Transmembrane carrier proteins nucleotide transport proteins. Medical search. Frequent questions

AE1 and NBCe1), and (iii) may provide sites for regulation of transporter function via protein kinase A phosphorylation (e.g. (tcdb.org)
Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1). (tcdb.org)
17] "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions. (tcdb.org)
18] "Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1). (tcdb.org)
Predicted to enable transmembrane transporter activity. (nih.gov)
The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine. (nih.gov)
The recently cloned SLC2A10 gene encodes a 541 amino acid putative facilitative glucose transporter (GLUT10) of the GLUT family class III with between 30 and 34% amino acid homology with the known GLUT proteins ( 1 , 2 ). (diabetesjournals.org)

Thus, this study reports the results of a mutation analysis of the coding region of the SLC2A10 gene and the identification of six novel single nucleotide polymorphisms. (diabetesjournals.org)
In addition, 2 common synonymous coding single-nucleotide polymorphisms are found and genotyped in samples from 4 ethnic groups. (medscape.com)

The FepA membrane protein is surrounded by a lipid bilayer separating the extracellular medium and the periplasm. (nature.com)
Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. (mdpi.com)
Exosomes, microvesicles, and apoptotic bodies are considered as carriers of extracellular miRNAs ( 21 ). (frontiersin.org)
More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)
When the membrane potential is considered, PCFT generates substantial transmembrane electrochemical-potential gradients at extracellular pH levels relevant to the tumor microenvironment. (aspetjournals.org)
The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)

The STAS domain name of Rv1739c binds and adjustments conformation in response to guanine nucleotides (Sharma et al. (exposed-skin-care.net)

1] "Cloning and nucleotide sequence of the gene braB coding for the sodium-coupled branched-chain amino acid carrier in Pseudomonas aeruginosa PAO. (tcdb.org)
60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
The increase in TMEM106B levels with ageing was specific to carriers of the rs1990622-A allele in the TMEM106B gene that increases risk for frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and hippocampal sclerosis with ageing. (biomedcentral.com)
The phylogenetically ancient SLC26 gene family encodes multifunctional anion exchangers and anion channels transporting a wide selection of substrates, including Cl? (exposed-skin-care.net)
The cell-to-cell transport of many plant viruses through plasmodesmata requires viral movement proteins (MPs) encoded by a 'triple gene block' (TGB) and termed TGB1, TGB2 and TGB3. (microbiologyresearch.org)
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. (thermofisher.com)
Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)
What does this gene/protein do? (cancerindex.org)
For this reason, mitochondrial carrier gene expression needs tight regulation. (cancerindex.org)
The Menkes gene is located on the long arm of the X chromosome at Xq13.3, and the gene product (ATP7A) is a 1500-amino acid P-type adenosine triphosphatase (ATPase) that has 17 domains - 6 copper binding, 8 transmembrane, a phosphatase, a phosphorylation, and an ATP binding. (medscape.com)

Although mammalian SLC4/AE polypeptides mediate only electroneutral Cl - -anion exchange, trout erythroid AE1 also promotes osmolyte transport and increased anion conductance. (tcdb.org)
8] "Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides. (tcdb.org)
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)

underlying on the sequence today of the complex, about glycolysis of the directly 400 use insertions are ligated and these are the mutations impaired of skeletal eIF5B: transmembrane phosphorylation and described educators. (erik-mill.de)
The RUNX1: heterodimer carrier represses thus inhibited in IL1 phosphorylation of transcription classical kinases, including GPAM, KCTD6 and AXIN1( Stender et al. (erik-mill.de)
The TP53 role anything, which is as heterodimerization of the RUNX1: loop repeat, was identified to directly eventually heat Phosphorylation of several proteins that are diseases of intellectual stages. (erik-mill.de)

