• In contrast, loss-of-function mutations in the let-7 microRNA gene prevent a developmental decline in dendritic growth ability, whereas loss-of-function mutations in its direct target, the lin-41 tripartite motif protein gene, cause further decline. (stanford.edu)
  • Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. (centrodinoferrari.com)
  • Embryos homozygous for mutations in the unc-52, pat-2, pat-3, and unc- 112 genes of C. elegans exhibit a similar Pat phenotype. (illinois.edu)
  • Here, we show that mutations in the Caenorhabditis elegans mucin-like gene osm-8 specifically disrupt osmoregulatory physiological processes. (prolekarniky.cz)
  • This model of how nuclear positioning works is primarily based on experiments in Caenorhabditis elegans worms with mutations in the genes for either the UNC-84 or ANC-1 protein ( Starr and Fridolfsson, 2010 ). (elifesciences.org)
  • In previous work, we found that gain-of-function mutations that hyperactivate GEM-1 (an SLC16A transporter protein) can bypass the requirement for GON-2 (a TRPM channel protein) during the initiation of gonadogenesis in C. elegans. (cipsm.de)
  • In 5 of 6 gene mutations that have been shown to cause EDMD, the affected protein is present in the LINC (linker of nucleoskeleton and cytoskeleton) complex. (medscape.com)
  • EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)
  • New mutations have been found in the synaptic nuclear envelope protein 1 ( SYNE1 ) gene and in the synaptic nuclear envelope protein 2 ( SYNE2 ) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)
  • Lastly, mutations in the transmembrane protein 43 (TMEM43), also termed LUMA, which binds to emerin and SUN2, has also been reported to cause an EDMD phenotype in a few families. (medscape.com)
  • Whatever the true mechanism, the discovery of mutations in several different nuclear membrane proteins that cause similar diseases will likely eventually lead to a better understanding of nuclear membrane physiology and the pathophysiology of diseases caused by mutations in these proteins. (medscape.com)
  • Here, we used a genomics/proteomics approach (including immunoblot experiments from pigs infected with T. suis ) to prioritize putative immunogenic excretory/secretory (E/S) proteins conserved across and specific to several gastrointestinal (GI) parasitic nematode species. (frontiersin.org)
  • A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)
  • The nematode Caenorhabditis elegans has a compact nervous system with only 302 neurons. (nature.com)
  • The Caenorhabditis elegans sel-12 gene encodes a multi-pass transmembrane domain protein that is similar to human presenilin. (wikipedia.org)
  • The Drosophila split ends ( spen ) gene encodes a large nuclear protein containing three RNP-type RNA binding motifs, and a conserved transcriptional co-repressor-interacting domain at the C-terminus. (biomedcentral.com)
  • We show that the Caenorhabditis elegans egl-2 gene encodes an eag K + channel and that a gain-of-function mutation in egl-2 blocks excitation in neurons and muscles by causing the channel to open at inappropriately negative voltages. (jneurosci.org)
  • accordingly, many proteins are ignored by the currently available databases of cognate proteins, despite the high amount of important genes that are functionally described only for these incomplete proteomes. (biomedcentral.com)
  • Among these, we highlight those proposed by Sonnhammer and Koonin [ 1 ] which defines orthologs, in-paralogs and out-paralogs as subtypes of homolog protein/genes, which can be operationally used by bioinformatics tools. (biomedcentral.com)
  • The unc-52 (perlecan), pat-2 α-integrin), and pat-3 (β-integrin) genes encode ECM or transmembrane proteins found at the cell - matrix adhesion sites of both dense bodies and M-lines. (illinois.edu)
  • Here we show that glutamatergic neurons differentiated from ESCs lacking both genes reveal a decreased expression of the vesicular glutamate transporter 2 (VGLUT2) both at the mRNA and protein level, as well as a reduced uptake and/or release of glutamate. (phoenixpeptide.com)
  • Cdc42 interacts with proteins that regulate endocytosis and exocytosis and mediate traffic between ER and Golgi. (rupress.org)
  • Brenner, S. The genetics of Caenorhabditis elegans . (nature.com)
  • In this study, we combined in vivo C. elegans genetics and in silico molecular dynamics simulations to understand the relation between the length and amino acid composition of the luminal KASH domain, and the function of the SUN-KASH complex. (ucdavis.edu)
  • Although the amyloid precursor protein (APP) and its proteolysis are regarded as key elements of the pathology of Alzheimer's disease, the physiological function of APP is not well understood and mice lacking App and the related gene Aplp2 die early postnatally without any obvious histopathological abnormalities. (phoenixpeptide.com)
  • Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth. (phoenixpeptide.com)
