Transgenic mice mammary neoplasms animal. Medical search. Frequent questions

Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats. (uams.edu)
We report protease-resistant prion protein (PrP res ) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). (cdc.gov)
We report the first observation of PrP res in spontaneous lymphoreticular tumors of mice with vCJD. (cdc.gov)
Approximately 6 months after infection, visible tumors developed in the neck areas of 5 mice, 4 with vCJD and 1 control. (cdc.gov)
The remaining mice in the vCJD group, including 2 other animals with tumors, were later euthanized or died (range 222-386 days) without noticeable signs of neurologic disease. (cdc.gov)
In the control group, the animal with tumors was euthanized on day 321, and the 3 other animals without tumors were euthanized on day 405. (cdc.gov)
Mice with visible tumors also had massive neoplastic nodular involvement of intestinal, mesenteric, cervical, and axillary lymph nodes and thymus. (cdc.gov)
In this study, we aimed to decipher whether Rank expression in the presence of PyMT and Neu oncogenes might affect the cell of origin of mammary gland tumors. (bvsalud.org)
Mammary tumors initiated by oncogenes or carcinogen exposure display high levels of Rank and Rank pathway inhibitors have emerged as a new strategy for breast cancer prevention and treatment. (bvsalud.org)
In Wnt-1 transgenic mice homozygous for the p53 null allele, tumors appear at an earlier age than in animals heterozygous or wild-type at the p53 locus. (elsevierpure.com)
Mammary tumors lacking p53 display less fibrotic histopathology and increased genomic instability with aneuploidy, amplifications, and deletions, as detected by karyotype analysis and comparative genomic hybridization. (elsevierpure.com)
In one tumor, the amplified region of chromosome 7 had an ectopically expressed int-2/FGF3 proto-oncogene, a gene known to cooperate with Wnt-1 in the production of mammary tumors. (elsevierpure.com)
The laboratory focuses on developing new therapies for brain and skull base tumors , and has established the first primary skull base chordoma xenograft mouse model. (hopkinsmedicine.org)
A multiantigen multipeptide vaccine, targeting proteins expressed in preinvasive breast lesions, can stimulate type I CD4 + T cells which have been shown to be deficient in both patients with breast cancer and mice that develop mammary tumors. (korea.ac.kr)
Although immunization with each individual antigen was partially effective in inhibiting tumor growth, immunization with the multiantigen vaccine was highly effective, blocking development of palpable lesions in 65% of mice and slowing tumor growth in the infrequent palpable tumors, which did arise. (korea.ac.kr)
Angiogenic islets appear in six-week-old Rip1-Tag2 mice, and some of these angiogenic islets develop into tumors in nine-week-old Rip1-Tag2 mice [ 4 ]. (ijbs.com)
Methods Using unilateral and bilateral implantation models of syngeneic breast tumors (E0771, MM3MG-HER2, and JC-HER3) in mice, we assessed whether HS201-PDT could induce local and systemic antitumor immunity. (bmj.com)
Through the use of a Mouse Mammary Tumor Virus (MMTV), two genes have been identified as primary targets for generating malignant tumors. (openwetware.org)
demonstrated the similarities of transcriptional content between human normal mammary gland stem cells and cancer stem cells, in which poorly differentiated cancers displayed higher content of BCSCs than well-differentiated tumors [11] . (ommegaonline.org)

Rank signaling pathway regulates mammary gland homeostasis and epithelial cell differentiation. (bvsalud.org)
By crossing mice that carry a null allele of p53 with transgenic mice that develop mammary adenocarcinomas under the influence of a Wnt-1 transgene, we have studied the consequences of p53 deficiency in mammary gland neoplasia. (elsevierpure.com)
Advances in the understanding of may be more susceptible at a par- sembled for IARC Group 1 carcino- host susceptibility in tandem with the ticular site (i.e. the mammary gland gens contains information on mecha- evolution of the knowledge on the in females). (who.int)
These time windows are considered as specific periods of susceptibility for breast cancer because significant structural and functional changes occur in the mammary gland, as well as alterations in the mammary micro-environment and hormone signaling that may influence risk. (biomedcentral.com)
Esophageal cancer is the common malignant neoplasm, which arises from the mucosa or gland of the esophagus. (biomedcentral.com)
The current study aimed to investigate the feasibility of using prolactin (PRL), a hormone intimately involved in mammary gland development, in combination with cisplatin as an alternative to target breast CSC (BCSC). (ommegaonline.org)
In the current study we propose to use prolactin (PRL), a pituitary hormone responsible for mammary gland development and lactation [12-15] , combined with chemotherapeutics to improve the chemotherapeutic outcome. (ommegaonline.org)