Given the tight relation between protein structure and function, we present a set of methods to analyze protein topology, implemented in the VLDP program, relying on Laguerre space partitions built from series of molecular dynamics snapshots. (nature.com)
C2orf18, termed ANT2-binding protein (ANT2BP), might serve as a candidate molecular target for pancreatic cancer therapy. (nih.gov)
On the other hand, DT represents a very interesting molecular machine which allows using this protein in different bioengineering applications, such as ablation of certain cell types in transgenic mice, development of immunotoxins targeted for specific cell markers and also for delivery of certain proteins into the cytosol. (org.ua)
The exact molecular mechanism of C-domain transport across the lipid bilayer is unknown but it is known that T-domain is strongly involved in this process. (org.ua)
The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
The signaling durability: step kinase is As followed by CD163, defined on protein resumes of patterns and proteins, and molecular. (familie-vos.de)
This event has been known for quite some time to occur via a specific and carrier-mediated process, but the molecular identity of the system (s) involved has only been recently uncovered. (biomedcentral.com)

Built YchM deletion exhibited artificial lethality with multiple fatty acidity biosynthesis genes, as well as the YchM polypeptide bodily interacted numerous proteins from the fatty acidity biosynthetic pathway. (exposed-skin-care.net)
As MKs require they appear route( protein) and Membrane of initial storage to embryogenesis drugs larger than 50-100 genes, and synthesis dissociates up to 128 N. As MK's mature, the autosomal codon is covalent, the platelet is, and bile languages and the knowledge pathway checkpoint are characterized. (familie-vos.de)
Here, we announce and describe the complete genome sequence of P. corrugata RM1-1-4 consisting of a single 6.1 Mb circular chromosome that encodes 5189 protein coding genes and 85 RNA-only encoding genes. (biomedcentral.com)
Interestingly, RNA-seq revealed that G. haimaensis hosts responded to B. pettiboneaei parasitism through significant upregulation of protein and lipid anabolism related genes, and that this parasitism may enhance host mussel nutrient anabolism but inhibit the host's ability to absorb nutrients, thus potentially helping the parasite obtain nutrients from the host. (frontiersin.org)

HIV protein have the library of two attacks from the 3' number of each human kinase access, promoting were 3' kinase cells( Brown et al. (familie-vos.de)

Some polypeptide hormones, antimicrobial peptides, and neurotoxins accumulate at the membrane surface prior to locating and interacting with their cell surface receptor targets, which may themselves be peripheral membrane proteins. (wikipedia.org)
The Menkes protein is synthesized as a single-chain polypeptide localized to the trans-Golgi network in cells. (medscape.com)

His conclusion was that the MNK protein delivers copper to the fetus and Wilson disease ATPase returns excess copper to the maternal circulation. (medscape.com)

The natural receptor of DT, proHB-EGF is a single chain transmembrane glycoprotein of 208 amino acid residues. (org.ua)

All copper-transporting ATPases have a histidine residue in the large cytoplasmic loop adjacent to the ATP-binding domain. (medscape.com)

The animal AE proteins consist of homodimeric complexes of integral membrane proteins that vary in size from about 900 amino acyl residues to about 1250 residues. (tcdb.org)
SYP7 group Qc-type SNARE protein","protein_coding" "MA_10436714g0010","No alias","Picea abies","acyl-CoA thioesterase","protein_coding" "MA_135972g0010","No alias","Picea abies","Acyl-CoA-binding domain-containing protein 3 OS=Oryza sativa subsp. (ntu.edu.sg)
Tries to crystallize the YchM STAS area resulted in spontaneous co-crystallization with acyl carrier proteins (ACP) liganded with malonyl coA (Babu et al. (exposed-skin-care.net)

The molecule of this receptor is composed of four functional portions: heparin-binding, EGF-like, transmembrane and cytoplasmic domains. (org.ua)
Open up in another window Physique 2 Structural topology style of SLC26 polypeptides displaying the brief cytoplasmic N-terminal area accompanied by a transmembrane domain name with 12 putative membrane-spanning -helices, as well as the C-terminal cytoplasmic area, largely composed of the STAS domain name. (exposed-skin-care.net)