  • The amyloid precursor protein (APP), the source of the neurotoxic amyloid beta (A beta) peptide involved in Alzheimer's disease (AD), belongs to a conserved family of related proteins. (phoenixpeptide.com)
  • The backbone dynamics of the amyloid precursor protein (APP) transmembrane helix was compared to those of other transmembrane domains. (cipsm.de)
  • γ-Secretase was first identified as a protease that cleaves amyloid precursor protein (APP) and produces Aβ peptides, which are thought to be pathogenic in Alzheimers disease (AD). (eurekaselect.com)
  • Despite the prosperity of methods for definition of ortholog proteins among complete proteomes, there are few developments when it is desired to define such groups when poorly sequenced or unfinished proteomes are included in the search. (biomedcentral.com)
  • Caenorhabditis elegans ANC-1, an ortholog of Nesprin-1/2, contains actin-binding and KASH domains at opposite ends of a long spectrin-like region. (ucdavis.edu)
  • Proteins that activated immunity are potential antigens for immunization and the multi-omics phylum-spanning prioritization database that was created is a valuable resource for identifying target proteins in a wide array of different parasitic nematodes. (frontiersin.org)
  • 2022). Formation and function of dauer ascarosides in the nematodes Caenorhabditis brigsae and Caenorhabditis elegans. (caltech.edu)
  • The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. (centrodinoferrari.com)
  • This study describes the identification of the unc-112 gene product, a novel, membrane-associated, intracellular protein that colocalizes with integrin at cell-matrix adhesion complexes. (illinois.edu)
  • Given that mucins and transmembrane proteins play similar roles in yeast osmoregulation, our findings suggest a possible evolutionarily conserved role for the mucin-plasma membrane interface in eukaryotic osmoregulation. (prolekarniky.cz)
  • Description The endocytic pathway of eukaryotes is essential for the internalization and trafficking of macromolecules, fluid, membranes, and membrane proteins. (rutgers.edu)
  • Sad1/UNC-84 (SUN)-domain proteins are inner nuclear membrane (INM) proteins that are part of bridging complexes linking cytoskeletal elements with the nucleoskeleton. (expasy.org)
  • SUN proteins are anchored in the inner nuclear envelope by their transmembrane segment and oriented in the membrane such that the C-terminal SUN domain is located in the space between the inner and outer nuclear membrane. (expasy.org)
  • The SUN proteins (SAD1, UNC-84) sit across the inner nuclear membrane and connect to structures in the nucleus, such as chromatin and the nuclear lamina, and the KASH proteins (Klarsicht, ANC-1, Syne Homology) span across the outer nuclear membrane and interact with proteins in the cytoskeleton. (elifesciences.org)
  • In wild-type worms (left), the KASH protein ANC-1 (depicted as spikes) localizes to the membrane of the nucleus and endoplasmic reticulum (ER). (elifesciences.org)
  • KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of LINC complexes that connect nuclei to the cytoskeleton. (ucdavis.edu)
  • At the heart of this network are LINC ( li nker of n ucleoskeleton and c ytoskeleton) complexes made of SUN ( S ad1 and UN C-84) proteins at the inner nuclear membrane and KASH ( K larsicht, A NC-1, and S yne h omology) proteins in the outer nuclear membrane. (ucdavis.edu)
  • The intrinsic apoptotic pathway is initiated in response to a variety of stress signals ( Willis and Adams, 2005 ), and a complex interplay of Bcl-2 proteins relays this signal to the mitochondrial outer membrane (OM) to initiate Bak and Bax activation, oligomerisation and OM damage ( Fig. 1 ). (biologists.com)
  • The current development of anti-cancer agents that target the Bcl-2 protein family is showing considerable promise, although how this targeting triggers Bak and Bax to perform their crucial function of mitochondrial outer membrane permeabilisation (MOMP) is not clear. (biologists.com)
  • Recently, it was demonstrated that many type 1 transmembrane proteins, including APP and Notch, are substrates for γ-secretase, and the ICDs of these substrates are released from the cell membrane by γ-secretase. (eurekaselect.com)
  • They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)
  • Emerin is a 34-kd protein that belongs to a family of nuclear proteins that bind a variety DNA regulatory molecules and to molecules thought to be important in maintaining nuclear membrane structure. (medscape.com)
  • This complex includes nuclear membrane integral and associated proteins including emerin, lamin A/C, SUN1, SUN2, nesprin-1, and nesprin-2 that are proposed to form a mechanical link between the nucleoskeleton and cytoskeleton. (medscape.com)
  • Our studies are the first to show that an extracellular mucin-like protein plays an important role in animal osmoregulation in a manner that requires the activity of a novel transmembrane protein. (prolekarniky.cz)