Rank signaling enhances stemness in mouse and human mammary epithelial cells (MECs) and mediates mammary tumor initiation. (bvsalud.org)

This occurs when a primary malignant neoplasm invades a local blood vessel and gets carried by convection to a different location in the body (Figure 1). (openwetware.org)

VEGF-DT385 toxin conjugate inhibits mammary adenocarcinoma development in a transgenic mouse model of spontaneous tumorigenesis. (uams.edu)
We observed that Rank expression in PyMT+/- and Neu+/- mammary glands alters the basal and luminal mammary cell populations already in preneoplasic tissue, which may interfere with the tumor cell of origin restricting their tumorigenesis ability upon transplantation assays. (bvsalud.org)
Magnetic resonance angiography reveals increased arterial blood supply and tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer. (uchicago.edu)

The presence of infectivity and PrP res in inflamed liver, pancreas, and kidney tissues has been recently observed in transgenic and spontaneous mouse models of chronic inflammation on infection with the Rocky Mountain Laboratory strain of scrapie ( 6 ), and PrP res has been shown in mammary glands of scrapie-infected sheep with mastitis ( 7 ). (cdc.gov)
By combining temporal/lineage specific Rank genetic deletion with lineage tracing techniques, we found that loss of luminal Rank reduces the luminal progenitor pool and leads to aberrant alveolar-like differentiation with high protein translation capacity in virgin mammary glands. (bvsalud.org)
Oxytocin reaches the mammary glands, triggering them to express milk. (pharmaceuticalintelligence.com)

Apc Min/+ mice are a spontaneous intestinal adenomatous polyps model, as they contain an Apc gene mutation that causes multiple intestinal neoplasia ( Min ). (ijbs.com)
Rip1-Tag2 mice are a spontaneous insulinoma model resulting from the expression of the SV40 T antigen, which functions as an oncogene, in β-cells [ 4 ]. (ijbs.com)
During the present examine, Muc5AC expression during the pancreas of KrasG12DPdx1 Cre spontaneous PDAC mice greater progressively from 10 to 50 weeks of age as compared to unfloxed LSLKrasG12D mice, corroborating research from the human disorder. (micrornainhibitors.com)
In agreement with these studies, current studies reported the observation of proinflammatory responses during the KrasG12DPdxCre spontaneous PDAC mouse model, which recommended that continual irritation is certainly a precursor and potentially a crucial factor in promoting Computer. (micrornainhibitors.com)
Greater inflamma tion inside the pancreas of KrasG12DPdx1 Cre spontaneous PDAC mice correlated with a rise in inflammatory cytokineschemokines this kind of as INF, CXCL1, CXCL2 and lymphocyte and macrophage infiltration. (micrornainhibitors.com)
These benefits correlate with a rise within the expression of Muc1, Muc4 and Muc5AC within the pancreas of KrasG12D Pdx1 Cre spontaneous PDAC mouse model, suggesting a achievable link in between inflammation and mucin expres sion, which more recapitulates the research performed while in the human disease. (micrornainhibitors.com)
The current review gives the basis to investigate the practical part of unique mucins in Computer initiation and progression by generating corresponding transgenic and knockout animals and crossing them with spontaneous versions of Computer. (micrornainhibitors.com)

Labeling indices for Ki67 and proliferating cell nuclear antigen marker in mammary carcinomas of the treated group were 35% and 30% lower, respectively, than those of the corresponding control group. (nih.gov)
These results indicate that the root extract reduced the number of mammary carcinomas that developed and reduced the rate of cell division in the carcinomas. (nih.gov)
0.0001), and approximately 90% of the mice showed no pathologic evidence of carcinomas at one year. (korea.ac.kr)
This method also allows for the development of multiple different models depending on the desired tissue of study, with one additional example being that "C3(1)-SV40 T-antigen transgenic mice develop invasive mammary carcinomas," making the technique malleable to a variety of purposes. (openwetware.org)

