Transplant complications transplanted stem cells. Medical search. Frequent questions

Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
[ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers the only curative modality for many hematological disorders. (hindawi.com)
PATIENTS AND METHODS: This retrospective study included paediatric cancer patients who underwent allogeneic hematopoietic stem cell transplant at the Children's Cancer Hospital Egypt 57357 from matched related donors with CSA as graft versus host disease prophylaxis. (bvsalud.org)
Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)

The current treatment for incomplete hematopoietic recovery includes administration of factors stimulating white and red blood cell growth, such as granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin. (drugdiscoverynews.com)
These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)

Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
When the donor's stem cells were successfully transplanted, it replaced the patients' own cells, conferring this HIV-resistance. (forbes.com)
The histocompatibility differences between the donor and the recipient, the presence of donor's immunocompetent cells, and the inability of the recipient to reject these cells were defined as the basic pathogenic prerequisites for GVHD development by Billingham in 1966 [ 10 ]. (hindawi.com)
The donor first has to be treated with G-CSF, and then the stem cells can only be harvested a couple of days after the donor since time is needed for the donor's body to form more stem cells and transport these cells into the bloodstream. (differencebetween.net)
A bone marrow transplant is when stem cells are removed from a donor's bone marrow for transplant into a patient. (differencebetween.net)

Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
The paper entitled "Intramedullary cervical spinal mass after stem cell transplantation using an olfactory mucosal cell autograft" is from authors Claire F. Woodworth , Gregory Jenkins , Jane Barron and Nanette Hache. (ipscell.com)
Both family physicians and specialists may need to counsel patients on stem cell transplantation or diagnose complications in those who have had these procedures. (ipscell.com)
Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)

In past work, this research team defined the role of molecules called JAK1/2 kinases and their signaling pathways in immune cell activation and graft-vs-host disease. (healthproblemsnews.com)
The transplants are also risky, with common complications being infection (often pneumonia), sepsis, bleeding, organ failure, and chronic graft vs. host disease, which happens when the donor cells attack the recipient's tissue. (forbes.com)
One potentially fatal complication, graft vs. host disease , occurs when the new, donated cells respond to the immune markers on a patient's own cells -- known as HLA antigens -- as if they are foreign, and mount an immune attack against the patient's body. (stanford.edu)
Before she came to Stanford, their doctor Alice Bertaina , MD, PhD, developed a technique that greatly reduces the risk of graft vs. host disease and broadens the potential pool of stem cell donors. (stanford.edu)

With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
A big disadvantage of this process is the necessity for anesthesia, which, at least in the case of general anesthesia could cause complications. (differencebetween.net)

The closer the match, the less risky the transplant. (mdanderson.org)
But traditional stem cell transplants are so risky that they've usually been offered only to patients who would otherwise die. (stanford.edu)

The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
About half of patients receiving donor stem cells develop graft-versus-host disease, which can linger for months or years after their transplants. (healthproblemsnews.com)
In some cases, patients die not from their cancer but from the complication itself. (healthproblemsnews.com)
For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
Additional presentations at ESMO include subgroup analyses of Libtayo in advanced non-small cell lung cancer (NSCLC), focusing on such populations as squamous cell carcinoma and patients with varying levels of PD-L1 expression. (biospace.com)
HIV treatment has been stymied because reservoirs of infected cells have remained latent, or "in hiding," in the bone marrow of patients, and can later reactivate. (forbes.com)
Stem cell transplants are typically used for patients with leukemia or specific cancers. (forbes.com)
Both the "Berlin" and "London" patients received the transplant as part of their cancer therapy, not specifically for their HIV. (forbes.com)
So while this new case of successful treatment of HIV with stem-cell replacement is exciting, it's limitations of side effects and cost will make it unfeasible for most patients. (forbes.com)
do a nice job of putting this tumor in context of previous reports of similar tumors in other patients who also have nasal stem cell transplants. (ipscell.com)
Given the vulnerability of patients who are chronically ill, especially those with spinal cord injury or neurologic disorders who may be targets of Internet-based marketing for stem cell therapy), physicians in Canada should be aware of the rationale behind stem cell therapy as well as the reported adverse events. (ipscell.com)
Pluristem Therapeutics, based in Haifa, Israel, is currently recruiting patients in the United States and Israel for its Phase 1 trial of PLX-R18 cells in this unmet need. (drugdiscoverynews.com)
A recent phase 2 study tested 156 patients, who underwent a transplant, to verify whether a new drug, Maribavir, is a safer and more effective alternative for the treatment of CMV reactivation. (uzleuven.be)
As a re-sult, patients can be safely transplanted us-ing stem cells from a donor with only 5 of 10 matching HLA antigens -- such as a parent. (stanford.edu)
Antibody-based hematopoietic stem cell transplants may transform the treatment of patients with blood and immune diseases including cancers. (stanford.edu)
In this context, patients experience the first psychological conflicts before this transplant. (bvsalud.org)
To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
This brings as oral dopamine therapies with the advantage that with it continued infective risks for the patients the cells can be targeted to the site where dopamine with DBS which is not so for patients with trans- is most needed, namely the striatum. (lu.se)