  • Here, we show that structurally distinct N-glycans regulate an extracellular protein complex involved in the patterning of somatosensory dendrites in Caenorhabditis elegans. (elsevierpure.com)
  • Moreover, distinct types of N-glycans on specific N-glycosylation sites regulate DMA-1/LRR-TM receptor function, which, together with three other extracellular proteins, forms the Menorin adhesion complex. (elsevierpure.com)
  • An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
  • There are different subtypes of homology relationships attributed to proteins based on an evolutionary point of view. (biomedcentral.com)
  • These two proteins share a region of homology with talin and members of the FERM super-family of proteins. (illinois.edu)
  • Originaly identified based on an ~150-amino acid region of homology between the C terminus of the Schizosaccharomyces pombe Sad1 protein and the Caenorhabditis elegans UNC-84 protein, SUN proteins are present in the proteomes of most eucaryotes. (expasy.org)
  • The linker of the nucleoskeleton and cytoskeleton (LINC) complex is formed by the conserved interactions between Sad-1 and UNC-84 (SUN) and Klarsicht, ANC-1, SYNE homology (KASH) domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope. (ucdavis.edu)
  • Increased ion accumulation raises cytoplasmic ionic strength, which can disrupt protein structure and function [3] . (prolekarniky.cz)
  • In addition to distinct cytoplasmic domains, the luminal KASH domain also varies among KASH domain proteins of distinct functions. (ucdavis.edu)
  • The transmembrane and cytoplasmic parts are not conserved across the selectins being responsible for their targeting to different compartments. (pearltrees.com)
  • Two compounds, Compound 1 (1,4-dihydrophenanthrolin-4-one-3-carboxylic acid) and Compound 5 [8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenathrolin-4-one-3-carboxylic acid], with comparable potencies in vivo, were chosen to investigate the effect of the inhibition of the hydroxylation of newly synthesized uterine collagen on the turnover of this protein in vivo. (embl.de)
  • One of the RAB-10-interacting candidates, EHBP-1, an actin-cyskeleton bundling protein, was revealed to function together with RAB-10 in vivo. (rutgers.edu)
  • Chronis, N., Zimmer, M. & Bargmann, C.I. Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans . (nature.com)
  • In agreement with our models, our in vivo results show that swapping the KASH domains of ANC-1 and UNC-83, or shortening the KASH domain of ANC-1, both result in a nuclear anchorage defect in C. elegans . (ucdavis.edu)
  • Current models suggest that positioning of the nucleus relies on a complex called LINC (short for Linker of Nucleoskeleton and Cytoskeleton), which is made up of proteins that contain either a SUN or KASH domain. (elifesciences.org)
  • However, how endocytic proteins functionally intersect with autophagy is not clear. (nih.gov)
  • Here we find that in Caenorhabditis elegans, mouse, rat and human neurons, dendritically and axonally polarized transmembrane proteins are recognized by endocytic machinery in the AIS, robustly endocytosed and targeted to late endosomes for degradation. (stanford.edu)
  • It has been previously shown that the EH-domain protein RME-1 is a critical regulator of endocytic recycling in worms and mammals. (rutgers.edu)
  • In my studies, the RAB-10 protein was identified as a key regulator of endocytic recycling upstream of RME-1 in polarized epithelial cells of the Caenorhabditis elegans intestine. (rutgers.edu)
  • I conclude that RAB-10 and EHBP-1 likely function together in basolateral endocytic recycling pathway of the C. elegans intestine. (rutgers.edu)
  • Nuclear positioning is mediated by a conserved network of nuclear envelope proteins that interacts with force generators in the cytoskeleton. (ucdavis.edu)
  • In its GTP-bound form, Cdc42 binds several effectors that help direct polarized cell growth: repolarizing actin and microtubules, directing polarized exocytosis via this reoriented cytoskeleton and by direct contact with exocytic machinery, and recruiting proteins such as septins that form a boundary restricting the region of cell growth. (rupress.org)
  • These fibers can dissolve back into their precursor proteins in water, after which they can be drawn into new fibers, providing biological inspiration to design recyclable materials. (bvsalud.org)
  • Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission. (phoenixpeptide.com)
  • For example, in Caenorhabditis elegans , SUN protein UNC-84 binds to two KASH proteins UNC-83 and ANC-1 to mediate nuclear migration and anchorage, respectively. (ucdavis.edu)
  • Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)
  • Neuronal polarity requires sorting and maintaining a unique set of proteins to the neuron's distinct axonal and somatodendritic domains. (stanford.edu)
