Loading...
  • Mechanism
  • We also observed accumulation of growth factor receptors such as ErbB2 and 3, insulin-like growth factor 1 receptor and platelet-derived growth factor receptor in peripheral nerves of Nf2-mutant mice and in human NF2 schwannomas, suggesting that this mechanism could play an important role in tumorigenesis. (nih.gov)
  • Notably, CD97 antibody-mediated granulocytopenia only happens under the condition of pro-inflammation via an Fc receptor-associated mechanism. (wikipedia.org)
  • All beta-barrel transmembrane proteins have simplest up-and-down topology, which may reflect their common evolutionary origin and similar folding mechanism. (wikipedia.org)
  • Two current models have been proposed to explain transmembrane receptors mechanism, dimerization considered as current standard. (wikipedia.org)
  • epidermal
  • The production of irisin is similar to the shedding and release of other hormones and hormone-like polypeptides, such as epidermal growth factor and TGF alpha, from transmembrane precursors. (wikipedia.org)
  • platelets
  • On the other hand, α2 receptors can be found in platelets, cholinergic nerve terminals, some vascular smooth muscle, postsynaptic CNS neurons, and fat cells. (wikipedia.org)
  • binds
  • They found that when adrenaline binds to a receptor, the receptor does not stimulate enzymes (inside the cell) directly. (wikipedia.org)
  • While it binds to the same receptors as opioid analgesics, TRV734 has very weak β-arrestin recruitment, unlike other available opioids, and produced fewer off-target effects. (wikipedia.org)
  • type A receptor
  • The hypothalamus and mesencephalon of adult male Wistar rats were immunostained with the antibodies to GnRH receptor and endothelin type A receptor, and observed under light-, electron- and conforcal laser scan microscopes. (nii.ac.jp)
  • domain
  • Its transmembrane domain (TMD) is the target of allosteric modulators such as general anesthetics and ethanol and is a major locus for hyperekplexic congenital mutations altering the allosteric transitions of activation or desensitization. (pnas.org)
  • Here we report the crystal structure of the transmembrane domain of the human receptor in complex with the negative allosteric modulator, mavoglurant. (rcsb.org)
  • With enzyme-linked receptors, the intracellular domain has enzymatic activity. (wikipedia.org)
  • angiotensin
  • Trevena's developed TRV027 for acute heart failure, targets the angiotensin receptor utilizing beta-arrestin bias, an approach that has shown numerous beneficial cardiovascular and renal actions in preclinical species. (wikipedia.org)