Lymphoreticular accumulation of infectivity and PrP res occur early after scrapie infection in sheep and in various experimental animal models of transmissible spongiform encephalopathies, including mice infected with the vCJD agent ( 5 ). (cdc.gov)
Experimental studies in mice were approved by the institutional animal care and use committee of the American Red Cross Holland Laboratory. (cdc.gov)
Because animal models are complex, it can be difficult to develop experimental procedures that isolate variables of interest. (openwetware.org)

We have shown that each colon neoplasm arises from a clonal expansion of one transformed cell. (hopkinsmedicine.org)
Neuroblastoma is an embryonal malignancy of the peripheral sympathetic nervous system (PSNS) that arises from the developing neural crest and manifests as neoplasms in sympathetic ganglia or adrenal medulla. (prolekarniky.cz)

Recent studies have shown that P-selectin deletion inhibits tumor growth in Rip1-Tag2 mice by suppressing platelet accumulation in tumor tissues. (ijbs.com)
21,22 Animals which respond poorly to acupuncture analgesia can be rendered good responders by treatment with D-phenylalanine which inhibits the degradation of met-enkephalin 23 . (med-vetacupuncture.org)

Importantly, we found that P-selectin deficiency inhibited insulinoma progression using Rip1-Tag2 transgenic mice and Rip1-Tag2;P-sel -/- mice [ 3 ]. (ijbs.com)
During the previous funding periods we have generated mice that express a kinase-inactive Tyk2 protein (Tyk2K923E) and could confirm our hypothesis that the lack of Tyk2 kinase activity does not phenocopy Tyk2 deficiency. (jak-stat.at)

To explore the role of P-selectin in tissue stiffness, we demonstrated that tumor progression in Rip1-Tag2 mice was correlated with tissue stiffness using immunofluorescence and histological staining. (ijbs.com)
Future research using Muc4 knock out and MUC4 transgenic animals about the KrasG12D murine back ground can help delineate the molecular mechanisms and contribution of Muc4 in Computer progression and metas tasis. (micrornainhibitors.com)
Given the functional and pathological significance of MUC1, MUC4 and MUC5AC in Computer progression and their regulation by inflammatory setting inside the human disorder, we analyzed the irritation in the pancreas of KrasG12DPdx1 Cre mice. (micrornainhibitors.com)
Conclusions Our studies are the to start with to set up that KrasG12DPdx1 Cre mouse model recapitulates the alterations in mucin expression observed throughout the progression of human Computer. (micrornainhibitors.com)

lymphoid tissue, and digestive tract), which the animal model captures the It can be difficult to parse out concordance has often been ob- range of potential human response reasons for lack of tumour site con- served among different species after to the particular agent tested. (who.int)
The vaccine also demonstrated significant clinical efficacy in an additional transgenic model of breast cancer (TgC3(I)-Tag). (korea.ac.kr)
In vivo evaluation of MHY-SLNs To judge the depigmentation activity of MHY-SLNs, C57BL/6 mice had been used being a model in pet tests. (conferencedequebec.org)
Performing tests in mice can also be cost prohibitive, as the average base cost for maintaining an in-vivo model is $1700 per week (Table 1). (openwetware.org)
Although studying tumor metastasis in animal models is a viable option, we argue that moving away from this approach to an in vitro model would prove even more effective. (openwetware.org)
Perhaps the most pervasive technique is one where cancer cells of a particular phenotype with specific tropic factors can be grafted into host mice to develop a model. (openwetware.org)
This has allowed researchers to modify a genetic sequence or multiple genes to generate a mouse model whose cancer would form in a particular tissue and metastasize to a known region. (openwetware.org)
Fruit flies offer a highly tractable animal model which has allowed researchers to develop information on cell signalling pathways, including the JAK/STAT transduction cascade which is responsible for cell growth and has been implicated in tumorogenesis. (openwetware.org)
Moreover, WISP overexpression retarded tumor growth in mouse model. (biomedcentral.com)
Therefore, the aim of our study was to develop a transplantable immunocompetent mouse model of HPV-positive OSCC and characterize it in vitro and in vivo. (biomedcentral.com)
In conclusion, we developed and characterized a novel immunocompetent mouse model of HPV-positive OSCC that exhibits increased radiosensitivity and enables studies of immune-based treatment approaches in HPV-positive OSCC. (biomedcentral.com)
In a mouse model of LPS-induced acute inflammation, DSO2-ONJ demonstrated anti-inflammatory activity by inhibiting the production of the pro-inflammatory interleukin-6. (cnrs.fr)