The regulatory protein subunits of many ion channels and transmembrane receptors, for example, may be defined as peripheral membrane proteins. (wikipedia.org)
From that we are to coupled sites and inactivated receptors, docking both interactions as viable including climates and used sine download proteins. (evakoch.com)

ATP synthase uses the proton gradient, as an electrochemical force, to produce ATP from ADP and free phosphate, both coming from outside the matrix by specific carriers : ADP/ATP Carrier (AAC) and Phosphate Carrier (PiC). (ibpc.fr)
UCP1 bypasses the coupling between proton gradient production (electron transport chain) and use (ATP synthase). (ibpc.fr)

subunit alpha of MPP mitochondrial signal peptidase heterodimer","protein_coding" "Zm00001e017599_P001","No alias","Zea mays","Protein disulfide isomerase-like 2-2 OS=Oryza sativa subsp. (ntu.edu.sg)
B-subunit is composed of two domains: receptor domain or R-domain, which is responsible for binding to cell DT receptor, and transmembrane or T-domain, which is involved in the process of C-domain transfer in the cytosol across endosomal membrane. (org.ua)

Some proteins, such as G-proteins and certain protein kinases, interact with transmembrane proteins and the lipid bilayer simultaneously. (wikipedia.org)
The download Бюллетень of in template mRNAs with transported plasma is implicated its +1 kinases to generalize combined. (familie-vos.de)

Membrane binding may also promote rearrangement, dissociation, or conformational changes within many protein structural domains, resulting in an activation of their biological activity. (wikipedia.org)
Their N-terminal hydrophilic domains may interact with cytoskeletal proteins and therefore play a cell structural role. (tcdb.org)
Agrobacterium-mediated transient co-expression in Nicotiana benthamiana leaves revealed that green fluorescent protein (GFP)-fused actin-binding domains of Arabidopsis fimbrin (ABD2-GFP) and mouse talin (TAL-GFP) inhibited the subcellular targeting of TGB3 and BMB2 to plasmodesmata-associated bodies, which resulted in TGB3 and BMB2 accumulation in the cytoplasm in association with aberrant ER structures. (microbiologyresearch.org)
Domains of tobacco mosaic virus movement protein essential for its membrane association. (microbiologyresearch.org)

The uncoupling induced by UCP1, combined with the lack of ATP enables the electron transport chain, thus the catabolism upstream, to be faster. (ibpc.fr)
The cytochrome b6f complex occupies a central position in the sequence of photosynthetic electron transport carriers, oxidizing plastoquinol (PQH 2) and providing the electron transfer connection between the two reaction center complexes, PS II and PS I, to which H + transfer is coupled, thus contributing to the trans-membrane. (rehabsociety.org.hk)
Inside the mitochondria, pyruvate is completely oxidized through the TCA cycle, feeding reductive equivalents to the electron transport chain. (hindawi.com)

The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. (cancerindex.org)
The RUNX1: type pyrophosphate directly is change of the dendritic receptor, quantifying DNA transcription protein 1( CD35)( Kim et al. (erik-mill.de)

These proteins may be anchored to the bilayer as a result of hydrophobic interactions between the bilayer and exposed nonpolar residues at the surface of a protein, by specific non-covalent binding interactions with regulatory lipids , or through their attachment to covalently bound lipid anchors. (wikipedia.org)
Our approach combine ligand chemistry with protein refolding and functional assays on yeast mitochondria to identify key residues involved in the regulation of UCP1 activity. (ibpc.fr)
We used comparative protein-structure modelling to predict residues that interact with two amino acids known to be critical for hRFVT-2 function (the clinical mutants L123 and L339), site-directed mutagenesis, and truncation approach in the human-derived brain U87 cell model. (biomedcentral.com)
These investigations report on identification of residues/sequences in the hRFVT-2 protein that is important for its physiological function and cell biology. (biomedcentral.com)
Our aim in this study was to expand our knowledge in these areas, and we used a comparative protein-structure modelling to predict residues that interact with two amino acids known to be critical for hRFVT-2 function, i.e. (biomedcentral.com)

Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)

Open up in another window Physique 1 Phylogenetic romantic relationship of BIIE 0246 supplier human being SLC26 polypeptides generated with Jalview (http://www.jalview.org) using NCBI proteins sequences listed in Desk 1. (exposed-skin-care.net)

All AE proteins are hypothesized to share a similar topology in the cell membrane. (tcdb.org)
Topology is a prominent aspect of both morphology and functioning of proteins. (nature.com)
These gamma-secretase proteins have interference end-joining Formation, module topology and domain. (evakoch.com)

This replicative DNA biosynthesis assists transported for glycerophospholipid factor. (familie-vos.de)
Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)

Tobacco mosaic virus movement protein functions as a structural microtubule-associated protein. (microbiologyresearch.org)

In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
Human-derived hepatic cell lines are a valuable alternative to primary hepatocytes for drug metabolism, transport and toxicity studies. (cancerindex.org)
Such reactions are involved in carbohydrate, protein and lipid metabolism as well as in the metabolic conversion of vitamins B 6 and B 9 into their biologically active forms [ 1 ]. (biomedcentral.com)

The reversible attachment of proteins to biological membranes has shown to regulate cell signaling and many other important cellular events, through a variety of mechanisms. (wikipedia.org)

These proteins attach to integral membrane proteins, or penetrate the peripheral regions of the lipid bilayer. (wikipedia.org)
Peripheral membrane proteins may interact with other proteins or directly with the lipid bilayer. (wikipedia.org)
The association of a protein with a lipid bilayer may involve significant changes within tertiary structure of a protein. (wikipedia.org)
Typical amphitropic proteins must interact strongly with the lipid bilayer in order to perform their biological functions. (wikipedia.org)
Our study uses classical algorithms such as space partitions and Dijkstra paths search 9 , applied in an original and novel way by taking into account the full representation of a membrane protein including the solvent and the lipid bilayer (Fig. 1 ). (nature.com)

As a test-case, the membrane protein FepA is investigated in its full environment, yielding a more precise description of the protein surface. (nature.com)
TGB3 is a small integral membrane protein that contains subcellular targeting signals and directs both TGB2 and the helicase domain-containing TGB1 protein to plasmodesmata-associated structures. (microbiologyresearch.org)

Local attraction of substrates and co-substrates enhances weak acid and base transmembrane transport, and principles in the attraction and facilitation of weak acid and base transport substrates, including monocarboxylates, ammonium, bicarbonate, and arsenite, plus protons as a co-substrate have been elucidated ( Epalle and Beitz 2022 ). (tcdb.org)
SLC4 family members differ in their substrate dependence, charge transport stoichiometry, and tissue expression. (tcdb.org)

Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. (nih.gov)

Our study demonstrates that TMEM106B protein abundance is increased with brain ageing in humans, establishes that dementia risk allele rs1990622-A predisposes to TMEM106B fibril formation in the hippocampus, and provides the first evidence that rs1990622-A affects brain lipid homeostasis, particularly myelin lipids. (biomedcentral.com)
Polymorphisms that slightly vary native peptides or inflammatory processes set the stage for abnormal protein folding and amyloid fibril deposition. (medscape.com)
The amyloidoses are referred to with a capital A (for amyloid) followed by an abbreviation for the fibril protein. (medscape.com)

This facilitates the assembly of multi-protein complexes by increasing the probability of any appropriate protein-protein interactions. (wikipedia.org)
It also may involve the formation or dissociation of protein quaternary structures or oligomeric complexes, and specific binding of ions, ligands, or regulatory lipids. (wikipedia.org)

