Transgenic mice expressing human. Medical search. Frequent questions

In this study, the problem was addressed through the use of transgenic mice, in which the gene for the normal mouse prion protein was replaced by the gene for the elk or the human prion protein precursor. (usda.gov)
In this report, brain homogenates fromelk with CWD were inoculated into transgenic mice expressing the human or elk prion protein. (usda.gov)
To investigate the APP in vivo interactome in an unbiased manner, we generated mice that harbor a mouse prion protein promoter-driven cDNA encoding human APP-695 fused to a C-terminal affinity tag. (jneurosci.org)
To readdress this question by rigorous quantitative methods, we analyzed transgenic mice expressing human beta-CTF with the I45F mutation (SPA4CT) under control of the prion protein promoter by stereological techniques. (amsterdamumc.org)

No evidence of a transmssible spongiform encephalopathy were detected in mice with the human transgene at 14 to 17 months after inoculation. (usda.gov)
We analyzed mice expressing human p53 transgene (Tg p53 ) selectively in the lens in the presence or absence of Mdm2 . (molvis.org)
Finally, gene therapy using a lentivirus-expressing CCR2 transgene in BMCs prevented cognitive decline in this mouse model of AD. (nih.gov)
The invention provides transgenic non-human animals, such as transgenic rodents and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation. (justia.com)
the invention also provides non-human animals and cells comprising a transgene encoding an APP comprising the Swedish mutation and further comprising functionally disrupted endogenous APP gene loci, transgenes and targeting constructs used to produce such transgenic cells and animals, transgenes encoding human Swedish mutation APP polypeptide sequences, and methods for using the transgenic animals in pharmaceutical screening and as commercial research animals for modeling neurodegenerative diseases (e.g. (justia.com)
The transgene was expressed in hippocampus and cortex in large pyramidal neurons and in dentate gyrus granule cells. (amsterdamumc.org)
Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)

The lethality of mdm2 −/− mice before implantation makes it impossible to analyze Mdm2 interaction with p53 in vivo at specific times of development, at postnatal/adult stages, or in specific cell types. (molvis.org)
Using a transgenic mouse model we examined the relevance of the Q192R polymorphism for exposure to CPS and CPO in vivo. (cdc.gov)
Thus, this study demonstrates that using proteomic methods on our transgenic model can uncover important in vivo APP-interacting proteins that will provide insights into the biology of APP. (jneurosci.org)
Thus, this study demonstrates that our transgenic model can uncover important in vivo APP-interacting proteins that will contribute to our understanding of APP processing in in vivo settings. (jneurosci.org)
In both wild-type and the SIRT6 overexpressing mice, the researchers used a combination of physiological assays, including in vivo multi-omics analyses and 13C lactate tracing. (genengnews.com)
TCR-transduced T cells induced cytotoxicity against Rac1P29S expressing melanoma cells and we observed regression of Rac1P29S expressing tumors in vivo after adoptive T cell therapy (ATT). (fu-berlin.de)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
To model the effect in vivo, the authors used a transgenic mouse which over-expressed UMOD leading to salt-sensitive hypertension and interstitial nephritis . (medscape.com)
In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)
2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)

In this study spatial reconstructions and electrophysiological measurements of layer II/III pyramidal neurons of the somatosensory cortex from wild-type (WT) and transgenic (TG) human amyloid precursor protein (hAPP) overexpressing Tg2576 mice were used to build faithful segmental cable models of these neurons. (frontiersin.org)
Disease progression was exacerbated in APP(Swe)/PS1 mice (transgenic mice expressing a chimeric amyloid precursor protein [APPSwe] and human presenilin 1 [PS1]) harboring CCR2-deficient BMCs. (nih.gov)
amyloid precursor protein (.beta.APP), which is expressed in differently spliced forms of 695, 751, and 770 amino acids. (justia.com)
In the cortex of transgenic Tg2576 mice over-expressing human β-amyloid precursor protein with the Swedish mutation known to lead to familial Alzheimer's disease, which have substantial levels of β-amyloid peptide but lack neurofibrillary tangles and neuron loss, no alterations of protein levels were detected. (eur.nl)