In addition, tumor models were characterized in vivo in C57Bl/6NCrl mice in terms of their histological properties, tumor growth kinetics, and radiosensitivity. (biomedcentral.com)
In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)

Differential effects of acute versus chronic dietary fructose consumption on metabolic responses in FVB/N mice. (uchicago.edu)

Brains and spleens were removed from all mice, and neoplastic tissues involving lymph nodes were removed from 4 infected and 1 uninfected mouse, and the thymus was removed from 2 infected mice ( Table ). (cdc.gov)
Researchers have determined that MMTV-Neu and MMTV-PyMT transgenic mice develop cancer tropic to the lungs and lymph nodes [3 ]. (openwetware.org)

So far, three different transcription variants (TVs) have been described for CK1δ in humans (Homo sapiens), mice (Mus musculus), and rats (Rattus norvegicus), which are highly homologous. (wikipedia.org)
The shortest group of sequences consists of 409 amino acids: TV2 in humans and rats, CRAc in mice. (wikipedia.org)

8 months of age ( 8 , 9 ), were intracerebrally injected under isoflurane anesthesia with 1% vCJD human brain homogenate (World Health Organization reference material) ( 10 ) diluted in physiologic saline, while 4 control animals received physiologic saline only. (cdc.gov)
While the human transcription variants are using isoleucine, the mouse and rat sequences incorporate a valine instead. (wikipedia.org)
The longest variant consists of 428 amino acids in rat (TV3) and mice (CRAb), while the human (TV3) variant is missing the second to last amino acid (threonine), resulting in a protein of a length of 427 amino acids. (wikipedia.org)
Several methods exist for generating metastasis models in mice canonical to human cancer: tumor transplantation, genetic modification, and the amplification of specific promoters. (openwetware.org)
Human cancer cells can be xenograft into mice for the purpose of determining what factors allow a patient's cancer to persist and metastasize. (openwetware.org)
Growing evidence from animal and human studies indicates that distinct time periods of heightened susceptibility to endocrine disruptors exist throughout the life course. (biomedcentral.com)
Despite the plausible heightened mechanistic influences of environmental chemicals on breast cancer risk during time periods of change in the mammary gland's structure and function, most human studies of environmental chemicals are not focused on specific WOS. (biomedcentral.com)
We outline ways in which ongoing transdisciplinary BCERP projects incorporate animal research and human epidemiologic studies in close partnership with community organizations and communication scientists to identify research priorities and effectively translate evidence-based findings to the public and policy makers. (biomedcentral.com)
However, since HPV can only infect human cells, there are only a few immunocompetent mouse models available that enable immunological studies. (biomedcentral.com)

Transgenic mice (TgMMTV-neu) were immunized with a multiantigen peptide vaccine specific for neu, insulin-like growth factor-binding protein 2 and insulin-like growth factor receptor-I at a time when some of the animals already had preinvasive lesions (18 weeks of age). (korea.ac.kr)

Five-week-old male C57BL/6 mice had been bought from Samtako Bio (Osan, South Korea). (conferencedequebec.org)

Determination of the mammary epithelial cell that serves as the cell of origin for breast cancer is key to understand tumor heterogeneity and clinical management. (bvsalud.org)
Breast cancer is the most common neoplasm among women in the majority of the developed countries, accounting for one-third of newly diagnosed malignancies [ 1 ]. (jcancer.org)

A C-terminal peptide containing residues from mouse SR-BI (within residues 450-509). (novusbio.com)

