Transmembrane 4 1bb ligand. Medical search. Frequent questions

4-1BBL is a type 2 transmembrane glycoprotein receptor that is found on APCs (antigen presenting cells) and binds to 4-1BB (also known as CD137). (wikipedia.org)
CD137 is a 39 kD transmembrane protein also known as 4-1BB. (biolegend.com)
CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. (biolegend.com)
The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. (bioxcell.com)
4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. (kactusbio.cn)
1)Vinay D S , Kwon B S. 4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy[J]. BMB Reports, 2014, 47(3):122-129. (kactusbio.cn)
The 4B4-1 monoclonal antibody specifically binds to CD137 which is also known as 4-1BB, and ILA (induced by lymphocyte activation). (bdbiosciences.com)
CD137 is a type I transmembrane glycoprotein that belongs to the TNF/NGF receptor family. (bdbiosciences.com)
CD137 (4-1BB) is a member of the TNFR family that mediates potent T cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies (mAbs). (unav.edu)
To make the most of these approaches, we have constructed chimeric mRNAs encoding single-chain IL-12 fused to single-chain fragment variable (scFv) antibodies that bind to transforming growth factor b (TGF-b) and CD137 (4-1BB). (unav.edu)

Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is encoded by the TNFSF9 gene. (wikipedia.org)
4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. (bioxcell.com)
2015). "c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival" Eur J Immunol 45(9): 2672-2682. (bioxcell.com)
Recombinant Human 4-1BB/TNFRSF9 Protein is expressed from HEK293 with His tag at the C-Terminus. (kactusbio.cn)
The main bioactive form is anchored on the cell surface as the extracellular domain of transmembrane protein (209 a. (biofargo.com)
Product Information Protein sequence A DNA sequence encoding the human 4-1BB Ligand (NP_003802.1) was expressed with a Fc-tag at the C-terminus. (biofargo.com)
Polysaccharide addition reduced saliva protein concentration in tannin-saliva protein-polysaccharide mixtures, indicating that native-wine polysaccharides compete with condensed tannins for salivary protein as ligand partners. (bvsalud.org)
TNFR superfamily, 234-amino acid type I transmembrane protein, 25 kD. (biolegend.com)
EGFR (epidermal growth factor receptor) is a transmembrane protein and receptor for members of the epidermal growth factor (EGF) family of extracellular protein ligands. (promab.com)
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN . (nih.gov)
The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)
Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. (acrobiosystems.com)
ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. (amjournals.org)
Chimeric antigen receptor (CAR) T cell therapy has emerged as a novel immunotherapy which modifies T cells with CAR, an artificial fusion protein that incorporates an extracellular antigen recognition domain, a transmembrane domain, and an intracellular domain including costimulation and signaling components [ 4 , 5 ]. (biomedcentral.com)
Surface receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and nuclear transcription factors attenuate T cell responses, where CTLA-4 competes with CD28 for binding to CD80/86, resulting in inhibitory downstream signalling [ 6 ] . (encyclopedia.pub)
ELISA plate pre-coated by 2 ug/ml (100 ul/well) Human CD47, mFc-His tagged protein (PME100008) can bind its native ligand Human SIRPα, hFc-His tagged protein (PME100009) in a linear range of 3.3-26.37 ng/ml. (dimabio.com)
The era of immune checkpoint blockers (ICB), which started in 2011 with the approval of an antibody targeting cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells (namely, ipilimumab) for the treatment of metastatic melanoma ( 1 ), has brought a new paradigm to cancer therapy whereby the immune system is being harnessed to cure the cancer. (aacrjournals.org)
Preparation and Characterization of EpCAM-Specific CAR-NK-92 Cells A second-generation CAR, consisting of EpCAM-specific scFv linked to a CD8 hinge and transmembrane domains and the KW-6002 biological activity intracellular signaling domains of 4-1BB and CD3in sequence (Figure 1(a)), was KW-6002 biological activity constructed and inserted into a lentiviral vector system with sequences encoding green fluorescent protein (GFP). (bioskinrevive.com)
B-cell activating factor ( BAFF ) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene . (wikidoc.org)
It is expressed as a membrane-bound type II transmembrane protein [2] on various cell types including monocytes , dendritic cells and bone marrow stromal cells. (wikidoc.org)
The transmembrane form can be cleaved from the membrane, generating a soluble protein fragment. (wikidoc.org)
[5] TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). (wikidoc.org)
All these ligands act as homotrimers (i.e. three of the same molecule) interacting with homotrimeric receptors, [6] although BAFF has been known to be active as either a hetero- or homotrimer (can aggregate into 60-mer depending on the primary structure of the protein). (wikidoc.org)

The 4-1BB/4-1BBL complex belongs to the TNFR:TNF superfamily, which is expressed on activated T Lymphocytes. (wikipedia.org)
Apogenix has developed a proprietary technology platform for the construction of novel TNF superfamily receptor agonists (HERA-ligands). (apogenix.com)
The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)

