• The middle tumor antigen (also called the middle T-antigen and abbreviated MTag or MT) is a protein encoded in the genomes of some polyomaviruses, which are small double-stranded DNA viruses. (wikipedia.org)
  • In this study, using polyoma middle T antigen (PyMT) mice, a widely used luminal B breast cancer model, we profiled microRNA (miRNA) expression at four time points that represent different key developmental stages of cancer progression. (biomedcentral.com)
  • The early unit encodes large T antigen (LT), small t antigen (sT), 17K T antigen The biochemical properties of the large T antigens encoded by simian virus 40 (SV40) mutants with deletions at DdeI sites in the SV40 A gene were determined. (netlify.app)
  • Murine lung epithelial (MLE) cell lines were produced from lung tumors derived from transgenic mice bearing the viral oncogene, SV40 large T antigen, under transcriptional control of the promoter-enhancer region of the human surfactant protein C (SP-C) gene. (elsevierpure.com)
  • Interferes with histone deacetylation mediated by HDAC1, leading to … SV40 large T antigen (click to see its coding sequence), [Simian Vacuolating Virus 40 Large T-Ag ] is a hexamer protein involved in viral genome replication and regulation of the host cell cycle. (netlify.app)
  • SV40 large T antigen (T-ag) is a multifunctional ~85 kD phosphoprotein, which is the sole viral protein required for SV40 replication. (netlify.app)
  • Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)
  • MCPyV integrates into the host genome, resulting in expression of oncoproteins including a truncated form of the viral large T antigen (LT) in infected cells. (bvsalud.org)
  • Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. (academicinfluence.com)
  • Tumor formation and progression in these mice can be divided into four stages: hyperplasia, adenoma/mammary intra-epithelial neoplasia, early carcinoma, and late carcinoma [ 4 ] (we refer to all these four stages as tumor in this study). (biomedcentral.com)
  • Epithelial membrane antigen-reactive feline chordoid meningioma in a European wildcat (Felis silvestris). (unibe.ch)
  • MTag is expressed early in the infectious cycle along with two other related proteins, the small tumor antigen and large tumor antigen. (wikipedia.org)
  • The genes for the small tumor antigen (STag), middle tumor antigen (MTag), and large tumor antigen (LTag) are encoded in the "early region" of the polyomavirus genome, so named because this region of the genome is expressed early in the infectious process. (wikipedia.org)
  • A somewhat more common tumor antigen variant, an overprinted gene encoding a protein called ALTO, may be evolutionarily related to MTag. (wikipedia.org)
  • A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. (academicinfluence.com)
  • The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. (netlify.app)
  • 18 The apparent absence of pro-B cell leukemias in IgH.T/IgH.TEμ mice indicates that transient expression of the SV40 T gene (until it is lost as a result of D to J H recombination) did not result in Background Simian Virus 40 (SV40) Large Tumor Antigen (LT) is an essential enzyme that plays a vital role in viral DNA replication in mammalian cells. (netlify.app)
  • We have identified a candidate etiologic agent, dubbed raccoon polyomavirus, that was present in the tumor tissue of all affected animals but not in tissues from 20 unaffected animals. (cdc.gov)
  • However, natural disease studies of human infection and experimental disease studies suggest that a potential outcome of some polyomavirus (PyV) infections is tumor formation ( 4 - 6 ). (cdc.gov)
  • Here, we used reflectance confocal microscopy (RCM) imaging in humans and in mice to visualize tumor architecture in vivo . (bioxcell.com)
  • Injection of IFN-gamma into tumor-bearing mice or transgenic overexpression of Ncr1 in NK cells in mice resulted in decreased metastasis formation. (bioxcell.com)
  • Recent advances have been made by an accumulation of studies on Merkel cell polyomavirus (MCPyV), which is highly associated and integrated in most Merkel cell carcinomas ( 5 ). (cdc.gov)
  • Introduction: Most cases of Merkel cell carcinoma (MCC), a rare and highly aggressive type of neuroendocrine skin cancer, are associated with Merkel cell polyomavirus (MCPyV) infection. (bvsalud.org)
  • Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells. (ox.ac.uk)
  • We have obtained transgenic mice in which an erythropoietin-SV40 virus T antigen fusion gene is homologously recombined into the native Epo locus. (ox.ac.uk)
  • Immunohistochemical detection of SV40 T antigen has been used to characterize the hepatic cell populations expressing the transgene. (ox.ac.uk)
  • In mice stimulated by anaemia or hypobaric hypoxia, SV40 T antigen was demonstrated in two liver cell populations: a subset of hepatocytes and a nonparenchymal cell type. (ox.ac.uk)
  • SV40 TAg thus appears to directly induce a neuroendocrine gene signature in gastric carcinomas of CEA424-SV40 TAg-transgenic mice. (netlify.app)
  • visa att polyomavirus SV40 rekryterar kinesin-1 för att konstruera expression av stort T-antigen (TAg) på ett koncentrationsberoende sätt (fig. However, as kinesin-1 is responsible for transforming small to large foci, we Hepatit C-virus: kval. (netlify.app)
  • SV40 large T antigen New Protein Search: Large T antigen Show on y-axis -References (HTP + LTP) References (LTP) References (HTP) log2 The SV40 large T antigen is probably expressed as part of an antisense transcript within the D-J H region of the IgH locus, similar to the antisense transcripts described in pro-B cells. (netlify.app)
  • SV40 is a powerful carcinogen that, in vitro , transforms human mesothelial cells. (sv40.org)
  • CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). (lookformedical.com)
  • In a widely used mouse model of breast cancer, mammary gland-specific expression of the polyoma middle T (PyMT) oncoprotein under the control of the MMTV promoter/enhancer in transgenic mice (MMTV-PyMT) results in widespread transformation of the mammary epithelium and subsequent development of multifocal mammary adenocarcinomas and metastatic lesions in the lymph nodes and in the lungs [ 2 ]. (biomedcentral.com)
