• Transgenic mouse technology enables the study of gene regulation, embryology and development. (tubitak.gov.tr)
  • Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes. (microbiologyresearch.org)
  • To examine the physiological consequences of GRF expression, we have established strains of transgenic mice containing a fusion gene including the promoter/regulatory region of the mouse metal-lothionein-I (MT-I) gene 13 and the coding region of the human GRF gene 12 . (northwestern.edu)
  • Unexpectedly, female transgenic mice carrying the MT-GRF fusion gene are fertile, in contrast to female transgenic mice expressing human or rat growth hormone, which are generally infertile. (northwestern.edu)
  • After four years of research and validation, GemPharmatech's independently developed fully antibody gene humanized mouse model, NeoMab™, is officially entering the market to serve the therapeutic antibody development needs of biotechnology companies and pharmaceutical enterprises. (gempharmatech.us)
  • It retains the native mouse constant region encoding genes while incorporating human variable gene repertoires at the endogenous loci. (gempharmatech.us)
  • NeoMab™ mice utilize human V(D)J genes to encode antibodies, exhibiting gene usage frequency and sequence diversity that closely resemble those of humans. (gempharmatech.us)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • Another mouse has had a gene altered that is involved in glucose metabolism and runs faster, lives longer, is more sexually active and eats more without getting fatter than the average mouse (see Metabolic supermice). (wikipedia.org)
  • Inactivation of the mouse Huntington's disease gene homolog hdh . (nature.com)
  • Basal cell carcinomas, the commonest human skin cancers, consistently have abnormalities of the hedgehog signaling pathway and often have PTCH gene mutations. (nature.com)
  • The mouse basal cell carcinomas and trichoblastoma-like tumors resemble human basal cell carcinomas in their loss of normal hemidesmosomal components, presence of p53 mutations, frequent loss of the normal remaining Ptch allele, and activation of hedgehog target gene transcription. (nature.com)
  • The Ptch mutant mice provide the first mouse model, to our knowledge, of ultraviolet and ionizing radiation-induced basal cell carcinoma-like tumors, and also demonstrate that Ptch inactivation and hedgehog target gene activation are essential for basal cell carcinoma tumorigenesis. (nature.com)
  • Human homolog of patched, a candidate gene for the basal cell nevus syndrome. (nature.com)
  • In this study, the problem was addressed through the use of transgenic mice, in which the gene for the normal mouse prion protein was replaced by the gene for the elk or the human prion protein precursor. (usda.gov)
  • The transgenic mice with the elk prion gene developed disease in approximately 4 months. (usda.gov)
  • The transgenic mice with the human prion gene showed no evidence of infection at 14 to 17 months, close to the lifespan of the mouse. (usda.gov)
  • A team of researchers in Japan in the 1990s were introducing a gene into mice. (mcgill.ca)
  • With a transgenic mouse, a foreign gene is introduced into the cells of mice. (mcgill.ca)
  • While the Japanese scientists were studying hypertension in mice by introducing a gene that coded for a molecule involved in heart failure, something happened. (mcgill.ca)
  • In this case, the transgene had disrupted a mouse gene which the researchers decided to call klotho . (mcgill.ca)
  • Even though the klotho gene was silent in most organs of the mouse and only made the klotho protein in a few anatomical sites, the physical changes to the mouse were all-encompassing, which made the scientists think that klotho might behave like a hormone, circulating from tissue to tissue as a molecular messenger. (mcgill.ca)
  • And the scientists found that we too had a klotho gene: it is 85% identical to the mouse version. (mcgill.ca)
  • When introduced into mouse brain, the human a-synuclein gene causes the same pathology as in Parkinson's disease patients, ultimately leading to severe movement disorder and death of the experimental animals. (michaeljfox.org)
  • Blockade of trans-signaling in the brain of the GFAP-IL6 mice significantly attenuated Serpina3n but not SOCS3 gene expression, whereas vascular changes including angiogenesis and blood-brain barrier leakage as well as gliosis were also reduced significantly. (jneurosci.org)
  • The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. (nih.gov)
  • Transgenic mice that were created that had a mutation in the gene which codes for the transcription factor (NGFIB). (freeonlineresearchpapers.com)
