Transgenic mice mice inbred balb c. Medical search. Frequent questions

Common inbred strains include BALB/c, C3H, C57BL/6 and DBA. (uwm.edu)
C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. (ncard.org.au)
Congenic BALB/c CL4 strain expressing C57Bl/6 Thy 1.1 allele. (ncard.org.au)
Although 100% of K14-HPV16 transgenic animals develop hyperplastic and/or dysplastic lesions in several inbred backgrounds, including C57BL/6, BALB/c, and SSIN/SENCAR, only mice backcrossed into the FVB/n background progress to malignant squamous cell carcinomas of two pathological grades, well differentiated and moderate/poorly differentiated (WDSC or MPDSC, respectively), each displaying characteristic patterns of malignant behavior. (elsevierpure.com)
In the present study a nest-building protocol was established using four different inbred mouse strains (CD1, BALB/c, C57Bl/6J, C3H) before assessing AD and FTD tau transgenic mice of Line 1 (L1) and Line 66 (L66) in this paradigm. (bvsalud.org)
HET3 mice used in this program are (F2) offspring of CByB6F1/J and C3D2F1/J (combining BALB/cBy, C57BL/6, C3H, and DBA/2) strains. (jax.org)
J:235854 lists J:27148 as the reference for these mice but then describes them as "B6C3F1" when the mice in the given reference were C57BL/6J mice fostered on C3Hf/Nctr mice. (jax.org)
One of the most common strains in mouse modeling is C57BL/6. (biomedcentral.com)
To determine if the phenotype of rTg4510 mice was similarly affected by the introduction of the C57BL/6 background, we compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 mice on an F1 FVB/N x C57BL/6NTac (B6/NTac) background, herein termed rTg4510 B6 . (biomedcentral.com)
Overall, our data shows that introduction of the C57BL/6 strain into the rTg4510 mouse background modestly alters the tau pathology that was originally reported in rTg4510 on the F1 FVB/129 background. (biomedcentral.com)
These studies support the use of the rTg4510 mouse model on a partial C57BL/6 strain background without losing fidelity of the phenotype and suggest that the C57BL/6 background does not inherently protect against tauopathy. (biomedcentral.com)
To test the hypothesis that crossing rTg4510 mice to a C57BL/6 strain background is protective against tauopathy, we have compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 on an F1 FVB/N x C57BL/6NTac background (rTg4510 B6 ) (Figure 1 ). (biomedcentral.com)
Breeding scheme used to produce rTg4510 mice on an F1 FVB/N x C57BL/6 (FVB/B6) strain background (rTg4510 B6 ) (Left) compared to the original rT4510 mice on an F1 FVB/N x 129S6 (FVB/129) strain background (Right). (biomedcentral.com)
For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
We hypothesized that oral doxycycline would alter the composition of the GM (as evidenced by changes in the fecal microbiota [FM]) in female C57BL/6NCrl mice, and that the GM would return to baseline when the drug was temporarily discontinued. (biomedcentral.com)
The C57BL/6 strain was chosen because it is most commonly used to generate transgenic animals. (biomedcentral.com)
On day 0, 20 female C57BL/6NCrl mice were divided into experimental (DOX, n = 10) and control ( n = 10) groups. (biomedcentral.com)
We offer pharmacokinetic (PK) studies in widely used murine inbred (C57BL/6, BALB/c), or custom strains. (flywithabird.com)
Mice, Inbred C57BL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Mice, Inbred C57BL" by people in this website by year, and whether "Mice, Inbred C57BL" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Mice, Inbred C57BL" by people in Profiles. (uchicago.edu)

C57BL6, 129, and FVB/N strains are emphasized because of their widespread use in the generation of knockout, transgenic, and conditional mutant GEM. (jax.org)
The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)

There are over 400 documented inbred strains of mice. (uwm.edu)
Quantitative trait locus (QTL) analysis is a common genetic approach that has been used in the past two decades to identify loci involved in differences in fibrotic response between inbred strains of mice [ 9 ]. (biomedcentral.com)

