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SynaptophysinMolecular Sequence DataAmino Acid SequenceMembrane ProteinsProtein Structure, TertiaryCell MembraneSequence Homology, Amino AcidRecombinant Fusion ProteinsProtein Structure, SecondaryMutagenesis, Site-DirectedCloning, MolecularProtein ConformationBase SequenceSynaptic VesiclesProtein BindingModels, MolecularMutationBinding SitesCell LineTransfectionSequence AlignmentRecombinant ProteinsNerve Tissue ProteinsProtein TransportCystic Fibrosis Transmembrane Conductance RegulatorStructure-Activity RelationshipDNA, ComplementaryAmino Acid SubstitutionDimerizationCricetinaeVesicle-Associated Membrane Protein 2Amino Acid MotifsProtein Interaction Domains and MotifsMembrane GlycoproteinsCysteineSynaptogyrinsCHO CellsMutagenesisCOS CellsSignal TransductionCarrier ProteinsChromograninsCytoplasmImmunohistochemistryLigandsEndoplasmic ReticulumBiological TransportSequence DeletionCarcinoma, NeuroendocrineMembrane Transport ProteinsKineticsConserved SequenceProtein MultimerizationSynapsinsCercopithecus aethiopsDNA PrimersChromogranin AR-SNARE ProteinsEscherichia coliPeptidesCells, CulturedPeptide FragmentsPoint MutationRNA, MessengerXenopus laevisGlycosylationBlotting, WesternBacterial Proteinssrc Homology DomainsFluorescent Antibody TechniqueProtein FoldingNeuronsMicroscopy, FluorescenceLipid BilayersProtein Sorting SignalsModels, BiologicalIntracellular MembranesCross-Linking ReagentsProtein Structure, QuaternaryCrystallography, X-RayIon Channel GatingGolgi ApparatusMesylatesHeLa CellsImmunoblottingOocytesPlasmidsElectrophoresis, Polyacrylamide GelPhosphorylationEscherichia coli ProteinsHydrophobic and Hydrophilic InteractionsGene ExpressionHEK293 CellsXenopusDNASaccharomyces cerevisiaeSynapsesPrecipitin TestsProtein IsoformsGreen Fluorescent Proteins
ProteinGlycoproteinMonoclonal antibodyMembraneProteinsIntracellular domainExtracellularSynapseRegulationReceptorsMarkerInteractionAnkyrin repeatKinaseComplexFERMInteractHumanShownExpressionCellsStorageDeath domainGrowthSynaptic vesicle proteinLigand-bindinMonoclonalImmunohistochemistryBindsDeficitsMoleculesCoiled-coil domainSequenceReceptor domainTyrosineBrainEffectRegionSource
Protein22
  • Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. (wikipedia.org)
  • The protein is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. (wikipedia.org)
  • The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally. (wikipedia.org)
  • Synaptophysin is an integral membrane protein involved in neurotransmitter exocytosis. (enzolifesciences.com)
  • This protein consists of four transmembrane domains, with its N- and C-terminus facing the cytoplasm. (enzolifesciences.com)
  • Studies have shown Synaptophysin to be a major cholesterol-binding protein in brain synaptic vesicles. (enzolifesciences.com)
  • C3G administration mitigated tau phosphorylation and improved synaptic function and plasticity by upregulating the expression of synapse-associated proteins synaptophysin and postsynaptic density protein-95. (biomedcentral.com)
  • The amyloid precursor protein (APP) is a transmembrane glycoprotein expressed in several cells, including central nervous system neurons. (biomedcentral.com)
  • A disintegrin and metalloproteinase domain-containing protein 10) and λ-secretase to produce soluble Aβ fragments. (biomedcentral.com)
  • HECT domain E3 ubiquitin protein li. (gsea-msigdb.org)
  • Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. (bjbms.org)
  • We generated a cyclic peptide library derived from the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and the angiotensin-converting enzyme 2 (ACE2) receptor. (bvsalud.org)
  • The cation-independent mannose 6-phosphate receptor and the low density lipoprotein receptor, both rapidly internalized from the cell surface, and the synaptic vesicle membrane protein synaptophysin, were transported to the Golgi apparatus with equivalent, nonlinear kinetics. (rupress.org)
  • In contrast, Thy-1, a protein anchored in the membrane by a glycosylphosphoinositide group, was internalized and transported to the Golgi apparatus more slowly than the three transmembrane proteins. (rupress.org)
  • The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). (abeomics.com)
  • The TRK family is composed of three transmembrane protein receptors (TRKA, TRKB, TRKC) that are encoded by the neurotrophic receptor tyrosine kinase (NTRK) genes (NTRK1, NTRK2, NTRK3), respectively. (roche.com)
  • Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (iiab.me)
  • NO levels, CD11b/c integrin expression, and synaptophysin Rabbit polyclonal to Vang-like protein 1 immunoreactivity were also reduced as compared with those in the LPS-challenged group. (health-e-nc.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse EGF Like Domain Protein, Multiple 7 (EGFL7) in serum, plasma, tissue homogenates and other biological fluids. (gkts.net)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse EGF Like Domain Protein, Multiple 7 (EGFL7) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (gkts.net)
  • Description: A sandwich ELISA kit for detection of EGF Like Domain Protein, Multiple 7 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (gkts.net)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human EGF Like Domain Protein, Multiple 7 (EGFL7) in samples from serum, plasma, tissue homogenates or other biological fluids. (gkts.net)
Glycoprotein2
  • Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. (thermofisher.com)
  • CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. (abeomics.com)
Monoclonal antibody1
  • The following product was used in this experiment: Synaptophysin Monoclonal Antibody (SYP, 3551) from Thermo Fisher Scientific, catalog # 6855-MSM1-P1. (thermofisher.com)
Membrane1