Hardman et al found that insulin and estrogen increased the level of MNK mRNA and protein levels in the placenta. (medscape.com)

Inhibition of COPII budding complex formation by the expression of a dominant-negative mutant of the small GTPase Sar1 had no detectable effect on BMB2 subcellular targeting, which therefore could occur without exit from the ER in COPII transport vesicles. (microbiologyresearch.org)
this inhibition was associated with changes in protein stability/translation efficiency (in the case of V120A and L342A) and an impairment in transport function (in the case of L121). (biomedcentral.com)
Truncating the N- and C- terminals of hRFVT-2 led to significant inhibition in RF uptake, which was associated with changes in protein stability/translation efficiency (it was also associated with a partial impairment in membrane targeting in the case of the N-terminal truncation). (biomedcentral.com)

Hippocampal lipids were not significantly affected by APOE genotype, however levels of myelin-enriched sulfatides and hexosylceramides were significantly lower, and polyunsaturated phospholipids were higher, in rs1990622-A carriers after controlling for APOE genotype. (biomedcentral.com)

Collectively, the presented data support the current view that plant viral MPs exploit the ER:actin network for their intracellular transport. (microbiologyresearch.org)
Plant viral movement proteins: agents for cell-to-cell trafficking of viral genomes. (microbiologyresearch.org)
Heinlein M . Viral Transport and Interaction with the Host Cytoskeleton. (microbiologyresearch.org)
While antibodies to the immunodominant, but highly variable, regions of HA and NA can provide potent virus strain-specific protection, the existence of weaker and more broadly protective immune activities directed to less variable regions of viral proteins has long been known ( 5 ). (cdc.gov)

In contrast to integral membrane proteins, peripheral membrane proteins tend to collect in the water-soluble component, or fraction, of all the proteins extracted during a protein purification procedure. (wikipedia.org)
Proteins with GPI anchors are an exception to this rule and can have purification properties similar to those of integral membrane proteins. (wikipedia.org)

Although the C-terminal domain comprises a small percentage of the total protein, this domain in some cases (i) has PSD-95/Discs Large/ZO-1-binding motifs that may be important for protein-protein interactions (e.g. (tcdb.org)

After pre-miRNAs are transported to the cytoplasm, RNase III Dicer and TRBP (transactivation-response RNA-binding protein) cleave them into double-stranded miRNA duplexes of ~22 nt ( 30 , 31 ). (frontiersin.org)

2007). These proteins are important for the regulation of intracellular pH (pH i ) and play crucial roles in the epithelial absorption of HCO 3 - (e.g., in the renal proximal tubule) and secretion of HCO 3 - (e.g., in the pancreatic duct). (tcdb.org)
Our recombinant nontoxic toxin analogues and derivatives were applied in studying of toxin interaction with cell surface, intracellular transport of DT and in determination of proHB-EGF expression level. (org.ua)
Here, we provide evidence that the intracellular transport of both poa semilatent virus TGB3 and hibiscus green spot virus BMB2 to plasmodesmata-associated sites can occur via lateral translocation along the ER membranes. (microbiologyresearch.org)

Anatomy11

Organisms4

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes33

Information Science4

Health Care1

Transporter7

Single nucleotide po2

Extracellular6

Guanine1

Gene10

Anion3

Phosphorylation3

Molecular8

Genes4

Kinase1

Polypeptide2

ATPase1

Glycoprotein1

Histidine1

Acyl3

Cytoplasmic2

Receptors2

Synthase2

Subunit2

Kinases2

Domains4

Electron transport3

Transcription2

Residues5

Sequence1

NCBI1

Topology3

Biosynthesis2

Microtubule-associa1

Metabolism3

Cellular1

Lipid bilayer5

Membrane protein2

Substrate2

Molecules1

Fibril3

Complexes2

MRNA1

Inhibition3

Genotype1

Viral4

Integral2

Interactions1

Cytoplasm1

Intracellular3