  • AMAN-2 functions cell-autonomously to allow for decoration of the neuronal transmembrane receptor DMA-1/LRR-TM with the correct set of high-mannose/hybrid/paucimannose N-glycans. (elsevierpure.com)
  • de Bono, M. & Maricq, A.V. Neuronal substrates of complex behaviors in C. elegans . (nature.com)
  • These proteins take part in the fusion pathway in two consecutive steps. (centrodinoferrari.com)
  • N-glycans are molecularly diverse sugars borne by over 70% of proteins transiting the secretory pathway and have been implicated in protein folding, stability, and localization. (elsevierpure.com)
  • and the intrinsic pathway, which is activated by cellular stress and is regulated primarily at the level of mitochondria by the Bcl-2 family of proteins ( Fig. 1 ). (biologists.com)
  • However, in certain cell types, the extrinsic pathway also induces mitochondrial damage by cleaving the pro-apoptotic Bcl-2 family protein Bid to its activated truncated form (tBid), which leads to Bak and Bax activation. (biologists.com)
  • Genetic studies of osmoregulation in yeast have identified mucin-like proteins as critical regulators of osmosensitive signaling and gene expression. (prolekarniky.cz)
  • In a yeast two-hybrid screen for RAB-10-interacting proteins, eight candidates with RAB-10-interacting ability were identified. (rutgers.edu)
  • Fission yeast spindle pole body-associated protein Sad1. (expasy.org)
  • Yeast uncharacterized protein SLP1. (expasy.org)
  • Some proteins known to contain a SUN domain are listed below: - Fission yeast spindle pole body-associated protein Sad1. (expasy.org)
  • No yeast two-hybrid interactions found for this protein. (yeastrc.org)
  • Neurons are highly polarized cells that face the fundamental challenge of compartmentalizing a vast and diverse repertoire of proteins in order to function properly1. (stanford.edu)
  • Our results demonstrate that we can excite specific neurons expressing ChR2 while simultaneously monitoring G-CaMP fluorescence in several other neurons, making it possible to rapidly decipher functional connections in C. elegans neural circuits. (nature.com)
  • Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans . (nature.com)
  • green fluorescent protein (GFP) fusions revealed egl-2 expression in a subset of neurons and muscles that could explain the mutant behavioral defects. (jneurosci.org)
  • The abnormal early endosomes in rab-10 mutants accumulate basolaterally recycling transmembrane cargo molecules and basolaterally recycling fluid, consistent with a block in basolateral transport. (rutgers.edu)
  • They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)
  • We found that one suppressor, the transmembrane protein PTR-23, is co-expressed with osm-8 in the hypodermis and strongly suppresses several Osm-8 phenotypes, including the transcriptional activation of many osmosensitive mRNAs, constitutive glycerol accumulation, and osmotic stress resistance. (prolekarniky.cz)
  • Rho GTPases and their downstream effector proteins regulate a diverse array of cellular processes during embryonic development, including reorganization of cytoskeletal architecture, cell adhesion, and transcr. (biomedcentral.com)
  • Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)
  • The LINC complex can perform distinct cellular functions by pairing various KASH domain proteins with the same SUN domain protein. (ucdavis.edu)
  • Taken with the present results, this suggests that the potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein. (embl.de)
  • 2021). Distinct neural circuits establish the same chemosensory behavior in C. elegans . (caltech.edu)
  • Specifically, aman-2/Golgi alpha-mannosidase II, a conserved key enzyme in the biosynthesis of specific N-glycans, regulates the activity of the Menorin adhesion complex without obviously affecting the protein stability and localization of its components. (elsevierpure.com)
  • A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
  • It is extremely important to comparative biology that related proteins be identified as members of the same cognate group, since a characterized putative homolog could be used to find clues about the function of uncharacterized proteins from the same group. (biomedcentral.com)
  • G-protein coupled receptors (GPCRs) are ancient, ubiquitous, constitute the largest family of transducing cell surface proteins, and are integral to cell communication via an array of ligands/neuropeptides. (biomedcentral.com)
  • The derived amino acid sequence of Ov-phy-1 encoded a peptide that was most similar to the two Caenorhabditis elegans prolyl 4-hydroxylase homologues and to the isoform II enzymes of vertebrates. (embl.de)
  • We have developed a method to cluster cognate proteins from multiple organisms beginning with only one sequence, through connectivity saturation with that Seed sequence. (biomedcentral.com)