  • Such processes require membrane traffic to particular domains of the cell surface, in order to insert proteins at restricted regions of the membrane, to enlarge particular regions of the cell membrane, or to signal asymmetrically to neighboring cells. (sdbonline.org)
Proteins4
  • Since each of the transmembrane proteins studied showed the same t1/2 for transport to the Golgi apparatus, we conclude that transport of these proteins from the cell surface to the Golgi apparatus does not require sorting information specific to any one of these proteins. (rupress.org)
  • Although the complete proteins topology isn't known, evidence shows that a little part of the peptide can be a transmembrane section with a brief cytoplasmic tail. (cell-signaling-pathways.com)
  • Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "VENTANA pan-TRK (EPR17341) Assay is intended for laboratory use in the qualitative immunohistochemical detection of the C-terminal region of the tropomyosin receptor kinase (TRK) proteins A, B and C by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument. (roche.com)
  • Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "VENTANA pan-TRK (EPR17341) Assay is a rabbit monoclonal primary antibody directed against the C-terminal region of TRK A, B and C proteins, also known as pan-TRK. (roche.com)
Intracellular domain2
  • The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. (abeomics.com)
  • All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. (iiab.me)
Extracellular1
  • Furthermore to carbohydrates for the extracellular part of the 2/1 subunit, additional conserved domains considered to c-Kit-IN-2 mediate cell signalling can be found in this area. (cell-signaling-pathways.com)
Synapse1
  • It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses. (wikipedia.org)
Regulation1
  • Subsequently, further distinctions in trafficking pathways have been invoked to explain different forms of regulation and fusion at different domains of the cell. (sdbonline.org)
Receptors2
  • Using these antibodies, in conjunction with GluR2-specific and synaptophysin antibodies, we have directly localized and quantified surface-expressed native AMPA and NMDA receptors on cultured living hippocampal neurons during development. (jneurosci.org)
  • Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (iiab.me)
Marker2
Interaction1
Ankyrin repeat1
Kinase2
  • 1-5 Preservation of the TRK kinase domain in these NTRK fusions drive carcinogenesis through constitutive activation of pathways that regulate cell survival, proliferation, invasion, and angiogenesis. (roche.com)
  • lacks kinase domain), and erbB-4. (iiab.me)
Complex1
  • Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. (thermofisher.com)
FERM2
Interact1
Human1
  • Aspartyl beta-hydroxylase: In vitro hydroxylation of a synthetic peptide based on the structure of the first growth factor-like domain of human factor IX. (bjbms.org)
Shown1
  • Recent research has shown, however, that elimination of synaptophysin in mice creates behavioral changes such as increased exploratory behavior, impaired object novelty recognition, and reduced spatial learning. (wikipedia.org)
Expression1
  • At the end of the behavioral tests, the levels of tumor necrosis factor- (TNF-), interleukin (IL)-1, nitric oxide (NO), inducible nitric oxide synthase (iNOS), CD11b/c integrin expression, and synaptophysin immunoreactivity were determined in the brain tissues. (health-e-nc.org)
Cells1
Storage2
  • We investigated the roles of storage and parsing in the visual domain for the productive Dutch plural suffix -en.Two experiments are reported that show that storage occurs for high-frequency noun plurals. (mpi.nl)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "VENTANA pan-TRK (EPR17341) Assay contains sufficient reagent for 50 tests. (roche.com)
Death domain1
Growth1
  • Hydroxylation of aspartic acid in domains homologous to the epidermal growth factor precursor is catalyzed by a 2-oxoglutarate-dependent dioxygenase. (bjbms.org)
Synaptic vesicle protein2
  • Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. (wikipedia.org)
  • The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally. (wikipedia.org)
Ligand-bindin2
  • In the accompanying work, we demonstrate that transgenic expression of the NgR ligand-binding domain allows axonal sprouting and improved recovery from SCI in mice (S. Li, S. Budel, J. E. Kim, T. G. Hampton, and S. M. Strittmatter, unpublished observations). (jneurosci.org)
  • All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. (iiab.me)
Monoclonal1
  • The primary antibody anti-Synaptophysin mouse monoclonal, SY38 (Cat. (progen.com)
Immunohistochemistry1
Binds1
  • We identified Zn(II)-BnPyP, a tetracationic porphyrin that binds to distinct domains of native PrPC, eliciting a dual anti-prion effect. (bvsalud.org)
Deficits1
  • Neurochemically, Alzheimer disease is characterized by brain amyloid depositions, hyperphosphorylation of tau, loss of the synaptophysin protein, and cholinergic deficits. (medscape.com)
Molecules1
  • Slitrk molecules are transmembrane proteins that are highly expressed in the central nervous system. (nih.gov)
Coiled-coil domain1
Sequence2
  • Cloning and characterization of mouse intestinal MUC3 mucin: 3' sequence contains epidermal-growth-factor-like domains. (harvard.edu)
  • HER2 is found in a variety of tumours and some of these tumours carry point mutations in the sequence specifying the transmembrane domain of HER2. (iiab.me)
Receptor domain1
  • 14. MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics. (nih.gov)
Tyrosine1
  • Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (iiab.me)
Brain1
  • Western blot analysis of mouse brain lysate with anti-Synaptophysin antibody. (progen.com)
Effect1
  • 6. The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy. (nih.gov)
Region1
Source2