CD30 Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
This graph shows the total number of publications written about "CD30 Ligand" by people in this website by year, and whether "CD30 Ligand" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "CD30 Ligand" by people in Profiles. (wakehealth.edu)

It is closely associated with B cell-activating factor of the TNF family (BAFF) receptor, transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) [ 14 ]. (biomedcentral.com)
[4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)

The 4-1BB/4-1BBL complex with the help of T-cell receptor signals can co-stimulate human CD28− T cells and trigger the increase in CD28− T cells. (wikipedia.org)

The anti-EGFR CAR in this product is approximately 56 kD and consists of anti-EGFR scFv (single-chain variable fragment) linked to a second-generation CAR (chimeric antigen receptor) containing the CD8 hinge and transmembrane domain and 4-1BB and CD3ζ signaling domains. (promab.com)
Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)

DLL-1 is one of proteins discovered as notch receptors, which are single-pass transmembrane proteins. (fujifilm.com)
On the other hand, other ligands, such as HLA, bind to inhibitory receptors NKG2A and killer immunoglobulin-like receptors (KIR) to inhibit NK cells, providing a form of protection for self-cells from innate immunity. (molcells.org)
Chronic T-cell exhaustion is marked by the progressive upregulation of coinhibitory receptors, PD-1 being one of the most prominent, but also other coregulated receptors such as LAG-3 ( 4, 5 ). (aacrjournals.org)
This cytokine is a ligand for receptors TNFRSF13B /TACI, TNFRSF17 /BCMA, and TNFRSF13C /BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. (wikidoc.org)

Trastuzumab is a monoclonal antibody targeting HER2, a 185 kDa transmembrane glycoprotein that contains an extracellular domain and intracellular tyrosine kinase activity. (abeomics.com)

All members of the TNFSF are transmembrane proteins. (apogenix.com)
This intracellular clustering allows signaling proteins (4) inside the cell to be recruited (5), thereby initiating a response from the cell. (apogenix.com)

Typically, CARs consist of a target binding domain, which is an extracellular domain that is specifically expressed by CAR-T cells, a transmembrane domain, and a signalling domain, which is an intracellular domain that provides an activation signal to T cells. (nature.com)
Exons 1, 2 and most of exon 3 encode the N-terminal extracellular domain while the remainder of exon 3 and exon 4 encode transmembrane and cytoplasmic domains. (wikidoc.org)
This product is an extracellular domain of DLL-1 functioning originally as a membrane-bound cell surface ligand. (fujifilm.com)

The interaction between 4-1BB and 4-1BBL provide costimulatory signals to a variety of T cells, which can be used to discover cancer immunotherapy. (wikipedia.org)
2019). "Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcgammaR affinity" Nat Commun 10(1): 2141. (bioxcell.com)
As a proof of this concept, we have developed LVGN6051, a humanized 4-1BB mAb-AG that shows high anti-tumor efficacy in the absence of liver toxicity in a mouse model of cancer immunotherapy. (bioxcell.com)

Studies on the poorly immunogenic Ag104A sarcoma and the extremely tumorigenic P815 mastocytoma provided the first systematic proof that anti-4-1BB antibodies have potent anti-tumor effects. (wikipedia.org)
Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. (bioxcell.com)
While intrinsically strong agonistic anti-4-1BB can activate 4-1BB in the absence of FcgammaRs, weak agonistic antibodies rely on FcgammaRs to activate 4-1BB. (bioxcell.com)
All FcgammaRs can crosslink anti-41BB antibodies to strengthen co-stimulation, but activating FcgammaR-induced antibody-dependent cell-mediated cytotoxicity compromises anti-tumor immunity by deleting 4-1BB(+) cells. (bioxcell.com)
Since then, several antibodies targeting another coinhibitory receptor, the programmed cell death 1 (PDCD1, best known as PD-1) or its main ligand CD274 (best known as PD-L1), have been approved for the treatment of multiple cancers ( 2 ). (aacrjournals.org)

FLT3 ligand is a growth factor that regulates the proliferation of early hematopoietic cells. (biofargo.com)
The FLT3 ligand itself does not stimulate the proliferation of early hematopoietic cells, but rather synergistically induces growth and differentiation with other CSFs and interleukins. (biofargo.com)
Unlike SCF, FLT3 ligand has no effect on mast cells. (biofargo.com)

PD-1 is an immunoinhibitory receptor that stymies lymphocyte proliferation and cytokine secretion when bound to its membrane-bound or secreted ligands, PD-L1 or PD-L2, expressed by both immune and tumour cells [ 7 ] . (encyclopedia.pub)

The 4-1BB/4-1BBL complex together with a signal provided by a T-cell receptor can provide costimulatory signals to CD4+ and CD8+ T cells in mice, leading to the activation of CD4+ and CD8+ T cells. (wikipedia.org)
Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. (bioxcell.com)

Currently, Apogenix utilizes its HERA-ligand platform primarily for the preclinical development of CD40, GITR, and 4-1BB agonists. (apogenix.com)
The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. (biolegend.com)