and a second, previously identified and constitutively expressed and non-oxygen-regulated protein known as ARNT. (nobelprize.org)
Mice producing the human CD155 protein were generated and infected with poliovirus. (wikipedia.org)
Mice, which are susceptible to SARS-CoV, are resistant to infection with SARS-CoV-2 because of incompatibilities between mouse ACE2 and the viral spike protein. (nature.com)
Recombinant full length protein corresponding to Human Alpha-synuclein. (abcam.com)
The other project involves the study of a single nucleotide polymorphism (SNP) in the human p53 gene that results in either arginine (R) or proline (P) at position 72 of the p53 protein. (mdanderson.org)
Analysis of human GRF complementary DNA 10,11 and genomic 12 clones indicates that the GRF peptides are first synthesized as a 107- or 108-amino-acid precursor protein. (northwestern.edu)
We report that expression of the human GRF precursor protein in these animals results in measurable levels of human GRF and increased levels of mouse growth hormone in plasma and accelerated growth rates relative to control littermates. (northwestern.edu)
UMOD codes for uromodulin (also known as Tamm-Horsfall protein), which is expressed exclusively in the thick ascending limb of the loop of Henle and is the most common protein in normal urine. (medscape.com)
Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
In animals receiving excitotoxic lesions of the striatum we detected an eightfold increase of green ¯uorescent protein (GFP)-expressing cells. (lu.se)

The predisposition to hepatotoxicity results directly from the keratin mutation since nontransgenic or transgenic mice that express normal human K18 are more resistant. (jci.org)

These findings indicate that differences in the prion genetics between humans and elk may limit the risk of transmission. (usda.gov)
Using a genetically modified mouse model, Nancy E. Cooke, MD, Stephen A. Liebhaber, MD, Professors of Genetics and Medicine, and colleagues, demonstrated a critical role of two non-coding regions on the activation of the hGH gene. (sciencedaily.com)
Human Genetics & Genomic Advances , 4 , 100204. (otago.ac.nz)
Human Molecular Genetics , 13(16), 1815 -1825. (gla.ac.uk)
Human Molecular Genetics , 12(1), 41 -50. (gla.ac.uk)

Gliosis in transgenic mice following inoculation with brain homogenate prepared from a postmortem sample from a person with variably protease-sensitive prionopathy. (cdc.gov)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

In this study, LM11A-31 (50 or 75 mg/kg) was administered orally to two AD mouse models, Thy-1 hAPP Lond/Swe (APP L/S ) and Tg2576, at age ranges during which marked AD-like pathology manifests. (plos.org)
Similar results were seen in female Tg2576 mice. (plos.org)

We focus our attention on the genes that are expressed in RGCs and eye angle tissues. (nih.gov)
Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. (abcam.com)
A metabolomic study of brain tissues from aged mice with low expression of the vesicular monoamine transporter 2 (VMAT2) gene. (neurotree.org)
We have developed mouse models that mimic this human SNP and have demonstrated that the humanized p53 variants are functional and display the expected difference in apoptotic capacity in mouse tissues. (mdanderson.org)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

We previously identified the causative agent as a novel SARS-related coronavirus ( SARS-CoV-2 ) that uses human angiotensin-converting enzyme 2 (hACE2) as the entry receptor. (bvsalud.org)
Here, we successfully developed a SARS-CoV-2 hACE2 transgenic mouse (HFH4-hACE2 in C3B6 mice ) infection model. (bvsalud.org)
Our results show that the hACE2 mouse would be a valuable tool for testing potential vaccines and therapeutics . (bvsalud.org)
Here, using K18-hACE2 transgenic mice that were originally developed for SARS studies 4 , we show that infection with SARS-CoV-2 causes severe disease in the lung and, in some mice, the brain. (nature.com)
Thus, K18-hACE2 mice provide a useful model for studying the pathological basis of both mild and lethal COVID-19 and for assessing therapeutic interventions. (nature.com)
SARS-CoV-2 uses the same receptor as SARS-CoV, human angiotensin-converting enzyme 2 (hACE2) 5 . (nature.com)
K18-hACE2 mice express hACE2 driven by the cytokeratin 18 ( KRT18 ) promoter, predominantly in epithelial cells 8 . (nature.com)
On the basis of these observations, we reasoned that SARS-CoV-2 infection of the K18-hACE2 mice might also show differences in pathogenesis. (nature.com)
Here we demonstrate the use of K18-hACE2 mice for studies of COVID-19 disease and treatments. (nature.com)
To assess the susceptibility of K18-hACE2 mice to SARS-CoV-2, we intranasally challenged male and female mice using inocula of 10 3 , 10 4 and 10 5 plaque-forming units (PFU). (nature.com)
Variability in brain infection was also described in a recent study of K18-hACE2 mice infected with SARS-CoV-2 11 . (nature.com)
Significantly, 58G6 and 510A5 both demonstrate prophylactic efficacy against authentic SARS-CoV-2 and B.1.351 viruses in the transgenic mice expressing human ACE2 (hACE2), protecting weight loss and reducing virus loads. (rcsb.org)