  • It was hypothesized that a growth hormone gene would speed up and increase overall growth of the mice. (freeonlineresearchpapers.com)
  • Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. (lu.se)
  • Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)
  • It developed an abnormal walking pattern reminiscent of how humans with Parkinson's disease move around. (mcgill.ca)
  • In the present project, we will take advantage of our transgenic pre-clinical model of Parkinson's disease pathology to test experimental drugs. (michaeljfox.org)
  • A heart attack is simulated by ligating a coronary vessel in dogs or mice, while Parkinson's and diabetes are induced through the injection of toxins. (aerzte-gegen-tierversuche.de)
  • The MPTP-treated mouse has been the most widely used model for assessing neuroprotective agents for Parkinson's disease. (researchgate.net)
  • After immunization with human recombinant protein antigens, NeoMab™ mice display antigen-specific serum titers similar to BALB/c mice, reaching approximately 10 5 -10 6 after three immunizations. (gempharmatech.us)
  • The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)
  • For example, genetically modified mice may be born with human leukocyte antigen genes in order to provide a more realistic environment when introducing human white blood cells into them in order to study immune system responses. (wikipedia.org)
  • The introduction of foreign genetic material into mouse genomes by microinjection is an important tool in studying the properties and effects of many genes in vivo. (tubitak.gov.tr)
  • HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. (microbiologyresearch.org)
  • Genetically modified mice are commonly used for research or as animal models of human diseases, and are also used for research on genes. (wikipedia.org)
  • In 1974 Beatrice Mintz and Rudolf Jaenisch created the first genetically modified animal by inserting a DNA virus into an early-stage mouse embryo and showing that the inserted genes were present in every cell. (wikipedia.org)
  • This method creates a transgenic mouse and is used to insert new genetic information into the mouse genome or to over-express endogenous genes. (wikipedia.org)
  • A humanised mouse can also be created by direct addition of human genes, thereby creating a murine form of human-animal hybrid. (wikipedia.org)
  • Mice are a useful model for genetic manipulation and research, as their tissues and organs are similar to that of a human and they carry virtually all the same genes that operate in humans. (wikipedia.org)
  • The most common type is the knockout mouse, where the activity of a single (or in some cases multiple) genes are removed. (wikipedia.org)
  • Transgenic mice generated to carry cloned oncogenes and knockout mice lacking tumor suppressing genes have provided good models for human cancer. (wikipedia.org)
  • In situ detection of hedgehog target genes and immunohistology of Ptch +/- mouse BCC differentiation markers, hemidesmosomal proteins and Bcl2 protein. (nature.com)
  • Mice have their own set of genes that code for the proteins that will make and sustain a mouse, much like we have our own genes that make us human. (mcgill.ca)
  • Importantly, though, we share the vast majority of our genes with mice, so we are not that dissimilar. (mcgill.ca)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • Moreover, our group has recently evidenced that early-life infection in 5xFAD mice induces a subpopulation of microglial cells with a monocyte-like profile presenting as potential markers genes corresponding to Gal3, and APOE. (lu.se)
  • In this report, brain homogenates fromelk with CWD were inoculated into transgenic mice expressing the human or elk prion protein. (usda.gov)
  • A Transgenic Mouse Model with Human Growth Hormone" by Benan DİNÇTÜRK, Abdullah TÜRKMENLER et al. (tubitak.gov.tr)
  • The objective of this research was the optimization of transgenic manipulation in the laboratory, by the production of model mice harbouring human growth hormone, and thwe identification of the transgenic mice. (tubitak.gov.tr)
  • This strategy results in a powerful model that combines the strengths of the mouse immune system with human-specific variable regions, making it ideal for advancing antibody discovery and research endeavors. (gempharmatech.us)
  • At present, we have established extensive repositories of model resources, encompassing KOAP mice and tool mice for drug screening purposes. (gempharmatech.us)
  • There is substantial evidence that both inflammation and oxidative damage contribute to the pathogenesis of motor neuron degeneration in the G93A SOD1 transgenic mouse model of amyotrophic lateral sclerosis (ALS). (karger.com)