The 3H3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling in vivo . (bioxcell.com)
The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. (bioxcell.com)
Costimulation of T cell responses with monoclonal antibody agonists (mAb-AG) targeting 4-1BB showed robust anti-tumor activity in preclinical models, but their clinical development was hampered by low efficacy (Utomilumab) or severe liver toxicity (Urelumab). (bioxcell.com)
Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody. (dimabio.com)
At the time, ICBs had just entered clinical testing, an endeavor that culminated in 2011 with the approval of the first anti-CTLA-4 antibody for use in metastatic melanoma patients (ipilimumab). (aacrjournals.org)

These lymphocytes successfully eliminate the genetically unstable tumour cells with intrinsically high immunogenicity [ 4 ] through a series of successive stages [ 5 ] . (encyclopedia.pub)

Each 4-1BB monomer binds to two 4-1BBLs via cysteine-rich domains (CRDs). (wikipedia.org)
FLT 3-ligand binds to cells expressing tyrosine kinase receptor FLT3. (biofargo.com)

The interaction between 4-1BB and the second 4-1BBL is required to stabilize their interactions. (wikipedia.org)
This suggests balancing agonistic activity with the strength of FcgammaR interaction as a strategy to engineer 4-1BB mAb-AG with optimal therapeutic performance. (bioxcell.com)
Novel understanding in the interaction between immune system and cancer cells of the patient holds great promise for immunotherapy development [ 4 - 6 ]. (hindawi.com)

Here we show that isotype and intrinsic agonistic strength co-determine the efficacy and toxicity of anti-4-1BB mAb-AG. (bioxcell.com)

This anti-tumor efficacy and IFN-γ production were further enhanced in a screen for potent coactivation domains other than 4-1BB that activate innate immunity. (bmj.com)

Designer T and NK cells are a modality within immunotherapy that manipulates receptor-ligand interactions to enhance cells of the immune system to destroy cancer more effectively. (encyclopedia.pub)

BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (wikidoc.org)

Additional reported applications (for the relevant formats) include: immunoprecipitation 1,4 , inhibition of cytokine production 2,3 , and ELISA. (biolegend.com)
Dose response curve for Human 4-1BB Ligand Trimer, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. (kactusbio.cn)

A) Schematic depiction of a CIT comprising the extracellular D1 and D2 domains of ILT2, a stalk and transmembrane domain derived from CD8-α and a replacement of the ITIM domains of ILT2 with engineered signalling domains driving NK cell activation. (bmj.com)
Description: TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. (cromauv.org)

Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)

CRD2 amino acids (T61, Q67, and K69) interact with the AA′ loop (Y110 and G114) and the intra-H-strand loop (Q227 and Q230) of 4-1BBL to form various hydrogen bond interactions. (wikipedia.org)

Human 4-1BB on Tris-Bis PAGE under reduced condition. (kactusbio.cn)
The purity of Human 4-1BB is greater than 95% as determined by SEC-HPLC. (kactusbio.cn)
Immobilized Human 4-1BB, His Tag at 1μg/ml (100μl/Well) on the plate. (kactusbio.cn)
Description: For quantitative detection of human TIMP-4 in cell culture supernates, serum, plasma(heparin, EDTA) and human milk. (cromauv.org)

Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation , apoptosis , [3] metabolism , homeostasis , immune response , wound repair , [4] and endocrine function. (wikidoc.org)

The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. (cromauv.org)

Here, we show that effector and memory T cells from mice expressing a dominant negative E3-inactive c-IAP2 (c-IAP2(H570A) ) have impaired signaling downstream of 4-1BB. (bioxcell.com)
Methods CD56 + NK cells were selected from PBMCs, incubated with IL-15 and activated with a feeder free cocktail of an immobilized cytokine and activating ligand. (bmj.com)

4-1BB is a TNF receptor family member that signals via a complex that includes TRAF family members and the c-IAPs to upregulate NF-kappaB and ERK, and has been implicated in memory T-cell survival. (bioxcell.com)
It is a member of the ErbB receptor family, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). (promab.com)

The first evidence that radiotherapy enhances the efficacy of immune checkpoint blockers (ICB) was obtained a dozen years ago in a mouse model of metastatic carcinoma refractory to anti-CTLA-4 treatment. (aacrjournals.org)

The link with 4-1BBL is largely made up of amino acids from the dynamic loops of the CRD2 and the β sheet of CRD3 of 4-1BB, according to a detailed study of the binding between the 4-1BB and 4-1BBL interface. (wikipedia.org)

Anatomy3

Organisms2

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes6

Information Science2

CD13710

Protein24

Superfamily3

CD30 Ligand3

Cyclophilin ligand interactor2

CD281

Antigen2

Receptors4

Glycoprotein1

Proteins2

Extracellular domain3

Cancer immunotherapy3

Antibodies5

FLT3 Ligand3

Membrane-bound1

Costimulatory2

GITR2

Antibody5

Lymphocytes1

Binds2

Interaction3

Isotype1

Immunity1

Immunotherapy1

BAFF1

ELISA2

Stalk2

Antigens1

Interactions1

Human4

Apoptosis1

Interacts1

Cells2

Receptor family2

Immune1

Amino1