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  • NSCs
  • In adult life, quiescent (non-cycling) and activated (cycling) NSCs coexist both in the VZ [ 4, 5 ] and SGZ [ 6, 7 ]. (iospress.com)
  • Delivery of constitutively active β-catenin yielded insights into mechanisms by which this key regulator modulates NSC function, indicating that this engineered AAV variant can be harnessed for preferential modulation of adult NSCs in the hippocampus. (biologists.org)
  • epithelium
  • By developing a novel quantitative approach for the analysis of somatic mitochondrial mutations that are accumulated over time, we demonstrate that the human upper airway epithelium is maintained by an equipotent basal progenitor cell population, in which the chance loss of cells due to lineage commitment is perfectly compensated by the duplication of neighbours, leading to "neutral drift" of the clone population. (elifesciences.org)
  • cellular
  • Recently, this cellular heterogeneity could also be demonstrated on the molecular level using single cell transcriptomics [ 10 ]. (iospress.com)
  • mouse
  • Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta. (nih.gov)
  • Thus, to examine the spatial generation of functional HSCs within the mouse embryo, we used the well-known HSC marker, Sca-1, and a transgenic approach with an Ly-6A (Sca-1) GFP marker gene. (nih.gov)
  • We made two triple-transgenic mouse strains: actinCreER;MADMGT/TG and Myh6CreERT2;MADMGT/TG. (ahajournals.org)
  • inflammation
  • These cells are the first to appear at sites of inflammation and infection, thus becoming the first line of defense against invading microorganisms. (jove.com)
  • Department of Cell Biology
  • He completed postdoctoral training at the Dana-Farber Cancer Institute and Harvard Medical School, was on the faculty in the Department of Cell Biology at Harvard Medical School for 12 years, and later at the Sanford-Burnham-Prebys Institute and Department of Bioengineering at the University of California, San Diego before relocating to Stanford in 2015. (stanford.edu)
  • distinct
  • However, TERT serves an additional function in stem cells, distinct from its role in telomere lengthening and we are actively studying this new role. (stanford.edu)
  • viability
  • Telomeres, the nucleotide repeats that cap the ends of eukaryotic chromosomes, serve critical roles in promoting cell viability and in maintaining chromosomal stability. (stanford.edu)
  • CTCF is essential for mammalian cell viability and is an important regulator of genome architecture. (genetics.org)
  • molecular
  • Since then, a number of new research lines have emerged whose common objective is the phenotypical and molecular characterization of brain stem cells. (indigo.ca)
  • Borrowing some concepts from the studies on cell-cell recognition and transcription factor networks, we will also touch upon the potential molecular mechanisms involved in the establishment of sibling-neuron circuits. (frontiersin.org)
  • We seek to understand in molecular detail how telomerase interacts with telomeres and adds telomere repeats in human cells. (stanford.edu)
  • radial glia
  • In the VZ, ventricle-contacting monociliated radial glia-like cells (RGLs) constantly produce olfactory bulb interneurons and their absence leads to olfactory bulb atrophy. (iospress.com)
  • Experiments
  • results reminiscent of recent experiments performed with human embryonic stem cells (hESC), a renewable source of cells that hold great promise as a potential therapeutic treatment for type 1 diabetes. (jove.com)
  • approaches
  • We are using iPS cell-based approaches to study the mechanisms at play in these diseases with the goal of reversing the life-threatening phenotypes in these patients. (stanford.edu)
  • methods
  • However, because neutrophils are short-lived cells, the study of transcriptionally regulated responses in these cells cannot be performed with conventional reporter gene methods since there are no efficient techniques for neutrophil transfection. (jove.com)
  • populations
  • This niche consists of a small pool of distinctly polarized stem cells that are demarcated by apical markers and flanked medially and laterally by two different populations of glia. (jneurosci.org)
  • receptor
  • When these retroviruses are pseudotyped with ASLV-A envelope glycoprotein that mediates infection specifically through the avian TVA receptor, they are capable of infecting only axolotl cells that have been made to express the receptor. (biologists.org)
  • We describe techniques to isolate pure neutrophils from human peripheral blood, stimulate these cells with anti-receptor antibodies, isolate and immunolabel nuclei, and analyze nuclei by flow cytometry. (jove.com)