Together they generated the DBA (Dilute, Brown and non-Agouti) inbred mouse strain and initiated the systematic generation of inbred strains. (wikipedia.org)
Strain background changes can influence the phenotype of mouse models and can confound crossbreeding studies. (biomedcentral.com)
We sought to determine if changing the strain background of a commonly used mouse model of tauopathy (rTg4510) would significantly impact the originally reported phenotype. (biomedcentral.com)
The strain background of transgenic mice can also alter disease progression and presentation. (biomedcentral.com)
Here we compare the phenotypes of both young and old rTg4510 mice on each strain background. (biomedcentral.com)
Breeding scheme for comparison of rTg4510 mice on different strain backgrounds. (biomedcentral.com)
Data were collected from studies that were deemed eligible for analysis based on set inclusion criteria, and findings were assessed in relation to strain of mouse, type of injury and organ of investigation. (biomedcentral.com)
There is evidence that mouse strain differences influence susceptibility to fibrosis and this appears to be organ specific. (biomedcentral.com)
Such mouse strain studies may prove useful in elucidating the genetic as well as epigenetic factors in humans that could help determine why some people are more susceptible to the development of certain organ specific fibrosis than others. (biomedcentral.com)
Clarence Cook Little begins to develop the first inbred strain, designated DBA for dilute, brown, and non-agouti. (jax.org)
This strain is commonly used as genetic background for transgenic mouse models. (uchicago.edu)

BALB/c nude mice: A spontaneous mutation in Foxn1 nu induces abnormal hair growth (nude phenotype). (ncard.org.au)
Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdcscid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironmentsevere combined immune deficient phenotype on Non obese diabetic genetic background. (ncard.org.au)
In infected mice, there was a small increase in mIgM(lo)mIgD(+) mature B2 cells, but no enrichment of B cells with regulatory phenotype or function compared to the naïve hepatic B cell population, as assessed by CD1d and CD5 expression and by IL-10 production. (ox.ac.uk)
Our idea was to make mice that had identical genetic backgrounds but differed in only one phenotype: the ability to stimulate a mixed lymphocyte response. (aai.org)

A combination of HS201-PDT with anti-PD-L1 antibody demonstrated the greatest antigen-specific immune response, tumor growth suppression, prolonged mouse survival time and abscopal effect. (bmj.com)
METHODS: Mice with K/BxN serum-induced arthritis, collagen-induced arthritis, and human tumor necrosis factor transgene insertion were studied. (cnrs.fr)

Cell populations derived from these transgenic mice can be distinguished from syngeneic host and other mice with the alternate allele via flow cytometry. (ncard.org.au)
Methods Using unilateral and bilateral implantation models of syngeneic breast tumors (E0771, MM3MG-HER2, and JC-HER3) in mice, we assessed whether HS201-PDT could induce local and systemic antitumor immunity. (bmj.com)
Anti-Id B cells from BCR knock-in mice, together with Id-specific CD4(+) T cells from previously established TCR-transgenic mice, enabled us to study Id-specific T cell-B cell collaboration by dilution of transferred cells into syngeneic BALB/c recipients. (ozgene.com)
Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. (uchicago.edu)

These animals carry the severe combined immune deficiency mutation ( scid ) on the BALB/c background. (ncard.org.au)
The severe-combined immunodeficient (SCID) mice have been exploited as a model for onchocerciasis and are permissive to mf of O. lienalis [ 12 ]. (biomedcentral.com)

The most commonly used methods for catching and picking up mice are grasping the animal near the tip of the tail, between thumb and forefinger, or by grasping the tail near the base or the neck between the ends of a smooth tipped forceps. (uwm.edu)
BALB/cJ : a commonly used inbred mouse stain. (ncard.org.au)
Cross-breeding of transgenic mice is commonly used to assess gene-gene interactions, particularly in the context of disease. (biomedcentral.com)

APPswe/PS1dE9 double transgenic (Tg) male and female mice and non-transgenic (non-Tg) littermates were trained on a delayed-matching-to-position (DMTP) or 3-choice serial reaction time (3CSRT) task. (abainternational.org)
Non-transgenic (NT) littermates of rTg4510 B6 (NT B6 ) mice also had greater amounts of cortical and hippocampal phospho-tau at 10.5 months of age when compared to NT littermates of rTg4510 mice. (biomedcentral.com)