  • The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. (cdc.gov)
  • Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons. (cdc.gov)
  • We characterized from these tumors a candidate etiologic agent, raccoon polyomavirus (RacPyV). (cdc.gov)
  • Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. (nature.com)
  • Until recently, these were the only two polyomaviruses known to encode MTag, but in 2015 the genome sequence of a rat polyomavirus was reported to contain MTag as well. (wikipedia.org)
  • Additionally, IFNγ induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. (bioxcell.com)
  • We demonstrated that signaling via the NK cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral NK cells. (bioxcell.com)
  • The use of chimeric antigen receptor (CAR)-T cell therapy for T-cell malignancies is challenging due to possible blast contamination of autologous T-cell products and fratricide of CAR-T cells targeting T-lineage antigens. (bvsalud.org)
  • However, evidence of MTag encoding and expression has also recently been reported in at least one virus of unrelated lineage, the trichodysplasia spinulosa polyomavirus, which is a normally asymptomatic infection in humans that sometimes causes the rare disease trichodysplasia spinulosa in immunocompromised individuals. (wikipedia.org)
  • In this study we profiled the expression of miRNAs during breast cancer progression in the PyMT mouse model. (biomedcentral.com)
  • Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi. (mdc-berlin.de)
  • Thus, the local immunological milieu in tissue compartments forms the nature and magnitude of the host responses, i.e., frequencies of regulatory T cells (Tregs) vs. T-helper 17 (Th17) cells, amount of pro-inflammatory cytokines vs. anti-inflammatory cytokines, extent of neutrophilia and antigen-presenting-cell (APC) activation, among others. (frontiersin.org)
  • Finally, Tfam+/− mice exposed to ionizing radiation exhibit enhanced nDNA repair responses in spleen. (regenerativemedicine.net)
  • Immunologic tolerance is a state of immune unresponsiveness specific to a particular antigen or set of antigens induced by previous exposure to that antigen or set. (medscape.com)
  • Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor. (academicinfluence.com)
  • Transforming growth factor production by chemically transformed cells. (academicinfluence.com)
  • If living cells from mouse strain CBA were injected into an adult mouse of strain A, some immunologic process destroyed the CBA cells, and the A-line mouse that received the CBA cells quickly destroyed any subsequent graft from the same donor strain. (medscape.com)
  • In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)
  • Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFβ-Smad3 pathway. (colorado.edu)
  • Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. (colorado.edu)
  • The replication fork movement is facilitated by Large T antigen helicase activity. (netlify.app)
  • These studies refine the understanding of how the large T antigen origin-binding domain s encoded by the polyomavirus family interact with single-stranded DNA, a critical step during the initiation of DNA replication. (netlify.app)
  • Kroppen känner igen detta omedelbart som en antigen komplex vilket är en often tell small lies in little matters but would be ashamed to resort to large-scale falsehoods. (netlify.app)
  • In this process, LT converts the chemical energy from ATP binding and hydrolysis into the mechanical work required for This peptide is generated from Large T antigen residue 47 to 55. (netlify.app)
  • In MTag-containing polyomaviruses, the early region contains at least three genes encoding STag, MTag, and LTag, and is transcribed as a single messenger RNA processed by alternative splicing. (wikipedia.org)
  • MTag is also well known from the hamster polyomavirus, although the sequence C-terminal to the J domain has little homology between the mouse and hamster viruses. (wikipedia.org)
  • Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity. (academicinfluence.com)
  • Breast cancer in PyMT mice is particularly noted by its short latency, high penetrance, and a high incidence of lung metastasis [ 3 ]. (biomedcentral.com)
  • Most genetically engineered mouse models that target oncogenes such as PyMT do not fully recapitulate several aspects of the development of human breast cancer. (biomedcentral.com)
  • Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium. (academicinfluence.com)
  • Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers. (harvard.edu)
  • Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. (mdc-berlin.de)
  • Users who start with a small keyboard naturally hope to have a mouse that matches its style to complete a set. (keyceo.com)
  • MTag occurs only in a few known polyomaviruses, while STag and LTag both appear in all known members of the family. (wikipedia.org)
  • This observation is consistent with expectations that it evolved uniquely in the rodent lineage of the polyomavirus family. (wikipedia.org)
  • Preference for members of the Src family varies, with mouse and hamster polyomavirus MTags having different distributions. (wikipedia.org)
  • Despite these limitations, the use of the PyMT mouse model and other similarly engineered models has been instrumental in elucidating the genetics and biology of breast cancer. (biomedcentral.com)
  • They are a bit higher in price but you do not have to sacrifice a usb port to connect wireless mouse . (keyceo.com)
  • Multichannel SQUID system with integrated magnetic shielding for magnetocardiography of mice. (mdc-berlin.de)
  • Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. (colorado.edu)
  • If you do not mind using up a usb slot, I would suggest the Logitech V320 wireless mouse. (keyceo.com)
  • MY usb mouse wont work with windows vista? (keyceo.com)
  • Will this pet mouse treat recipe work? (keyceo.com)
  • It Will Work and cause the mouse no harm (I would try it,but im no expert) not too much honey because of the sugar. (keyceo.com)