Here, we show that APP can coimmunoprecipitate NEEP21 from nontransgenic mouse brain and from mammalian cells stably coexpressing both proteins. (jneurosci.org)

Altogether, these experiments suggest that ERRγ-deficient mice could provide a model for understanding the regulation of transcription in DAergic neurons and that amplifying ERRγ - mediated transcriptional programs should be considered as a strategy to promote DAergic maintenance in PD. (nature.com)
Our simulations predict the way how subthreshold dendritic signaling and pattern recognition are preserved in TG neurons: amyloid-related membrane alterations compensate for the pathological effects that dendritic atrophy has on subthreshold dendritic signal transfer and integration in layer II/III somatosensory neurons of this hAPP mouse model for AD. (frontiersin.org)
The MPTP-treated mouse has been the most widely used model for assessing neuroprotective agents for Parkinson's disease. (researchgate.net)
A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease. (neurotree.org)
The physiological relevance of E2F1 in the DNA damage response is now being explored using a novel knock-in mouse model we developed that blocks E2F1 phosphorylation by ATM/ATR. (mdanderson.org)
Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. (cdc.gov)
These mice mimic human infection to a much greater extent as compared to wild type mice, leading to a superior model to both study gonococcal pathogenesis and immunity. (bu.edu)
Previous work found that a lead p75 NTR ligand, LM11A-31, prevents degeneration of cholinergic neurites when given to an AD mouse model in the early stages of disease pathology. (plos.org)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
Using a transgenic mouse model to specifically direct expression of reprogramming genes to parenchymal astrocytes residing in the striatum, we also show that endogenous mouse astrocytes can be directly converted into neural nuclei (NeuN)-expressing neurons in situ. (lu.se)
Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model. (lu.se)
Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)
Effects of Deletion of Mutant Huntingtin in Steroidogenic Factor 1 Neurons on the Psychiatric and Metabolic Phenotype in the BACHD Mouse Model of Huntington Disease. (lu.se)
IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)

Mice infected with any of these viruses exhibited symptoms of poliomyelitis. (wikipedia.org)
These viruses include enteroviruses D68 (EV-D68) and 70 (EV70), human rhinovirus, coxsackievirus A21 and echovirus 1. (wikipedia.org)
MERS-CoV, like SARS-CoV and SARS-CoV-2, is a member of the β-CoV family that contains a large group of enveloped RNA viruses and has zoonotic origin but can be transmitted from human to human. (frontiersin.org)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)

Viral quantification revealed the lungs as the major site of infection , although viral RNA could also be found in the eye , heart , and brain in some mice . (bvsalud.org)
To understand the cause(s) of this morbidity and mortality better, we assessed the tissue distribution of infectious virus and viral genomic RNA at 2, 4 and 6 days post infection (dpi) in mice receiving 10 5 PFU of SARS-CoV-2. (nature.com)
Manipulation of UPR markers has been made possible by the use of knockout mice, pharmacological agents, and viral vector-mediated augmentation of gene expression. (molvis.org)
By viral expression of neural fate determinants, it is possible to directly reprogram mouse and human fibroblasts into functional neurons, also known as induced neurons. (lu.se)
The use of viral vectors to deliver foreign genes to the brain is highly logical states in the human brain (Eng et al. (lu.se)