CD8 TCR transgenic mouse whose CD8 T cells predominantly recognise the MHC class I (H-2K d ) restricted CL4 epitope of PR8 influenza HA protein. (ncard.org.au)
Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice. (ox.ac.uk)
These defects were correlated to a decrease in the content of brain lipid-binding protein (Blbp) and were detected exclusively in the cerebral cortex, but not in the basal ganglia of reeler mice. (silverchair.com)
Numerous transgenic mice expressing wild-type or mutant human tau have been created to model the neuropathology of tauopathies-a group of neurodegenerative diseases characterized by the accumulation of tau protein aggregates. (biomedcentral.com)
Many of the behaviors and pathologies reported for these mouse models, even those that express the same tau protein, are different. (biomedcentral.com)
Several factors may contribute to these differences, including the levels and regions of transgenic tau protein expression, the characteristics of the promoters used to drive transgenic tau expression, and the behavioral tests used to characterize the models. (biomedcentral.com)
To address this issue, we generated a double knock-in mouse that expresses V regions of a somatically mutated anti-Id mAb with intermediate affinity (affinity constant [Ka] = 0.77 × 10(7) M(-1)) for the myeloma protein M315. (ozgene.com)

One naturally occurring genetic defect in mice results in an animal with no hair that is called a nude. (uwm.edu)
homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. (ncard.org.au)

The laboratory mouse genome has been sequenced and many mouse genes have human homologues. (wikipedia.org)
The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse Genome Informatics database. (wikipedia.org)
Mice provide a suitable model for the study of human genetics because more than 95% of the genome is identical. (biomedcentral.com)
To date, the Mouse Genome Database through The Jackson Laboratory, lists 24 QTL in mice associated with fibrosis of which all but 3 are phenotypes in the lung. (biomedcentral.com)
A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice. (uchicago.edu)

There is mounting evidence suggesting that inbred mouse strains with different genetic backgrounds demonstrate variable susceptibility to a fibrotic injury. (biomedcentral.com)

On the original F1 FVB/N x 129S6 background, rTg4510 mice present with progressive cognitive decline, increased insoluble tau, robust tau pathology and age-dependent neurodegeneration. (biomedcentral.com)

The transgenic T cells were also able to enhance clearance of recombinant vaccinia virus containing influenza nucleoprotein in vivo. (ox.ac.uk)

We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. (umassmed.edu)

The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
BALB/c based mouse model in which the administration of diphtheria toxin (DT) leads to specific depletion of regulatory T cells (Treg) due to expression of DT receptor-enhanced GFP under the control of the Foxp3 promoter. (ncard.org.au)
Asbestos induced mesothelioma mouse model in which expression of the Simian Virus 40 large T antigen (SV40 TAg) is controlled by mesothelin tissue‑specific promoter. (ncard.org.au)
By introducing a human-derived HLA B27-restricted TCR into HLA B27 transgenic mice, we have obtained a functional TCR transgenic model, GRb, dependent on HLA B27 for response. (ox.ac.uk)
The first paper will examine correlates among attending, impulsive behavior, and short-term remembering in a mouse model of Alzheimer's disease. (abainternational.org)
The aim of this study was to evaluate cognitive impairment in a mouse model of AD-associated amyloidosis. (abainternational.org)
Potential factors contributing to lack of impairment in DMTP/3CSRT performance in the APPswe/PS1dE9 double mouse model of AD-associated amyloidosis will be discussed. (abainternational.org)
In a mouse model of LPS-induced acute inflammation, DSO2-ONJ demonstrated anti-inflammatory activity by inhibiting the production of the pro-inflammatory interleukin-6. (cnrs.fr)
First, we use a mouse model of vitiligo that we developed, where the mice get spots of vitiligo on their ears, tails, feet and noses. (umassmed.edu)
Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. (umassmed.edu)
Thus, we provide a new mouse model to investigate the molecular mechanisms of fibrocystic mastopathy and the transition from benign to malignant tumors. (biomedcentral.com)
We recently addressed the question of interchangeability of the two cadherins by generating a mouse model in which N-cad cDNA was introduced into the E-cad locus. (biomedcentral.com)
The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
The model is simple and well-described ( ref). and typical study requires 8-10 mice/ group to be completed. (flywithabird.com)
The Ferric Chloride- induced thrombosis model is a widely used technique to produce thrombus formation in the left carotid artery of the mouse. (flywithabird.com)

Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)

Immunodeficient mouse strains are invaluable when assessing the role of immune cell subsets in anti‑tumour immunity. (ncard.org.au)

Here, we show that expression of SPDEF or FOXA3 in airway epithelial cells in neonatal mice caused goblet cell differentiation, spontaneous eosinophilic inflammation, and airway hyperresponsiveness to methacholine. (nih.gov)
SPDEF was required for goblet cell differentiation and pulmonary Th2 inflammation in response to house dust mite (HDM) extract, as both were decreased in neonatal and adult Spdef(-/-) mice compared with control animals. (nih.gov)

Reproducible multi-stage progression to invasive squamous carcinoma of the epidermis has been achieved in transgenic mice expressing the HPV16 early-region genes, including the E6/E7 oncogenes, under the control of the human keratin-14 promoter/enhancer. (elsevierpure.com)
The Ferric Chloride - induced thrombosis technique allows assessment of thrombosis progression in coisogenic strains, and in isogenic mice dosed with study compounds. (flywithabird.com)

In 1902 Lucien Cuénot published the results of his experiments using mice which showed that Mendel's laws of inheritance were also valid for animals - results that were soon confirmed and extended to other species. (wikipedia.org)
Most recently, mice were recognized to offer unique opportunities to explore the genetic basis of the response, as well as to evaluate associated detrimental effects of pathophysiological significance in animals exposed to carcinogens. (biomedcentral.com)

The investment in training should be outweighed by the benefits observed with more reliable behavioral and physiological responses in the mice. (uwm.edu)

1939 International Committee on Standardized Nomenclature for Mice begins, bringing order to the naming of mice and their genes. (jax.org)

In the early part of the 20th century, Harvard undergraduate Clarence Cook Little was conducting studies on mouse genetics in the laboratory of William Ernest Castle. (wikipedia.org)

NCARD uses a variety of immunodeficient mice, which are mostly sourced from commercial vendors. (ncard.org.au)

Concordantly, 55% of Ncadk.i. mice harboring a heterozygous p53 deletion developed malignant and invasive tumors. (biomedcentral.com)
Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)

A total of 44 studies were included covering 21 mouse strains and focusing on fibrosis in the lung, liver, kidney, intestine and heart. (biomedcentral.com)
Gut microbiota modulates bleomycin-induced acute lung injury response in mice. (uchicago.edu)

The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. (jax.org)
Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. (jax.org)

These findings suggested that STOP mutant mice may be useful in studies of synaptic function, and could be especially relevant to schizophrenia, postulated to be a disorder of the synapse. (ox.ac.uk)
We describe a significant reduction in ventricular zone cells with long radial processes in the absence of reelin in the cortex of reeler mutant mice. (silverchair.com)

Hepatic resistance to Leishmania donovani infection in mice is associated with the development of granulomas, in which a variety of lymphoid and non-lymphoid populations accumulate. (ox.ac.uk)
Although previous studies have identified B cells in hepatic granulomas and functional studies in B cell-deficient mice have suggested a role for B cells in the control of experimental visceral leishmaniasis, little is known about the behaviour of B cells in the granuloma microenvironment. (ox.ac.uk)
Here, we first compared the hepatic B cell population in infected mice, where ≈60% of B cells are located within granulomas, with that of naïve mice. (ox.ac.uk)
However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. (biomedcentral.com)

Fully functional HLA B27-restricted CD4+ as well as CD8+ T cell responses in TCR transgenic mice. (ox.ac.uk)