  • A genetically modified mouse or genetically engineered mouse model (GEMM) is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques. (wikipedia.org)
  • A transgenic mouse model was developed by introducing a human mutant UMOD (C148W) cDNA under control of the mouse umod promoter. (elsevierpure.com)
  • Here, we successfully developed a SARS-CoV-2 hACE2 transgenic mouse (HFH4-hACE2 in C3B6 mice ) infection model. (bvsalud.org)
  • Here we show that Abetae fragment Abeta25-35, but not Abeta42-1, can at least double the level of p75NTR receptors in the membranes of model SH-SY5Y human neuroblastoma cells. (univr.it)
  • These mice require niacin as a vitamin in food, just as humans do, which now allows us to study niacin in a rodent model that more closely resembles human vitamin metabolism. (usu.edu)
  • We demonstrate that the R6/2 transgenic mouse model expressing a short fragment of mutant HTT displays hypothalamic neuropathology with discrete loss of the neuronal populations expressing orexin, MCH, CART, and orexin at 12 weeks of age. (lu.se)
  • The BACHD mouse model expressing full-length mutant HTT does not display any hypothalamic neuropathology at 2 months of age. (lu.se)
  • There was no effect of hypothalamic injections of QA on the neuronal populations expressing orexin, MCH, CART or oxytocin in neither HD mouse model. (lu.se)
  • Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. (cdc.gov)
  • Using mouse transgenic and human stem cell technologies to model genetic mutations associated with schizophrenia and autism. (bvsalud.org)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • APOE4-specific changes in Abeta accumulation in a new transgenic mouse model of Alzheimer disease. (lu.se)
  • Human APOE4 increases microglia reactivity at Abeta plaques in a mouse model of Abeta deposition. (lu.se)
  • IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)
  • Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model. (lu.se)
  • Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)
  • For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
  • Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation. (nature.com)
  • Led by Dr. Hersch, the laboratory investigates Huntington's disease (HD) using transgenic mouse models and human brain tissue. (massgeneral.org)
  • Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)
  • The human immunodeficiency virus (HIV) epidemic and HIV-associated nephropathy. (medscape.com)
  • Hippocampal region (A) and striatum (B) from a transgenic 129MM Tg35c mouse with subclinical prion infection culled 700 days after inoculation with cattle BSE prion inoculum I038. (cdc.gov)
  • Viral quantification revealed the lungs as the major site of infection , although viral RNA could also be found in the eye , heart , and brain in some mice . (bvsalud.org)
  • Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
  • These transgenic mouse strains should provide useful animal models for the study of several types of human growth disorders. (northwestern.edu)
  • We also show that p75NTR is upregulated in the hippocampi of two strains of AD transgenic mice. (univr.it)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • Figure 2: Distribution of CAG repeats before and after the major GeneScan peak for various tissues from Msh2 -/- and Msh2 +/+ mice. (nature.com)
  • Figure 3: Levels of CAG repeat instability in various tissues from Msh2 -/- , Msh2 +/- and Msh2 +/+ mice. (nature.com)
  • The infected mice generated typical interstitial pneumonia and pathology that were similar to those of COVID-19 patients . (bvsalud.org)
  • Compensating for the loss of ClpP in the substantia nigra of αSyn A53T mice by viral expression of ClpP suppresses mitochondrial oxidative damage, and reduces αSyn pathology and behavioral deficits of mice. (springer.com)
  • The hypothalamus has emerged as an important area of pathology with selective loss of neurons expressing the neuropeptides orexin (hypocretin), oxytocin and vasopressin in human postmortem HD tissue. (lu.se)
  • Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice. (medscape.com)
  • Cellular factors regulate transactivation of human immunodeficiency virus type 1. (microbiologyresearch.org)
  • Cytotoxic effect on lymphocytes of Tat from human immunodeficiency virus (HIV-1). (microbiologyresearch.org)
  • Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines. (microbiologyresearch.org)
  • Human immunodeficiency virus Vpr product is a virion-associated regulatory protein. (microbiologyresearch.org)