We demonstrate that deletion of ERRγ from DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial gene expression and number, that partial deficiency of ERRγ hastens synuclein-mediated toxicity, and that ERRγ overexpression reduces inclusion load and delays synuclein-mediated cell loss. (nature.com)
Despite the widespread dendritic degeneration and membrane alterations in mutant mouse neurons, surprisingly little, or no change was detected in steady-state and 50 Hz sinusoidal voltage transfers, current transfers, and local and propagation delays of PSPs traveling along dendrites of TG neurons. (frontiersin.org)
Here, we generated two types of α-synuclein fibrils from identical monomer and investigated their seeding and propagation ability in mice and primary-cultured neurons. (elifesciences.org)
Neurodegeneration was evaluated by investigating the numbers of hippocampal pyramidal and granule neurons, as well as the number of synaptophysin-immunopositive presynaptic boutons in the hippocampus of 15-month-old SPA4CT mice with design-based stereological techniques. (amsterdamumc.org)
In this study, we show that transplanted human fibroblasts and human astrocytes, which are engineered to express inducible forms of neural reprogramming genes, convert into neurons when reprogramming genes are activated after transplantation. (lu.se)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)

However, in an mdm2 null background, just one allele of Tg p53 ( mdm2 −/− /Tg p53 t/0 mice) was sufficient to cause lens damage and microphthalmia. (molvis.org)
These results indicate that individuals expressing only the PON1Q192 allele would be more sensitive to the adverse effects of CPO or CPS exposure, especially if they are expressing a low level of plasma PON1Q192. (cdc.gov)

OPV/Sabin infected animals including, but not limited to, non-human primates and transgenic mice expressing the human PV receptor (CD155). (cdc.gov)

When the researchers transferred human-derived microbiota into transgenic mice expressing a myelin autoantigen-specific T-cell receptor, they found that microbiome fecal transplants could exacerbate MS symptoms. (genomeweb.com)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)

Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant. (jci.org)
These models are being used to explore the roles of this human SNP in modulating cancer susceptibility and the response to DNA damaging agents, including chemotherapeutic drugs. (mdanderson.org)

The infected mice generated typical interstitial pneumonia and pathology that were similar to those of COVID-19 patients . (bvsalud.org)
These mice exhibited all symptoms and pathology of poliomyelitis observed in humans, including flaccid paralysis and spinal cord lesions. (wikipedia.org)
To extend its potential clinical applications, we sought to determine whether LM11A-31 could reverse cholinergic neurite atrophy when treatment begins in AD mouse models having mid- to late stages of pathology. (plos.org)
Importantly, a 1 month LM11A-31 treatment given to male APP L/S mice (12-13 months old) with late-stage pathology reversed the degeneration of cholinergic neurites in basal forebrain, ameliorated cortical dystrophic neurites, and normalized increased basal forebrain levels of p75 NTR . (plos.org)

Humans are the only known natural host for poliovirus. (wikipedia.org)
These mice today are used not only to continue to understand poliovirus pathogenesis but as a means to test the safety of stocks of the polio vaccine. (wikipedia.org)
Newborn mice producing PVR were infected with wild-type poliovirus and a chimeric poliovirus in which this element was replaced with the same region from hepatitis C virus, a liver specific virus, or coxsackievirus B3, a virus that infects the heart or meninges. (wikipedia.org)

Here we examined the role of rhodopsin glycosylation in biosynthesis, trafficking, and retinal degeneration (RD) using transgenic Xenopus laevis expressing glycosylation-defective human rhodopsin mutants. (jneurosci.org)

Two forms of human GRF, 40 and 44 amino acids long, have been characterized from extra-hypothalamic tumours 7,8 as well as from the hypothalamus 9 . (northwestern.edu)
Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease. (lu.se)

This problem has been circumvented with the use of several knockout, knock-in, and overexpressing transgenic mouse models. (molvis.org)

Mice developed anosmia at early time points after infection. (nature.com)
The transgenic mice with the human prion gene showed no evidence of infection at 14 to 17 months, close to the lifespan of the mouse. (usda.gov)

This zoonotic transmission from camels to humans continues in the Arabian Peninsula, with 19 cases of MERS-CoV reported in 2021 (European Center for Disease Prevention and Control, 2022). (frontiersin.org)

In a wild-type genetic background ( mdm2 +/+ ), lens damage and microphthalmia were observed only in mice homozygous for Tg p53 ( t/t ). (molvis.org)
By contrast, transplantation of wild-type bone marrow stem cells restored memory capacities and diminished soluble Aβ accumulation in APP(Swe)/PS1 and APP(Swe)/PS1/CCR2⁻/⁻ mice. (nih.gov)
These assays identified an age-dependent decline in glucose homeostasis and hepatic glucose output in wild-type mice. (genengnews.com)
In contrast to wild-type mice, the transgenic UMOD mice had marked improvement in blood pressure with furosemide (an inhibitor of NKCC2). (medscape.com)
These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)