Studying mice, the researchers found the drug prevented what's known as graft-versus-host disease, a debilitating, sometimes lethal condition that develops when transplanted stem cells attack the body's own organs or tissues. (healthproblemsnews.com)
In other words, the drug appears to stop graft-versus-host disease by simply keeping the donor T cells circulating in the bloodstream, away from vital organs. (healthproblemsnews.com)
Sometimes, that transplanted immune system can react against your child's body, attacking its organs. (uclahealth.org)
Of the 70 000 or so solid organs transplanted annually, 50 000 are kidney replacements, more than one-third of the latter operations are done in low- or medium-income countries. (who.int)
The supply of cadaveric organs is limited by an inadequately informed and educated public, inefficient or non-existent organizations for procuring transplant material, and cultural and religious barriers in some countries. (who.int)

The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Bone Marrow Transplant Rejection is a complication that can occur after a stem cell or bone marrow transplant. (globaldata.com)
The Bone Marrow Transplant Rejection - drugs in development research report provides a comprehensive overview on the therapeutics under development for Bone Marrow Transplant Rejection, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (globaldata.com)
Additionally, the report provides an overview of key players involved in therapeutic development for Bone Marrow Transplant Rejection and features dormant and discontinued projects. (globaldata.com)
The key targets in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1, Tyrosine Protein Kinase JAK2, Tyrosine Protein Kinase BTK, Interleukin 2 Receptor, Programmed Cell Death Protein 1, Alpha 1 Antitrypsin, Cells Expressing B Lymphocyte Antigen CD20, Interleukin 2 Receptor Subunit Beta, Macrophage Colony Stimulating Factor 1 Receptor, and Tyrosine Protein Kinase ITK/TSK among others. (globaldata.com)
The key mechanisms of action in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1 Inhibitor, Tyrosine Protein Kinase JAK2 Inhibitor, Tyrosine Protein Kinase BTK Inhibitor, Interleukin 2 Receptor Agonist, Alpha 1 Antitrypsin Replacement, Cytotoxic To Cells Expressing B Lymphocyte Antigen CD20 , Interleukin 2 Receptor Subunit Beta Antagonist, Programmed Cell Death Protein 1 Agonist, Tyrosine Protein Kinase ITK/TSK Inhibitor, and CD40 Ligand Inhibitor among others. (globaldata.com)
It also considerably increases the risk of other infections and rejection of the transplanted tissue. (uzleuven.be)

A second patient appears to have been "cured" of HIV following a stem cell transplant procedure, which replaces unhealthy, infected cells, with healthy blood cell precursors. (forbes.com)
The upper part of this scheme shows transplant procedure in time with important time points of transplant management. (hindawi.com)
Further benefits are that the platelets and neutrophil cells (one of the white blood cells) are more easily able to recover if this method is used compared with the bone marrow procedure. (differencebetween.net)
The procedure is also a more painful one than simply removing stem cells from the blood since the needle has to go into bone. (differencebetween.net)
In case you're interested in details of stem cell hair transplant, here is a complete direction to the procedure including its results, cost, and post complications. (dynamiclinic.com)
The procedure of Stem cell Hair transplant in Dubai begins by giving local anesthesia to relieve any kind of discomfort. (dynamiclinic.com)
The procedure, which was not available at any other U.S. hospital when the brothers received it last year, is now offered to most transplant recipients at Packard Children's. (stanford.edu)

Whill risks of tumor formation come along even with standard bone marrow and whole organ transplants (both extremely low), there's a lot more data in those contexts to understand these tiny risks. (ipscell.com)
Maribavir offers an effective and safe treatment for cytomegalovirus (CMV) reactivation, a common complication following stem cell and organ transplants. (uzleuven.be)
This is a common complication, particularly with stem cell and organ transplants. (uzleuven.be)
If given in tandem with solid-organ transplants, they could also remove the need for immune-suppressing therapy in organ recipients. (stanford.edu)

The newly transplanted stem cells are replacing your child's immune system. (uclahealth.org)
The newly transplanted donor cells attack the transplant recipient's body. (globaldata.com)
In the relatively newly reported cases of olfactory stem cell-related tumors, things are only now coming into focus. (ipscell.com)

One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
In another trial, this group is evaluating whether peripheral blood stem cells combined with MSCs can treat poor graft function. (drugdiscoverynews.com)

An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)

Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
Other groups are also working on cell therapies for the treatment of poor graft function after HSCT. (drugdiscoverynews.com)
Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
Due to advances in transplant approaches and supportive care, the use of HSCT is increasing worldwide. (hindawi.com)
Despite such a progress, HSCT is still associated with substantial transplant-related mortality (TRM). (hindawi.com)
HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)

Incomplete engraftment (poor graft function) requires the patient to undergo more transfusions of red cells or platelets. (drugdiscoverynews.com)

GVHD pathogenesis corresponding to transplant time axis is shown in 3 phase-based concepts in the middle of the scheme. (hindawi.com)
Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)

Both transplants relied on selecting donors who had this mutation in their genes , so were resistant to HIV. (forbes.com)
A method that broadens the pool of potential donors for stem cell transplants recently saved two young brothers from a severe genetic disease. (stanford.edu)

Stem cell transplants are also curative for sickle cell disease, but are not widely used because of these issues. (forbes.com)

There are complications of serial transfusions of either of these cell types, and a patient needs intense prophylactic treatments to protect from infections if his or her white counts are low. (drugdiscoverynews.com)

Stem cell transplants remove blood-forming stem cells from a healthy donor, and then inject them into a patient, where they take hold and grow in the bone marrow. (stanford.edu)

The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
A stem cell transplant is when stem cells are harvested from the bloodstream or the umbilical cord. (differencebetween.net)
Stem cell transplants involve cells that are taken out of the blood or umbilical cord. (differencebetween.net)

Despite advances in the field, transplant recipients may face several avoidable risks. (who.int)

It actually boosted the ability of the donor T cells to fight the cancer. (healthproblemsnews.com)
We think at least part of the explanation is the drug strips the leukemia cells of their immune defenses, making them more vulnerable to attack by the donor T cells. (healthproblemsnews.com)
At the same time, the drug also stops the donor T cells from being able to make their way to important healthy tissues, such as the skin, liver and gastrointestinal tract, where they often do the most damage. (healthproblemsnews.com)
Simultaneously, the drug makes the leukemia cells more vulnerable to immune attack from the donor T cells, which are now mostly confined to the bloodstream, where the cancer is. (healthproblemsnews.com)

Rest assured that our skilled care team will work to minimize risks and optimize your child's bone marrow transplant recovery. (uclahealth.org)
There's some risk of tumor development with just about any stem cell transplant, but risks are higher with experimental injections of unproven stem cells. (ipscell.com)

Bone marrow, the spongy tissue inside our bones, is the factory for blood cells. (mdanderson.org)
note that the nasal tissue/cell transplant in some of these cases may or may not have contained stem cells. (ipscell.com)
In Europe, hundreds of thousands of tissue transplants are performed each year, and in 1999 an estimated 750 000 people in the United States of America received human tissue, twice as many as in 1990. (who.int)

The cells are also being evaluated in a variety of other hematologic indications. (drugdiscoverynews.com)

A hematopoietic stem cell transplant replaces faulty cells so the body can produce normal, healthy cells again. (mdanderson.org)

Transplanted donor stem cells - and more specifically, the T cells in the donor stem cell product - are particularly good at fighting off leukemia, but these cells can go haywire, unfortunately, and attack the patient's healthy tissues, causing graft-versus-host disease," said senior author John F. DiPersio, MD, PhD, the Virginia E. and Sam J. Golman Professor of Medicine in Oncology. (healthproblemsnews.com)
The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
The main, huge difference is that with gene therapy we correct the patient's cells,' Bacchetta said. (stanford.edu)

Overall, this report also highlights how transplants of adult stem cells are not by definition safe or free from risk of tumors, contrary to some myths out there. (ipscell.com)

But in severe cases, injections can't do much as our unique stem cell technique does also see FUT Transplant . (dynamiclinic.com)

A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
Stem cell transplant can be used to treat conditions such as multiple myeloma, and other cancers such as certain kinds of lymphoma and leukemia. (differencebetween.net)
Bone marrow transplants are also used in cases where a person has cancers such as some types of lymphomas and leukemias, and multiple myeloma. (differencebetween.net)
The transplants were first developed for people with blood cancers, but have the potential to be used much more widely for a variety of genetic diseases. (stanford.edu)

4. They should over time become cheaper to make encing many of the neuropsychiatric and autonomic and easier to deliver, which will facilitate the off target effects that can occur with oral dopamin- switch from DBS surgery to cell implantation. (lu.se)

Figure 1 spinal tumor imaging after nasal stem cell transplant. (ipscell.com)
In this case a patient developed a nasal-like tumor a dozen years after getting an olfactory mucosal stem cell transplant. (ipscell.com)
It's unclear if these transplants have much upside for potential benefit so the tumor risk in my view makes it inadvisable to continue this type of research without some serious contemplation of how to make it safer first. (ipscell.com)