CD4 TCR transgenic mouse whose CD4 T cells predominantly recognise the MHC class II (I‑A d )‑restricted TCR specific for the PR8 influenza HA peptide 126-138 (HNTngvtaacshe) ( PMID: 7889402 ). (ncard.org.au)
Mice homozygous for the Rag1 tm1Mom mutation produce no mature T cells or B cells. (ncard.org.au)
CD4(+) T cells from DO11.10 TCR transgenic mice were labeled with the fluorescent dye carboxyfluorescein diacetate succinimidyl ester (CFSE) and were stimulated with specific antigen (OVA323-339). (unboundmedicine.com)
Using 2-photon microscopy to quantify the entire intra-granuloma B cell population, in conjunction with the adoptive transfer of polyclonal and HEL-specific BCR-transgenic B cells isolated from L. donovani-infected mice, we demonstrated that B cells accumulate in granulomas over time in an antigen-independent manner. (ox.ac.uk)
Intra-vital dynamic imaging was used to demonstrate that within the polyclonal B cell population obtained from L. donovani-infected mice, the frequency of B cells that made multiple long contacts with endogenous T cells was greater than that observed using HEL-specific B cells obtained from the same inflammatory environment. (ox.ac.uk)
We generated a CD8 T-cell receptor (TCR) transnuclear (TN) mouse specific to the Ld -restricted immunodominant epitope of GRA6 from Toxoplasma gondii as a source of cells to facilitate further investigation into the CD8 T-cell-mediated response against this pathogen. (figshare.com)
The brain of Toxoplasma-infected mice carried Gra6 TN cells already at day 8 post-infection. (figshare.com)
Both Gra6 TN mice as well as adoptively transferred Gra6 TN cells were able to significantly reduce the parasite burden in the acute phase of Toxoplasma infection. (figshare.com)
We demonstrate that TRPC6 deficiency in mice not only results in anxious and depressive behavior, but also reduces excitability of hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. (afpm.org.my)
Second, we are developing humanized mouse models of vitiligo, where we transfer human T cells, or both T cells and skin, from vitiligo patients to immunosuppressed mice that permit the growth of human tissues. (umassmed.edu)
The benefit of this approach is that we can study the key cells that participate in vitiligo directly from patients, without variables that may change them, including their transfer into mice. (umassmed.edu)
Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism. (uchicago.edu)

however, 10.5-month-old rTg4510 B6 mice had greater amounts of phospho-tau in the cortex and hippocampus when compared to age-matched rTg4510 mice. (biomedcentral.com)

Overall, the Gra6 TN mouse represents a functional tool to study the protective and immunodominant specific CD8 T-cell response to Toxoplasma in both the acute and the chronic phases of infection. (figshare.com)

Differences evident between the L1 and L66 tau transgenic mouse models are likely due to the different human tau species expressed in these mice. (bvsalud.org)

In contrast, enhancing PDC recruitment and activation to arthritic joints by topical application of the Toll-like receptor 7 (TLR-7) agonist imiquimod significantly ameliorated arthritis in various mouse models. (cnrs.fr)

This study aimed to further characterize synaptic alterations in STOP null and heterozygous mice. (ox.ac.uk)
MAP2) proteins, was quantified in female STOP null (n = 7), heterozygous (n = 5) and wild type (n = 6) mice. (ox.ac.uk)
For STOP null and heterozygous mice, synaptophysin, VGlut1, GAP-43 and spinophilin mRNAs were decreased in the hippocampus, whilst in addition in the null mice, synaptophysin, VGlut1 and spinophilin mRNAs were decreased in the cerebellum. (ox.ac.uk)

The anti-Id mice have normal peripheral B cell populations, and allelic exclusion is efficient. (ozgene.com)

Little and Castle collaborated closely with Abbie Lathrop who was a breeder of fancy mice and rats which she marketed to rodent hobbyists and keepers of exotic pets, and later began selling in large numbers to scientific researchers. (wikipedia.org)

Mice are mammals of the clade (a group consisting of an ancestor and all its descendants) Euarchontoglires, which means they are amongst the closest non-primate relatives of humans along with lagomorphs, treeshrews, and flying lemurs. (wikipedia.org)