  • In human immunodeficiency virus (HIV)-associated FSGS, the renal functional deterioration is rapid, leading to ESRD within a few weeks to 1 year. (medscape.com)
  • Quantitative biochemical analysis confirmed the presence of differential phospho-tau species in G2019S mice but surprisingly, upon dephosphorylation the tau isoform banding pattern in G2019S mice remained altered. (elsevierpure.com)
  • When beneficial effects on the life span and locomotor behavior are observed for a given drug, the mechanism of action will be elucidated by histological and biochemical analysis of the transgenic mouse brains. (michaeljfox.org)
  • Transgenic models of tumour development. (microbiologyresearch.org)
  • For decades, cancer research for example is based on mice that have been implanted with tumour cells, which is followed by attempts to cure the artificially induced illness. (aerzte-gegen-tierversuche.de)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
  • These in vitro, and their expression in these human tumour virus. (who.int)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Transgenic expression of IEX-1 specifically in lymphocytes impaired apoptosis in activated T cells, extended a duration of an effector-phase of a specific immune response, and increased the accumulation of effector/memory-like T cells and the susceptibility to a lupus-like autoimmune disease. (nih.gov)
  • GemPharmatech exemplifies dedication in furnishing mouse models and support services for the advancement of disease mechanism research, pharmaceutical development, and translational studies. (gempharmatech.us)
  • Genetically modified mice are used extensively in research as models of human disease. (wikipedia.org)
  • The disease symptoms and potential drugs or treatments can be tested against these mouse models. (wikipedia.org)
  • Consequently, the onset of the disease was not observed in transgenic mice until 24 weeks of age. (elsevierpure.com)
  • It can be used to study a human disease in mice, for example. (mcgill.ca)
  • Crucial aspects of causes for disease in humans, such as nutrition, stress, or lack of exercise, are not taken into account in this kind of research. (aerzte-gegen-tierversuche.de)
  • the disease caused by the cognate cel s from human cord blood. (who.int)
  • No evidence of a transmssible spongiform encephalopathy were detected in mice with the human transgene at 14 to 17 months after inoculation. (usda.gov)
  • Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
  • We report here that Ptch +/- mice develop primordial follicular neoplasms resembling human trichoblastomas, and that exposure to ultraviolet radiation or ionizing radiation results in an increase in the number and size of these tumors and a shift in their histologic features so that they more closely resemble human basal cell carcinoma. (nature.com)
  • 1991. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. (cdc.gov)
  • NeoMab™ mice exhibit normal antibody class switching, somatic hypermutation, and B-cell development, with comparable levels of immunoglobulin in their serum to BALB/c background mice. (gempharmatech.us)
  • Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice. (upenn.edu)
  • These findings indicate that differences in the prion genetics between humans and elk may limit the risk of transmission. (usda.gov)
  • In vivo analysis of the dopaminergic system revealed abnormal dopamine neurotransmission in both hWT and G2019S transgenic mice evidenced by a decrease in extra-cellular dopamine levels, which was detected without pharmacological manipulation. (elsevierpure.com)
  • Analysis of human GRF complementary DNA 10,11 and genomic 12 clones indicates that the GRF peptides are first synthesized as a 107- or 108-amino-acid precursor protein. (northwestern.edu)
  • To facilitate the study of these neurons, transgenic mice were generated that express enhanced green fluorescent protein (EGFP) in subpopulations of GABAergic neurons. (jneurosci.org)
  • Immunopathological analysis revealed changes in localization and increased phosphorylation of microtubule binding protein tau in G2019S mice. (elsevierpure.com)
  • For this purpose, a transgenic mouse line expressing a green fluorecescent protein (GFP) under the control of the GAD65 (GAD: glutamate decarboxilase enzyme involved in the synthesis of GABA) promoter will be used. (europa.eu)
  • Here, we show that the protein level of ClpP is selectively decreased in αSyn-expressing cell culture and neurons derived from iPS cells of PD patient carrying αSyn A53T mutant, and in dopaminergic (DA) neurons of αSyn A53T mice and PD patient postmortem brains. (springer.com)