All macrophages express common markers such as CD11b (Mac1 or CR3), CD68, and CD115 (M-CSF receptor). (hindawi.com)
Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. (ancell.com)
1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)

To examine the physiological consequences of GRF expression, we have established strains of transgenic mice containing a fusion gene including the promoter/regulatory region of the mouse metal-lothionein-I (MT-I) gene 13 and the coding region of the human GRF gene 12 . (northwestern.edu)
These transgenic mouse strains should provide useful animal models for the study of several types of human growth disorders. (northwestern.edu)

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2. (bvsalud.org)
Dr. Gray-Owen has developed transgenic mice that express human gonococcal adhesins and other molecules that enhance gonococcal pathogenesis, that are normally lacking in mice. (bu.edu)

A) Immunohistochemical staining for GFAP in the hippocampus of a HuVV mouse showing microplaque-like deposits. (cdc.gov)

In contrast, the authors noted, "Aged SIRT6-transgenic mice preserve hepatic glucose output and glucose homeostasis through an improvement in the utilization of two major gluconeogenic precursors, lactate and glycerol. (genengnews.com)
Unexpectedly, female transgenic mice carrying the MT-GRF fusion gene are fertile, in contrast to female transgenic mice expressing human or rat growth hormone, which are generally infertile. (northwestern.edu)

Differential gene expression in the striatum of mice with very low expression of the vesicular monoamine transporter type 2 gene. (neurotree.org)
Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)

1991. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. (cdc.gov)

The mutant rhodopsins were rendered less toxic in their dark inactive states, because RD was abolished or significantly reduced when transgenic tadpoles expressing T4K, T17M, and N2S/N15S were protected from light exposure. (jneurosci.org)
Mice expressing PON1Q192 were significantly more sensitive to CPO, and to a lesser extent CPS, than were mice expressing PON1R192. (cdc.gov)

Expression of T17M was more toxic than T4K to transgenic photoreceptors, further suggesting that glycosylation at N15 plays a more important physiological role than glycosylation at N2. (jneurosci.org)
Researchers recently discovered a novel mechanism that works over an extensive genomic distance and controls the expression of human growth hormone (hGH) in the pituitary gland. (sciencedaily.com)
Researchers at the University of Pennsylvania School of Medicine recently discovered a novel mechanism that works over an extensive genomic distance and controls the expression of human growth hormone (hGH) in the pituitary gland. (sciencedaily.com)
The effects of the locus control region on human growth hormone expression is as if you turn a key in the lock of a house at one end of your street and find that this action opens the lock and door of a house a block away," notes Liebhaber. (sciencedaily.com)
To test whether the transcription of the locus control region and CD79b played a significant role in hGH expression in transgenic mice, Ho then inserted a special piece of DNA into the locus control region. (sciencedaily.com)
Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain. (neurotree.org)
The renal phosphate wasting in the transgenic mice was accompanied by the reduced expression of sodium phosphate cotransporter type IIa in renal proximal tubules. (nih.gov)
These in vitro, and their expression in these human tumour virus. (who.int)
Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)
Jakobsson expression under a human GFAP (hGFAP) promoter. (lu.se)
Materials and methods approach to regulate transgenic expression. (lu.se)

In one new study, published yesterday in Proceedings of the National Academy of Sciences, a team led by University of California, San Francisco researchers discovered specific gut microbes connected to MS in patients, demonstrating that these microbes engage in regulating immune responses in mouse disease models and suggesting that the microbes play a role in the neurodegeneration inherent in MS. (genomeweb.com)
Peptide immunization elicited immune responses in transgenic mice expressing a diverse human TCR repertoire restricted to HLA-A*02:01, which enabled isolation of high-affinity TCRs. (fu-berlin.de)

Monocytes emigrate from bone marrow, can infiltrate into brain, differentiate into microglia and clear amyloid β (Aβ) from the brain of mouse models of Alzheimer's disease (AD). (nih.gov)