Quantitative trait loci analysis can be time consuming and can only analyse two different mouse strains at a time. (biomedcentral.com)

Despite a small, but significant increase in soluble human tau levels, young rTg4510 B6 mice had equivalent levels of tau phosphorylation, aggregation and cognitive impairments as age-matched rTg4510 mice. (biomedcentral.com)

Young mice ( pups) should be grasped by the cupping the hands around the whole body or by grasping the skin across the shoulder blades with a forceps. (uwm.edu)

Data indicating a role for microtubules in synaptic function has come from studies of the STOP null mouse, which exhibits synaptic deficits, in association with behavioural changes that are alleviated by antipsychotic treatment. (ox.ac.uk)

This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
In the tau mouse models, L66 presented with impaired nesting compared to wild-type on days 1 and 2 (not day 7), whereas L1 performed like wild-type on all days. (bvsalud.org)
This suggests that the GM of mouse models should be considered as a variable in animal experiments. (biomedcentral.com)
Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. (uchicago.edu)

More laboratory mice are used in research every year than any other animal species. (uwm.edu)
Laboratory mice are usually of the species Mus musculus. (wikipedia.org)
The Jackson Laboratory in Bar Harbor, Maine is currently one of the world's largest suppliers of laboratory mice, at around 3 million mice a year. (wikipedia.org)

The transition to the malignant state, in 21% of FVB/n transgenic mice, is characterized by alteration of the repertoire of keratin intermediate filament proteins expressed within neoplastic epidermis, such that WDSCs maintain expression of keratins common to terminally differentiating stratified keratinocytes (K10), whereas MPDSCs are distinguished from WDSCs by activation of embryonic and mucosal keratins (K13, K8, and K19). (elsevierpure.com)

Mice belong to the Euarchontoglires clade, which includes humans. (wikipedia.org)

These mice have deficiencies in their immune systems and thereby prove valuable in the study of immune diseases and cancer. (uwm.edu)
During the 18th century Joseph Priestley and Antoine Lavoisier both used mice to study respiration. (wikipedia.org)
Mice are also easy to breed with a short generation time and a short life span allowing direct study of disease development and can accurately eludicidate how genetic sequences may vary in different strains and result in susceptibility to fibrotic pathologies. (biomedcentral.com)
The benefit of this system is the powerful tools available to study diseases in mice. (umassmed.edu)
This study aims to demonstrate the effect of oral doxycycline on fecal microbiota of mice. (biomedcentral.com)
A typical PK study in mice involves one or two drug delivery routes (e.g. (flywithabird.com)

To block apoptosis, we conditionally deleted one allele of p53 in Ncadk.i. mice and observed a temporal rescue of alveolar morphology and function. (biomedcentral.com)

Female mice aged 5 - 6 months were assessed in the home cage over a period of 7 days with nest-building behaviour scored by three independent experimenters at intervals of 1-, 2- and 7-days post nestlet introduction. (bvsalud.org)
Inbred mouse strains displayed different levels of nesting behaviour. (bvsalud.org)
BALB/c mice were more proficient than CD1 and C3H mice, while all strains displayed similar nest-building behaviour by day 7. (bvsalud.org)

The first epithelial cell layer in the development of mouse embryos, the trophectoderm of blastocysts, requires E-cad for proper function. (biomedcentral.com)
Here, we investigated the capacity of N-cad in supporting epithelial integrity in the mammary gland of adult mice. (biomedcentral.com)

We found that mice with an MHC class II-peptide repertoire reduced to a single complex demonstrated various autoimmune reactions. (umass.edu)
Furthermore, mice with a limited MHC-peptide repertoire selected elevated numbers of TCRs with dual MHC class I/MHC class II restriction, a likely source of autoreactivity. (umass.edu)

Mice have been used in biomedical research since the 17th century (from May 30, 1678) when William Harvey used them for his studies on reproduction and blood circulation and Robert Hooke used them to investigate the biological consequences of an increase in air pressure. (wikipedia.org)

Anatomy15

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