  • We previously identified the causative agent as a novel SARS-related coronavirus ( SARS-CoV-2 ) that uses human angiotensin-converting enzyme 2 (hACE2) as the entry receptor. (bvsalud.org)
  • Amyloid-beta Peptides Stimulate the Expression of the p75NTR / Neurotrophin Receptor in SHSY5Y Human Neuroblastoma Cells and AD Transgenic Mice. (univr.it)
  • Specifically, the level of the p75NTR receptor in the hippocampal membranes from 12-15 monthold AD-triple transgenic mice (3xTg-AD) harboring PS1_M146V, AbetaPP_Swe, and tau_P301L was nearly twice that in hippocampal membranes from age-matched wild-type mice. (univr.it)
  • Similarly, the level of p75NTR receptor in 7 month-old B6.Cg-Tg AD mice harboring PSEN1dE9 and AbetaPP_Swe was also increased above the level in the corresponding wild-type mice. (univr.it)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • 1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
  • 1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)
  • Second messenger signaling bypasses CGRP receptor blockade to provoke migraine attacks in humans. (medscape.com)
  • Relevant mouse models of human uveal melanoma still remain to be developed. (molvis.org)
  • Our results reaffirm the clinical relevance of transgenic mouse models for human diseases," says Professor Wood. (ucl.ac.uk)
  • Earlier studies using creatine with HD mouse models as well as smaller pilot clinical trials led by Drs. Hersch and Rosas demonstrated impressive results. (massgeneral.org)
  • Transgenic mouse models pro- fection. (who.int)
  • Precise physiological experiments showed that the nervous systems of the transgenic mice contained around twice the levels of naturally-produced opioids as unmodified mice from the same litter. (ucl.ac.uk)
  • This is due to the fact that, as proven by many scientific studies, the transferability of findings from animal experiments to humans is by no means assured. (aerzte-gegen-tierversuche.de)
  • Given the significant differences in organ function and metabolism between animals and humans, the results of such experiments do not accurately predict the toxicity for humans. (aerzte-gegen-tierversuche.de)
  • First transgenic experiments were carried out on mice. (freeonlineresearchpapers.com)
  • 100% sequence homology with Mouse, Rat, Canine, Equine and all other mammalian proteins examined. (novusbio.com)
  • Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. (microbiologyresearch.org)
  • The scientists were able to reproduce these findings in other mice. (mcgill.ca)
  • The findings were made possible by the use of 'transgenic' mice, meaning they were modified to carry genetic material from another organism - in this case, the mutation that prevents humans from feeling pain. (ucl.ac.uk)
  • Studying the mice showed us what was going on in the nervous system that led to painlessness and our findings were directly translatable to humans, as confirmed by the painless patient. (ucl.ac.uk)
  • Thus, high expression of mutant human α-synuclein resulted in a progressive motor and widespread CNS gliotic phenotype independent of dopaminergic dysfunction in the Tg5093 line. (umn.edu)
  • Choroidal melanoma is the most common primary malignant ocular tumor in human adults. (molvis.org)
  • This offers significant advantages for studying tumor pathogenesis and molecular mechanisms of oncogenesis caused by a single initiating oncogenic event introduced through the mouse germ line. (molvis.org)
  • This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. (iiarjournals.org)
  • The NeoMab™ mouse is developed on the widely used BALB/c genetic background, making it highly suitable for antibody discovery in the industry. (gempharmatech.us)
  • Antibodies obtained from NeoMab™ mice demonstrate an affinity of approximately 10 -10 to 10 -8 (as determined by SPR detection), which is comparable to or even higher than that of FDA-approved therapeutic antibody drugs. (gempharmatech.us)
  • Merus B.V. , a leader in developing best-in-class antibody therapeutics to treat cancer patients, today announced a series of pivotal events in its litigation with Regeneron Pharmaceuticals Inc. Previously, Regeneron sued Merus accusing it of infringing U.S. Patent No. 8,502,018 ('018 patent') directed to a particular method of making a genetically modified mouse, which Regeneron asserted was useful to produce therapeutic antibodies. (akampion.com)
  • Our results demonstrated that the Y-5A15 remarkably enhanced the Aβ epitope immunogenicity and elicited high antibody titers against Aβ in AD mice. (mdpi.com)
  • We recently described transgenic mice that express point-mutant human K18 (Ku, N.-O., S. Michie, R.G. Oshima, and M.B. Omary. (jci.org)