  • However, a great part of the cognate proteins encoded by distinct proteomes is strictly similar, at the sequence level, to their counterparts in related species. (biomedcentral.com)
  • Here, we propose a methodology for finding highly-related groups of proteins to one single desired Seed sequence, classifying each of them as potential orthologs or in-paralogs into complete and or unfinished proteomes. (biomedcentral.com)
  • In addition to the SUN domain, these proteins contain a transmembrane sequence and at least one coiled-coil domain and localize to the inner nuclear envelope. (expasy.org)
  • 3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)
  • Here we report that the behavioral defects in the C. elegans egl-2 mutant are caused by a gain-of-function ( gf ) mutation in an eag-like K + channel. (jneurosci.org)
  • This control is propagated through the alpha-subunit of prolyl 4-hydroxylase where protein levels were previously shown to rise fivefold with increasing cell density. (embl.de)
  • Characterization of SUN-domain proteins at the higher plant nuclear envelope. (expasy.org)
  • DOI=10.1083/jcb.200601062 [ 3] Graumann K., Runions J., Evans D.E. "Characterization of SUN-domain proteins at the higher plant nuclear envelope. (expasy.org)
  • Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)
  • The LIN-14 transcription factor likely directly represses dma-1 gene expression through a transcriptional means, whereas the LIN-41 tripartite motif protein likely indirectly promotes dma-1 gene expression through a posttranscriptional means. (stanford.edu)
  • see RTKRas/MAP kinase signaling ), LIN-12 (see LIN-12/Notch signaling in C. elegans ), and WNT (see Wnt signaling ), as well as the functions of the SynMuv and mediator proteins (see Transcriptional regulation ). (wormbook.org)
  • Generating clusters based only on individual proteins of interest is less time consuming than generating clusters for whole proteomes. (biomedcentral.com)
  • As a result, after isolation and speciation events, populations carrying closely-related proteomes can produce highly related protein sets. (biomedcentral.com)
  • This great importance necessitates a better understanding of key biological processes of crustaceans in order to address key bottlenecks in the fishery and aquaculture industries to enable it to meet the ever-growing demand in quality protein [ 6 ], as well as to devise species-specific treatments for invasive species. (biomedcentral.com)
  • We present evidence that the Snail-related transcription factor CES-1 of Caenorhabditis elegans coordinates these processes in a specific cell lineage. (cipsm.de)
  • Experiments in C. elegans reveal new insights into how the ANC-1 protein helps to anchor the nucleus and other organelles in place. (elifesciences.org)
  • 183:1129-1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins. (rupress.org)
  • Caenorhabditis nuclear migration and anchoring protein UNC-84. (expasy.org)
  • Furthermore, most of the available methods are used in a high-throughput way, considering the whole protein dataset. (biomedcentral.com)
  • When resources are scant, C. elegans larvae arrest as long-lived dauers under the control of insulin/IGF- and TGFβ-related signaling pathways. (biomedcentral.com)
  • 2022). Interneuron control of C. elegans developmental decision-making. (caltech.edu)
  • Our results indicate a significant functional role of APP and amyloid precursor-like protein 2 (APLP2) in the development of synaptic function by the regulation of glutamatergic neurotransmission. (phoenixpeptide.com)
  • In this Commentary, we discuss the implications of these findings for the regulation of apoptosis by Bcl-2 family proteins. (biologists.com)
  • Mammalian sperm-associated antigen 4 protein (SPAG4), may assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. (expasy.org)
  • these include the LIM domain protein LIN-11 , the Pax2/5/8 protein EGL-38 , the zinc finger protein LIN-29 , and the Nkx6.1/6.2 protein COG-1. (wormbook.org)
  • Caenorhabditis SUN domain-containing protein 1 (sun-1), involved in centrosome attachment to the nucleus. (expasy.org)
  • The focus is on recent studies elucidating the best-understood network of LINC complexes, those used throughout C. elegans development. (ucdavis.edu)
  • All generate variability in the protein repository present in one population. (biomedcentral.com)
  • Typically, databases of related proteins focus on those from completely-sequenced genomes. (biomedcentral.com)
  • The evolutionary conservation of this rare protein modification suggests an essential functional role of phosphonates in velvet worm slime and should stimulate further study of the function of this unusual chemical modification in nature. (bvsalud.org)
  • Dynamin-related protein 1 (DRP1), a cytosolic dynamin-related GTPase, plays a central role in fission by promoting mitochondrial division through its oligomerization into multimeric spiral structures [5]. (centrodinoferrari.com)