In Dubai, our expert doctors aren't always intended with stem cell injections, however, sometimes they do. (dynamiclinic.com)

We're looking for a treatment strategy that stops the disease without shutting down T cells' assault on the cancer. (healthproblemsnews.com)
Yet the expense of immunosuppressive therapy or treatment of the resulting complications can be catastrophic for individuals, even in rich countries. (who.int)
DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. (lu.se)
The effi- risk of infection - DBS requires battery changes cacy of dopaminergic drug treatment provides a com- with a clear physical and somewhat unsightly pelling rationale for the use of dopamine cell thera- reminder of an intervention, as is evident by pies to restore striatal dopamine neurotransmission. (lu.se)

We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)

How susceptible an individual is to HIV infection is in part dependent on viral receptors on the surface of their own white blood cells. (forbes.com)

People with a specific mutation (called Δ32) on the CCR5 gene develop defective receptors, so the HIV virus can't enter the cell. (forbes.com)
Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)

At least four cases of spinal tumors have now been reported following experimental nasal stem cell transplants for paralysis. (ipscell.com)

5. While the surgical implantation of the cells car- of L-dopa-induced dyskinesias (LIDs) [5, 6]. (lu.se)

Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research from Washington University School of Medicine in St. Louis shows. (healthproblemsnews.com)
The results of Stem cell hair transplants are proven in clinical studies. (dynamiclinic.com)

There are some disadvantages to obtaining stem cells from blood rather than from bone marrow. (differencebetween.net)

With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
For the Pediatric Blood and Bone Marrow Transplant & Cellular Therapies Program, please call 310-825-6708 . (uclahealth.org)
The goal of BMT is for the donated cells to enter your child's bone marrow and start making new blood cells. (uclahealth.org)
A stem cell transplant is when cells are taken out of the blood for use in a transplant. (differencebetween.net)
Before cells can be extracted from the blood various substances have to be introduced, to help trigger the growth of the stem cells. (differencebetween.net)
The G-CSF is added and used to ensure that there will be enough stem cells in the blood for harvesting to be successful. (differencebetween.net)
The blood cells are harvested from the blood about 6 days later. (differencebetween.net)
The stem cells are then separated from the other blood cells by the process of apheresis, and then they are given to the patient through a catheter placed into a vein. (differencebetween.net)
Harvesting stem cells from the blood is in many ways an easier process since it does not involve or require the use of anesthesia. (differencebetween.net)
A team of researchers have found a new way to remove blood-producing stem cells, introducing the possibility of safer, and non-matched, transplants. (stanford.edu)

Notably, we are presenting the first survival data for neoadjuvant Libtayo therapy in cutaneous squamous cell carcinoma and the first results for Libtayo in combination with ubamatamab, our investigational MUC16xCD3 bispecific antibody, in recurrent ovarian cancer. (biospace.com)

The drug also appeared to boost levels of specific immune cells that put the brakes on a runaway immune response that can make graft-versus-host disease worse. (healthproblemsnews.com)
Technicians process stem cells from the donor to elimi-nate alpha-beta T cells, immune cells that instigate graft-versus-host disease. (stanford.edu)

The typical ways we can reduce the effects of the disease also tend to weaken the T cells' ability to attack the cancer. (healthproblemsnews.com)
Ubamatamab is a CD3-targeting bispecific designed to bridge MUC16 on cancer cells with CD3-expressing T cells to facilitate local T-cell activation. (biospace.com)

This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
The first successful stem cell transplant occurred in the "Berlin patient," Timothy Ray Brown, in 2008 and, ten years later, he is still free of HIV. (forbes.com)

In the first case, a second transplant is possible or other therapies can be considered, but the prognosis is usually disheartening. (drugdiscoverynews.com)

Anatomy41

Organisms11

Diseases38

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment84

Phenomena and Processes41

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science5

Named Groups3

Health Care26

Geographicals1

Allogeneic9

Granulocyte-colony4

Donor's5

Transplantation8

Graft-vs-host4

General anesthesia2

Risky2

Patients18

Organs5

Rejection7

Procedure7

Organ4

Newly3

Peripheral blood stem cells2

Autologous1

HSCT6

Platelets1

GVHD2

Donors2

Curative1

Treatments1

Healthy donor1

Umbilical cord5

Recipients1

Donor T cells4

Risks2

Tissue3

Hematologic1

Replaces1

Patient's5

Adult1

Severe1

Cancers5

Occur1

Tumor3

Injections1

Treatment4

Chemotherapy1

Infection1

Receptors2

Experimental1

Surgical1

Clinical3

Disadvantages1

Blood10

Therapy1

Immune cells2

Cancer2

Patient2

Therapies1