Together, the human disease and animal models suggest that glycosylation plays a crucial role in the structure and/or function of rhodopsin. (jneurosci.org)
Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. (mdpi.com)
Two different groups, using two separate cohorts of patients and controls, and two distinct mouse models of the disease, saw very similar results," Cekanaviciute said in a statement. (genomeweb.com)
We have been able to demonstrate that at early time points more inflammation and cytokine induction occurs in these transgenic mice as opposed to other commonly used models, demonstrating that these previously used models my not be the best approach to study gonococcal infections. (bu.edu)
Transgenic mouse models pro- fection. (who.int)

We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
The presence of these cells in the brain of non-irradiated APP(Swe)/PS1/CCR2⁻/⁻ mice supports the concept that they can be used as gene vehicles for AD. (nih.gov)
The researchers initially exposed human immune cells in laboratory dishes to the bacterial extracts, and found that Akkermansia muciniphila and Acinetobacter calcoaceticus , two species that were more common in people with MS, triggered the cells to become pro-inflammatory. (genomeweb.com)
The team decided to perform fecal transplants on mice with an experimentally induced form of MS. They discovered that swapping the mice's microbiomes with those of MS patients caused the animals to lose key immune-regulatory cells and instead develop more severe neurodegeneration, indicating that the microbiome alone could affect the progression of MS. (genomeweb.com)
Antibody JOVI-3 is specific for the human V beta 3 TCR gene product and reacts with 1-10 of T cells in normal human blood (1, 5). (ancell.com)
Antibody JOVI-3 is mitogenic for T cells expressing TCR V beta 3. (ancell.com)
Utilizing conditional KO mice (using the Cre-Lox system) we have discerned that MyD88 signaling in B cells, Dendritic Cells (DC) and Macrophages are essential for the PorB adjuvant activity. (bu.edu)
1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
Taken together, our data provide proof of principle that direct neural conversion can take place in the adult rodent brain when using transplanted human cells or endogenous mouse cells as a starting cell for neural conversion. (lu.se)

In the central nervous system of rodents, the extracellular matrix glycoproteins tenascin-C and tenascin-R are expressed predominantly by astrocytes and oligodendrocytes respectively. (researchgate.net)

In some but not all mice, brain titres gradually increased from 2 to 6 dpi. (nature.com)
These transgenic mice were inoculated with brain homogenates from elk with CWD. (usda.gov)
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain. (neurotree.org)
The time course of inhibition following exposure to 1.2 mg/kg CPO revealed maximum inhibition of brain AChE at 6-12 h, with PON1R192, PON1Q192, and PON1 mice exhibiting 40, 70 and 85% inhibition, respectively, relative to control mice. (cdc.gov)
Using this tag, we prepared mild detergent lysates from transgenic mouse brain cortical membrane preparations and isolated a number of previously identified APP-interacting proteins. (jneurosci.org)
To assess the native APP interactome in brain, we generated mice expressing human APP-695 fused to a C-terminal affinity tag (APP-AT). (jneurosci.org)
Here we apply 2-dimensional polarization imaging [1] to visualize aggregation of human α-synuclein expressed in brain tissue from transgenic mice. (lu.se)

Transgenic mice were generated that expressed either human PON1Q192 or PON1R192 at equivalent levels, in the absence of endogenous mouse PON1. (cdc.gov)

Eye phenotype and lens histology and ultrastructure were analyzed in adult mice. (molvis.org)
Dose-response and time course experiments were performed on adult mice exposed dermally to CPS or CPO. (cdc.gov)

Keratin glycosylation decreased in all griseofulvin-fed mice, whereas keratin phosphorylation increased dramatically preferentially in mice expressing normal K18. (jci.org)

Synthesized by the pituitary gland, human growth hormone activates growth and cell reproduction. (sciencedaily.com)
As a result, the transgenic mice expressed high levels of human growth hormone in the pituitary as well as mouse growth hormone. (sciencedaily.com)

We recently described transgenic mice that express point-mutant human K18 (Ku, N.-O., S. Michie, R.G. Oshima, and M.B. Omary. (jci.org)
Here we show that mutant K18 expressing transgenic mice are highly susceptible to hepatotoxicity after acute administration of acetaminophen (400 mg/Kg) or chronic ingestion of griseofulvin (1.25% wt/wt of diet). (jci.org)