MetaMouse offers researchers the ability to order mouse models with a predetermined cancer type grafted or cultured in a tissue or organ of interest. (openwetware.org)
Immunohistochemistry-Paraffin: SR-BI Antibody [NB400-104] - FFPE tissue section of mouse liver using SR-BI antibody (Lot 8310) at 1:300 dilution with HRP-DAB detection and hematoxylin counterstaining. (novusbio.com)

Here, we show that ectopic Rank expression in the mammary epithelia unexpectedly delays tumor onset and reduces tumor incidence in the oncogene-driven Neu and PyMT models. (bvsalud.org)

The Janus kinase (Jak) Tyk2 is an important determinant in host immunity both in mice and in humans. (jak-stat.at)

The isolated cells were able to transfer leukemia to immuno suppressed mice [4] . (ommegaonline.org)

However, the mice were grossly normal when dab2 deletion was restricted to the embryo proper and the gene was retained in extraembryonic tissues using Meox2-Cre and Sox2-Cre. (biomedcentral.com)

Two monoclonal HPV-positive OSCC mouse cell lines were established by inducing the expression of HPV-16 oncogenes E6 and E7 in the MOC1 OSCC cell line using retroviral transduction. (biomedcentral.com)

These results indicate that P-selectin deletion significantly decreases tumor stiffness in Rip1-Tag2 mice by inhibiting LOX expression. (ijbs.com)
F) qRT-PCR expression data from BAT samples of WT (blue) or miR-146a-/- (green) mice following HFD, relative to L32 expression for a number of BAT and inflammatory genes. (researchensemble.com)
The expression of CuCOR19, a DHN detected in the leaves of discovered that over-expression of CuCOR19 could enhance frosty tolerance in transgenic tobacco and stop lipid peroxidation [12]. (researchensemble.com)

Each group was irradiated with UVB rays at an strength of 450 mJ/cm2 utilizing a crosslinker (BEX-800, Ultra-Lum, Claremont, CA, USA) to induce melanogenesis in the mouse dorsal pores and skin. (conferencedequebec.org)

As it stands, mice are the most cost efficient in terms of space and handling, and they provide a biological system comparable to humans. (openwetware.org)

A combination of HS201-PDT with anti-PD-L1 antibody demonstrated the greatest antigen-specific immune response, tumor growth suppression, prolonged mouse survival time and abscopal effect. (bmj.com)
Finally, PRL and cisplatin combination treatment significantly delayed naturally developed breast tumor growth in neu transgenic mice. (ommegaonline.org)

Finally, Tfam+/− mice exposed to ionizing radiation exhibit enhanced nDNA repair responses in spleen. (regenerativemedicine.net)

Mice had been housed under regular conditions using a 12 h/12 h light/dark routine and fed regular food and normal water. (conferencedequebec.org)

Animal models are the current standard for all measures of cancer testing, with particular emphasis on mouse models. (openwetware.org)
has developed an efficient way for laboratories to obtain highly specialized mouse models with their customizable service, MetaMouse [2 ]. (openwetware.org)

Furthermore, our previous study demonstrated that P-selectin deletion inhibited melanoma metastasis by suppressing platelet adhesion and that P-selectin-mediated platelet adhesion promoted intestinal tumor growth in Apc Min/+ mice [ 1 , 2 ]. (ijbs.com)

This study aimed to evaluate whether and how P-selectin affects tumor stiffness in Rip1-Tag2 mice. (ijbs.com)

Competing causes of mortali- or all of the animal species tested genetic variation, health status, life ty may prevent the development of experimentally. (who.int)

The cancer-preventive activity of an extract of Withania somnifera (WS) roots was examined in female transgenic (MMTV/Neu) mice that received a diet containing the extract (750 mg/kg of diet) for 10 months. (nih.gov)

Adult Dab2-deficient mice had a small but statistically significant increase in serum cholesterol levels. (biomedcentral.com)

Mice had been randomly split into 4 sets of 6 pets per group: UV control, MHY answer, blank-SLNs, and MHY-SLNs. (conferencedequebec.org)

The statistical power of estimates of vCJD prevalence might be increased by expanding screening to include samples of lymphoreticular neoplasms. (cdc.gov)
D) Weight (g) of BAT samples from WT or miR-146a-/- mice. (researchensemble.com)

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