  • Here we show that mutant K18 expressing transgenic mice are highly susceptible to hepatotoxicity after acute administration of acetaminophen (400 mg/Kg) or chronic ingestion of griseofulvin (1.25% wt/wt of diet). (jci.org)
  • Our results indicate that hepatocyte intermediate filament disruption renders mice highly susceptible to hepatotoxicity, and raises the possibility that K18 mutations may predispose to drug hepatotoxicity. (jci.org)
  • In hippocampal area CA1, two previously uncharacterized subtypes of interneurons were identified using the GIN mice: stratum pyramidale interneurons with lacunosum-moleculare axon arborization (P-LM cells) and stratum radiatum interneurons with lacunosum-moleculare axon arborization (R-LM cells). (jneurosci.org)
  • Hippocampal neurogenesis which was impaired in GFAP-IL6 mice was rescued in young GFAP-IL6 mice with cerebral sgp130 production. (jneurosci.org)
  • However, the mice did not pass the transgene to their offspring, and the impact and applicability of this experiment were, therefore, limited. (wikipedia.org)
  • Transgene-encoded IL-6 mRNA levels were similar in the brain of GFAP-IL6 and GFAP-IL6/sgp130 mice. (jneurosci.org)
  • Indeed, several human diseases are characterized by attenuated repair responses and imbalances in the inflammatory response with increased number of infiltrating macrophages [ 3 - 5 ]. (hindawi.com)
  • Mice are genetically altered to replicate conditions like cancer, Alzheimer's, diabetes, and other human diseases. (aerzte-gegen-tierversuche.de)
  • There are two basic technical approaches to produce genetically modified mice. (wikipedia.org)
  • In one of the resulting transgenic lines, called GIN ( G FP-expressing I nhibitory N eurons), EGFP was found to be expressed in a subpopulation of somatostatin-containing GABAergic interneurons in the hippocampus and neocortex. (jneurosci.org)
  • Results: Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). (iiarjournals.org)
  • Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin. (nature.com)
  • When the scientists would neutralize klotho 's expression in mice, the animals would develop premature ageing. (mcgill.ca)
  • In both live and fixed brain preparations from these mice, detailed microanatomical features of EGFP-expressing interneurons were readily observed. (jneurosci.org)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • In 1981 the laboratories of Frank Ruddle from Yale University, Frank Costantini and Elizabeth Lacy from Oxford, and Ralph L. Brinster and Richard Palmiter in collaboration from the University of Pennsylvania and the University of Washington injected purified DNA into a single-cell mouse embryo utilizing techniques developed by Brinster in the 1960s and 1970s, showing transmission of the genetic material to subsequent generations for the first time. (wikipedia.org)
  • Organisms which have altered or foreign genetic material, are now being referred to as transgenic. (freeonlineresearchpapers.com)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • The new study, published in Nature Communications, reveals that mice and people who lack Nav1.7 also produce higher than normal levels of natural opioid peptides. (ucl.ac.uk)
  • A research team consisting of USU faculty members Mirella Meyer-Ficca, Ralph Meyer, Rakesh Kaundal, in the College of Agriculture and Applied Sciences , Clara Cho at the University of Guelph, and Kevin Welch from the USDA Poisonous Plant Research Laboratory on the USU campus, received the 5-year grant of $311,000 per year from the NIH to study how male mouse diets affect the health of their offspring. (usu.edu)
  • In the present study, we wanted to examine whether transgenic HD mice display altered sensitivity to excitotoxicity in the hypothalamus. (lu.se)
  • According to Meyer-Ficca, fortified flour has made pellagra rare, but niacin metabolism remains a hot topic in human health research. (usu.edu)
  • Normal laboratory mice tend to survive for a couple of years at least . (mcgill.ca)
  • Embryonic stem cells that recombine with the genomic DNA are selected for and they are then injected into the mice blastocysts. (wikipedia.org)
  • The immune system of NeoMab™ mice remains intact, with proportions of various immune cell subsets similar to those of the BALB/c mice. (gempharmatech.us)
  • However, the urinary excretion of uromodulin in transgenic mice did not decrease and LC-MS/MS analysis indicated it was of mouse origin. (elsevierpure.com)
  • Uromodulin accumulation was observed in the thick ascending limb cells in the kidney of transgenic mice. (elsevierpure.com)
  • In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)