To clarify the pathophysiological roles of FGF-23 in these diseases, we generated its transgenic mice. (nih.gov)
The transgenic mice expressing human FGF-23 reproduced the common clinical features of these diseases such as hypophosphatemia probably due to increased renal phosphate wasting, inappropriately low serum 1,25-dihydroxyvitamin D level, and rachitic bone. (nih.gov)
Indeed, several human diseases are characterized by attenuated repair responses and imbalances in the inflammatory response with increased number of infiltrating macrophages [ 3 - 5 ]. (hindawi.com)

These data indicate that there is a substantial species barrier for transmission of elk CWD to humans. (usda.gov)
For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)
In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)

B) A serial section from the same HuVV mouse immunolabeled for PrP by using monoclonal antibody (Purified [3F4], Cambridge Bioscience, Cambridge, UK). (cdc.gov)

Last, we showed that pre-exposure to SARS-CoV-2 could protect mice from severe pneumonia . (bvsalud.org)
Rapidly determining human exposure to BoNT is an important public health goal. (cdc.gov)

Keratins 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in simple-type epithelia. (jci.org)

The licensed technologies enable the development of a clinically validated bispecific antibody format most similar to native antibodies, use natural mechanisms to generate long CDR3 antibodies to improve the chance of success against challenging drug targets such as GPCRs and ion channels, and increase access to transgenic mice expressing full human antibody diversity. (bignewsnetwork.com)
The agreement also provides Gilead with non-exclusive rights to future AbTherx-developed transgenic mouse technologies, which will add to Gilead's existing portfolio of antibody discovery technologies. (bignewsnetwork.com)
Combining this platform with our decades of experience in antibody discovery and developing transgenic mice, AbTherx is uniquely positioned to deliver the next generation of antibody therapeutics,' said Justin Mika, Chief Executive Officer of AbTherx. (bignewsnetwork.com)
The company was founded by a leadership team with over 100 years of combined experience in antibody discovery and platform development, including development of the HuMAb Mouse ® technology, the most successful human antibody discovery platform with 13 marketed therapeutics. (bignewsnetwork.com)
AbTherx's Atlas™ Mouse platform enables the development of a clinically validated bispecific antibody format most similar to native antibodies and uses natural mechanisms to generate long CDR3 antibodies to improve the chance of success against challenging drug targets such as GPCRs and ion channels. (bignewsnetwork.com)
AbTherx is also increasing access to transgenic mice expressing full human antibody diversity. (bignewsnetwork.com)

Several genes encoding olfactomedin domain-containing proteins are expressed in the eye. (nih.gov)

Evidence of thrombosis and vasculitis was detected in mice with severe pneumonia. (nature.com)

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
Studies in animals infected experimentally with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19, provide opportunities to study aspects of the disease that are not easily investigated in human patients. (nature.com)
The transgenic mice with the elk prion gene developed disease in approximately 4 months. (usda.gov)
More recently we have begun a programme to test the effect of antioxidant compounds on biochemical markers of heart disease in both animal and human trials. (otago.ac.nz)
The data suggests that MS-derived microbiota potentially contain factors that precipitate an MS-like autoimmune disease in mice, and more importantly, in humans. (genomeweb.com)
the disease caused by the cognate cel s from human cord blood. (who.int)

Anatomy39

Organisms22

Diseases25

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Psychiatry and Psychology4

Phenomena and Processes63

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Prion protein4

Transgene8

Vivo11

Amyloid precurs4

Protein10

Mutation1

Genetics5

Inoculation2

Tg25762

Tissues5

HACE212

Mammalian cells1

Model14

Viruses6

Viral5

Neurons6

Allele2

Primates1

Myelin2

Susceptibility2

Pathology4

Poliovirus3

Degeneration1

Hypothalamus2

Knockout1

Infection2

20221

Wild-type5

Receptor5

Strains2

Pathogenesis2

Hippocampus1

Contrast2

Gene expression2

Tumors1

Significantly2

Expression11

Immune responses2

Alzheimer's1

Models5

Cells9

Predominantly1

Brain7

Endogenous1

Adult mice2

Phosphorylation1

Growth hormone2

Mutant2

Diseases3

Species3

Monoclonal1

Exposure2

Filament1

Antibody6

Proteins1

Pneumonia1

Disease6