com)
The pathophysiology of cor pulmonale is a result of increased right-sided filling pressures from pulmonary hypertension that is associated with diseases of the lung. (medscape.com)

The first surgeries involved transplanting both lungs and the heart together. (physio-pedia.com)

Furthermore, renal transplantation reduced the risk of death compared with dialysis by 43% for KAH and 54% for KAL recipients. (johnshopkins.edu)

Registry of the international society for heart and lung transplantation: twenty-second official adult lung and heart-lung transplant report-2005. (medigraphic.com)

ECIL-6 guidelines recommend quantitative PCR of whole blood, plasma, or serum to screen for EBV DNA in allogeneic hematopoietic stem cell transplant (HSCT) recipients and to monitor EBV DNA-emia. (medscape.com)
In the section on aspergillosis, the revised recommendations include the use of a room with high-efficiency particulate air filters rather than laminar airflow as the protective environment for allogeneic HSCT recipients and the use of high-efficiency respiratory-protection devices (e.g. (cdc.gov)
Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)

Four recipients (50%) required dialysis for tubular injury and calcineurin inhibitor toxicity. (ersjournals.com)

The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
In Europe, hundreds of thousands of tissue transplants are performed each year, and in 1999 an estimated 750 000 people in the United States of America received human tissue, twice as many as in 1990. (who.int)

Additionally, he is active in the International Society for Heart and Lung Transplantation as part of the Advocacy Committee, and in the Pulmonary Hypertension Association, where he serves on the steering committee for the Pulmonary Hypertension Association Registry. (ucsf.edu)
In this chapter, we review the experience of heart and lung transplantation as reported to the Organ Procurement Transplant Network/United Network of Organ Sharing registry and investigate the factors responsible for causing failure in the first post-transplant year. (terasaki.org)

Coagulation factor-XII induces interleukin-6 by primary lung fibroblasts: a role in idiopathic pulmonary fibrosis? (monash.edu)

The heart cohort had lower levels of donor-derived cfDNA, so inferring the donor genotype was harder, the authors wrote in the study. (genomeweb.com)
In the heart cohort, however, the one-genome method's accuracy was slightly reduced for predicting moderate rejection. (genomeweb.com)

On September 17, 2015, the Pennsylvania Department of Health (PADOH) notified CDC of a cluster of three potentially health care-associated mucormycete infections that occurred among solid organ transplant recipients during a 12-month period at hospital A. On September 18, hospital B reported that it had identified an additional transplant recipient with mucormycosis. (cdc.gov)
Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
Transplant recipients who receive immunosuppressive therapy are at increased risk for opportunistic infections. (elsevierpure.com)
Before the procedure, the recipient is often given antibiotics to prevent infections from developing. (msdmanuals.com)
In 6 clusters of organ transplant-transmitted West Nile Virus infections reported to public health agencies in the United States, 12 of 16 recipients were infected. (cdc.gov)

SAN FRANCISCO (GenomeWeb) - Noninvasive shotgun sequencing can be used to detect organ transplant rejection without prior knowledge of the donor's genotype, according to researchers from Stanford University and Cornell University. (genomeweb.com)
The size of the donor's and recipient's lungs must match. (msdmanuals.com)

The median age at transplant was 52 years. (ersjournals.com)

Thromboxane B2 and lung transplantation: Correlation of rejection with levels detected in bronchoalveolar lavage. (medigraphic.com)

Lung procurement in M xico. (medigraphic.com)

The researchers compared their so-called one-genome model to the two-genome method, where both donor and recipient genotypes are known. (genomeweb.com)
They found that the statistical model was able to learn the relationship between the donor and recipient and that the one-genome method was comparable to the two-genome method. (genomeweb.com)
Focus theme: Donor and recipient size match. (smw.ch)

Whether the alternated microbiota in the gut contribute to the risk of allograft rejection (AR) and pulmonary infection (PI) in the setting of lung transplant recipients (LTRs) remains unexplored. (nature.com)

Anatomy3

Diseases6

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes6

Named Groups2

Health Care6

Donors10

Journal of Heart and Lung Transplantation2

Mortality5

Outcomes5

Immunosuppression7

20222

Centers5

Dysfunction10

Graft4

20212

Complications5

Clinical12

20171

Infection in a Lung Transplant Recipient1

20182

Rejection after lung transplantation1

Kidney transplant3

Underwent5

Bone marrow5

Tissues11

Severe5

Prophylaxis4

Patients28

Single lung3

20191

Allograft recipients1

Survival7

American Journal of Transplantation2

Solid organ transplants1

Thoracic2

Congenital heart d1

Biopsy3

Acute5

20201

Diseases4

Surgeries1

Renal transplantation1

Adult lung1

Allogeneic3

Calcineurin-inhibitor1

Tissue transplants2

Registry2

Idiopathic pulmonar1

Cohort2

Infections5

Donor's2

Median1

Bronchoalveolar Lavage1

Procurement1

Donor and recipient3

Pulmonary infection1